This term is obsolete.

GO:0004067 JSON

asparaginase activity

Molecular Function

Definition (GO:0004067 GONUTS page)

Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.

43,359 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-asparaginase activity related
alpha-asparaginase activity related
colaspase activity related
leunase activity related
L-asparagine amidohydrolase activity related
asparaginase II related
crasnitin related
elspar related

Ancestor Chart

Ancestor chart for GO:0004067
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.5.1.1
InterPro IPR004550 L-asparaginase, type II
InterPro IPR006033 Type I L-asparaginase family
InterPro IPR033844 Asparaginase-like 1, metazoa
MetaCyc ASPARAGHYD-RXN
RHEA 21016
Reactome R-HSA-6797627

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58048 L-asparagine zwitterion
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:29991 L-aspartate(1-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004067 based on ALL annotations
The top 100 of 280 co-occurring terms
Co-occurring Term PR S% #Together #Compared
asparaginase activity
4,514.04 100.00 43,185 43,185
asparagine metabolic process
3,375.97 33.21 16,152 21,597
aspartate family amino acid metabolic process
4,487.42 8.58 3,709 3,731
asparagine catabolic process via L-aspartate
3,433.69 3.23 1,408 1,851
beta-aspartyl-peptidase activity
1,149.72 3.16 1,504 5,905
amino acid metabolic process
133.94 2.83 16,019 539,854
asparagine catabolic process
4,510.11 2.66 1,148 1,149
regulation of translational fidelity
150.37 2.39 3,357 100,776
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
89.85 1.51 2,519 126,552
glutamin-(asparagin-)ase activity
4,472.82 0.50 217 219
Totals 129717 103041973
No co-occurrence statistics for GO:0004067 based on MANUAL annotations
The top 31 of 31 co-occurring terms
Co-occurring Term PR S% #Together #Compared
asparaginase activity
4,749.26 100.00 272 272
beta-aspartyl-peptidase activity
4,695.29 63.50 174 176
asparagine catabolic process via L-aspartate
4,643.72 16.12 44 45
asparagine catabolic process
4,573.36 9.52 26 27
periplasmic space
663.30 5.87 25 179
cell wall-bounded periplasmic space
1,266.47 1.41 4 15
photoreceptor inner segment
86.58 1.08 7 384
asparagine metabolic process
92.52 0.71 3 154
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
94.04 0.54 2 101
aspartate family amino acid metabolic process
2,374.63 0.37 1 2
Totals 778 750614

Change Log

Timestamp Action Category Detail
2024-09-02 Added RELATION is a GO:0004040 (amidase activity)
2024-09-02 Deleted RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2020-10-08 Deleted SYNONYM leunase activity
2020-10-08 Deleted SYNONYM L-asparagine amidohydrolase activity
2020-10-08 Added SYNONYM leunase activity
2020-10-08 Deleted SYNONYM alpha-asparaginase activity
2020-10-08 Deleted SYNONYM L-asparaginase activity
2020-10-08 Deleted SYNONYM colaspase activity
2020-10-08 Added SYNONYM alpha-asparaginase activity
2020-10-08 Added SYNONYM L-asparaginase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM asparaginase activity
2002-02-06 Updated TERM asparaginase
2001-04-03 Updated TERM asparaginase
2001-03-30 Added TERM asparaginase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM leunase activity
2020-10-08 Deleted SYNONYM L-asparagine amidohydrolase activity
2020-10-08 Added SYNONYM leunase activity
2020-10-08 Deleted SYNONYM alpha-asparaginase activity
2020-10-08 Deleted SYNONYM L-asparaginase activity
2020-10-08 Deleted SYNONYM colaspase activity
2020-10-08 Added SYNONYM alpha-asparaginase activity
2020-10-08 Added SYNONYM L-asparaginase activity
2020-10-08 Added SYNONYM L-asparagine amidohydrolase activity
2020-10-08 Added SYNONYM colaspase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
2007-11-08 Added SYNONYM asparaginase II
2007-11-08 Added SYNONYM colaspase activity
2007-11-08 Added SYNONYM crasnitin
2007-11-08 Added SYNONYM elspar
2007-11-08 Added SYNONYM leunase activity
2007-11-08 Added SYNONYM alpha-asparaginase activity
2007-09-06 Added SYNONYM L-asparagine amidohydrolase activity
2007-09-06 Added SYNONYM L-asparaginase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-asparagine + H2O = L-aspartate + ammonia.
Timestamp Action Category Detail
2024-09-02 Added RELATION is a GO:0004040 (amidase activity)
2024-09-02 Deleted RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
2008-04-01 Updated RELATION is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-6797627
2019-04-01 Deleted XREF reactome:R-HSA-6797627
2018-12-11 Added XREF reactome:R-HSA-6797627
2018-07-13 Added XREF RHEA:21016
2018-07-13 Deleted XREF RHEA:21019
2011-09-16 Added XREF RHEA:21019
2003-10-27 Added XREF MetaCyc:ASPARAGHYD-RXN
2001-03-30 Added XREF EC:3.5.1.1
Timestamp Action Category Detail
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