GO:0004108
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citrate (Si)-synthase activity
Molecular Function
Definition (GO:0004108 GONUTS page)
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
citrate synthetase activity | related |
citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity | related |
condensing enzyme activity | broad |
citrate synthase activity | broad |
oxalacetic transacetase activity | related |
citric-condensing enzyme activity | related |
(R)-citric synthase activity | related |
citrate oxaloacetate-lyase, CoA-acetylating activity | related |
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] | related |
citrate condensing enzyme activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.3.1 | |
InterPro | IPR010109 | Citrate synthase, eukaryotic-type |
InterPro | IPR010953 | Citrate synthase, type I |
Reactome | R-HSA-70975 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004108 based on ALL annotations
The top 100 of 244 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
citrate (Si)-synthase activity
|
2,780.79 | 100.00 | 70,102 | 70,102 |
citrate synthase activity
|
2,454.07 | 57.93 | 44,001 | 49,859 |
acyltransferase activity, acyl groups converted into alkyl on transfer
|
1,745.38 | 53.88 | 55,517 | 88,451 |
2-methylcitrate synthase activity
|
2,759.56 | 12.41 | 8,709 | 8,776 |
tricarboxylic acid cycle
|
282.29 | 10.14 | 69,527 | 684,903 |
propionate metabolic process, methylcitrate cycle
|
1,161.63 | 9.39 | 7,571 | 18,124 |
citrate metabolic process
|
1,514.05 | 5.97 | 4,408 | 8,096 |
mitochondrial matrix
|
92.77 | 2.60 | 7,408 | 222,050 |
carbohydrate metabolic process
|
40.52 | 1.45 | 45,711 | 3,137,227 |
acyltransferase activity
|
31.24 | 1.11 | 28,627 | 2,548,217 |
Totals | 448019 | 144549846 |
No co-occurrence statistics for GO:0004108 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
citrate (Si)-synthase activity
|
4,911.78 | 100.00 | 263 | 263 |
carbohydrate metabolic process
|
904.53 | 18.35 | 258 | 1,401 |
tricarboxylic acid cycle
|
506.54 | 10.23 | 244 | 2,366 |
2-methylcitrate synthase activity
|
3,726.18 | 8.15 | 22 | 29 |
mitochondrial matrix
|
277.95 | 5.60 | 222 | 3,923 |
propionate metabolic process, methylcitrate cycle
|
1,315.66 | 4.93 | 15 | 56 |
citrate synthase activity
|
1,964.71 | 2.91 | 8 | 20 |
citrate metabolic process
|
99.03 | 0.99 | 5 | 248 |
acyltransferase activity, acyl groups converted into alkyl on transfer
|
4,911.78 | 0.76 | 2 | 2 |
glyoxylate cycle
|
86.93 | 0.53 | 2 | 113 |
Totals | 1127 | 729961 |
Change Log
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-19 | Deleted | XREF | MetaCyc:CITSYN-RXN |
2020-10-08 | Added | SYNONYM | oxalacetic transacetase activity |
2020-10-08 | Added | SYNONYM | citrate synthetase activity |
2020-10-08 | Deleted | SYNONYM | (R)-citric synthase activity |
2020-10-08 | Deleted | SYNONYM | citrate condensing enzyme activity |
2020-10-08 | Deleted | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity |
2020-10-08 | Deleted | SYNONYM | citrate oxaloacetate-lyase, CoA-acetylating activity |
2020-10-08 | Deleted | SYNONYM | citrate synthetase activity |
2020-10-08 | Deleted | SYNONYM | citric synthase activity |
2020-10-08 | Deleted | SYNONYM | citric-condensing enzyme activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-06 | Updated | TERM | citrate (Si)-synthase activity |
2003-03-19 | Updated | TERM | citrate (SI)-synthase activity |
2002-02-06 | Updated | TERM | citrate (SI)-synthase |
2001-04-03 | Updated | TERM | citrate (SI)-synthase |
2001-03-30 | Added | TERM | citrate (SI)-synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | oxalacetic transacetase activity |
