GO:0004149
JSON
dihydrolipoyllysine-residue succinyltransferase activity
Molecular Function
Definition (GO:0004149 GONUTS page)
Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
lipoyl transsuccinylase activity | related |
dihydrolipoyl transsuccinylase activity | related |
lipoate succinyltransferase (Escherichia coli) activity | related |
dihydrolipoamide succinyltransferase activity | related |
succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity | related |
lipoic transsuccinylase activity | related |
succinyl-CoA:dihydrolipoate S-succinyltransferase activity | related |
enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity | related |
lipoate succinyltransferase activity | related |
dihydrolipoic transsuccinylase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | G4U500 | 197054 | G4U500_9ASCO | GO:0004149 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.61 | |
InterPro | IPR006255 | Dihydrolipoamide succinyltransferase |
RHEA | 15213 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:83100 | N(6)-[(R)-dihydrolipoyl]-L-lysine residue |
has_participant | CHEBI | CHEBI:83120 | N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysine(1-) residue |
has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
has_participant | CHEBI | CHEBI:57292 | succinyl-CoA(5-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004149 based on ALL annotations
The top 100 of 190 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydrolipoyllysine-residue succinyltransferase activity
|
6,081.20 | 100.00 | 32,056 | 32,056 |
L-lysine catabolic process to acetyl-CoA via saccharopine
|
5,559.28 | 63.85 | 21,772 | 23,816 |
oxoglutarate dehydrogenase complex
|
2,419.49 | 37.56 | 27,903 | 70,132 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
604.17 | 5.97 | 4,164 | 41,912 |
lysine catabolic process
|
5,670.30 | 5.36 | 1,725 | 1,850 |
tricarboxylic acid cycle
|
281.46 | 4.63 | 31,700 | 684,903 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
252.56 | 3.26 | 4,212 | 101,417 |
acyltransferase activity
|
72.70 | 1.19 | 30,462 | 2,548,217 |
2-hydroxy-3-oxoadipate synthase activity
|
5,970.63 | 1.01 | 324 | 330 |
2-oxoglutarate decarboxylase activity
|
2,509.95 | 1.00 | 324 | 785 |
Totals | 209673 | 118301618 |
No co-occurrence statistics for GO:0004149 based on MANUAL annotations
The top 38 of 38 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydrolipoyllysine-residue succinyltransferase activity
|
6,763.35 | 100.00 | 191 | 191 |
tricarboxylic acid cycle
|
540.27 | 7.98 | 189 | 2,366 |
succinyl-CoA metabolic process
|
203.19 | 1.68 | 7 | 233 |
2-oxoglutarate metabolic process
|
158.02 | 1.64 | 10 | 428 |
oxoadipate dehydrogenase complex
|
2,254.45 | 1.52 | 3 | 9 |
oxoglutarate dehydrogenase complex
|
103.91 | 1.23 | 11 | 716 |
oxoglutarate dehydrogenase (succinyl-transferring) activity
|
92.23 | 0.74 | 3 | 220 |
acyltransferase activity
|
61.26 | 0.68 | 5 | 552 |
dihydrolipoyl dehydrogenase activity
|
68.55 | 0.62 | 3 | 296 |
lipoic acid binding
|
75.57 | 0.54 | 2 | 179 |
Totals | 654 | 781748 |
Change Log
- All changes
- All changes
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9853512 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9858590 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9858590 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9853512 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9858590 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | dihydrolipoyllysine-residue succinyltransferase activity |
2003-03-19 | Updated | TERM | dihydrolipoamide S-succinyltransferase activity |
2002-02-06 | Updated | TERM | dihydrolipoamide S-succinyltransferase |
2001-04-03 | Updated | TERM | dihydrolipoamide S-succinyltransferase |
2001-03-30 | Added | TERM | dihydrolipoamide S-succinyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | dihydrolipolyl transsuccinylase activity |
2020-10-08 | Deleted | SYNONYM | dihydrolipoyl transsuccinylase activity |
2020-10-08 | Deleted | SYNONYM | lipoate succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | lipoic transsuccinylase activity |
2020-10-08 | Added | SYNONYM | enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | lipoyl transsuccinylase activity |
2020-10-08 | Deleted | SYNONYM | succinyl-CoA:dihydrolipoamide S-succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | succinyl-CoA:dihydrolipoate S-succinyltransferase activity |
2020-10-08 | Added | SYNONYM | dihydrolipoic transsuccinylase activity |
2020-10-08 | Added | SYNONYM | dihydrolipoamide succinyltransferase activity |
