This term is obsolete.

GO:0004044 JSON

amidophosphoribosyltransferase activity

Molecular Function

Definition (GO:0004044 GONUTS page)

Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.

42,744 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
5-phosphoribosyl-1-pyrophosphate amidotransferase activity related
glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity related
glutamine 5-phosphoribosylpyrophosphate amidotransferase activity related
phosphoribose pyrophosphate amidotransferase activity related
phosphoribosyl pyrophosphate amidotransferase activity related
glutamine phosphoribosylpyrophosphate amidotransferase activity related
glutamine phosphoribosyldiphosphate amidotransferase activity related
phosphoribosyldiphosphate 5-amidotransferase activity related
alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity related
5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating) related

Ancestor Chart

Ancestor chart for GO:0004044
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016757 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A6KJI3 10116 A6KJI3_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D6WQD5 7070 D6WQD5_TRICA GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q6AYL7 10116 Q6AYL7_RAT GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7JRM5 7227 Q7JRM5_DROME GO:0016757 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 2.4.2.14
InterPro IPR005854 Amidophosphoribosyltransferase
KEGG_REACTION R01072
MetaCyc PRPPAMIDOTRANS-RXN
RHEA 14905
Reactome R-HSA-73815

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:58017 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
has_participant CHEBI CHEBI:58359 L-glutamine zwitterion
has_participant CHEBI CHEBI:58681 5-phospho-beta-D-ribosylaminium(1-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004044 based on ALL annotations
The top 100 of 225 co-occurring terms
Co-occurring Term PR S% #Together #Compared
amidophosphoribosyltransferase activity
4,580.22 100.00 42,561 42,561
purine nucleobase biosynthetic process
1,945.06 41.94 41,347 97,364
'de novo' IMP biosynthetic process
357.39 7.75 39,357 504,385
purine nucleotide biosynthetic process
252.77 5.51 41,245 747,372
iron-sulfur cluster binding
68.86 1.49 24,684 1,641,943
glycosyltransferase activity
62.35 1.36 42,505 3,122,630
magnesium ion binding
45.50 0.99 31,323 3,152,949
4 iron, 4 sulfur cluster binding
38.66 0.84 19,953 2,363,962
adenine metabolic process
2,611.76 0.48 203 356
'de novo' XMP biosynthetic process
643.63 0.20 86 612
Totals 323785 69733073
No co-occurrence statistics for GO:0004044 based on MANUAL annotations
The top 40 of 40 co-occurring terms
Co-occurring Term PR S% #Together #Compared
amidophosphoribosyltransferase activity
7,176.66 100.00 180 180
purine nucleotide biosynthetic process
1,298.84 18.04 177 978
plastid stroma
683.49 1.01 2 21
purine nucleobase biosynthetic process
683.49 1.01 2 21
'de novo' XMP biosynthetic process
478.44 0.96 2 30
'de novo' IMP biosynthetic process
70.88 0.69 4 405
adenine metabolic process
717.67 0.53 1 10
glutathione hydrolase complex
377.72 0.51 1 19
GMP biosynthetic process
62.41 0.49 2 230
omega peptidase activity
231.51 0.48 1 31
Totals 522 416349

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
2020-10-08 Added SYNONYM 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2020-10-08 Added SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM 5'-phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
2020-10-08 Added SYNONYM 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM phosphoribosylpyrophosphate glutamyl amidotransferase activity
2020-10-08 Added SYNONYM glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM amidophosphoribosyltransferase activity
2002-02-06 Updated TERM amidophosphoribosyltransferase
2001-04-03 Updated TERM amidophosphoribosyltransferase
2001-03-30 Added TERM amidophosphoribosyltransferase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
2020-10-08 Added SYNONYM 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2020-10-08 Added SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM 5'-phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
2020-10-08 Added SYNONYM 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM phosphoribosylpyrophosphate glutamyl amidotransferase activity
2020-10-08 Added SYNONYM glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM phosphoribosyldiphosphate 5-amidotransferase activity
2020-10-08 Added SYNONYM glutamine phosphoribosyldiphosphate amidotransferase activity
2020-10-08 Added SYNONYM alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM phosphoribosyl pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM phosphoribose pyrophosphate amidotransferase activity
2020-10-08 Added SYNONYM phosphoribosyldiphosphate 5-amidotransferase activity
2020-10-08 Deleted SYNONYM 5'-phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2020-10-08 Deleted SYNONYM 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM glutamine phosphoribosyldiphosphate amidotransferase activity
2020-10-08 Deleted SYNONYM glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
2020-10-08 Deleted SYNONYM phosphoribose pyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM phosphoribosyl pyrophosphate amidotransferase activity
2020-10-08 Deleted SYNONYM phosphoribosylpyrophosphate glutamyl amidotransferase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.
2007-11-08 Added SYNONYM 5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM 5'-phosphoribosylpyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM phosphoribosylpyrophosphate glutamyl amidotransferase activity
2007-11-08 Added SYNONYM phosphoribosyl pyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM 5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2007-11-08 Added SYNONYM phosphoribose pyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity
2007-11-08 Added SYNONYM glutamine phosphoribosyldiphosphate amidotransferase activity
2007-11-08 Added SYNONYM glutamine 5-phosphoribosylpyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity
2007-11-08 Added SYNONYM 5-phosphororibosyl-1-pyrophosphate amidotransferase activity
2007-09-06 Added SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase activity
2007-09-06 Added SYNONYM phosphoribosyldiphosphate 5-amidotransferase activity
2007-09-06 Deleted SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase
2007-08-09 Added SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase
2007-08-09 Deleted SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase
2005-01-17 Added SYNONYM glutamine phosphoribosylpyrophosphate amidotransferase
2002-11-27 Added DEFINITION Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016763 (pentosyltransferase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01072
2019-06-20 Deleted XREF KEGG:R01072
2019-04-01 Deleted XREF reactome:R-HSA-73815
2019-04-01 Added XREF Reactome:R-HSA-73815
2018-12-11 Added XREF reactome:R-HSA-73815
2018-07-13 Added XREF RHEA:14905
2018-07-13 Deleted XREF RHEA:14908
2010-10-11 Added XREF RHEA:14908
2010-10-11 Added XREF KEGG:R01072
2003-10-27 Added XREF MetaCyc:PRPPAMIDOTRANS-RXN
2001-03-30 Added XREF EC:2.4.2.14
Timestamp Action Category Detail
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