GO:0004144
JSON
diacylglycerol O-acyltransferase activity
Molecular Function
Definition (GO:0004144 GONUTS page)
Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
1,2-diacylglycerol acyltransferase activity | related |
diacylglycerol acyltransferase activity | related |
diglyceride O-acyltransferase activity | related |
diglyceride acyltransferase activity | related |
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity | related |
acyl-CoA:1,2-diacylglycerol O-acyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | G4U4U0 | 479092 | G4U4U0_9ASCO | GO:0004144 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.20 | |
InterPro | IPR004255 | O-acyltransferase, WSD1-like, N-terminal |
InterPro | IPR027251 | Diacylglycerol O-acyltransferase 1 |
MetaCyc | DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN | |
RHEA | 10868 | |
Reactome | R-HSA-1482889 | |
Reactome | R-HSA-549192 | |
Reactome | R-HSA-75900 | |
Reactome | R-HSA-8848580 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17815 | 1,2-diacyl-sn-glycerol |
has_participant | CHEBI | CHEBI:64615 | triacyl-sn-glycerol |
has_participant | CHEBI | CHEBI:58342 | acyl-CoA(4-) |
has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004144 based on ALL annotations
The top 100 of 423 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
diacylglycerol O-acyltransferase activity
|
4,986.16 | 100.00 | 39,096 | 39,096 |
triglyceride biosynthetic process
|
2,985.23 | 56.97 | 36,030 | 60,180 |
glycerolipid biosynthetic process
|
4,552.43 | 51.27 | 21,076 | 23,084 |
response to nitric oxide
|
4,803.87 | 34.66 | 13,730 | 14,251 |
O-acyltransferase activity
|
1,364.76 | 26.34 | 34,200 | 124,950 |
biological process involved in interaction with host
|
2,330.39 | 25.08 | 13,730 | 29,377 |
response to hypoxia
|
1,955.61 | 22.74 | 13,730 | 35,007 |
glycerol metabolic process
|
704.76 | 13.01 | 24,270 | 171,709 |
diacylglycerol biosynthetic process
|
3,911.26 | 4.28 | 1,692 | 2,157 |
trehalose O-mycolyltransferase activity
|
4,167.89 | 4.01 | 1,579 | 1,889 |
Totals | 354636 | 88680547 |
No co-occurrence statistics for GO:0004144 based on MANUAL annotations
The top 100 of 103 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
diacylglycerol O-acyltransferase activity
|
3,454.01 | 100.00 | 374 | 374 |
triglyceride biosynthetic process
|
1,235.25 | 35.56 | 368 | 1,029 |
2-acylglycerol O-acyltransferase activity
|
2,590.51 | 8.57 | 33 | 44 |
diacylglycerol biosynthetic process
|
804.11 | 8.48 | 44 | 189 |
monoacylglycerol biosynthetic process
|
1,809.24 | 5.58 | 22 | 42 |
chloroplast envelope
|
212.87 | 4.70 | 62 | 1,006 |
diacylglycerol metabolic process
|
274.33 | 3.50 | 22 | 277 |
perinuclear endoplasmic reticulum membrane
|
1,360.67 | 3.30 | 13 | 33 |
endoplasmic reticulum membrane
|
73.20 | 2.12 | 356 | 16,799 |
fatty acid homeostasis
|
383.78 | 1.63 | 7 | 63 |
Totals | 1561 | 263872 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | diglyceride acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | diglyceride O-acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | diacylglycerol acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:1,2-diacylglycerol O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | diglyceride O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | 1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Added | SYNONYM | palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Added | SYNONYM | acyl-CoA:1,2-diacylglycerol O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | diglyceride acyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | diacylglycerol O-acyltransferase activity |
2002-02-06 | Updated | TERM | diacylglycerol O-acyltransferase |
2001-04-03 | Updated | TERM | diacylglycerol O-acyltransferase |
2001-03-30 | Added | TERM | diacylglycerol O-acyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | diglyceride acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | diglyceride O-acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | diacylglycerol acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:1,2-diacylglycerol O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | diglyceride O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | 1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Added | SYNONYM | palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity |
2020-10-08 | Added | SYNONYM | acyl-CoA:1,2-diacylglycerol O-acyltransferase activity |
2020-10-08 | Added | SYNONYM | diglyceride acyltransferase activity |
2020-10-08 | Added | SYNONYM | diacylglycerol acyltransferase activity |
2020-10-08 | Deleted | SYNONYM | 1,2-diacylglycerol acyltransferase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
2007-11-08 | Added | SYNONYM | diglyceride O-acyltransferase activity |
2007-11-08 | Added | SYNONYM | palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity |
2007-11-08 | Added | SYNONYM | diacylglycerol acyltransferase activity |
2007-11-08 | Added | SYNONYM | acyl-CoA:1,2-diacylglycerol O-acyltransferase activity |
2007-11-08 | Added | SYNONYM | 1,2-diacylglycerol acyltransferase activity |
2007-09-06 | Added | SYNONYM | diglyceride acyltransferase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016411 (acylglycerol O-acyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-8848580 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1482889 |
2019-04-01 | Added | XREF | Reactome:R-HSA-75900 |
2019-04-01 | Added | XREF | Reactome:R-HSA-549192 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-75900 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-549192 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1482889 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8848580 |
2018-12-11 | Added | XREF | reactome:R-HSA-8848580 |
2018-12-11 | Added | XREF | reactome:R-HSA-75900 |
2018-12-11 | Added | XREF | reactome:R-HSA-549192 |
2018-12-11 | Added | XREF | reactome:R-HSA-1482889 |
2018-07-13 | Added | XREF | RHEA:10868 |
2018-07-13 | Deleted | XREF | RHEA:10871 |
2011-09-16 | Added | XREF | RHEA:10871 |
2003-10-27 | Added | XREF | MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN |
2001-03-30 | Added | XREF | EC:2.3.1.20 |
Timestamp | Action | Category | Detail |
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