2020-10-08 | Added | SYNONYM | succinyl-CoA:dihydrolipoamide S-succinyltransferase activity |
2020-10-08 | Added | SYNONYM | succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity |
2020-10-08 | Added | SYNONYM | succinyl-CoA:dihydrolipoate S-succinyltransferase activity |
2020-10-08 | Added | SYNONYM | succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity |
2020-10-08 | Added | SYNONYM | lipoyl transsuccinylase activity |
2020-10-08 | Added | SYNONYM | lipoic transsuccinylase activity |
2020-10-08 | Added | SYNONYM | dihydrolipolyl transsuccinylase activity |
2020-10-08 | Added | SYNONYM | lipoate succinyltransferase activity |
2020-10-08 | Added | SYNONYM | dihydrolipoyl transsuccinylase activity |
2020-10-08 | Added | SYNONYM | lipoate succinyltransferase (Escherichia coli) activity |
2020-10-08 | Deleted | SYNONYM | dihydrolipoic transsuccinylase activity |
2020-10-08 | Deleted | SYNONYM | dihydrolipoamide succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity |
2020-10-08 | Deleted | SYNONYM | lipoate succinyltransferase (Escherichia coli) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. |
2007-12-14 | Added | SYNONYM | lipoate succinyltransferase (Escherichia coli) activity |
2007-12-14 | Added | SYNONYM | succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity |
2007-12-14 | Added | SYNONYM | succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity |
2007-12-14 | Added | SYNONYM | enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity |
2007-09-06 | Added | SYNONYM | dihydrolipoamide succinyltransferase activity |
2007-09-06 | Added | SYNONYM | dihydrolipolyl transsuccinylase activity |
2007-09-06 | Added | SYNONYM | succinyl-CoA:dihydrolipoate S-succinyltransferase activity |
2007-09-06 | Added | SYNONYM | succinyl-CoA:dihydrolipoamide S-succinyltransferase activity |
2007-09-06 | Added | SYNONYM | lipoate succinyltransferase activity |
2007-09-06 | Added | SYNONYM | lipoyl transsuccinylase activity |
2007-09-06 | Added | SYNONYM | dihydrolipoyl transsuccinylase activity |
2007-09-06 | Added | SYNONYM | lipoic transsuccinylase activity |
2007-09-06 | Added | SYNONYM | dihydrolipoic transsuccinylase activity |
2007-08-09 | Added | SYNONYM | dihydrolipoamide S-succinyltransferase activity |
2007-08-09 | Deleted | SYNONYM | dihydrolipoamide S-succinyltransferase activity |
2004-04-19 | Added | SYNONYM | dihydrolipoamide S-succinyltransferase activity |
2004-04-16 | Deleted | SYNONYM | dihydrolipoamide S-succinyltransferase activity |
2004-01-07 | Added | SYNONYM | dihydrolipoamide S-succinyltransferase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2008-04-01 | Updated | RELATION | is a GO:0016751 (S-succinyltransferase activity) |
Timestamp | Action | Category | Detail |
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2024-11-05 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9853512 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9858590 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9858590 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9853512 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9858590 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9853512 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9853512 |
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2024-09-08 | Deleted | XREF | Reactome:R-HSA-9858590 |
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2024-09-05 | Added | XREF | Reactome:R-HSA-9858590 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-9858590 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-9853512 |
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2024-04-24 | Added | XREF | Reactome:R-HSA-9853512 |
2024-04-21 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-04-19 | Added | XREF | Reactome:R-HSA-9853512 |
2024-04-18 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-04-14 | Added | XREF | Reactome:R-HSA-9853512 |
2024-04-13 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-04-12 | Added | XREF | Reactome:R-HSA-9853512 |
2024-04-11 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-04-09 | Added | XREF | Reactome:R-HSA-9853512 |
2024-04-07 | Deleted | XREF | Reactome:R-HSA-9853512 |
2024-04-06 | Added | XREF | Reactome:R-HSA-9853512 |
2020-06-22 | Added | XREF | RHEA:15213 |
2009-05-21 | Deleted | XREF | MetaCyc:DIHYDLIPSUCCTRANS-RXN |
2003-10-27 | Added | XREF | MetaCyc:DIHYDLIPSUCCTRANS-RXN |
2001-03-30 | Added | XREF | EC:2.3.1.61 |
Timestamp | Action | Category | Detail |
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