GO:0004143
JSON
ATP-dependent diacylglycerol kinase activity
Molecular Function
Definition (GO:0004143 GONUTS page)
Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
diglyceride kinase activity | broad |
diacylglycerol kinase activity | broad |
diacylglycerol kinase activity (ATP) | exact |
DGK activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004143
Child Term | Relationship to GO:0004143 |
---|---|
positive regulation of diacylglycerol kinase activity
|
positively_regulates |
regulation of diacylglycerol kinase activity
|
regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | G4U4T9 | 479092 | G4U4T9_9ASCO | GO:0004143 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0D1CPS5 | 237631 | A0A0D1CPS5_USTMA | GO:0001727 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3Q0M1 | 9615 | A0A8I3Q0M1_CANLF | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J0TR01 | 8355 | A0A8J0TR01_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.1.107 | |
InterPro | IPR000756 | Diacylglycerol kinase, accessory domain |
InterPro | IPR016961 | Diacylglycerol kinase, plant |
InterPro | IPR033718 | Diacylglycerol kinase, prokaryotic |
InterPro | IPR037606 | Diacylglycerol kinase delta, SAM domain |
InterPro | IPR037607 | Diacylglycerol kinase |
InterPro | IPR037997 | CTP-dependent diacylglycerol kinase 1-like |
MetaCyc | DIACYLGLYKIN-RXN | |
RHEA | 10272 | |
Reactome | R-HSA-426240 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58608 | 1,2-diacyl-sn-glycerol 3-phosphate(2-) |
has_participant | CHEBI | CHEBI:17815 | 1,2-diacyl-sn-glycerol |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004143 based on ALL annotations
The top 100 of 480 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ATP-dependent diacylglycerol kinase activity
|
3,108.77 | 100.00 | 62,706 | 62,706 |
phospholipase C-activating G protein-coupled receptor signaling pathway
|
1,094.45 | 22.34 | 23,793 | 67,584 |
glycerolipid metabolic process
|
1,825.08 | 21.33 | 15,733 | 26,799 |
phosphatidic acid biosynthetic process
|
283.12 | 6.72 | 12,824 | 140,815 |
phospholipid biosynthetic process
|
120.43 | 3.61 | 21,944 | 566,440 |
glutamatergic synapse
|
176.09 | 3.26 | 4,485 | 79,179 |
lipid kinase activity
|
689.05 | 2.77 | 1,927 | 8,694 |
acylglycerol kinase activity
|
3,105.07 | 2.67 | 1,675 | 1,677 |
ceramide kinase activity
|
991.52 | 2.53 | 1,677 | 5,258 |
D-erythro-sphingosine kinase activity
|
597.27 | 2.37 | 1,654 | 8,609 |
Totals | 402242 | 146833362 |
No co-occurrence statistics for GO:0004143 based on MANUAL annotations
The top 100 of 162 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ATP-dependent diacylglycerol kinase activity
|
2,121.18 | 100.00 | 609 | 609 |
glycerolipid metabolic process
|
2,051.11 | 51.94 | 322 | 333 |
diacylglycerol metabolic process
|
1,868.48 | 38.01 | 244 | 277 |
phosphatidic acid biosynthetic process
|
720.85 | 22.53 | 244 | 718 |
lipid phosphorylation
|
2,076.99 | 7.70 | 47 | 48 |
acylglycerol kinase activity
|
2,121.18 | 5.42 | 33 | 33 |
intracellular signal transduction
|
101.55 | 4.76 | 543 | 11,342 |
ceramide kinase activity
|
498.16 | 4.37 | 31 | 132 |
sphingolipid metabolic process
|
120.78 | 1.83 | 16 | 281 |
ceramide biosynthetic process
|
42.07 | 1.45 | 31 | 1,563 |
Totals | 2860 | 113878 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-24 | Deleted | SYNONYM | 1,2-diacylglycerol kinase (phosphorylating) |
2023-04-24 | Added | SYNONYM | diglyceride kinase activity |
2023-04-24 | Deleted | SYNONYM | diglyceride kinase activity |
2023-04-24 | Deleted | SYNONYM | diacylglycerol:ATP kinase activity |
2023-04-24 | Deleted | SYNONYM | ATP:diacylglycerol phosphotransferase activity |
2023-04-24 | Deleted | SYNONYM | ATP:1,2-diacylglycerol 3-phosphotransferase activity |
2023-04-24 | Deleted | SYNONYM | CTP:diacylglycerol kinase activity |
2023-04-24 | Deleted | SYNONYM | DG kinase activity |
2023-04-24 | Deleted | SYNONYM | sn-1,2-diacylglycerol kinase activity |
2023-04-24 | Updated | TERM | ATP-dependent diacylglycerol kinase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-24 | Updated | TERM | ATP-dependent diacylglycerol kinase activity |
2003-03-19 | Updated | TERM | diacylglycerol kinase activity |
2002-02-06 | Updated | TERM | diacylglycerol kinase |
2001-04-03 | Updated | TERM | diacylglycerol kinase |
