This term is obsolete.

GO:0004149 JSON

dihydrolipoyllysine-residue succinyltransferase activity

Molecular Function

Definition (GO:0004149 GONUTS page)

Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.

32,225 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
lipoyl transsuccinylase activity related
dihydrolipoyl transsuccinylase activity related
lipoate succinyltransferase (Escherichia coli) activity related
dihydrolipoamide succinyltransferase activity related
succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity related
lipoic transsuccinylase activity related
succinyl-CoA:dihydrolipoate S-succinyltransferase activity related
enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity related
lipoate succinyltransferase activity related
dihydrolipoic transsuccinylase activity related

Ancestor Chart

Ancestor chart for GO:0004149
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein G4U500 197054 G4U500_9ASCO GO:0004149 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.1.61
InterPro IPR006255 Dihydrolipoamide succinyltransferase
RHEA 15213

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:83100 N(6)-[(R)-dihydrolipoyl]-L-lysine residue
has_participant CHEBI CHEBI:83120 N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysine(1-) residue
has_participant CHEBI CHEBI:57287 coenzyme A(4-)
has_participant CHEBI CHEBI:57292 succinyl-CoA(5-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004149 based on ALL annotations
The top 100 of 190 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydrolipoyllysine-residue succinyltransferase activity
6,081.20 100.00 32,056 32,056
L-lysine catabolic process to acetyl-CoA via saccharopine
5,559.28 63.85 21,772 23,816
oxoglutarate dehydrogenase complex
2,419.49 37.56 27,903 70,132
oxoglutarate dehydrogenase (succinyl-transferring) activity
604.17 5.97 4,164 41,912
lysine catabolic process
5,670.30 5.36 1,725 1,850
tricarboxylic acid cycle
281.46 4.63 31,700 684,903
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
252.56 3.26 4,212 101,417
acyltransferase activity
72.70 1.19 30,462 2,548,217
2-hydroxy-3-oxoadipate synthase activity
5,970.63 1.01 324 330
2-oxoglutarate decarboxylase activity
2,509.95 1.00 324 785
Totals 209673 118301618
No co-occurrence statistics for GO:0004149 based on MANUAL annotations
The top 38 of 38 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydrolipoyllysine-residue succinyltransferase activity
6,763.35 100.00 191 191
tricarboxylic acid cycle
540.27 7.98 189 2,366
succinyl-CoA metabolic process
203.19 1.68 7 233
2-oxoglutarate metabolic process
158.02 1.64 10 428
oxoadipate dehydrogenase complex
2,254.45 1.52 3 9
oxoglutarate dehydrogenase complex
103.91 1.23 11 716
oxoglutarate dehydrogenase (succinyl-transferring) activity
92.23 0.74 3 220
acyltransferase activity
61.26 0.68 5 552
dihydrolipoyl dehydrogenase activity
68.55 0.62 3 296
lipoic acid binding
75.57 0.54 2 179
Totals 654 781748

