This term is obsolete.

GO:0004146 JSON

dihydrofolate reductase activity

Molecular Function

Definition (GO:0004146 GONUTS page)

Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.

43,039 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
7,8-dihydrofolate reductase activity related
dihydrofolate reduction exact
NADPH-dihydrofolate reductase activity related
dihydrofolate reductase:thymidylate synthase activity related
folic reductase activity related
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity related
thymidylate synthetase-dihydrofolate reductase activity related
pteridine reductase:dihydrofolate reductase activity related
tetrahydrofolate dehydrogenase activity related
dihydrofolic reductase activity related

Ancestor Chart

Ancestor chart for GO:0004146
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein G4U4X7 1608523 G4U4X7_9ASCO GO:0004146 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.5.1.3
InterPro IPR001796 Dihydrofolate reductase domain
InterPro IPR009159 Dihydrofolate reductase, type II
InterPro IPR012259 Dihydrofolate reductase
InterPro IPR012262 Bifunctional dihydrofolate reductase/thymidylate synthase
InterPro IPR017925 Dihydrofolate reductase conserved site
MetaCyc DIHYDROFOLATEREDUCT-RXN
RHEA 15009
Reactome R-HSA-1497794

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57453 (6S)-5,6,7,8-tetrahydrofolate(2-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:57451 dihydrofolate(2-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006762 obsolete dihydrofolate reduction consider GO:0004146

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004146 based on ALL annotations
The top 100 of 383 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydrofolate reductase activity
4,551.45 100.00 42,830 42,830
dihydrofolate metabolic process
4,550.97 88.08 37,727 37,731
folic acid metabolic process
4,509.26 87.36 37,726 38,079
tetrahydrofolate biosynthetic process
867.10 18.93 41,468 217,667
one-carbon metabolic process
378.35 8.07 31,564 379,709
NADP binding
198.46 4.34 37,823 867,427
thymidylate synthase activity
155.33 2.04 2,057 60,274
dTMP biosynthetic process
126.86 1.67 1,719 61,674
response to methotrexate
4,536.08 1.38 590 592
nucleotide biosynthetic process
33.34 0.63 1,880 256,651
Totals 321961 52717504
No co-occurrence statistics for GO:0004146 based on MANUAL annotations
The top 52 of 52 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydrofolate reductase activity
7,510.46 100.00 172 172
dihydrofolate metabolic process
7,432.23 54.91 95 96
folic acid metabolic process
5,800.76 47.50 95 123
tetrahydrofolate biosynthetic process
3,081.21 30.97 96 234
thymidylate synthase activity
2,901.77 24.29 68 176
dTMP biosynthetic process
2,679.41 22.68 66 185
NADP binding
1,035.55 12.40 95 689
10-formyltetrahydrofolate biosynthetic process
1,112.66 2.05 4 27
regulation of removal of superoxide radicals
1,502.09 1.63 3 15
folic acid binding
381.89 1.32 3 59
Totals 1013 664251

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM NADPH-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM tetrahydrofolate dehydrogenase activity
2020-10-08 Deleted SYNONYM thymidylate synthetase-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM pteridine reductase:dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM folic reductase activity
2020-10-08 Deleted SYNONYM folic acid reductase activity
2020-10-08 Deleted SYNONYM dihydrofolic reductase activity
2020-10-08 Deleted SYNONYM dihydrofolic acid reductase activity
2020-10-08 Deleted SYNONYM dihydrofolate reductase:thymidylate synthase activity
2020-10-08 Deleted SYNONYM NADPH-dihydrofolate reductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM dihydrofolate reductase activity
2002-02-06 Updated TERM dihydrofolate reductase
2001-04-03 Updated TERM dihydrofolate reductase
2001-03-30 Added TERM dihydrofolate reductase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM NADPH-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM tetrahydrofolate dehydrogenase activity
2020-10-08 Deleted SYNONYM thymidylate synthetase-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM pteridine reductase:dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM folic reductase activity
2020-10-08 Deleted SYNONYM folic acid reductase activity
2020-10-08 Deleted SYNONYM dihydrofolic reductase activity
2020-10-08 Deleted SYNONYM dihydrofolic acid reductase activity
2020-10-08 Deleted SYNONYM dihydrofolate reductase:thymidylate synthase activity
2020-10-08 Deleted SYNONYM NADPH-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM 7,8-dihydrofolate reductase activity
2020-10-08 Deleted SYNONYM 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM 7,8-dihydrofolate reductase activity
2020-10-08 Added SYNONYM 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM folic acid reductase activity
2020-10-08 Added SYNONYM dihydrofolate reductase:thymidylate synthase activity
2020-10-08 Added SYNONYM dihydrofolic reductase activity
2020-10-08 Added SYNONYM dihydrofolic acid reductase activity
2020-10-08 Added SYNONYM pteridine reductase:dihydrofolate reductase activity
2020-10-08 Added SYNONYM thymidylate synthetase-dihydrofolate reductase activity
2020-10-08 Added SYNONYM folic reductase activity
2020-10-08 Added SYNONYM tetrahydrofolate dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
2007-11-08 Added SYNONYM dihydrofolic reductase activity
2007-11-08 Added SYNONYM dihydrofolic acid reductase activity
2007-11-08 Added SYNONYM dihydrofolate reductase:thymidylate synthase activity
2007-11-08 Added SYNONYM NADPH-dihydrofolate reductase activity
2007-11-08 Added SYNONYM DHFR
2007-11-08 Added SYNONYM 7,8-dihydrofolate reductase activity
2007-11-08 Added SYNONYM 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
2007-11-08 Added SYNONYM folic acid reductase activity
2007-11-08 Added SYNONYM folic reductase activity
2007-11-08 Added SYNONYM thymidylate synthetase-dihydrofolate reductase activity
2007-11-08 Added SYNONYM pteridine reductase:dihydrofolate reductase activity
2007-09-06 Added SYNONYM tetrahydrofolate dehydrogenase activity
2007-08-09 Added SYNONYM dihydrofolate reduction
2007-08-09 Deleted SYNONYM dihydrofolate reduction
2005-08-10 Added SYNONYM dihydrofolate reduction
2002-11-27 Added DEFINITION Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-1497794
2019-04-01 Added XREF Reactome:R-HSA-1497794
2018-12-11 Added XREF reactome:R-HSA-1497794
2018-07-13 Deleted XREF RHEA:15012
2018-07-13 Added XREF RHEA:15009
2011-09-16 Added XREF RHEA:15012
2003-10-27 Added XREF MetaCyc:DIHYDROFOLATEREDUCT-RXN
2001-03-30 Added XREF EC:1.5.1.3
Timestamp Action Category Detail
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