This term is obsolete.

GO:0004045 JSON

aminoacyl-tRNA hydrolase activity

Molecular Function

Definition (GO:0004045 GONUTS page)

Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

Secondary IDs

GO:0019850, GO:0019851

83,873 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
aminoacyl-tRNA aminoacylhydrolase activity related
N-substituted aminoacyl transfer RNA hydrolase activity related
D-tyrosyl-tRNA hydrolase activity narrow
aminoacyl-transfer ribonucleate hydrolase activity related
aminoacyl-tRNA hydrolase reaction exact
peptidyl-tRNA hydrolase activity related

Ancestor Chart

Ancestor chart for GO:0004045
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q6DFZ6 7955 NOT1B_DANRE GO:0052689 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 21st April 2015. IPR004963
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P33438 7227 GLT_DROME GO:0052689 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:2108864
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 3.1.1.29
InterPro IPR001328 Peptidyl-tRNA hydrolase
InterPro IPR002833 Peptidyl-tRNA hydrolase, PTH2
InterPro IPR018171 Peptidyl-tRNA hydrolase, conserved site
InterPro IPR034759 Peptidyl-tRNA hydrolase, archaea
InterPro IPR036416 Peptidyl-tRNA hydrolase superfamily
MetaCyc AMINOCYL-TRNA-HYDROLASE-RXN
RHEA 54448

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:59874 N-acyl-L-alpha-amino acid anion
has_participant CHEBI CHEBI:138191 3'-end 3'-(N-acyl-L-alpha-aminoacyl)adenylyl(1-) residue
has_participant CHEBI CHEBI:78442 AMP 3'-end(1-) residue
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006439 obsolete aminoacyl-tRNA hydrolase reaction replaced_by GO:0004045

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004045 based on ALL annotations
The top 100 of 552 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aminoacyl-tRNA hydrolase activity
2,336.28 100.00 83,440 83,440
translation release factor activity
908.72 18.64 21,990 56,535
rescue of stalled ribosome
723.51 15.10 18,993 61,330
translational termination
247.43 8.17 21,999 207,717
mitochondrial translational termination
1,410.03 3.55 3,037 5,032
ribosome binding
88.85 3.36 18,779 493,807
translation release factor activity, codon nonspecific
253.91 2.97 3,276 30,143
mitochondrial large ribosomal subunit
48.52 1.34 3,038 146,273
positive regulation of anoikis
1,682.79 0.96 806 1,119
negative regulation of anoikis
950.55 0.95 806 1,981
Totals 348975 127426656
No co-occurrence statistics for GO:0004045 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aminoacyl-tRNA hydrolase activity
2,796.10 100.00 462 462
translation release factor activity, codon nonspecific
1,755.69 10.93 54 86
mitochondrial translational termination
1,509.89 10.63 54 100
positive regulation of anoikis
1,586.98 4.39 21 37
negative regulation of anoikis
876.39 4.13 21 67
rescue of stalled ribosome
82.64 1.92 24 812
mitochondrial large ribosomal subunit
51.80 1.62 53 2,861
translation release factor activity
66.57 0.64 4 168
cytoplasmic translational termination
40.72 0.45 3 206
translation release factor activity, codon specific
40.52 0.45 3 207
Totals 1154 977570

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM aminoacyl-transfer ribonucleate hydrolase activity
2020-10-08 Deleted SYNONYM N-substituted aminoacyl transfer RNA hydrolase activity
2020-10-08 Deleted SYNONYM aminoacyl-transfer ribonucleate hydrolase activity
2020-10-08 Deleted SYNONYM aminoacyl-tRNA aminoacylhydrolase activity
2020-10-08 Deleted SYNONYM peptidyl-tRNA hydrolase activity
2020-10-08 Added SYNONYM N-substituted aminoacyl transfer RNA hydrolase activity
2020-10-08 Added SYNONYM aminoacyl-tRNA aminoacylhydrolase activity
2020-10-08 Added SYNONYM peptidyl-tRNA hydrolase activity
2020-06-22 Added XREF RHEA:54448
2017-09-19 Added RELATION is a GO:0140101 (catalytic activity, acting on a tRNA)
Timestamp Action Category Detail
2003-03-19 Updated TERM aminoacyl-tRNA hydrolase activity
2002-02-06 Updated TERM aminoacyl-tRNA hydrolase
2001-04-03 Updated TERM aminoacyl-tRNA hydrolase
2001-03-30 Added TERM aminoacyl-tRNA hydrolase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM aminoacyl-transfer ribonucleate hydrolase activity
2020-10-08 Deleted SYNONYM N-substituted aminoacyl transfer RNA hydrolase activity
2020-10-08 Deleted SYNONYM aminoacyl-transfer ribonucleate hydrolase activity
2020-10-08 Deleted SYNONYM aminoacyl-tRNA aminoacylhydrolase activity
2020-10-08 Deleted SYNONYM peptidyl-tRNA hydrolase activity
2020-10-08 Added SYNONYM N-substituted aminoacyl transfer RNA hydrolase activity
2020-10-08 Added SYNONYM aminoacyl-tRNA aminoacylhydrolase activity
2020-10-08 Added SYNONYM peptidyl-tRNA hydrolase activity
2009-04-29 Added SYNONYM D-tyrosyl-tRNA hydrolase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
2007-11-08 Added SYNONYM N-substituted aminoacyl transfer RNA hydrolase activity
2007-11-08 Added SYNONYM aminoacyl-transfer ribonucleate hydrolase activity
2007-11-08 Added SYNONYM aminoacyl-tRNA aminoacylhydrolase activity
2007-09-06 Deleted SYNONYM peptidyl-tRNA hydrolase
2007-09-06 Added SYNONYM peptidyl-tRNA hydrolase activity
2007-08-09 Added SYNONYM peptidyl-tRNA hydrolase
2007-08-09 Added SYNONYM aminoacyl-tRNA hydrolase reaction
2007-08-09 Deleted SYNONYM peptidyl-tRNA hydrolase
2007-08-09 Deleted SYNONYM aminoacyl-tRNA hydrolase reaction
2005-08-10 Added SYNONYM aminoacyl-tRNA hydrolase reaction
2004-04-19 Added SYNONYM peptidyl-tRNA hydrolase
2004-04-16 Deleted SYNONYM peptidyl-tRNA hydrolase
2003-10-27 Added SYNONYM peptidyl-tRNA hydrolase
2003-08-21 Deleted SYNONYM peptidyl-tRNA hydrolase
2003-03-26 Updated DEFINITION Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of the peptidyl-tRNA released from the ribosomal P-site upon termination of translation. Considered part of the large ribosomal subunit.
2001-12-10 Added SYNONYM peptidyl-tRNA hydrolase
2001-08-06 Added DEFINITION enzyme catalyzing the hydrolysis of the peptidyl-tRNA released from the ribosomal P-site upon termination of translation. Considered part of the large ribosomal subunit.
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140101 (catalytic activity, acting on a tRNA)
2011-05-03 Added RELATION is a GO:0052689 (carboxylic ester hydrolase activity)
2011-05-03 Deleted RELATION is a GO:0004091 (carboxylesterase activity)
2008-04-01 Updated RELATION is a GO:0004091 (carboxylesterase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:54448
2003-10-27 Added XREF MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
2001-03-30 Added XREF EC:3.1.1.29
Timestamp Action Category Detail
2009-04-29 Added SECONDARY GO:0019851 (D-tyrosyl-tRNA hydrolase activity)
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