Change Log

Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-9853512
2024-11-05 Deleted XREF Reactome:R-HSA-9858590
2024-11-03 Added XREF Reactome:R-HSA-9853512
2024-11-03 Added XREF Reactome:R-HSA-9858590
2024-11-02 Deleted XREF Reactome:R-HSA-9858590
2024-11-02 Deleted XREF Reactome:R-HSA-9853512
2024-11-01 Added XREF Reactome:R-HSA-9858590
2024-11-01 Added XREF Reactome:R-HSA-9853512
2024-10-26 Deleted XREF Reactome:R-HSA-9853512
2024-10-26 Deleted XREF Reactome:R-HSA-9858590
Timestamp Action Category Detail
2004-01-07 Updated TERM dihydrolipoyllysine-residue succinyltransferase activity
2003-03-19 Updated TERM dihydrolipoamide S-succinyltransferase activity
2002-02-06 Updated TERM dihydrolipoamide S-succinyltransferase
2001-04-03 Updated TERM dihydrolipoamide S-succinyltransferase
2001-03-30 Added TERM dihydrolipoamide S-succinyltransferase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM dihydrolipolyl transsuccinylase activity
2020-10-08 Deleted SYNONYM dihydrolipoyl transsuccinylase activity
2020-10-08 Deleted SYNONYM lipoate succinyltransferase activity
2020-10-08 Deleted SYNONYM lipoic transsuccinylase activity
2020-10-08 Added SYNONYM enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
2020-10-08 Deleted SYNONYM lipoyl transsuccinylase activity
2020-10-08 Deleted SYNONYM succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
2020-10-08 Deleted SYNONYM succinyl-CoA:dihydrolipoate S-succinyltransferase activity
2020-10-08 Added SYNONYM dihydrolipoic transsuccinylase activity
2020-10-08 Added SYNONYM dihydrolipoamide succinyltransferase activity
2020-10-08 Added SYNONYM succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
2020-10-08 Added SYNONYM succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
2020-10-08 Added SYNONYM succinyl-CoA:dihydrolipoate S-succinyltransferase activity
2020-10-08 Added SYNONYM succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
2020-10-08 Added SYNONYM lipoyl transsuccinylase activity
2020-10-08 Added SYNONYM lipoic transsuccinylase activity
2020-10-08 Added SYNONYM dihydrolipolyl transsuccinylase activity
2020-10-08 Added SYNONYM lipoate succinyltransferase activity
2020-10-08 Added SYNONYM dihydrolipoyl transsuccinylase activity
2020-10-08 Added SYNONYM lipoate succinyltransferase (Escherichia coli) activity
2020-10-08 Deleted SYNONYM dihydrolipoic transsuccinylase activity
2020-10-08 Deleted SYNONYM dihydrolipoamide succinyltransferase activity
2020-10-08 Deleted SYNONYM succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
2020-10-08 Deleted SYNONYM succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
2020-10-08 Deleted SYNONYM enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
2020-10-08 Deleted SYNONYM lipoate succinyltransferase (Escherichia coli) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
2007-12-14 Added SYNONYM lipoate succinyltransferase (Escherichia coli) activity
2007-12-14 Added SYNONYM succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity
2007-12-14 Added SYNONYM succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity
2007-12-14 Added SYNONYM enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity
2007-09-06 Added SYNONYM dihydrolipoamide succinyltransferase activity
2007-09-06 Added SYNONYM dihydrolipolyl transsuccinylase activity
2007-09-06 Added SYNONYM succinyl-CoA:dihydrolipoate S-succinyltransferase activity
2007-09-06 Added SYNONYM succinyl-CoA:dihydrolipoamide S-succinyltransferase activity
