GO:0004045
JSON
aminoacyl-tRNA hydrolase activity
Molecular Function
Definition (GO:0004045 GONUTS page)
Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
Secondary IDs
GO:0019850, GO:0019851
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
aminoacyl-tRNA aminoacylhydrolase activity | related |
N-substituted aminoacyl transfer RNA hydrolase activity | related |
D-tyrosyl-tRNA hydrolase activity | narrow |
aminoacyl-transfer ribonucleate hydrolase activity | related |
aminoacyl-tRNA hydrolase reaction | exact |
peptidyl-tRNA hydrolase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q6DFZ6 | 7955 | NOT1B_DANRE | GO:0052689 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 21st April 2015. | IPR004963 |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P33438 | 7227 | GLT_DROME | GO:0052689 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:2108864 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.1.29 | |
InterPro | IPR001328 | Peptidyl-tRNA hydrolase |
InterPro | IPR002833 | Peptidyl-tRNA hydrolase, PTH2 |
InterPro | IPR018171 | Peptidyl-tRNA hydrolase, conserved site |
InterPro | IPR034759 | Peptidyl-tRNA hydrolase, archaea |
InterPro | IPR036416 | Peptidyl-tRNA hydrolase superfamily |
MetaCyc | AMINOCYL-TRNA-HYDROLASE-RXN | |
RHEA | 54448 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:59874 | N-acyl-L-alpha-amino acid anion |
has_participant | CHEBI | CHEBI:138191 | 3'-end 3'-(N-acyl-L-alpha-aminoacyl)adenylyl(1-) residue |
has_participant | CHEBI | CHEBI:78442 | AMP 3'-end(1-) residue |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0006439 | obsolete aminoacyl-tRNA hydrolase reaction | replaced_by GO:0004045 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004045 based on ALL annotations
The top 100 of 552 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aminoacyl-tRNA hydrolase activity
|
2,336.28 | 100.00 | 83,440 | 83,440 |
translation release factor activity
|
908.72 | 18.64 | 21,990 | 56,535 |
rescue of stalled ribosome
|
723.51 | 15.10 | 18,993 | 61,330 |
translational termination
|
247.43 | 8.17 | 21,999 | 207,717 |
mitochondrial translational termination
|
1,410.03 | 3.55 | 3,037 | 5,032 |
ribosome binding
|
88.85 | 3.36 | 18,779 | 493,807 |
translation release factor activity, codon nonspecific
|
253.91 | 2.97 | 3,276 | 30,143 |
mitochondrial large ribosomal subunit
|
48.52 | 1.34 | 3,038 | 146,273 |
positive regulation of anoikis
|
1,682.79 | 0.96 | 806 | 1,119 |
negative regulation of anoikis
|
950.55 | 0.95 | 806 | 1,981 |
Totals | 348975 | 127426656 |
No co-occurrence statistics for GO:0004045 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aminoacyl-tRNA hydrolase activity
|
2,796.10 | 100.00 | 462 | 462 |
translation release factor activity, codon nonspecific
|
1,755.69 | 10.93 | 54 | 86 |
mitochondrial translational termination
|
1,509.89 | 10.63 | 54 | 100 |
positive regulation of anoikis
|
1,586.98 | 4.39 | 21 | 37 |
negative regulation of anoikis
|
876.39 | 4.13 | 21 | 67 |
rescue of stalled ribosome
|
82.64 | 1.92 | 24 | 812 |
mitochondrial large ribosomal subunit
|
51.80 | 1.62 | 53 | 2,861 |
translation release factor activity
|
66.57 | 0.64 | 4 | 168 |
cytoplasmic translational termination
|
40.72 | 0.45 | 3 | 206 |
translation release factor activity, codon specific
|
40.52 | 0.45 | 3 | 207 |
Totals | 1154 | 977570 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | aminoacyl-transfer ribonucleate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-substituted aminoacyl transfer RNA hydrolase activity |
2020-10-08 | Deleted | SYNONYM | aminoacyl-transfer ribonucleate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | aminoacyl-tRNA aminoacylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | peptidyl-tRNA hydrolase activity |
