GO:0004067
JSON
asparaginase activity
Molecular Function
Definition (GO:0004067 GONUTS page)
Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-asparaginase activity | related |
alpha-asparaginase activity | related |
colaspase activity | related |
leunase activity | related |
L-asparagine amidohydrolase activity | related |
asparaginase II | related |
crasnitin | related |
elspar | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.1.1 | |
InterPro | IPR004550 | L-asparaginase, type II |
InterPro | IPR006033 | Type I L-asparaginase family |
InterPro | IPR033844 | Asparaginase-like 1, metazoa |
MetaCyc | ASPARAGHYD-RXN | |
RHEA | 21016 | |
Reactome | R-HSA-6797627 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58048 | L-asparagine zwitterion |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:28938 | ammonium |
has_participant | CHEBI | CHEBI:29991 | L-aspartate(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004067 based on ALL annotations
The top 100 of 280 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
asparaginase activity
|
4,514.04 | 100.00 | 43,185 | 43,185 |
asparagine metabolic process
|
3,375.97 | 33.21 | 16,152 | 21,597 |
aspartate family amino acid metabolic process
|
4,487.42 | 8.58 | 3,709 | 3,731 |
asparagine catabolic process via L-aspartate
|
3,433.69 | 3.23 | 1,408 | 1,851 |
beta-aspartyl-peptidase activity
|
1,149.72 | 3.16 | 1,504 | 5,905 |
amino acid metabolic process
|
133.94 | 2.83 | 16,019 | 539,854 |
asparagine catabolic process
|
4,510.11 | 2.66 | 1,148 | 1,149 |
regulation of translational fidelity
|
150.37 | 2.39 | 3,357 | 100,776 |
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
|
89.85 | 1.51 | 2,519 | 126,552 |
glutamin-(asparagin-)ase activity
|
4,472.82 | 0.50 | 217 | 219 |
Totals | 129717 | 103041973 |
No co-occurrence statistics for GO:0004067 based on MANUAL annotations
The top 31 of 31 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
asparaginase activity
|
4,749.26 | 100.00 | 272 | 272 |
beta-aspartyl-peptidase activity
|
4,695.29 | 63.50 | 174 | 176 |
asparagine catabolic process via L-aspartate
|
4,643.72 | 16.12 | 44 | 45 |
asparagine catabolic process
|
4,573.36 | 9.52 | 26 | 27 |
periplasmic space
|
663.30 | 5.87 | 25 | 179 |
cell wall-bounded periplasmic space
|
1,266.47 | 1.41 | 4 | 15 |
photoreceptor inner segment
|
86.58 | 1.08 | 7 | 384 |
asparagine metabolic process
|
92.52 | 0.71 | 3 | 154 |
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
|
94.04 | 0.54 | 2 | 101 |
aspartate family amino acid metabolic process
|
2,374.63 | 0.37 | 1 | 2 |
Totals | 778 | 750614 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-02 | Added | RELATION | is a GO:0004040 (amidase activity) |
2024-09-02 | Deleted | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2020-10-08 | Deleted | SYNONYM | leunase activity |
2020-10-08 | Deleted | SYNONYM | L-asparagine amidohydrolase activity |
2020-10-08 | Added | SYNONYM | leunase activity |
2020-10-08 | Deleted | SYNONYM | alpha-asparaginase activity |
2020-10-08 | Deleted | SYNONYM | L-asparaginase activity |
2020-10-08 | Deleted | SYNONYM | colaspase activity |
2020-10-08 | Added | SYNONYM | alpha-asparaginase activity |
2020-10-08 | Added | SYNONYM | L-asparaginase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | asparaginase activity |
2002-02-06 | Updated | TERM | asparaginase |
2001-04-03 | Updated | TERM | asparaginase |
2001-03-30 | Added | TERM | asparaginase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | leunase activity |
2020-10-08 | Deleted | SYNONYM | L-asparagine amidohydrolase activity |
2020-10-08 | Added | SYNONYM | leunase activity |
2020-10-08 | Deleted | SYNONYM | alpha-asparaginase activity |
2020-10-08 | Deleted | SYNONYM | L-asparaginase activity |
2020-10-08 | Deleted | SYNONYM | colaspase activity |
2020-10-08 | Added | SYNONYM | alpha-asparaginase activity |
2020-10-08 | Added | SYNONYM | L-asparaginase activity |
2020-10-08 | Added | SYNONYM | L-asparagine amidohydrolase activity |
2020-10-08 | Added | SYNONYM | colaspase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. |
2007-11-08 | Added | SYNONYM | asparaginase II |
2007-11-08 | Added | SYNONYM | colaspase activity |
2007-11-08 | Added | SYNONYM | crasnitin |
2007-11-08 | Added | SYNONYM | elspar |
2007-11-08 | Added | SYNONYM | leunase activity |
2007-11-08 | Added | SYNONYM | alpha-asparaginase activity |
2007-09-06 | Added | SYNONYM | L-asparagine amidohydrolase activity |
2007-09-06 | Added | SYNONYM | L-asparaginase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + ammonia. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-02 | Added | RELATION | is a GO:0004040 (amidase activity) |
2024-09-02 | Deleted | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
2008-04-01 | Updated | RELATION | is a GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-6797627 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6797627 |
2018-12-11 | Added | XREF | reactome:R-HSA-6797627 |
2018-07-13 | Added | XREF | RHEA:21016 |
2018-07-13 | Deleted | XREF | RHEA:21019 |
2011-09-16 | Added | XREF | RHEA:21019 |
2003-10-27 | Added | XREF | MetaCyc:ASPARAGHYD-RXN |
2001-03-30 | Added | XREF | EC:3.5.1.1 |
Timestamp | Action | Category | Detail |
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