This term is obsolete.

GO:0004143 JSON

ATP-dependent diacylglycerol kinase activity

Molecular Function

Definition (GO:0004143 GONUTS page)

Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.

63,407 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
diglyceride kinase activity broad
diacylglycerol kinase activity broad
diacylglycerol kinase activity (ATP) exact
DGK activity related

Ancestor Chart

Ancestor chart for GO:0004143
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004143

Child Term Relationship to
GO:0004143
positive regulation of diacylglycerol kinase activity
positively_regulates
regulation of diacylglycerol kinase activity
regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein G4U4T9 479092 G4U4T9_9ASCO GO:0004143 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0D1CPS5 237631 A0A0D1CPS5_USTMA GO:0001727 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.107
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR016961 Diacylglycerol kinase, plant
InterPro IPR033718 Diacylglycerol kinase, prokaryotic
InterPro IPR037606 Diacylglycerol kinase delta, SAM domain
InterPro IPR037607 Diacylglycerol kinase
InterPro IPR037997 CTP-dependent diacylglycerol kinase 1-like
MetaCyc DIACYLGLYKIN-RXN
RHEA 10272
Reactome R-HSA-426240

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58608 1,2-diacyl-sn-glycerol 3-phosphate(2-)
has_participant CHEBI CHEBI:17815 1,2-diacyl-sn-glycerol
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:456216 ADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004143 based on ALL annotations
The top 100 of 480 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent diacylglycerol kinase activity
3,108.77 100.00 62,706 62,706
phospholipase C-activating G protein-coupled receptor signaling pathway
1,094.45 22.34 23,793 67,584
glycerolipid metabolic process
1,825.08 21.33 15,733 26,799
phosphatidic acid biosynthetic process
283.12 6.72 12,824 140,815
phospholipid biosynthetic process
120.43 3.61 21,944 566,440
glutamatergic synapse
176.09 3.26 4,485 79,179
lipid kinase activity
689.05 2.77 1,927 8,694
acylglycerol kinase activity
3,105.07 2.67 1,675 1,677
ceramide kinase activity
991.52 2.53 1,677 5,258
D-erythro-sphingosine kinase activity
597.27 2.37 1,654 8,609
Totals 402242 146833362
No co-occurrence statistics for GO:0004143 based on MANUAL annotations
The top 100 of 162 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent diacylglycerol kinase activity
2,121.18 100.00 609 609
glycerolipid metabolic process
2,051.11 51.94 322 333
diacylglycerol metabolic process
1,868.48 38.01 244 277
phosphatidic acid biosynthetic process
720.85 22.53 244 718
lipid phosphorylation
2,076.99 7.70 47 48
acylglycerol kinase activity
2,121.18 5.42 33 33
intracellular signal transduction
101.55 4.76 543 11,342
ceramide kinase activity
498.16 4.37 31 132
sphingolipid metabolic process
120.78 1.83 16 281
ceramide biosynthetic process
42.07 1.45 31 1,563
Totals 2860 113878

Change Log

Timestamp Action Category Detail
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2023-04-24 Added SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diacylglycerol:ATP kinase activity
2023-04-24 Deleted SYNONYM ATP:diacylglycerol phosphotransferase activity
2023-04-24 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2023-04-24 Deleted SYNONYM CTP:diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM DG kinase activity
2023-04-24 Deleted SYNONYM sn-1,2-diacylglycerol kinase activity
2023-04-24 Updated TERM ATP-dependent diacylglycerol kinase activity
Timestamp Action Category Detail
2023-04-24 Updated TERM ATP-dependent diacylglycerol kinase activity
2003-03-19 Updated TERM diacylglycerol kinase activity
2002-02-06 Updated TERM diacylglycerol kinase
2001-04-03 Updated TERM diacylglycerol kinase
2001-03-30 Added TERM diacylglycerol kinase
Timestamp Action Category Detail
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2023-04-24 Added SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diacylglycerol:ATP kinase activity
2023-04-24 Deleted SYNONYM ATP:diacylglycerol phosphotransferase activity
2023-04-24 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2023-04-24 Deleted SYNONYM CTP:diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM DG kinase activity
2023-04-24 Deleted SYNONYM sn-1,2-diacylglycerol kinase activity
2023-04-24 Added DEFINITION Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.
2023-04-24 Deleted DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2023-04-24 Added SYNONYM diacylglycerol kinase activity
2023-04-24 Added SYNONYM diacylglycerol kinase activity (ATP)
2020-10-08 Added SYNONYM 1,2-diacylglycerol kinase activity
2020-10-08 Added SYNONYM DG kinase activity
2020-10-08 Added SYNONYM sn-1,2-diacylglycerol kinase activity
2020-10-08 Added SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2020-10-08 Added SYNONYM DGK activity
2020-10-08 Added SYNONYM diglyceride kinase activity
2020-10-08 Added SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2020-10-08 Deleted SYNONYM diglyceride kinase activity
2020-10-08 Deleted SYNONYM DGK activity
2020-10-08 Deleted SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2020-10-08 Deleted SYNONYM sn-1,2-diacylglycerol kinase activity
2020-10-08 Deleted SYNONYM DG kinase activity
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol kinase activity
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate.
2008-06-14 Added SYNONYM CTP:diacylglycerol kinase activity
2008-06-07 Deleted SYNONYM diacylglycerol:ATP kinase activity
2008-06-07 Deleted SYNONYM ATP:diacylglycerol phosphotransferase activity
2008-06-07 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2008-06-07 Added SYNONYM diacylglycerol:ATP kinase activity
2008-06-07 Added SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2008-06-07 Added SYNONYM ATP:diacylglycerol phosphotransferase activity
2008-06-07 Added DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate.
2008-06-07 Deleted DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2007-11-08 Added SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2007-11-08 Added SYNONYM 1,2-diacylglycerol kinase activity
2007-11-08 Added SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2007-11-08 Added SYNONYM sn-1,2-diacylglycerol kinase activity
2007-11-08 Added SYNONYM diacylglycerol:ATP kinase activity
2007-11-08 Added SYNONYM DG kinase activity
2007-11-08 Added SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2007-11-08 Added SYNONYM ATP:diacylglycerol phosphotransferase activity
2007-09-06 Added SYNONYM diglyceride kinase activity
2007-09-06 Added SYNONYM DGK activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
Timestamp Action Category Detail
2023-01-08 Deleted RELATION is a GO:0016301 (kinase activity)
2023-01-08 Added RELATION is a GO:0001727 (lipid kinase activity)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-426240
2019-04-01 Added XREF Reactome:R-HSA-426240
2018-12-11 Added XREF reactome:R-HSA-426240
2018-07-13 Deleted XREF RHEA:10275
2018-07-13 Added XREF RHEA:10272
2011-09-16 Added XREF RHEA:10275
2003-10-27 Added XREF MetaCyc:DIACYLGLYKIN-RXN
2001-03-30 Added XREF EC:2.7.1.107
Timestamp Action Category Detail
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