2020-10-08 | Added | SYNONYM | N-substituted aminoacyl transfer RNA hydrolase activity |
2020-10-08 | Added | SYNONYM | aminoacyl-tRNA aminoacylhydrolase activity |
2020-10-08 | Added | SYNONYM | peptidyl-tRNA hydrolase activity |
2020-06-22 | Added | XREF | RHEA:54448 |
2017-09-19 | Added | RELATION | is a GO:0140101 (catalytic activity, acting on a tRNA) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | aminoacyl-tRNA hydrolase activity |
2002-02-06 | Updated | TERM | aminoacyl-tRNA hydrolase |
2001-04-03 | Updated | TERM | aminoacyl-tRNA hydrolase |
2001-03-30 | Added | TERM | aminoacyl-tRNA hydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | aminoacyl-transfer ribonucleate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | N-substituted aminoacyl transfer RNA hydrolase activity |
2020-10-08 | Deleted | SYNONYM | aminoacyl-transfer ribonucleate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | aminoacyl-tRNA aminoacylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | peptidyl-tRNA hydrolase activity |
2020-10-08 | Added | SYNONYM | N-substituted aminoacyl transfer RNA hydrolase activity |
2020-10-08 | Added | SYNONYM | aminoacyl-tRNA aminoacylhydrolase activity |
2020-10-08 | Added | SYNONYM | peptidyl-tRNA hydrolase activity |
2009-04-29 | Added | SYNONYM | D-tyrosyl-tRNA hydrolase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
2007-11-08 | Added | SYNONYM | N-substituted aminoacyl transfer RNA hydrolase activity |
2007-11-08 | Added | SYNONYM | aminoacyl-transfer ribonucleate hydrolase activity |
2007-11-08 | Added | SYNONYM | aminoacyl-tRNA aminoacylhydrolase activity |
2007-09-06 | Deleted | SYNONYM | peptidyl-tRNA hydrolase |
2007-09-06 | Added | SYNONYM | peptidyl-tRNA hydrolase activity |
2007-08-09 | Added | SYNONYM | peptidyl-tRNA hydrolase |
2007-08-09 | Added | SYNONYM | aminoacyl-tRNA hydrolase reaction |
2007-08-09 | Deleted | SYNONYM | peptidyl-tRNA hydrolase |
2007-08-09 | Deleted | SYNONYM | aminoacyl-tRNA hydrolase reaction |
2005-08-10 | Added | SYNONYM | aminoacyl-tRNA hydrolase reaction |
2004-04-19 | Added | SYNONYM | peptidyl-tRNA hydrolase |
2004-04-16 | Deleted | SYNONYM | peptidyl-tRNA hydrolase |
2003-10-27 | Added | SYNONYM | peptidyl-tRNA hydrolase |
2003-08-21 | Deleted | SYNONYM | peptidyl-tRNA hydrolase |
2003-03-26 | Updated | DEFINITION | Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. |
2002-11-27 | Updated | DEFINITION | Catalysis of the hydrolysis of the peptidyl-tRNA released from the ribosomal P-site upon termination of translation. Considered part of the large ribosomal subunit. |
2001-12-10 | Added | SYNONYM | peptidyl-tRNA hydrolase |
2001-08-06 | Added | DEFINITION | enzyme catalyzing the hydrolysis of the peptidyl-tRNA released from the ribosomal P-site upon termination of translation. Considered part of the large ribosomal subunit. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Added | RELATION | is a GO:0140101 (catalytic activity, acting on a tRNA) |
2011-05-03 | Added | RELATION | is a GO:0052689 (carboxylic ester hydrolase activity) |
2011-05-03 | Deleted | RELATION | is a GO:0004091 (carboxylesterase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004091 (carboxylesterase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:54448 |
2003-10-27 | Added | XREF | MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN |
2001-03-30 | Added | XREF | EC:3.1.1.29 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-04-29 | Added | SECONDARY | GO:0019851 (D-tyrosyl-tRNA hydrolase activity) |
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