GO:0004136
JSON
deoxyadenosine kinase activity
Molecular Function
Definition (GO:0004136 GONUTS page)
Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP:deoxyadenosine 5'-phosphotransferase activity | related |
purine-deoxyribonucleoside kinase activity | related |
deoxyadenosine kinase (phosphorylating) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | C7U029 | 559304 | C7U029_PICSO | GO:0004136 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z6G6 | 7227 | A1Z6G6_DROME | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6IDC6 | 10116 | A6IDC6_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8L7 | 10116 | A6K8L7_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8L8 | 10116 | A6K8L8_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZHG3 | 10116 | D3ZHG3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.1.76 | |
KEGG_REACTION | R02089 | |
MetaCyc | DEOXYADENOSINE-KINASE-RXN | |
RHEA | 23452 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17256 | 2'-deoxyadenosine |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:58245 | 2'-deoxyadenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004136 based on ALL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
deoxyadenosine kinase activity
|
346,866.16 | 100.00 | 562 | 562 |
dAMP biosynthetic process
|
346,866.16 | 67.97 | 382 | 382 |
dAMP salvage
|
224,589.60 | 27.27 | 180 | 278 |
nucleoside phosphate biosynthetic process
|
343,176.10 | 16.52 | 93 | 94 |
dATP biosynthetic process
|
346,866.20 | 15.48 | 87 | 87 |
deoxyguanosine kinase activity
|
57,748.12 | 14.61 | 306 | 1,838 |
deoxycytidine kinase activity
|
49,010.52 | 10.61 | 168 | 1,189 |
deoxynucleoside kinase activity
|
7,527.33 | 2.16 | 445 | 20,506 |
nucleobase-containing compound biosynthetic process
|
5,223.34 | 1.39 | 86 | 5,711 |
adenosine kinase activity
|
3,981.71 | 1.08 | 87 | 7,579 |
Totals | 6288 | 203470662 |
No co-occurrence statistics for GO:0004136 based on MANUAL annotations
The top 40 of 40 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
deoxyadenosine kinase activity
|
117,436.27 | 100.00 | 11 | 11 |
deoxycytidine kinase activity
|
36,134.24 | 27.59 | 8 | 26 |
nucleoside phosphate biosynthetic process
|
88,077.20 | 25.00 | 3 | 4 |
deoxyguanosine kinase activity
|
27,632.07 | 21.62 | 8 | 34 |
dAMP salvage
|
36,134.24 | 20.00 | 4 | 13 |
deoxyribonucleoside monophosphate biosynthetic process
|
33,553.22 | 19.05 | 4 | 14 |
dATP biosynthetic process
|
117,436.27 | 18.18 | 2 | 2 |
pyrimidine deoxyribonucleoside binding
|
117,436.27 | 9.09 | 1 | 1 |
deoxyribonucleoside binding
|
117,436.27 | 9.09 | 1 | 1 |
dGMP salvage
|
117,436.27 | 9.09 | 1 | 1 |
Totals | 97 | 642029 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). |
2020-10-08 | Deleted | SYNONYM | purine-deoxyribonucleoside kinase activity |
2020-10-08 | Deleted | SYNONYM | deoxyadenosine kinase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | ATP:deoxyadenosine 5'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | deoxyadenosine kinase (phosphorylating) |
2020-10-08 | Added | SYNONYM | ATP:deoxyadenosine 5'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | purine-deoxyribonucleoside kinase activity |
2019-06-20 | Deleted | XREF | KEGG:R02089 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02089 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | deoxyadenosine kinase activity |
2002-02-06 | Updated | TERM | deoxyadenosine kinase |
2001-04-03 | Updated | TERM | deoxyadenosine kinase |
2001-03-30 | Added | TERM | deoxyadenosine kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). |
2020-10-08 | Deleted | SYNONYM | purine-deoxyribonucleoside kinase activity |
2020-10-08 | Deleted | SYNONYM | deoxyadenosine kinase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | ATP:deoxyadenosine 5'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | deoxyadenosine kinase (phosphorylating) |
2020-10-08 | Added | SYNONYM | ATP:deoxyadenosine 5'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | purine-deoxyribonucleoside kinase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP. |
2007-11-08 | Added | SYNONYM | purine-deoxyribonucleoside kinase activity |
2007-11-08 | Added | SYNONYM | ATP:deoxyadenosine 5'-phosphotransferase activity |
2007-11-08 | Added | SYNONYM | deoxyadenosine kinase (phosphorylating) |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-03-11 | Added | RELATION | part of GO:0006170 (dAMP biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0019136 (deoxynucleoside kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R02089 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02089 |
2018-07-13 | Deleted | XREF | RHEA:23455 |
2018-07-13 | Added | XREF | RHEA:23452 |
2010-10-11 | Added | XREF | RHEA:23455 |
2010-10-11 | Added | XREF | KEGG:R02089 |
2003-10-27 | Added | XREF | MetaCyc:DEOXYADENOSINE-KINASE-RXN |
2002-12-19 | Deleted | XREF | EC:2.7.1.75 |
2002-12-19 | Added | XREF | EC:2.7.1.76 |
2001-03-30 | Added | XREF | EC:2.7.1.75 |
Timestamp | Action | Category | Detail |
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