This term is obsolete.

GO:0004143 JSON

ATP-dependent diacylglycerol kinase activity

Molecular Function

Definition (GO:0004143 GONUTS page)

Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.

65,206 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DGK activity related
diglyceride kinase activity broad
diacylglycerol kinase activity broad
diacylglycerol kinase activity (ATP) exact

Ancestor Chart

Ancestor chart for GO:0004143
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein G4U4T9 479092 G4U4T9_9ASCO GO:0004143 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0D1CPS5 5270 A0A0D1CPS5_MYCMD GO:0001727 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.107
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR016961 Diacylglycerol kinase, plant
InterPro IPR033718 Diacylglycerol kinase, prokaryotic
InterPro IPR037606 Diacylglycerol kinase delta, SAM domain
InterPro IPR037607 Diacylglycerol kinase
InterPro IPR037997 CTP-dependent diacylglycerol kinase 1-like
MetaCyc DIACYLGLYKIN-RXN
RHEA 10272
Reactome R-HSA-426240

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58608 1,2-diacyl-sn-glycerol 3-phosphate(2-)
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:17815 1,2-diacyl-sn-glycerol
has_participant CHEBI CHEBI:30616 ATP(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004143 based on ALL annotations
The top 100 of 478 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent diacylglycerol kinase activity
3,075.41 100.00 64,432 64,432
phospholipase C-activating G protein-coupled receptor signaling pathway
1,088.62 22.57 24,729 69,861
glycerolipid metabolic process
1,809.13 20.93 15,800 26,859
phosphatidic acid biosynthetic process
277.17 6.64 12,963 143,835
lipid kinase activity
926.02 4.95 3,603 11,966
phospholipid biosynthetic process
118.41 3.59 22,307 579,385
glutamatergic synapse
174.99 3.26 4,565 80,227
acylglycerol kinase activity
3,071.86 2.68 1,730 1,732
ceramide kinase activity
950.84 2.54 1,732 5,602
D-erythro-sphingosine kinase activity
594.77 2.43 1,739 8,992
Totals 420219 158253836
No co-occurrence statistics for GO:0004143 based on MANUAL annotations
The top 100 of 159 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ATP-dependent diacylglycerol kinase activity
2,069.70 100.00 682 682
glycerolipid metabolic process
2,017.24 61.04 423 434
diacylglycerol metabolic process
1,756.36 29.58 213 251
phosphatidic acid biosynthetic process
549.00 16.75 213 803
lipid phosphorylation
2,026.58 6.88 47 48
acylglycerol kinase activity
2,069.70 5.28 36 36
intracellular signal transduction
105.24 5.06 613 12,055
D-erythro-sphingosine kinase activity
598.67 4.56 35 121
ceramide kinase activity
341.70 4.07 35 212
sphingosine biosynthetic process
96.07 2.50 35 754
Totals 3378 266392

Change Log

Timestamp Action Category Detail
2023-04-24 Deleted SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diacylglycerol:ATP kinase activity
2023-04-24 Updated TERM ATP-dependent diacylglycerol kinase activity
2023-04-24 Added DEFINITION Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.
2023-04-24 Deleted DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
2023-04-24 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2023-04-24 Deleted SYNONYM CTP:diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM DG kinase activity
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase activity
Timestamp Action Category Detail
2023-04-24 Updated TERM ATP-dependent diacylglycerol kinase activity
2003-03-19 Updated TERM diacylglycerol kinase activity
2002-02-06 Updated TERM diacylglycerol kinase
2001-04-03 Updated TERM diacylglycerol kinase
2001-03-30 Added TERM diacylglycerol kinase
Timestamp Action Category Detail
2023-04-24 Deleted SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM diacylglycerol:ATP kinase activity
2023-04-24 Added DEFINITION Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+.
2023-04-24 Deleted DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
2023-04-24 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2023-04-24 Deleted SYNONYM CTP:diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM DG kinase activity
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase activity
2023-04-24 Added SYNONYM diacylglycerol kinase activity (ATP)
2023-04-24 Added SYNONYM diacylglycerol kinase activity
2023-04-24 Added SYNONYM diglyceride kinase activity
2023-04-24 Deleted SYNONYM sn-1,2-diacylglycerol kinase activity
2023-04-24 Deleted SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2023-04-24 Deleted SYNONYM ATP:diacylglycerol phosphotransferase activity
2020-10-08 Deleted SYNONYM sn-1,2-diacylglycerol kinase activity
2020-10-08 Added SYNONYM diglyceride kinase activity
2020-10-08 Added SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2020-10-08 Deleted SYNONYM diglyceride kinase activity
2020-10-08 Deleted SYNONYM DGK activity
2020-10-08 Added SYNONYM 1,2-diacylglycerol kinase activity
2020-10-08 Deleted SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2020-10-08 Added SYNONYM sn-1,2-diacylglycerol kinase activity
2020-10-08 Added SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2020-10-08 Added SYNONYM DGK activity
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol kinase activity
2020-10-08 Deleted SYNONYM DG kinase activity
2020-10-08 Added SYNONYM DG kinase activity
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate.
2008-06-14 Added SYNONYM CTP:diacylglycerol kinase activity
2008-06-07 Added SYNONYM ATP:diacylglycerol phosphotransferase activity
2008-06-07 Added SYNONYM diacylglycerol:ATP kinase activity
2008-06-07 Deleted SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2008-06-07 Deleted DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2008-06-07 Added SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2008-06-07 Added DEFINITION Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate.
2008-06-07 Deleted SYNONYM diacylglycerol:ATP kinase activity
2008-06-07 Deleted SYNONYM ATP:diacylglycerol phosphotransferase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
2007-11-08 Added SYNONYM sn-1,2-diacylglycerol kinase activity
2007-11-08 Added SYNONYM diacylglycerol:ATP kinase activity
2007-11-08 Added SYNONYM arachidonoyl-specific diacylglycerol kinase activity
2007-11-08 Added SYNONYM DG kinase activity
2007-11-08 Added SYNONYM ATP:diacylglycerol phosphotransferase activity
2007-11-08 Added SYNONYM 1,2-diacylglycerol kinase activity
2007-11-08 Added SYNONYM 1,2-diacylglycerol kinase (phosphorylating)
2007-11-08 Added SYNONYM ATP:1,2-diacylglycerol 3-phosphotransferase activity
2007-09-06 Added SYNONYM DGK activity
2007-09-06 Added SYNONYM diglyceride kinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate.
Timestamp Action Category Detail
2023-01-08 Added RELATION is a GO:0001727 (lipid kinase activity)
2023-01-08 Deleted RELATION is a GO:0016301 (kinase activity)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-426240
2019-04-01 Deleted XREF reactome:R-HSA-426240
2018-12-11 Added XREF reactome:R-HSA-426240
2018-07-13 Added XREF RHEA:10272
2018-07-13 Deleted XREF RHEA:10275
2011-09-16 Added XREF RHEA:10275
2003-10-27 Added XREF MetaCyc:DIACYLGLYKIN-RXN
2001-03-30 Added XREF EC:2.7.1.107
Timestamp Action Category Detail
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