GO:0004070
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aspartate carbamoyltransferase activity
Molecular Function
Definition (GO:0004070 GONUTS page)
Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
aspartic acid transcarbamoylase activity | related |
carbamoyl-phosphate:L-aspartate carbamoyltransferase activity | related |
L-aspartate transcarbamoylase activity | related |
carbamoylaspartotranskinase activity | related |
aspartic carbamyltransferase activity | related |
carbamylaspartotranskinase activity | related |
aspartate transcarbamoylase activity | related |
aspartate transcarbamylase activity | related |
aspartate carbamyltransferase activity | related |
L-aspartate transcarbamylase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004070
Child Term | Relationship to GO:0004070 |
---|---|
aspartate carbamoyltransferase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.3.2 | |
InterPro | IPR002082 | Aspartate carbamoyltransferase |
KEGG_REACTION | R01397 | |
MetaCyc | ASPCARBTRANS-RXN | |
RHEA | 20013 | |
Reactome | R-HSA-73573 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:32814 | N-carbamoyl-L-aspartate(2-) |
has_participant | CHEBI | CHEBI:29991 | L-aspartate(1-) |
has_participant | CHEBI | CHEBI:58228 | carbamoyl phosphate(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004070 based on ALL annotations
The top 100 of 260 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aspartate carbamoyltransferase activity
|
2,756.64 | 100.00 | 70,716 | 70,716 |
amino acid binding
|
1,069.65 | 32.02 | 45,732 | 117,858 |
'de novo' pyrimidine nucleobase biosynthetic process
|
704.03 | 25.40 | 69,219 | 271,028 |
dihydroorotase activity
|
913.26 | 21.14 | 26,082 | 78,728 |
citrulline biosynthetic process
|
901.21 | 20.72 | 25,546 | 78,141 |
UTP biosynthetic process
|
901.08 | 20.71 | 25,542 | 78,140 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
|
605.56 | 16.46 | 28,039 | 127,639 |
'de novo' UMP biosynthetic process
|
408.67 | 13.57 | 43,588 | 294,019 |
pyrimidine nucleotide biosynthetic process
|
310.59 | 10.89 | 54,044 | 479,672 |
amino acid metabolic process
|
219.33 | 7.57 | 42,953 | 539,854 |
Totals | 684799 | 115983537 |
No co-occurrence statistics for GO:0004070 based on MANUAL annotations
The top 67 of 67 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aspartate carbamoyltransferase activity
|
11,743.63 | 100.00 | 110 | 110 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
|
3,636.52 | 30.88 | 109 | 352 |
glutamine metabolic process
|
2,824.75 | 23.95 | 108 | 449 |
dihydroorotase activity
|
4,173.36 | 22.87 | 43 | 121 |
'de novo' pyrimidine nucleobase biosynthetic process
|
1,694.35 | 12.78 | 58 | 402 |
'de novo' UMP biosynthetic process
|
6,151.42 | 9.17 | 11 | 21 |
UTP biosynthetic process
|
6,217.21 | 7.63 | 9 | 17 |
response to cortisol
|
2,856.56 | 6.52 | 9 | 37 |
response to amine
|
2,577.87 | 6.34 | 9 | 41 |
response to caffeine
|
1,601.40 | 5.39 | 9 | 66 |
Totals | 932 | 670103 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. |
2020-10-08 | Deleted | SYNONYM | L-aspartate transcarbamylase activity |
2020-10-08 | Deleted | SYNONYM | carbamylaspartotranskinase activity |
2020-10-08 | Deleted | SYNONYM | L-aspartate transcarbamoylase activity |
2020-10-08 | Deleted | SYNONYM | aspartate transcarbamoylase activity |
2020-10-08 | Deleted | SYNONYM | aspartate carbamyltransferase activity |
2020-10-08 | Added | SYNONYM | aspartic transcarbamylase activity |
2020-10-08 | Added | SYNONYM | carbamoyl-phosphate:L-aspartate carbamoyltransferase activity |
