This term is obsolete.

GO:0004070 JSON

aspartate carbamoyltransferase activity

Molecular Function

Definition (GO:0004070 GONUTS page)

Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.

71,506 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATCase activity related
L-aspartate transcarbamoylase activity related
aspartic transcarbamylase activity related
carbamylaspartotranskinase activity related
aspartate transcarbamylase activity related
aspartic carbamyltransferase activity related
aspartic acid transcarbamoylase activity related
carbamoylaspartotranskinase activity related
aspartate transcarbamoylase activity related
L-aspartate transcarbamylase activity related

Ancestor Chart

Ancestor chart for GO:0004070
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004070

Child Term Relationship to
GO:0004070
aspartate carbamoyltransferase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.1.3.2
InterPro IPR002082 Aspartate carbamoyltransferase
KEGG_REACTION R01397
MetaCyc ASPCARBTRANS-RXN
RHEA 20013
Reactome R-HSA-73573

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29991 L-aspartate(1-)
has_participant CHEBI CHEBI:32814 N-carbamoyl-L-aspartate(2-)
has_participant CHEBI CHEBI:58228 carbamoyl phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:43474 hydrogenphosphate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004070 based on ALL annotations
The top 100 of 255 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aspartate carbamoyltransferase activity
2,776.44 100.00 71,370 71,370
amino acid binding
1,068.57 31.87 46,368 120,477
'de novo' pyrimidine nucleobase biosynthetic process
706.60 25.31 69,872 274,547
dihydroorotase activity
913.74 20.95 26,101 79,309
citrulline biosynthetic process
898.99 20.49 25,573 78,980
UTP biosynthetic process
896.12 20.45 25,569 79,220
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
605.18 16.33 28,128 129,045
'de novo' UMP biosynthetic process
410.98 13.55 43,959 296,973
pyrimidine nucleotide biosynthetic process
268.84 9.16 44,771 462,376
amino acid metabolic process
206.06 7.09 43,528 586,483
Totals 680553 111807956
No co-occurrence statistics for GO:0004070 based on MANUAL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aspartate carbamoyltransferase activity
12,168.39 100.00 116 116
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
3,930.80 32.21 115 356
glutamine metabolic process
2,914.28 23.85 114 476
dihydroorotase activity
4,185.93 21.72 43 125
'de novo' pyrimidine nucleobase biosynthetic process
1,633.72 11.84 58 432
'de novo' UMP biosynthetic process
6,373.92 8.73 11 21
UTP biosynthetic process
6,442.09 7.26 9 17
response to cortisol
2,808.09 6.16 9 39
response to amine
2,671.11 6.08 9 41
response to caffeine
1,659.33 5.20 9 66
Totals 925 716480

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.
2020-10-08 Deleted SYNONYM L-aspartate transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartate carbamyltransferase activity
2020-10-08 Deleted SYNONYM L-aspartate transcarbamylase activity
2020-10-08 Deleted SYNONYM aspartate transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartic acid transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartic carbamyltransferase activity
2020-10-08 Added SYNONYM aspartic transcarbamylase activity
2020-10-08 Added SYNONYM carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM aspartate carbamoyltransferase activity
2002-02-06 Updated TERM aspartate carbamoyltransferase
2001-04-03 Updated TERM aspartate carbamoyltransferase
2001-03-30 Added TERM aspartate carbamoyltransferase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate.
2020-10-08 Deleted SYNONYM L-aspartate transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartate carbamyltransferase activity
2020-10-08 Deleted SYNONYM L-aspartate transcarbamylase activity
2020-10-08 Deleted SYNONYM aspartate transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartic acid transcarbamoylase activity
2020-10-08 Deleted SYNONYM aspartic carbamyltransferase activity
2020-10-08 Added SYNONYM aspartic transcarbamylase activity
2020-10-08 Added SYNONYM carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
2020-10-08 Added SYNONYM aspartic carbamyltransferase activity
2020-10-08 Added SYNONYM L-aspartate transcarbamylase activity
2020-10-08 Deleted SYNONYM carbamylaspartotranskinase activity
2020-10-08 Deleted SYNONYM aspartate transcarbamylase activity
2020-10-08 Deleted SYNONYM ATCase activity
2020-10-08 Added SYNONYM carbamylaspartotranskinase activity
2020-10-08 Added SYNONYM aspartate carbamyltransferase activity
2020-10-08 Deleted SYNONYM carbamoylaspartotranskinase activity
2020-10-08 Deleted SYNONYM carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
2020-10-08 Deleted SYNONYM aspartic transcarbamylase activity
2020-10-08 Added SYNONYM L-aspartate transcarbamoylase activity
2020-10-08 Added SYNONYM aspartate transcarbamylase activity
2020-10-08 Added SYNONYM aspartic acid transcarbamoylase activity
2020-10-08 Added SYNONYM carbamoylaspartotranskinase activity
2020-10-08 Added SYNONYM ATCase activity
2020-10-08 Added SYNONYM aspartate transcarbamoylase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
2010-10-11 Added DEFINITION Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
2007-11-08 Added SYNONYM L-aspartate transcarbamylase activity
2007-11-08 Added SYNONYM carbamoylaspartotranskinase activity
2007-11-08 Added SYNONYM carbamoyl-phosphate:L-aspartate carbamoyltransferase activity
2007-11-08 Added SYNONYM aspartic transcarbamylase activity
2007-11-08 Added SYNONYM aspartic carbamyltransferase activity
2007-11-08 Added SYNONYM aspartate carbamyltransferase activity
2007-11-08 Added SYNONYM aspartate transcarbamoylase activity
2007-11-08 Added SYNONYM aspartic acid transcarbamoylase activity
2007-11-08 Added SYNONYM L-aspartate transcarbamoylase activity
2007-09-06 Added SYNONYM ATCase activity
2007-09-06 Added SYNONYM aspartate transcarbamylase activity
2007-09-06 Added SYNONYM carbamylaspartotranskinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016743 (carboxyl- or carbamoyltransferase activity)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01397
2019-06-20 Deleted XREF KEGG:R01397
2019-04-01 Deleted XREF reactome:R-HSA-73573
2019-04-01 Added XREF Reactome:R-HSA-73573
2018-12-11 Added XREF reactome:R-HSA-73573
2018-07-13 Added XREF RHEA:20013
2018-07-13 Deleted XREF RHEA:20016
2010-10-11 Added XREF RHEA:20016
2010-10-11 Added XREF KEGG:R01397
2003-10-27 Added XREF MetaCyc:ASPCARBTRANS-RXN
2001-03-30 Added XREF EC:2.1.3.2
Timestamp Action Category Detail
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