GO:0004115
JSON
3',5'-cyclic-AMP phosphodiesterase activity
Molecular Function
Definition (GO:0004115 GONUTS page)
Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
3',5' cAMP-specific phosphodiesterase activity | exact |
adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity | exact |
cAMP-specific phosphodiesterase activity | exact |
3',5'-cAMP-specific phosphodiesterase activity | exact |
cyclic AMP-specific phosphodiesterase activity | exact |
3',5'-cyclic-AMP-specific phosphodiesterase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004115
Child Term | Relationship to GO:0004115 |
---|---|
calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
|
is_a |
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.4.53 | |
InterPro | IPR000396 | Cyclic-AMP phosphodiesterase, class-II |
InterPro | IPR046379 | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA |
MetaCyc | RXN0-5038 | |
RHEA | 25277 | |
Reactome | R-HSA-111962 | |
Reactome | R-HSA-418553 | |
Reactome | R-HSA-9629675 | |
Reactome | R-HSA-9644869 | |
Reactome | R-HSA-9705507 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:58165 | 3',5'-cyclic AMP(1-) |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004115 based on ALL annotations
The top 100 of 619 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3',5'-cyclic-AMP phosphodiesterase activity
|
8,176.62 | 100.00 | 23,841 | 23,841 |
cAMP catabolic process
|
6,312.65 | 41.86 | 11,386 | 14,748 |
3',5'-cyclic-GMP phosphodiesterase activity
|
7,394.28 | 25.05 | 6,134 | 6,783 |
cyclic-nucleotide phosphodiesterase activity
|
2,728.53 | 16.32 | 5,772 | 17,297 |
negative regulation of glucose mediated signaling pathway
|
6,835.62 | 15.95 | 3,925 | 4,695 |
3',5'-cyclic-nucleotide phosphodiesterase activity
|
1,349.31 | 12.84 | 8,735 | 52,933 |
cAMP-mediated signaling
|
821.29 | 2.39 | 724 | 7,208 |
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
|
1,128.47 | 1.36 | 354 | 2,565 |
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
3,704.83 | 1.18 | 285 | 629 |
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
|
1,325.69 | 1.15 | 292 | 1,801 |
Totals | 104845 | 17180229 |
No co-occurrence statistics for GO:0004115 based on MANUAL annotations
The top 100 of 325 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3',5'-cyclic-AMP phosphodiesterase activity
|
1,717.82 | 100.00 | 752 | 752 |
3',5'-cyclic-GMP phosphodiesterase activity
|
1,682.57 | 93.35 | 716 | 731 |
cAMP-mediated signaling
|
1,258.15 | 68.49 | 687 | 938 |
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
|
1,540.72 | 11.42 | 87 | 97 |
cGMP catabolic process
|
1,678.33 | 11.27 | 85 | 87 |
negative regulation of cGMP-mediated signaling
|
1,461.97 | 10.44 | 80 | 94 |
perinuclear region of cytoplasm
|
108.91 | 5.72 | 277 | 4,369 |
negative regulation of cAMP-mediated signaling
|
804.08 | 5.49 | 44 | 94 |
photoreceptor outer segment membrane
|
385.41 | 4.01 | 35 | 156 |
cGMP-mediated signaling
|
233.67 | 3.75 | 37 | 272 |
Totals | 4271 | 134815 |
Change Log
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- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9865748 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9865748 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9865748 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9865748 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9708261 |
2022-02-17 | Deleted | DEFINITION | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
2022-02-17 | Added | DEFINITION | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-02-25 | Updated | TERM | 3',5'-cyclic-AMP phosphodiesterase activity |
2003-03-19 | Updated | TERM | cAMP-specific phosphodiesterase activity |
2002-02-06 | Updated | TERM | cAMP-specific phosphodiesterase |
2001-04-03 | Updated | TERM | cAMP-specific phosphodiesterase |
2001-03-30 | Added | TERM | cAMP-specific phosphodiesterase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | DEFINITION | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
2022-02-17 | Added | DEFINITION | Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
2007-08-09 | Deleted | SYNONYM | 3',5' cAMP-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | 3',5' cAMP-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | 3',5'-cAMP-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | 3',5'-cyclic-AMP-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | cAMP-specific phosphodiesterase activity |
2007-08-09 | Added | SYNONYM | cyclic AMP-specific phosphodiesterase activity |
2007-08-09 | Deleted | SYNONYM | 3',5'-cAMP-specific phosphodiesterase activity |
2007-08-09 | Deleted | SYNONYM | 3',5'-cyclic-AMP-specific phosphodiesterase activity |
2007-08-09 | Deleted | SYNONYM | adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity |
2007-08-09 | Deleted | SYNONYM | cAMP-specific phosphodiesterase activity |
2007-08-09 | Deleted | SYNONYM | cyclic AMP-specific phosphodiesterase activity |
2006-02-25 | Added | SYNONYM | 3',5'-cyclic-AMP-specific phosphodiesterase activity |
2006-02-25 | Added | SYNONYM | cAMP-specific phosphodiesterase activity |
2005-12-26 | Added | SYNONYM | cyclic AMP-specific phosphodiesterase activity |
2005-12-26 | Added | SYNONYM | 3',5'-cAMP-specific phosphodiesterase activity |
2005-12-26 | Added | SYNONYM | 3',5' cAMP-specific phosphodiesterase activity |
2005-12-26 | Added | SYNONYM | adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity |
2003-10-24 | Added | DEFINITION | Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-04 | Added | RELATION | has part GO:0140676 (oscillatory cAMP signaling) |
2008-04-01 | Updated | RELATION | is a GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9865748 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9865748 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9865748 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9865748 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9865748 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9708261 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9705507 |
2020-10-16 | Deleted | XREF | EC:3.1.4 |
2020-10-16 | Added | XREF | EC:3.1.4.53 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9644869 |
2020-06-22 | Added | XREF | RHEA:25277 |
2019-05-04 | Added | XREF | Reactome:R-HSA-9629675 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9629675 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9629675 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9629675 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9629675 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9629675 |
2019-04-01 | Added | XREF | Reactome:R-HSA-111962 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-418553 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-111962 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9629675 |
2019-04-01 | Added | XREF | Reactome:R-HSA-418553 |
2018-12-11 | Added | XREF | reactome:R-HSA-418553 |
2018-12-11 | Added | XREF | reactome:R-HSA-111962 |
2016-10-03 | Added | XREF | EC:3.1.4 |
2016-10-03 | Deleted | XREF | EC:3.1.4.- |
2009-05-21 | Added | XREF | MetaCyc:RXN0-5038 |
2001-03-30 | Added | XREF | EC:3.1.4.- |
Timestamp | Action | Category | Detail |
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