This term is obsolete.

GO:0004160 JSON

dihydroxy-acid dehydratase activity

Molecular Function

Definition (GO:0004160 GONUTS page)

Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.

51,504 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
2,3-dihydroxy-acid hydro-lyase activity related
acetohydroxyacid dehydratase activity related
2,3-dihydroxyisovalerate dehydratase activity related
DHAD related
dihydroxy acid dehydrase activity related
alpha,beta-dihydroxyacid dehydratase activity related
2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) related
alpha,beta-dihydroxyisovalerate dehydratase activity related

Ancestor Chart

Ancestor chart for GO:0004160
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q35061 56867 Q35061_MARPA GO:0004160 To remove over-annotation from InterPro entry IPR000883; protein is truncated by an intron-encoded endonuclease. Reported by InterPro on 28-02-2012
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.2.1.9
InterPro IPR004404 Dihydroxy-acid dehydratase
MetaCyc DIHYDROXYISOVALDEHYDRAT-RXN
RHEA 24809
RHEA 27694

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:49072 (R)-2,3-dihydroxy-3-methylbutanoate
has_participant CHEBI CHEBI:11851 3-methyl-2-oxobutanoate
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004160 based on ALL annotations
The top 100 of 174 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroxy-acid dehydratase activity
3,791.33 100.00 51,417 51,417
branched-chain amino acid biosynthetic process
727.76 18.67 44,840 233,599
hydro-lyase activity
526.95 13.89 51,180 368,235
L-valine biosynthetic process
529.37 13.40 39,604 283,644
isoleucine biosynthetic process
358.98 9.21 39,604 418,276
amino acid biosynthetic process
197.04 5.13 40,459 778,477
2 iron, 2 sulfur cluster binding
183.60 4.78 40,790 842,312
carboxylic acid metabolic process
73.38 1.75 7,816 403,849
lyase activity
43.11 1.14 51,028 4,487,410
magnesium ion binding
42.84 1.12 35,623 3,152,949
Totals 481007 85699219
No co-occurrence statistics for GO:0004160 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dihydroxy-acid dehydratase activity
13,890.31 100.00 93 93
branched-chain amino acid biosynthetic process
9,465.99 67.65 92 135
L-isoleucine biosynthetic process
1,736.29 1.00 1 8
L-valine biosynthetic process
48.82 0.30 2 569
isoleucine biosynthetic process
36.89 0.24 2 753
L-leucine biosynthetic process
37.85 0.22 1 367
iron-sulfur cluster binding
37.64 0.22 1 369
hydro-lyase activity
23.00 0.14 1 604
4 iron, 4 sulfur cluster binding
9.40 0.06 1 1,477
mitochondrial matrix
3.54 0.02 1 3,923
Totals 203 374790

Change Log

Timestamp Action Category Detail
2024-09-19 Deleted DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O.
2024-09-19 Added DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2024-08-05 Added XREF RHEA:24809
2024-08-05 Added XREF RHEA:27694
2024-08-05 Deleted XREF RHEA:20936
2024-08-05 Deleted DEFINITION Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2024-08-05 Added DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O.
2020-10-08 Deleted SYNONYM alpha,beta-dihydroxyacid dehydratase activity
2020-10-08 Deleted SYNONYM 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
2020-10-08 Deleted SYNONYM dihydroxy acid dehydrase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM dihydroxy-acid dehydratase activity
2002-02-06 Updated TERM dihydroxy-acid dehydratase
2001-04-03 Updated TERM dihydroxy-acid dehydratase
2001-03-30 Added TERM dihydroxy-acid dehydratase
Timestamp Action Category Detail
2024-09-19 Deleted DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O.
2024-09-19 Added DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2024-08-05 Deleted DEFINITION Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2024-08-05 Added DEFINITION Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O.
2020-10-08 Deleted SYNONYM alpha,beta-dihydroxyacid dehydratase activity
2020-10-08 Deleted SYNONYM 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
2020-10-08 Deleted SYNONYM dihydroxy acid dehydrase activity
2020-10-08 Deleted SYNONYM alpha,beta-dihydroxyisovalerate dehydratase activity
2020-10-08 Deleted SYNONYM 2,3-dihydroxy-acid hydro-lyase activity
2020-10-08 Deleted SYNONYM acetohydroxyacid dehydratase activity
2020-10-08 Deleted SYNONYM 2,3-dihydroxyisovalerate dehydratase activity
2020-10-08 Added SYNONYM 2,3-dihydroxyisovalerate dehydratase activity
2020-10-08 Added SYNONYM alpha,beta-dihydroxyacid dehydratase activity
2020-10-08 Added SYNONYM dihydroxy acid dehydrase activity
2020-10-08 Added SYNONYM alpha,beta-dihydroxyisovalerate dehydratase activity
2020-10-08 Added SYNONYM acetohydroxyacid dehydratase activity
2020-10-08 Added SYNONYM 2,3-dihydroxy-acid hydro-lyase activity
2020-10-08 Added SYNONYM 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
2008-05-13 Added DEFINITION Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
2007-11-08 Added SYNONYM alpha,beta-dihydroxyacid dehydratase activity
2007-11-08 Added SYNONYM acetohydroxyacid dehydratase activity
2007-11-08 Added SYNONYM DHAD
2007-11-08 Added SYNONYM alpha,beta-dihydroxyisovalerate dehydratase activity
2007-11-08 Added SYNONYM dihydroxy acid dehydrase activity
2007-11-08 Added SYNONYM 2,3-dihydroxyisovalerate dehydratase activity
2007-11-08 Added SYNONYM 2,3-dihydroxy-acid hydro-lyase activity
2007-11-08 Added SYNONYM 2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)
2002-11-27 Added DEFINITION Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.
Timestamp Action Category Detail
2018-03-31 Added RELATION has part GO:0009099 (L-valine biosynthetic process)
2008-04-01 Updated RELATION is a GO:0016836 (hydro-lyase activity)
Timestamp Action Category Detail
2024-08-05 Added XREF RHEA:24809
2024-08-05 Added XREF RHEA:27694
2024-08-05 Deleted XREF RHEA:20936
2018-07-13 Deleted XREF RHEA:20939
2018-07-13 Added XREF RHEA:20936
2011-09-16 Added XREF RHEA:20939
2003-10-27 Added XREF MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN
2001-03-30 Added XREF EC:4.2.1.9
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.