This term is obsolete.

GO:0004108 JSON

citrate (Si)-synthase activity

Molecular Function

Definition (GO:0004108 GONUTS page)

Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.

70,280 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
citrate synthetase activity related
citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity related
condensing enzyme activity broad
citrate synthase activity broad
oxalacetic transacetase activity related
citric-condensing enzyme activity related
(R)-citric synthase activity related
citrate oxaloacetate-lyase, CoA-acetylating activity related
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] related
citrate condensing enzyme activity related

Ancestor Chart

Ancestor chart for GO:0004108
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.3.1
InterPro IPR010109 Citrate synthase, eukaryotic-type
InterPro IPR010953 Citrate synthase, type I
Reactome R-HSA-70975

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004108 based on ALL annotations
The top 100 of 244 co-occurring terms
Co-occurring Term PR S% #Together #Compared
citrate (Si)-synthase activity
2,780.79 100.00 70,102 70,102
citrate synthase activity
2,454.07 57.93 44,001 49,859
acyltransferase activity, acyl groups converted into alkyl on transfer
1,745.38 53.88 55,517 88,451
2-methylcitrate synthase activity
2,759.56 12.41 8,709 8,776
tricarboxylic acid cycle
282.29 10.14 69,527 684,903
propionate metabolic process, methylcitrate cycle
1,161.63 9.39 7,571 18,124
citrate metabolic process
1,514.05 5.97 4,408 8,096
mitochondrial matrix
92.77 2.60 7,408 222,050
carbohydrate metabolic process
40.52 1.45 45,711 3,137,227
acyltransferase activity
31.24 1.11 28,627 2,548,217
Totals 448019 144549846
No co-occurrence statistics for GO:0004108 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term PR S% #Together #Compared
citrate (Si)-synthase activity
4,911.78 100.00 263 263
carbohydrate metabolic process
904.53 18.35 258 1,401
tricarboxylic acid cycle
506.54 10.23 244 2,366
2-methylcitrate synthase activity
3,726.18 8.15 22 29
mitochondrial matrix
277.95 5.60 222 3,923
propionate metabolic process, methylcitrate cycle
1,315.66 4.93 15 56
citrate synthase activity
1,964.71 2.91 8 20
citrate metabolic process
99.03 0.99 5 248
acyltransferase activity, acyl groups converted into alkyl on transfer
4,911.78 0.76 2 2
glyoxylate cycle
86.93 0.53 2 113
Totals 1127 729961

Change Log

Timestamp Action Category Detail
2024-06-19 Deleted XREF MetaCyc:CITSYN-RXN
2020-10-08 Added SYNONYM oxalacetic transacetase activity
2020-10-08 Added SYNONYM citrate synthetase activity
2020-10-08 Deleted SYNONYM (R)-citric synthase activity
2020-10-08 Deleted SYNONYM citrate condensing enzyme activity
2020-10-08 Deleted SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2020-10-08 Deleted SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2020-10-08 Deleted SYNONYM citrate synthetase activity
2020-10-08 Deleted SYNONYM citric synthase activity
2020-10-08 Deleted SYNONYM citric-condensing enzyme activity
Timestamp Action Category Detail
2003-09-06 Updated TERM citrate (Si)-synthase activity
2003-03-19 Updated TERM citrate (SI)-synthase activity
2002-02-06 Updated TERM citrate (SI)-synthase
2001-04-03 Updated TERM citrate (SI)-synthase
2001-03-30 Added TERM citrate (SI)-synthase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM oxalacetic transacetase activity
2020-10-08 Added SYNONYM citrate synthetase activity
2020-10-08 Deleted SYNONYM (R)-citric synthase activity
2020-10-08 Deleted SYNONYM citrate condensing enzyme activity
2020-10-08 Deleted SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2020-10-08 Deleted SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2020-10-08 Deleted SYNONYM citrate synthetase activity
2020-10-08 Deleted SYNONYM citric synthase activity
2020-10-08 Deleted SYNONYM citric-condensing enzyme activity
2020-10-08 Deleted SYNONYM citrogenase activity
2020-10-08 Deleted SYNONYM oxalacetic transacetase activity
2020-10-08 Added SYNONYM (R)-citric synthase activity
2020-10-08 Added SYNONYM citric-condensing enzyme activity
2020-10-08 Added SYNONYM oxaloacetate transacetase activity
2020-10-08 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
2020-10-08 Added SYNONYM citrogenase activity
2020-10-08 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2020-10-08 Added SYNONYM citrate condensing enzyme activity
2020-10-08 Added SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2020-10-08 Added SYNONYM citric synthase activity
2020-10-08 Deleted SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
2020-10-08 Deleted SYNONYM oxaloacetate transacetase activity
2009-03-29 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
2009-03-29 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2007-11-08 Added SYNONYM acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
2007-09-06 Added SYNONYM citrate synthase activity
2007-09-06 Added SYNONYM citrate condensing enzyme activity
2007-09-06 Added SYNONYM citric synthase activity
2007-09-06 Added SYNONYM (R)-citric synthase activity
2007-09-06 Added SYNONYM citrate synthetase activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2007-09-06 Added SYNONYM oxaloacetate transacetase activity
2007-09-06 Added SYNONYM oxalacetic transacetase activity
2007-09-06 Added SYNONYM condensing enzyme activity
2007-09-06 Added SYNONYM citrogenase activity
2007-09-06 Added SYNONYM citric-condensing enzyme activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2002-11-27 Added DEFINITION Catalysis of the reaction: citrate + CoA = acetyl-CoA + H2O + oxaloacetate.
Timestamp Action Category Detail
2013-10-02 Added RELATION is a GO:0036440 (citrate synthase activity)
2013-10-02 Deleted RELATION is a GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer)
2008-04-01 Updated RELATION is a GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer)
Timestamp Action Category Detail
2024-06-19 Deleted XREF MetaCyc:CITSYN-RXN
2019-04-01 Added XREF Reactome:R-HSA-70975
2019-04-01 Deleted XREF reactome:R-HSA-70975
2018-12-11 Added XREF reactome:R-HSA-70975
2013-10-02 Deleted XREF RHEA:16848
2011-09-16 Added XREF RHEA:16848
2003-10-27 Added XREF MetaCyc:CITSYN-RXN
2003-09-05 Deleted XREF EC:4.1.3.7
2003-09-05 Added XREF EC:2.3.3.1
2001-03-30 Added XREF EC:4.1.3.7
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.