GO:0004160
JSON
dihydroxy-acid dehydratase activity
Molecular Function
Definition (GO:0004160 GONUTS page)
Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
2,3-dihydroxy-acid hydro-lyase activity | related |
acetohydroxyacid dehydratase activity | related |
2,3-dihydroxyisovalerate dehydratase activity | related |
DHAD | related |
dihydroxy acid dehydrase activity | related |
alpha,beta-dihydroxyacid dehydratase activity | related |
2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) | related |
alpha,beta-dihydroxyisovalerate dehydratase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q35061 | 56867 | Q35061_MARPA | GO:0004160 | To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.2.1.9 | |
InterPro | IPR004404 | Dihydroxy-acid dehydratase |
MetaCyc | DIHYDROXYISOVALDEHYDRAT-RXN | |
RHEA | 24809 | |
RHEA | 27694 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:49072 | (R)-2,3-dihydroxy-3-methylbutanoate |
has_participant | CHEBI | CHEBI:11851 | 3-methyl-2-oxobutanoate |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004160 based on ALL annotations
The top 100 of 174 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydroxy-acid dehydratase activity
|
3,791.33 | 100.00 | 51,417 | 51,417 |
branched-chain amino acid biosynthetic process
|
727.76 | 18.67 | 44,840 | 233,599 |
hydro-lyase activity
|
526.95 | 13.89 | 51,180 | 368,235 |
L-valine biosynthetic process
|
529.37 | 13.40 | 39,604 | 283,644 |
isoleucine biosynthetic process
|
358.98 | 9.21 | 39,604 | 418,276 |
amino acid biosynthetic process
|
197.04 | 5.13 | 40,459 | 778,477 |
2 iron, 2 sulfur cluster binding
|
183.60 | 4.78 | 40,790 | 842,312 |
carboxylic acid metabolic process
|
73.38 | 1.75 | 7,816 | 403,849 |
lyase activity
|
43.11 | 1.14 | 51,028 | 4,487,410 |
magnesium ion binding
|
42.84 | 1.12 | 35,623 | 3,152,949 |
Totals | 481007 | 85699219 |
No co-occurrence statistics for GO:0004160 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dihydroxy-acid dehydratase activity
|
13,890.31 | 100.00 | 93 | 93 |
branched-chain amino acid biosynthetic process
|
9,465.99 | 67.65 | 92 | 135 |
L-isoleucine biosynthetic process
|
1,736.29 | 1.00 | 1 | 8 |
L-valine biosynthetic process
|
48.82 | 0.30 | 2 | 569 |
isoleucine biosynthetic process
|
36.89 | 0.24 | 2 | 753 |
L-leucine biosynthetic process
|
37.85 | 0.22 | 1 | 367 |
iron-sulfur cluster binding
|
37.64 | 0.22 | 1 | 369 |
hydro-lyase activity
|
23.00 | 0.14 | 1 | 604 |
4 iron, 4 sulfur cluster binding
|
9.40 | 0.06 | 1 | 1,477 |
mitochondrial matrix
|
3.54 | 0.02 | 1 | 3,923 |
Totals | 203 | 374790 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Deleted | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O. |
2024-09-19 | Added | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2024-08-05 | Added | XREF | RHEA:24809 |
2024-08-05 | Added | XREF | RHEA:27694 |
2024-08-05 | Deleted | XREF | RHEA:20936 |
2024-08-05 | Deleted | DEFINITION | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2024-08-05 | Added | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O. |
2020-10-08 | Deleted | SYNONYM | alpha,beta-dihydroxyacid dehydratase activity |
2020-10-08 | Deleted | SYNONYM | 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) |
2020-10-08 | Deleted | SYNONYM | dihydroxy acid dehydrase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | dihydroxy-acid dehydratase activity |
2002-02-06 | Updated | TERM | dihydroxy-acid dehydratase |
2001-04-03 | Updated | TERM | dihydroxy-acid dehydratase |
2001-03-30 | Added | TERM | dihydroxy-acid dehydratase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Deleted | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O. |
2024-09-19 | Added | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2024-08-05 | Deleted | DEFINITION | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2024-08-05 | Added | DEFINITION | Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O. |
2020-10-08 | Deleted | SYNONYM | alpha,beta-dihydroxyacid dehydratase activity |
2020-10-08 | Deleted | SYNONYM | 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) |
2020-10-08 | Deleted | SYNONYM | dihydroxy acid dehydrase activity |
2020-10-08 | Deleted | SYNONYM | alpha,beta-dihydroxyisovalerate dehydratase activity |
2020-10-08 | Deleted | SYNONYM | 2,3-dihydroxy-acid hydro-lyase activity |
2020-10-08 | Deleted | SYNONYM | acetohydroxyacid dehydratase activity |
2020-10-08 | Deleted | SYNONYM | 2,3-dihydroxyisovalerate dehydratase activity |
2020-10-08 | Added | SYNONYM | 2,3-dihydroxyisovalerate dehydratase activity |
2020-10-08 | Added | SYNONYM | alpha,beta-dihydroxyacid dehydratase activity |
2020-10-08 | Added | SYNONYM | dihydroxy acid dehydrase activity |
2020-10-08 | Added | SYNONYM | alpha,beta-dihydroxyisovalerate dehydratase activity |
2020-10-08 | Added | SYNONYM | acetohydroxyacid dehydratase activity |
2020-10-08 | Added | SYNONYM | 2,3-dihydroxy-acid hydro-lyase activity |
2020-10-08 | Added | SYNONYM | 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
2007-11-08 | Added | SYNONYM | alpha,beta-dihydroxyacid dehydratase activity |
2007-11-08 | Added | SYNONYM | acetohydroxyacid dehydratase activity |
2007-11-08 | Added | SYNONYM | DHAD |
2007-11-08 | Added | SYNONYM | alpha,beta-dihydroxyisovalerate dehydratase activity |
2007-11-08 | Added | SYNONYM | dihydroxy acid dehydrase activity |
2007-11-08 | Added | SYNONYM | 2,3-dihydroxyisovalerate dehydratase activity |
2007-11-08 | Added | SYNONYM | 2,3-dihydroxy-acid hydro-lyase activity |
2007-11-08 | Added | SYNONYM | 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-31 | Added | RELATION | has part GO:0009099 (L-valine biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0016836 (hydro-lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-05 | Added | XREF | RHEA:24809 |
2024-08-05 | Added | XREF | RHEA:27694 |
2024-08-05 | Deleted | XREF | RHEA:20936 |
2018-07-13 | Deleted | XREF | RHEA:20939 |
2018-07-13 | Added | XREF | RHEA:20936 |
2011-09-16 | Added | XREF | RHEA:20939 |
2003-10-27 | Added | XREF | MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN |
2001-03-30 | Added | XREF | EC:4.2.1.9 |
Timestamp | Action | Category | Detail |
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