This term is obsolete.

GO:0004115 JSON

3',5'-cyclic-AMP phosphodiesterase activity

Molecular Function

Definition (GO:0004115 GONUTS page)

Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.

26,858 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
3',5' cAMP-specific phosphodiesterase activity exact
adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity exact
cAMP-specific phosphodiesterase activity exact
3',5'-cAMP-specific phosphodiesterase activity exact
cyclic AMP-specific phosphodiesterase activity exact
3',5'-cyclic-AMP-specific phosphodiesterase activity exact

Ancestor Chart

Ancestor chart for GO:0004115
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004115

Child Term Relationship to
GO:0004115
calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
is_a
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.1.4.53
InterPro IPR000396 Cyclic-AMP phosphodiesterase, class-II
InterPro IPR046379 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
MetaCyc RXN0-5038
RHEA 25277
Reactome R-HSA-111962
Reactome R-HSA-418553
Reactome R-HSA-9629675
Reactome R-HSA-9644869
Reactome R-HSA-9705507

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:58165 3',5'-cyclic AMP(1-)
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004115 based on ALL annotations
The top 100 of 619 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3',5'-cyclic-AMP phosphodiesterase activity
8,176.62 100.00 23,841 23,841
cAMP catabolic process
6,312.65 41.86 11,386 14,748
3',5'-cyclic-GMP phosphodiesterase activity
7,394.28 25.05 6,134 6,783
cyclic-nucleotide phosphodiesterase activity
2,728.53 16.32 5,772 17,297
negative regulation of glucose mediated signaling pathway
6,835.62 15.95 3,925 4,695
3',5'-cyclic-nucleotide phosphodiesterase activity
1,349.31 12.84 8,735 52,933
cAMP-mediated signaling
821.29 2.39 724 7,208
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
1,128.47 1.36 354 2,565
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
3,704.83 1.18 285 629
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
1,325.69 1.15 292 1,801
Totals 104845 17180229
No co-occurrence statistics for GO:0004115 based on MANUAL annotations
The top 100 of 325 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3',5'-cyclic-AMP phosphodiesterase activity
1,717.82 100.00 752 752
3',5'-cyclic-GMP phosphodiesterase activity
1,682.57 93.35 716 731
cAMP-mediated signaling
1,258.15 68.49 687 938
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
1,540.72 11.42 87 97
cGMP catabolic process
1,678.33 11.27 85 87
negative regulation of cGMP-mediated signaling
1,461.97 10.44 80 94
perinuclear region of cytoplasm
108.91 5.72 277 4,369
negative regulation of cAMP-mediated signaling
804.08 5.49 44 94
photoreceptor outer segment membrane
385.41 4.01 35 156
cGMP-mediated signaling
233.67 3.75 37 272
Totals 4271 134815

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9865748
2024-11-05 Deleted XREF Reactome:R-HSA-9865748
2024-11-03 Added XREF Reactome:R-HSA-9865748
2024-11-02 Deleted XREF Reactome:R-HSA-9865748
2024-11-01 Added XREF Reactome:R-HSA-9865748
2024-10-26 Deleted XREF Reactome:R-HSA-9865748
2024-10-09 Added XREF Reactome:R-HSA-9865748
2023-04-02 Added XREF Reactome:R-HSA-9708261
2022-02-17 Deleted DEFINITION Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2022-02-17 Added DEFINITION Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
Timestamp Action Category Detail
2006-02-25 Updated TERM 3',5'-cyclic-AMP phosphodiesterase activity
2003-03-19 Updated TERM cAMP-specific phosphodiesterase activity
2002-02-06 Updated TERM cAMP-specific phosphodiesterase
2001-04-03 Updated TERM cAMP-specific phosphodiesterase
2001-03-30 Added TERM cAMP-specific phosphodiesterase
Timestamp Action Category Detail
2022-02-17 Deleted DEFINITION Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2022-02-17 Added DEFINITION Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
2007-08-09 Deleted SYNONYM 3',5' cAMP-specific phosphodiesterase activity
2007-08-09 Added SYNONYM 3',5' cAMP-specific phosphodiesterase activity
2007-08-09 Added SYNONYM 3',5'-cAMP-specific phosphodiesterase activity
2007-08-09 Added SYNONYM 3',5'-cyclic-AMP-specific phosphodiesterase activity
2007-08-09 Added SYNONYM adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
2007-08-09 Added SYNONYM cAMP-specific phosphodiesterase activity
2007-08-09 Added SYNONYM cyclic AMP-specific phosphodiesterase activity
2007-08-09 Deleted SYNONYM 3',5'-cAMP-specific phosphodiesterase activity
2007-08-09 Deleted SYNONYM 3',5'-cyclic-AMP-specific phosphodiesterase activity
2007-08-09 Deleted SYNONYM adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
2007-08-09 Deleted SYNONYM cAMP-specific phosphodiesterase activity
2007-08-09 Deleted SYNONYM cyclic AMP-specific phosphodiesterase activity
2006-02-25 Added SYNONYM 3',5'-cyclic-AMP-specific phosphodiesterase activity
2006-02-25 Added SYNONYM cAMP-specific phosphodiesterase activity
2005-12-26 Added SYNONYM cyclic AMP-specific phosphodiesterase activity
2005-12-26 Added SYNONYM 3',5'-cAMP-specific phosphodiesterase activity
2005-12-26 Added SYNONYM 3',5' cAMP-specific phosphodiesterase activity
2005-12-26 Added SYNONYM adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity
2003-10-24 Added DEFINITION Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Timestamp Action Category Detail
2021-07-04 Added RELATION has part GO:0140676 (oscillatory cAMP signaling)
2008-04-01 Updated RELATION is a GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9865748
2024-11-05 Deleted XREF Reactome:R-HSA-9865748
2024-11-03 Added XREF Reactome:R-HSA-9865748
2024-11-02 Deleted XREF Reactome:R-HSA-9865748
2024-11-01 Added XREF Reactome:R-HSA-9865748
2024-10-26 Deleted XREF Reactome:R-HSA-9865748
2024-10-09 Added XREF Reactome:R-HSA-9865748
2023-04-02 Added XREF Reactome:R-HSA-9708261
2020-12-17 Added XREF Reactome:R-HSA-9705507
2020-10-16 Deleted XREF EC:3.1.4
2020-10-16 Added XREF EC:3.1.4.53
2020-07-19 Added XREF Reactome:R-HSA-9644869
2020-06-22 Added XREF RHEA:25277
2019-05-04 Added XREF Reactome:R-HSA-9629675
2019-04-30 Deleted XREF Reactome:R-HSA-9629675
2019-04-29 Added XREF Reactome:R-HSA-9629675
2019-04-28 Deleted XREF Reactome:R-HSA-9629675
2019-04-27 Added XREF Reactome:R-HSA-9629675
2019-04-23 Deleted XREF Reactome:R-HSA-9629675
2019-04-01 Added XREF Reactome:R-HSA-111962
2019-04-01 Deleted XREF reactome:R-HSA-418553
2019-04-01 Deleted XREF reactome:R-HSA-111962
2019-04-01 Added XREF Reactome:R-HSA-9629675
2019-04-01 Added XREF Reactome:R-HSA-418553
2018-12-11 Added XREF reactome:R-HSA-418553
2018-12-11 Added XREF reactome:R-HSA-111962
2016-10-03 Added XREF EC:3.1.4
2016-10-03 Deleted XREF EC:3.1.4.-
2009-05-21 Added XREF MetaCyc:RXN0-5038
2001-03-30 Added XREF EC:3.1.4.-
Timestamp Action Category Detail
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