2020-10-08 | Added | SYNONYM | aspartic carbamyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | aspartate carbamoyltransferase activity |
2002-02-06 | Updated | TERM | aspartate carbamoyltransferase |
2001-04-03 | Updated | TERM | aspartate carbamoyltransferase |
2001-03-30 | Added | TERM | aspartate carbamoyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. |
2020-10-08 | Deleted | SYNONYM | L-aspartate transcarbamylase activity |
2020-10-08 | Deleted | SYNONYM | carbamylaspartotranskinase activity |
2020-10-08 | Deleted | SYNONYM | L-aspartate transcarbamoylase activity |
2020-10-08 | Deleted | SYNONYM | aspartate transcarbamoylase activity |
2020-10-08 | Deleted | SYNONYM | aspartate carbamyltransferase activity |
2020-10-08 | Added | SYNONYM | aspartic transcarbamylase activity |
2020-10-08 | Added | SYNONYM | carbamoyl-phosphate:L-aspartate carbamoyltransferase activity |
2020-10-08 | Added | SYNONYM | aspartic carbamyltransferase activity |
2020-10-08 | Added | SYNONYM | aspartate transcarbamoylase activity |
2020-10-08 | Added | SYNONYM | carbamoylaspartotranskinase activity |
2020-10-08 | Added | SYNONYM | aspartic acid transcarbamoylase activity |
2020-10-08 | Deleted | SYNONYM | aspartate transcarbamylase activity |
2020-10-08 | Deleted | SYNONYM | ATCase activity |
2020-10-08 | Added | SYNONYM | L-aspartate transcarbamylase activity |
2020-10-08 | Added | SYNONYM | carbamylaspartotranskinase activity |
2020-10-08 | Added | SYNONYM | aspartate carbamyltransferase activity |
2020-10-08 | Deleted | SYNONYM | carbamoylaspartotranskinase activity |
2020-10-08 | Deleted | SYNONYM | carbamoyl-phosphate:L-aspartate carbamoyltransferase activity |
2020-10-08 | Deleted | SYNONYM | aspartic transcarbamylase activity |
2020-10-08 | Deleted | SYNONYM | aspartic carbamyltransferase activity |
2020-10-08 | Deleted | SYNONYM | aspartic acid transcarbamoylase activity |
2020-10-08 | Added | SYNONYM | L-aspartate transcarbamoylase activity |
2020-10-08 | Added | SYNONYM | ATCase activity |
2020-10-08 | Added | SYNONYM | aspartate transcarbamylase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. |
2007-11-08 | Added | SYNONYM | aspartate transcarbamoylase activity |
2007-11-08 | Added | SYNONYM | aspartate carbamyltransferase activity |
2007-11-08 | Added | SYNONYM | carbamoyl-phosphate:L-aspartate carbamoyltransferase activity |
2007-11-08 | Added | SYNONYM | L-aspartate transcarbamoylase activity |
2007-11-08 | Added | SYNONYM | carbamoylaspartotranskinase activity |
2007-11-08 | Added | SYNONYM | aspartic acid transcarbamoylase activity |
2007-11-08 | Added | SYNONYM | aspartic carbamyltransferase activity |
2007-11-08 | Added | SYNONYM | aspartic transcarbamylase activity |
2007-11-08 | Added | SYNONYM | L-aspartate transcarbamylase activity |
2007-09-06 | Added | SYNONYM | carbamylaspartotranskinase activity |
2007-09-06 | Added | SYNONYM | aspartate transcarbamylase activity |
2007-09-06 | Added | SYNONYM | ATCase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016743 (carboxyl- or carbamoyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R01397 |
2019-06-20 | Added | XREF | KEGG_REACTION:R01397 |
2019-04-01 | Added | XREF | Reactome:R-HSA-73573 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-73573 |
2018-12-11 | Added | XREF | reactome:R-HSA-73573 |
2018-07-13 | Deleted | XREF | RHEA:20016 |
2018-07-13 | Added | XREF | RHEA:20013 |
2010-10-11 | Added | XREF | KEGG:R01397 |
2010-10-11 | Added | XREF | RHEA:20016 |
2003-10-27 | Added | XREF | MetaCyc:ASPCARBTRANS-RXN |
2001-03-30 | Added | XREF | EC:2.1.3.2 |
Timestamp | Action | Category | Detail |
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