2020-10-08 | Added | SYNONYM | citrate synthetase activity |
2020-10-08 | Deleted | SYNONYM | (R)-citric synthase activity |
2020-10-08 | Deleted | SYNONYM | citrate condensing enzyme activity |
2020-10-08 | Deleted | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity |
2020-10-08 | Deleted | SYNONYM | citrate oxaloacetate-lyase, CoA-acetylating activity |
2020-10-08 | Deleted | SYNONYM | citrate synthetase activity |
2020-10-08 | Deleted | SYNONYM | citric synthase activity |
2020-10-08 | Deleted | SYNONYM | citric-condensing enzyme activity |
2020-10-08 | Deleted | SYNONYM | citrogenase activity |
2020-10-08 | Deleted | SYNONYM | oxalacetic transacetase activity |
2020-10-08 | Added | SYNONYM | (R)-citric synthase activity |
2020-10-08 | Added | SYNONYM | citric-condensing enzyme activity |
2020-10-08 | Added | SYNONYM | oxaloacetate transacetase activity |
2020-10-08 | Added | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA) |
2020-10-08 | Added | SYNONYM | citrogenase activity |
2020-10-08 | Added | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity |
2020-10-08 | Added | SYNONYM | citrate condensing enzyme activity |
2020-10-08 | Added | SYNONYM | citrate oxaloacetate-lyase, CoA-acetylating activity |
2020-10-08 | Added | SYNONYM | citric synthase activity |
2020-10-08 | Deleted | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA) |
2020-10-08 | Deleted | SYNONYM | oxaloacetate transacetase activity |
2009-03-29 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. |
2009-03-29 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
2007-11-08 | Added | SYNONYM | acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] |
2007-11-08 | Added | SYNONYM | citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA] |
2007-11-08 | Added | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA) |
2007-09-06 | Added | SYNONYM | citrate synthase activity |
2007-09-06 | Added | SYNONYM | citrate condensing enzyme activity |
2007-09-06 | Added | SYNONYM | citric synthase activity |
2007-09-06 | Added | SYNONYM | (R)-citric synthase activity |
2007-09-06 | Added | SYNONYM | citrate synthetase activity |
2007-09-06 | Added | SYNONYM | citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity |
2007-09-06 | Added | SYNONYM | citrate oxaloacetate-lyase, CoA-acetylating activity |
2007-09-06 | Added | SYNONYM | oxaloacetate transacetase activity |
2007-09-06 | Added | SYNONYM | oxalacetic transacetase activity |
2007-09-06 | Added | SYNONYM | condensing enzyme activity |
2007-09-06 | Added | SYNONYM | citrogenase activity |
2007-09-06 | Added | SYNONYM | citric-condensing enzyme activity |
2006-02-04 | Updated | DEFINITION | Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: citrate + CoA = acetyl-CoA + H2O + oxaloacetate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-10-02 | Added | RELATION | is a GO:0036440 (citrate synthase activity) |
2013-10-02 | Deleted | RELATION | is a GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer) |
2008-04-01 | Updated | RELATION | is a GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-19 | Deleted | XREF | MetaCyc:CITSYN-RXN |
2019-04-01 | Added | XREF | Reactome:R-HSA-70975 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70975 |
2018-12-11 | Added | XREF | reactome:R-HSA-70975 |
2013-10-02 | Deleted | XREF | RHEA:16848 |
2011-09-16 | Added | XREF | RHEA:16848 |
2003-10-27 | Added | XREF | MetaCyc:CITSYN-RXN |
2003-09-05 | Deleted | XREF | EC:4.1.3.7 |
2003-09-05 | Added | XREF | EC:2.3.3.1 |
2001-03-30 | Added | XREF | EC:4.1.3.7 |
Timestamp | Action | Category | Detail |
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