2007-09-06 Added SYNONYM lipoate succinyltransferase activity
2007-09-06 Added SYNONYM lipoyl transsuccinylase activity
2007-09-06 Added SYNONYM dihydrolipoyl transsuccinylase activity
2007-09-06 Added SYNONYM lipoic transsuccinylase activity
2007-09-06 Added SYNONYM dihydrolipoic transsuccinylase activity
2007-08-09 Added SYNONYM dihydrolipoamide S-succinyltransferase activity
2007-08-09 Deleted SYNONYM dihydrolipoamide S-succinyltransferase activity
2004-04-19 Added SYNONYM dihydrolipoamide S-succinyltransferase activity
2004-04-16 Deleted SYNONYM dihydrolipoamide S-succinyltransferase activity
2004-01-07 Added SYNONYM dihydrolipoamide S-succinyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2008-04-01 Updated RELATION is a GO:0016751 (S-succinyltransferase activity)
Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-9853512
2024-11-05 Deleted XREF Reactome:R-HSA-9858590
2024-11-03 Added XREF Reactome:R-HSA-9853512
2024-11-03 Added XREF Reactome:R-HSA-9858590
2024-11-02 Deleted XREF Reactome:R-HSA-9858590
2024-11-02 Deleted XREF Reactome:R-HSA-9853512
2024-11-01 Added XREF Reactome:R-HSA-9858590
2024-11-01 Added XREF Reactome:R-HSA-9853512
2024-10-26 Deleted XREF Reactome:R-HSA-9853512
2024-10-26 Deleted XREF Reactome:R-HSA-9858590
2024-10-09 Added XREF Reactome:R-HSA-9858590
2024-10-09 Added XREF Reactome:R-HSA-9853512
2024-10-08 Deleted XREF Reactome:R-HSA-9853512
2024-10-08 Deleted XREF Reactome:R-HSA-9858590
2024-09-21 Added XREF Reactome:R-HSA-9858590
2024-09-21 Added XREF Reactome:R-HSA-9853512
2024-09-20 Deleted XREF Reactome:R-HSA-9858590
2024-09-20 Deleted XREF Reactome:R-HSA-9853512
2024-09-19 Added XREF Reactome:R-HSA-9858590
2024-09-19 Added XREF Reactome:R-HSA-9853512
2024-09-13 Deleted XREF Reactome:R-HSA-9853512
2024-09-13 Deleted XREF Reactome:R-HSA-9858590
2024-09-10 Added XREF Reactome:R-HSA-9853512
2024-09-10 Added XREF Reactome:R-HSA-9858590
2024-09-08 Deleted XREF Reactome:R-HSA-9858590
2024-09-08 Deleted XREF Reactome:R-HSA-9853512
2024-09-07 Added XREF Reactome:R-HSA-9853512
2024-09-07 Added XREF Reactome:R-HSA-9858590
2024-09-06 Deleted XREF Reactome:R-HSA-9858590
2024-09-06 Deleted XREF Reactome:R-HSA-9853512
2024-09-05 Added XREF Reactome:R-HSA-9853512
2024-09-05 Added XREF Reactome:R-HSA-9858590
2024-09-02 Deleted XREF Reactome:R-HSA-9858590
2024-09-02 Deleted XREF Reactome:R-HSA-9853512
2024-08-20 Added XREF Reactome:R-HSA-9853512
2024-08-20 Added XREF Reactome:R-HSA-9858590
2024-08-16 Deleted XREF Reactome:R-HSA-9858590
2024-08-16 Deleted XREF Reactome:R-HSA-9853512
2024-08-15 Added XREF Reactome:R-HSA-9853512
2024-08-15 Added XREF Reactome:R-HSA-9858590
2024-08-08 Deleted XREF Reactome:R-HSA-9858590
2024-08-08 Added XREF Reactome:R-HSA-9853512
2024-08-08 Added XREF Reactome:R-HSA-9858590
2024-08-08 Deleted XREF Reactome:R-HSA-9853512
2024-08-06 Deleted XREF Reactome:R-HSA-9858590
2024-08-06 Deleted XREF Reactome:R-HSA-9853512
2024-08-05 Added XREF Reactome:R-HSA-9858590
2024-08-05 Added XREF Reactome:R-HSA-9853512
2024-07-28 Deleted XREF Reactome:R-HSA-9858590
2024-07-28 Deleted XREF Reactome:R-HSA-9853512
2024-07-27 Added XREF Reactome:R-HSA-9858590
2024-07-27 Added XREF Reactome:R-HSA-9853512
2024-07-26 Deleted XREF Reactome:R-HSA-9858590
2024-07-26 Deleted XREF Reactome:R-HSA-9853512
2024-07-25 Added XREF Reactome:R-HSA-9858590
2024-07-25 Added XREF Reactome:R-HSA-9853512
2024-07-20 Deleted XREF Reactome:R-HSA-9853512
2024-07-20 Deleted XREF Reactome:R-HSA-9858590
