GO:0004146
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dihydrofolate reductase activity
Molecular Function
Definition (GO:0004146 GONUTS page)
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
7,8-dihydrofolate reductase activity | related |
dihydrofolate reduction | exact |
NADPH-dihydrofolate reductase activity | related |
dihydrofolate reductase:thymidylate synthase activity | related |
folic reductase activity | related |
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity | related |
thymidylate synthetase-dihydrofolate reductase activity | related |
pteridine reductase:dihydrofolate reductase activity | related |
tetrahydrofolate dehydrogenase activity | related |
dihydrofolic reductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | G4U4X7 | 1608523 | G4U4X7_9ASCO | GO:0004146 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.5.1.3 | |
InterPro | IPR001796 | Dihydrofolate reductase domain |
InterPro | IPR009159 | Dihydrofolate reductase, type II |
InterPro | IPR012259 | Dihydrofolate reductase |
InterPro | IPR012262 | Bifunctional dihydrofolate reductase/thymidylate synthase |
InterPro | IPR017925 | Dihydrofolate reductase conserved site |
MetaCyc | DIHYDROFOLATEREDUCT-RXN | |
RHEA | 15009 | |
Reactome | R-HSA-1497794 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57453 | (6S)-5,6,7,8-tetrahydrofolate(2-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:57451 | dihydrofolate(2-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0006762 | obsolete dihydrofolate reduction | consider GO:0004146 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004146 based on ALL annotations
The top 100 of 383 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydrofolate reductase activity
|
4,551.45 | 100.00 | 42,830 | 42,830 |
dihydrofolate metabolic process
|
4,550.97 | 88.08 | 37,727 | 37,731 |
folic acid metabolic process
|
4,509.26 | 87.36 | 37,726 | 38,079 |
tetrahydrofolate biosynthetic process
|
867.10 | 18.93 | 41,468 | 217,667 |
one-carbon metabolic process
|
378.35 | 8.07 | 31,564 | 379,709 |
NADP binding
|
198.46 | 4.34 | 37,823 | 867,427 |
thymidylate synthase activity
|
155.33 | 2.04 | 2,057 | 60,274 |
dTMP biosynthetic process
|
126.86 | 1.67 | 1,719 | 61,674 |
response to methotrexate
|
4,536.08 | 1.38 | 590 | 592 |
nucleotide biosynthetic process
|
33.34 | 0.63 | 1,880 | 256,651 |
Totals | 321961 | 52717504 |
No co-occurrence statistics for GO:0004146 based on MANUAL annotations
The top 52 of 52 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydrofolate reductase activity
|
7,510.46 | 100.00 | 172 | 172 |
dihydrofolate metabolic process
|
7,432.23 | 54.91 | 95 | 96 |
folic acid metabolic process
|
5,800.76 | 47.50 | 95 | 123 |
tetrahydrofolate biosynthetic process
|
3,081.21 | 30.97 | 96 | 234 |
thymidylate synthase activity
|
2,901.77 | 24.29 | 68 | 176 |
dTMP biosynthetic process
|
2,679.41 | 22.68 | 66 | 185 |
NADP binding
|
1,035.55 | 12.40 | 95 | 689 |
10-formyltetrahydrofolate biosynthetic process
|
1,112.66 | 2.05 | 4 | 27 |
regulation of removal of superoxide radicals
|
1,502.09 | 1.63 | 3 | 15 |
folic acid binding
|
381.89 | 1.32 | 3 | 59 |
Totals | 1013 | 664251 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | NADPH-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | tetrahydrofolate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | thymidylate synthetase-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | pteridine reductase:dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | folic reductase activity |
2020-10-08 | Deleted | SYNONYM | folic acid reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolic reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolic acid reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolate reductase:thymidylate synthase activity |
2020-10-08 | Deleted | SYNONYM | NADPH-dihydrofolate reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | dihydrofolate reductase activity |
2002-02-06 | Updated | TERM | dihydrofolate reductase |
2001-04-03 | Updated | TERM | dihydrofolate reductase |
2001-03-30 | Added | TERM | dihydrofolate reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | NADPH-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | tetrahydrofolate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | thymidylate synthetase-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | pteridine reductase:dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | folic reductase activity |
2020-10-08 | Deleted | SYNONYM | folic acid reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolic reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolic acid reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydrofolate reductase:thymidylate synthase activity |
2020-10-08 | Deleted | SYNONYM | NADPH-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | 7,8-dihydrofolate reductase activity |
2020-10-08 | Deleted | SYNONYM | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 7,8-dihydrofolate reductase activity |
2020-10-08 | Added | SYNONYM | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | folic acid reductase activity |
2020-10-08 | Added | SYNONYM | dihydrofolate reductase:thymidylate synthase activity |
2020-10-08 | Added | SYNONYM | dihydrofolic reductase activity |
2020-10-08 | Added | SYNONYM | dihydrofolic acid reductase activity |
2020-10-08 | Added | SYNONYM | pteridine reductase:dihydrofolate reductase activity |
2020-10-08 | Added | SYNONYM | thymidylate synthetase-dihydrofolate reductase activity |
2020-10-08 | Added | SYNONYM | folic reductase activity |
2020-10-08 | Added | SYNONYM | tetrahydrofolate dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
2007-11-08 | Added | SYNONYM | dihydrofolic reductase activity |
2007-11-08 | Added | SYNONYM | dihydrofolic acid reductase activity |
2007-11-08 | Added | SYNONYM | dihydrofolate reductase:thymidylate synthase activity |
2007-11-08 | Added | SYNONYM | NADPH-dihydrofolate reductase activity |
2007-11-08 | Added | SYNONYM | DHFR |
2007-11-08 | Added | SYNONYM | 7,8-dihydrofolate reductase activity |
2007-11-08 | Added | SYNONYM | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity |
2007-11-08 | Added | SYNONYM | folic acid reductase activity |
2007-11-08 | Added | SYNONYM | folic reductase activity |
2007-11-08 | Added | SYNONYM | thymidylate synthetase-dihydrofolate reductase activity |
2007-11-08 | Added | SYNONYM | pteridine reductase:dihydrofolate reductase activity |
2007-09-06 | Added | SYNONYM | tetrahydrofolate dehydrogenase activity |
2007-08-09 | Added | SYNONYM | dihydrofolate reduction |
2007-08-09 | Deleted | SYNONYM | dihydrofolate reduction |
2005-08-10 | Added | SYNONYM | dihydrofolate reduction |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-1497794 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1497794 |
2018-12-11 | Added | XREF | reactome:R-HSA-1497794 |
2018-07-13 | Deleted | XREF | RHEA:15012 |
2018-07-13 | Added | XREF | RHEA:15009 |
2011-09-16 | Added | XREF | RHEA:15012 |
2003-10-27 | Added | XREF | MetaCyc:DIHYDROFOLATEREDUCT-RXN |
2001-03-30 | Added | XREF | EC:1.5.1.3 |
Timestamp | Action | Category | Detail |
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