This term is obsolete.

GO:0004144 JSON

diacylglycerol O-acyltransferase activity

Molecular Function

Definition (GO:0004144 GONUTS page)

Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.

40,859 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acyl-CoA:1,2-diacylglycerol O-acyltransferase activity related
diacylglycerol acyltransferase activity related
diglyceride acyltransferase activity related
diglyceride O-acyltransferase activity related
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity related
1,2-diacylglycerol acyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0004144
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein G4U4U0 479092 G4U4U0_9ASCO GO:0004144 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.1.20
InterPro IPR004255 O-acyltransferase, WSD1-like, N-terminal
InterPro IPR027251 Diacylglycerol O-acyltransferase 1
MetaCyc DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
RHEA 10868
Reactome R-HSA-1482889
Reactome R-HSA-549192
Reactome R-HSA-75900
Reactome R-HSA-8848580

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58342 acyl-CoA(4-)
has_participant CHEBI CHEBI:57287 coenzyme A(4-)
has_participant CHEBI CHEBI:17815 1,2-diacyl-sn-glycerol
has_participant CHEBI CHEBI:64615 triacyl-sn-glycerol

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004144 based on ALL annotations
The top 100 of 431 co-occurring terms
Co-occurring Term PR S% #Together #Compared
diacylglycerol O-acyltransferase activity
4,894.41 100.00 40,486 40,486
triglyceride biosynthetic process
2,929.56 57.05 37,409 62,499
glycerolipid biosynthetic process
4,458.49 51.10 21,775 23,904
response to nitric oxide
4,720.49 34.22 14,033 14,550
O-acyltransferase activity
1,337.14 26.24 35,173 128,746
biological process involved in interaction with host
2,281.38 24.81 14,033 30,106
response to hypoxia
1,933.87 22.65 14,033 35,516
glycerol metabolic process
584.73 10.80 21,397 179,102
diacylglycerol biosynthetic process
3,839.06 4.19 1,717 2,189
trehalose O-mycolyltransferase activity
4,080.89 3.76 1,535 1,841
Totals 356019 90898665
No co-occurrence statistics for GO:0004144 based on MANUAL annotations
The top 100 of 104 co-occurring terms
Co-occurring Term PR S% #Together #Compared
diacylglycerol O-acyltransferase activity
3,313.46 100.00 426 426
triglyceride biosynthetic process
1,181.37 35.47 420 1,178
2-acylglycerol O-acyltransferase activity
2,678.97 8.74 38 47
diacylglycerol biosynthetic process
804.24 8.59 50 206
monoacylglycerol biosynthetic process
1,893.40 5.41 24 42
chloroplast envelope
190.84 4.44 69 1,198
diacylglycerol metabolic process
356.43 4.15 27 251
perinuclear endoplasmic reticulum membrane
1,506.12 3.38 15 33
endoplasmic reticulum membrane
72.51 2.19 408 18,644
fatty acid homeostasis
356.83 1.45 7 65
Totals 1740 231553

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
2020-10-08 Deleted SYNONYM diglyceride O-acyltransferase activity
2020-10-08 Deleted SYNONYM diacylglycerol acyltransferase activity
2020-10-08 Deleted SYNONYM acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM diglyceride acyltransferase activity
2020-10-08 Added SYNONYM diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM diglyceride O-acyltransferase activity
2020-10-08 Deleted SYNONYM diglyceride acyltransferase activity
2020-10-08 Added SYNONYM 1,2-diacylglycerol acyltransferase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM diacylglycerol O-acyltransferase activity
2002-02-06 Updated TERM diacylglycerol O-acyltransferase
2001-04-03 Updated TERM diacylglycerol O-acyltransferase
2001-03-30 Added TERM diacylglycerol O-acyltransferase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
2020-10-08 Deleted SYNONYM diglyceride O-acyltransferase activity
2020-10-08 Deleted SYNONYM diacylglycerol acyltransferase activity
2020-10-08 Deleted SYNONYM acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
2020-10-08 Deleted SYNONYM 1,2-diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM diglyceride acyltransferase activity
2020-10-08 Added SYNONYM diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM diglyceride O-acyltransferase activity
2020-10-08 Deleted SYNONYM diglyceride acyltransferase activity
2020-10-08 Added SYNONYM 1,2-diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
2020-10-08 Added SYNONYM acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
2007-11-08 Added SYNONYM palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity
2007-11-08 Added SYNONYM diglyceride O-acyltransferase activity
2007-11-08 Added SYNONYM diacylglycerol acyltransferase activity
2007-11-08 Added SYNONYM acyl-CoA:1,2-diacylglycerol O-acyltransferase activity
2007-11-08 Added SYNONYM 1,2-diacylglycerol acyltransferase activity
2007-09-06 Added SYNONYM diglyceride acyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016411 (acylglycerol O-acyltransferase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-8848580
2019-04-01 Added XREF Reactome:R-HSA-1482889
2019-04-01 Added XREF Reactome:R-HSA-75900
2019-04-01 Added XREF Reactome:R-HSA-549192
2019-04-01 Deleted XREF reactome:R-HSA-75900
2019-04-01 Deleted XREF reactome:R-HSA-549192
2019-04-01 Deleted XREF reactome:R-HSA-1482889
2019-04-01 Deleted XREF reactome:R-HSA-8848580
2018-12-11 Added XREF reactome:R-HSA-75900
2018-12-11 Added XREF reactome:R-HSA-1482889
2018-12-11 Added XREF reactome:R-HSA-549192
2018-12-11 Added XREF reactome:R-HSA-8848580
2018-07-13 Deleted XREF RHEA:10871
2018-07-13 Added XREF RHEA:10868
2011-09-16 Added XREF RHEA:10871
2003-10-27 Added XREF MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
2001-03-30 Added XREF EC:2.3.1.20
Timestamp Action Category Detail
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