GO:0004044
JSON
amidophosphoribosyltransferase activity
Molecular Function
Definition (GO:0004044 GONUTS page)
Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
5-phosphoribosyl-1-pyrophosphate amidotransferase activity | related |
glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity | related |
glutamine 5-phosphoribosylpyrophosphate amidotransferase activity | related |
phosphoribose pyrophosphate amidotransferase activity | related |
phosphoribosyl pyrophosphate amidotransferase activity | related |
glutamine phosphoribosylpyrophosphate amidotransferase activity | related |
glutamine phosphoribosyldiphosphate amidotransferase activity | related |
phosphoribosyldiphosphate 5-amidotransferase activity | related |
alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity | related |
5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016757 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A6KJI3 | 10116 | A6KJI3_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D6WQD5 | 7070 | D6WQD5_TRICA | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q6AYL7 | 10116 | Q6AYL7_RAT | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7JRM5 | 7227 | Q7JRM5_DROME | GO:0016757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.4.2.14 | |
InterPro | IPR005854 | Amidophosphoribosyltransferase |
KEGG_REACTION | R01072 | |
MetaCyc | PRPPAMIDOTRANS-RXN | |
RHEA | 14905 | |
Reactome | R-HSA-73815 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:58017 | 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) |
has_participant | CHEBI | CHEBI:58359 | L-glutamine zwitterion |
has_participant | CHEBI | CHEBI:58681 | 5-phospho-beta-D-ribosylaminium(1-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004044 based on ALL annotations
The top 100 of 225 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
amidophosphoribosyltransferase activity
|
4,580.22 | 100.00 | 42,561 | 42,561 |
purine nucleobase biosynthetic process
|
1,945.06 | 41.94 | 41,347 | 97,364 |
'de novo' IMP biosynthetic process
|
357.39 | 7.75 | 39,357 | 504,385 |
purine nucleotide biosynthetic process
|
252.77 | 5.51 | 41,245 | 747,372 |
iron-sulfur cluster binding
|
68.86 | 1.49 | 24,684 | 1,641,943 |
glycosyltransferase activity
|
62.35 | 1.36 | 42,505 | 3,122,630 |
magnesium ion binding
|
45.50 | 0.99 | 31,323 | 3,152,949 |
4 iron, 4 sulfur cluster binding
|
38.66 | 0.84 | 19,953 | 2,363,962 |
adenine metabolic process
|
2,611.76 | 0.48 | 203 | 356 |
'de novo' XMP biosynthetic process
|
643.63 | 0.20 | 86 | 612 |
Totals | 323785 | 69733073 |
No co-occurrence statistics for GO:0004044 based on MANUAL annotations
The top 40 of 40 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
amidophosphoribosyltransferase activity
|
7,176.66 | 100.00 | 180 | 180 |
purine nucleotide biosynthetic process
|
1,298.84 | 18.04 | 177 | 978 |
plastid stroma
|
683.49 | 1.01 | 2 | 21 |
purine nucleobase biosynthetic process
|
683.49 | 1.01 | 2 | 21 |
'de novo' XMP biosynthetic process
|
478.44 | 0.96 | 2 | 30 |
'de novo' IMP biosynthetic process
|
70.88 | 0.69 | 4 | 405 |
adenine metabolic process
|
717.67 | 0.53 | 1 | 10 |
glutathione hydrolase complex
|
377.72 | 0.51 | 1 | 19 |
GMP biosynthetic process
|
62.41 | 0.49 | 2 | 230 |
omega peptidase activity
|
231.51 | 0.48 | 1 | 31 |
Totals | 522 | 416349 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. |
2020-10-08 | Added | SYNONYM | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) |
2020-10-08 | Added | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5'-phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5-phosphororibosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | phosphoribosylpyrophosphate glutamyl amidotransferase activity |
2020-10-08 | Added | SYNONYM | glutamine 5-phosphoribosylpyrophosphate amidotransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | amidophosphoribosyltransferase activity |
2002-02-06 | Updated | TERM | amidophosphoribosyltransferase |
2001-04-03 | Updated | TERM | amidophosphoribosyltransferase |
2001-03-30 | Added | TERM | amidophosphoribosyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. |
2020-10-08 | Added | SYNONYM | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) |
2020-10-08 | Added | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5'-phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | 5-phosphororibosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | phosphoribosylpyrophosphate glutamyl amidotransferase activity |
2020-10-08 | Added | SYNONYM | glutamine 5-phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | phosphoribosyldiphosphate 5-amidotransferase activity |
2020-10-08 | Added | SYNONYM | glutamine phosphoribosyldiphosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | phosphoribosyl pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | phosphoribose pyrophosphate amidotransferase activity |
2020-10-08 | Added | SYNONYM | phosphoribosyldiphosphate 5-amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | 5'-phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | 5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) |
2020-10-08 | Deleted | SYNONYM | 5-phosphororibosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | glutamine 5-phosphoribosylpyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | glutamine phosphoribosyldiphosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | phosphoribose pyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | phosphoribosyl pyrophosphate amidotransferase activity |
2020-10-08 | Deleted | SYNONYM | phosphoribosylpyrophosphate glutamyl amidotransferase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. |
2007-11-08 | Added | SYNONYM | 5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | 5'-phosphoribosylpyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | phosphoribosylpyrophosphate glutamyl amidotransferase activity |
2007-11-08 | Added | SYNONYM | phosphoribosyl pyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) |
2007-11-08 | Added | SYNONYM | phosphoribose pyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | glutamine phosphoribosyldiphosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | glutamine 5-phosphoribosylpyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity |
2007-11-08 | Added | SYNONYM | 5-phosphororibosyl-1-pyrophosphate amidotransferase activity |
2007-09-06 | Added | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase activity |
2007-09-06 | Added | SYNONYM | phosphoribosyldiphosphate 5-amidotransferase activity |
2007-09-06 | Deleted | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase |
2007-08-09 | Added | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase |
2007-08-09 | Deleted | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase |
2005-01-17 | Added | SYNONYM | glutamine phosphoribosylpyrophosphate amidotransferase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016763 (pentosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R01072 |
2019-06-20 | Deleted | XREF | KEGG:R01072 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-73815 |
2019-04-01 | Added | XREF | Reactome:R-HSA-73815 |
2018-12-11 | Added | XREF | reactome:R-HSA-73815 |
2018-07-13 | Added | XREF | RHEA:14905 |
2018-07-13 | Deleted | XREF | RHEA:14908 |
2010-10-11 | Added | XREF | RHEA:14908 |
2010-10-11 | Added | XREF | KEGG:R01072 |
2003-10-27 | Added | XREF | MetaCyc:PRPPAMIDOTRANS-RXN |
2001-03-30 | Added | XREF | EC:2.4.2.14 |
Timestamp | Action | Category | Detail |
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