2001-03-30 | Added | TERM | diacylglycerol kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-24 | Deleted | SYNONYM | 1,2-diacylglycerol kinase (phosphorylating) |
2023-04-24 | Added | SYNONYM | diglyceride kinase activity |
2023-04-24 | Deleted | SYNONYM | diglyceride kinase activity |
2023-04-24 | Deleted | SYNONYM | diacylglycerol:ATP kinase activity |
2023-04-24 | Deleted | SYNONYM | ATP:diacylglycerol phosphotransferase activity |
2023-04-24 | Deleted | SYNONYM | ATP:1,2-diacylglycerol 3-phosphotransferase activity |
2023-04-24 | Deleted | SYNONYM | CTP:diacylglycerol kinase activity |
2023-04-24 | Deleted | SYNONYM | DG kinase activity |
2023-04-24 | Deleted | SYNONYM | sn-1,2-diacylglycerol kinase activity |
2023-04-24 | Added | DEFINITION | Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. |
2023-04-24 | Deleted | DEFINITION | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. |
2023-04-24 | Deleted | SYNONYM | 1,2-diacylglycerol kinase activity |
2023-04-24 | Deleted | SYNONYM | arachidonoyl-specific diacylglycerol kinase activity |
2023-04-24 | Added | SYNONYM | diacylglycerol kinase activity |
2023-04-24 | Added | SYNONYM | diacylglycerol kinase activity (ATP) |
2020-10-08 | Added | SYNONYM | 1,2-diacylglycerol kinase activity |
2020-10-08 | Added | SYNONYM | DG kinase activity |
2020-10-08 | Added | SYNONYM | sn-1,2-diacylglycerol kinase activity |
2020-10-08 | Added | SYNONYM | arachidonoyl-specific diacylglycerol kinase activity |
2020-10-08 | Added | SYNONYM | DGK activity |
2020-10-08 | Added | SYNONYM | diglyceride kinase activity |
2020-10-08 | Added | SYNONYM | 1,2-diacylglycerol kinase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | diglyceride kinase activity |
2020-10-08 | Deleted | SYNONYM | DGK activity |
2020-10-08 | Deleted | SYNONYM | arachidonoyl-specific diacylglycerol kinase activity |
2020-10-08 | Deleted | SYNONYM | sn-1,2-diacylglycerol kinase activity |
2020-10-08 | Deleted | SYNONYM | DG kinase activity |
2020-10-08 | Deleted | SYNONYM | 1,2-diacylglycerol kinase activity |
2020-10-08 | Deleted | SYNONYM | 1,2-diacylglycerol kinase (phosphorylating) |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. |
2008-06-14 | Added | SYNONYM | CTP:diacylglycerol kinase activity |
2008-06-07 | Deleted | SYNONYM | diacylglycerol:ATP kinase activity |
2008-06-07 | Deleted | SYNONYM | ATP:diacylglycerol phosphotransferase activity |
2008-06-07 | Deleted | SYNONYM | ATP:1,2-diacylglycerol 3-phosphotransferase activity |
2008-06-07 | Added | SYNONYM | diacylglycerol:ATP kinase activity |
2008-06-07 | Added | SYNONYM | ATP:1,2-diacylglycerol 3-phosphotransferase activity |
2008-06-07 | Added | SYNONYM | ATP:diacylglycerol phosphotransferase activity |
2008-06-07 | Added | DEFINITION | Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. |
2008-06-07 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. |
2007-11-08 | Added | SYNONYM | ATP:1,2-diacylglycerol 3-phosphotransferase activity |
2007-11-08 | Added | SYNONYM | 1,2-diacylglycerol kinase activity |
2007-11-08 | Added | SYNONYM | 1,2-diacylglycerol kinase (phosphorylating) |
2007-11-08 | Added | SYNONYM | sn-1,2-diacylglycerol kinase activity |
2007-11-08 | Added | SYNONYM | diacylglycerol:ATP kinase activity |
2007-11-08 | Added | SYNONYM | DG kinase activity |
2007-11-08 | Added | SYNONYM | arachidonoyl-specific diacylglycerol kinase activity |
2007-11-08 | Added | SYNONYM | ATP:diacylglycerol phosphotransferase activity |
2007-09-06 | Added | SYNONYM | diglyceride kinase activity |
2007-09-06 | Added | SYNONYM | DGK activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-08 | Deleted | RELATION | is a GO:0016301 (kinase activity) |
2023-01-08 | Added | RELATION | is a GO:0001727 (lipid kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016301 (kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-426240 |
2019-04-01 | Added | XREF | Reactome:R-HSA-426240 |
2018-12-11 | Added | XREF | reactome:R-HSA-426240 |
2018-07-13 | Deleted | XREF | RHEA:10275 |
2018-07-13 | Added | XREF | RHEA:10272 |
2011-09-16 | Added | XREF | RHEA:10275 |
2003-10-27 | Added | XREF | MetaCyc:DIACYLGLYKIN-RXN |
2001-03-30 | Added | XREF | EC:2.7.1.107 |
Timestamp | Action | Category | Detail |
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