2024-07-19 Added XREF Reactome:R-HSA-9853512
2024-07-19 Added XREF Reactome:R-HSA-9858590
2024-07-18 Deleted XREF Reactome:R-HSA-9853512
2024-07-18 Deleted XREF Reactome:R-HSA-9858590
2024-07-14 Added XREF Reactome:R-HSA-9858590
2024-07-14 Added XREF Reactome:R-HSA-9853512
2024-07-11 Deleted XREF Reactome:R-HSA-9858590
2024-07-11 Deleted XREF Reactome:R-HSA-9853512
2024-07-10 Added XREF Reactome:R-HSA-9853512
2024-07-10 Added XREF Reactome:R-HSA-9858590
2024-07-09 Deleted XREF Reactome:R-HSA-9853512
2024-07-09 Deleted XREF Reactome:R-HSA-9858590
2024-07-06 Added XREF Reactome:R-HSA-9858590
2024-07-06 Added XREF Reactome:R-HSA-9853512
2024-07-04 Deleted XREF Reactome:R-HSA-9853512
2024-07-04 Deleted XREF Reactome:R-HSA-9858590
2024-07-03 Added XREF Reactome:R-HSA-9858590
2024-07-03 Added XREF Reactome:R-HSA-9853512
2024-06-30 Deleted XREF Reactome:R-HSA-9853512
2024-06-30 Deleted XREF Reactome:R-HSA-9858590
2024-06-29 Added XREF Reactome:R-HSA-9858590
2024-06-29 Added XREF Reactome:R-HSA-9853512
2024-06-28 Deleted XREF Reactome:R-HSA-9858590
2024-06-28 Deleted XREF Reactome:R-HSA-9853512
2024-06-27 Added XREF Reactome:R-HSA-9858590
2024-06-27 Added XREF Reactome:R-HSA-9853512
2024-06-26 Deleted XREF Reactome:R-HSA-9853512
2024-06-26 Deleted XREF Reactome:R-HSA-9858590
2024-06-23 Added XREF Reactome:R-HSA-9858590
2024-06-23 Added XREF Reactome:R-HSA-9853512
2024-06-20 Deleted XREF Reactome:R-HSA-9853512
2024-06-20 Deleted XREF Reactome:R-HSA-9858590
2024-06-19 Added XREF Reactome:R-HSA-9858590
2024-06-19 Added XREF Reactome:R-HSA-9853512
2024-06-14 Deleted XREF Reactome:R-HSA-9853512
2024-06-13 Added XREF Reactome:R-HSA-9853512
2024-06-12 Deleted XREF Reactome:R-HSA-9853512
2024-06-11 Added XREF Reactome:R-HSA-9853512
2024-06-07 Deleted XREF Reactome:R-HSA-9853512
2024-06-01 Added XREF Reactome:R-HSA-9853512
2024-05-31 Deleted XREF Reactome:R-HSA-9853512
2024-05-30 Added XREF Reactome:R-HSA-9853512
2024-05-29 Deleted XREF Reactome:R-HSA-9853512
2024-05-25 Added XREF Reactome:R-HSA-9853512
2024-05-24 Deleted XREF Reactome:R-HSA-9853512
2024-05-23 Added XREF Reactome:R-HSA-9853512
2024-05-22 Deleted XREF Reactome:R-HSA-9853512
2024-05-16 Added XREF Reactome:R-HSA-9853512
2024-05-15 Deleted XREF Reactome:R-HSA-9853512
2024-05-14 Added XREF Reactome:R-HSA-9853512
2024-05-11 Deleted XREF Reactome:R-HSA-9853512
2024-05-09 Deleted XREF Reactome:R-HSA-9853512
2024-05-09 Added XREF Reactome:R-HSA-9853512
2024-05-08 Added XREF Reactome:R-HSA-9853512
2024-05-05 Deleted XREF Reactome:R-HSA-9853512
2024-05-03 Added XREF Reactome:R-HSA-9853512
2024-05-02 Deleted XREF Reactome:R-HSA-9853512
2024-05-01 Added XREF Reactome:R-HSA-9853512
2024-04-25 Deleted XREF Reactome:R-HSA-9853512
2024-04-24 Added XREF Reactome:R-HSA-9853512
2024-04-21 Deleted XREF Reactome:R-HSA-9853512
2024-04-19 Added XREF Reactome:R-HSA-9853512
2024-04-18 Deleted XREF Reactome:R-HSA-9853512
2024-04-14 Added XREF Reactome:R-HSA-9853512
2024-04-13 Deleted XREF Reactome:R-HSA-9853512
2024-04-12 Added XREF Reactome:R-HSA-9853512
2024-04-11 Deleted XREF Reactome:R-HSA-9853512
2024-04-09 Added XREF Reactome:R-HSA-9853512
2024-04-07 Deleted XREF Reactome:R-HSA-9853512
2024-04-06 Added XREF Reactome:R-HSA-9853512
2020-06-22 Added XREF RHEA:15213
2009-05-21 Deleted XREF MetaCyc:DIHYDLIPSUCCTRANS-RXN
2003-10-27 Added XREF MetaCyc:DIHYDLIPSUCCTRANS-RXN
2001-03-30 Added XREF EC:2.3.1.61
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.