GO:0004300
JSON
enoyl-CoA hydratase activity
Molecular Function
Definition (GO:0004300 GONUTS page)
Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.
Secondary IDs
GO:0016510
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
beta-hydroxyacyl-CoA dehydrase activity | related |
2-enoyl-CoA hydratase activity | related |
enoyl hydrase activity | related |
(3S)-3-hydroxyacyl-CoA hydro-lyase activity | related |
3-hydroxy-fatty acyl-CoA dehydratase | exact |
short-chain enoyl-CoA hydratase activity | exact |
acyl coenzyme A hydrase activity | related |
enol-CoA hydratase activity | related |
2-octenoyl coenzyme A hydrase activity | related |
unsaturated acyl-CoA hydratase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004300
Child Term | Relationship to GO:0004300 |
---|---|
3-hydroxyacyl-CoA dehydratase activity
|
is_a |
fatty acid beta-oxidation multienzyme complex
|
capable_of |
3-hydroxypropionyl-CoA dehydratase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.2.1.17 | |
InterPro | IPR012799 | Fatty oxidation complex, alpha subunit FadB |
InterPro | IPR012802 | Fatty oxidation complex, alpha subunit FadJ |
InterPro | IPR012803 | Fatty acid oxidation complex, alpha subunit, mitochondrial |
MetaCyc | ENOYL-COA-HYDRAT-RXN | |
MetaCyc | RXN-10697 | |
MetaCyc | RXN-10704 | |
MetaCyc | RXN-10705 | |
RHEA | 16105 | |
RHEA | 20724 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0102073 | obsolete OPC8-trans-2-enoyl-CoA hydratase activity | replaced_by GO:0004300 |
GO:0102074 | obsolete OPC6-trans-2-enoyl-CoA hydratase activity | replaced_by GO:0004300 |
GO:0102075 | obsolete OPC4-trans-2-enoyl-CoA hydratase activity | replaced_by GO:0004300 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004300 based on ALL annotations
The top 100 of 349 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
enoyl-CoA hydratase activity
|
2,280.65 | 100.00 | 85,475 | 85,475 |
3-hydroxyacyl-CoA dehydrogenase activity
|
1,402.23 | 34.00 | 36,929 | 60,063 |
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
|
2,280.02 | 33.46 | 28,601 | 28,609 |
fatty acid beta-oxidation
|
409.88 | 16.92 | 63,506 | 353,360 |
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
|
2,259.54 | 11.26 | 9,632 | 9,722 |
3-hydroxybutyryl-CoA epimerase activity
|
2,268.49 | 10.03 | 8,580 | 8,626 |
NAD+ binding
|
256.75 | 9.21 | 28,780 | 255,642 |
fatty acid metabolic process
|
179.11 | 7.28 | 42,575 | 542,123 |
delta(3)-delta(2)-enoyl-CoA isomerase activity
|
607.44 | 6.70 | 7,027 | 26,383 |
fatty acid beta-oxidation multienzyme complex
|
2,280.15 | 5.27 | 4,504 | 4,505 |
Totals | 535806 | 81375786 |
No co-occurrence statistics for GO:0004300 based on MANUAL annotations
The top 100 of 120 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
enoyl-CoA hydratase activity
|
3,999.38 | 100.00 | 323 | 323 |
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
|
3,847.02 | 30.89 | 101 | 105 |
3-hydroxyacyl-CoA dehydrogenase activity
|
1,544.52 | 26.82 | 151 | 391 |
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
|
3,943.05 | 21.60 | 70 | 71 |
fatty acid beta-oxidation
|
692.16 | 17.19 | 311 | 1,797 |
mitochondrial fatty acid beta-oxidation multienzyme complex
|
1,999.69 | 11.99 | 44 | 88 |
peroxisome
|
126.51 | 3.03 | 134 | 4,236 |
delta(3)-delta(2)-enoyl-CoA isomerase activity
|
203.67 | 2.08 | 11 | 216 |
3-hydroxyacyl-CoA dehydratase activity
|
171.18 | 1.93 | 11 | 257 |
3-hydroxybutyryl-CoA epimerase activity
|
3,999.38 | 1.86 | 6 | 6 |
Totals | 1427 | 109146 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9916717 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9916717 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9916717 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9916717 |
2024-07-16 | Deleted | XREF | UM-BBD_enzymeID:e0014 |
2023-03-14 | Added | XREF | MetaCyc:RXN-10705 |
2023-03-14 | Added | XREF | MetaCyc:RXN-10704 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | enoyl-CoA hydratase activity |
2002-02-06 | Updated | TERM | enoyl-CoA hydratase |
2001-04-03 | Updated | TERM | enoyl-CoA hydratase |
2001-03-30 | Added | TERM | enoyl-CoA hydratase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-14 | Deleted | SYNONYM | trans-2-enoyl-CoA hydratase activity |
2023-01-28 | Deleted | SYNONYM | hydratase, enoyl coenzyme A |
2023-01-28 | Deleted | SYNONYM | enoyl coenzyme A hydrase (L) |
2023-01-28 | Deleted | SYNONYM | short chain enoyl coenzyme A hydratase activity |
2023-01-28 | Added | SYNONYM | 3-hydroxy-fatty acyl-CoA dehydratase |
2023-01-28 | Added | SYNONYM | 3-hydroxyacyl-CoA dehydratase |
2023-01-28 | Deleted | SYNONYM | crotonyl hydrase activity |
2023-01-28 | Deleted | SYNONYM | enoyl coenzyme A hydratase activity |
2023-01-28 | Deleted | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
2023-01-28 | Added | DEFINITION | Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. |
2023-01-28 | Deleted | SYNONYM | enoyl coenzyme A hydrase (D) |
2023-01-28 | Deleted | SYNONYM | ECH |
2023-01-28 | Deleted | SYNONYM | D-3-hydroxyacyl-CoA dehydratase |
2020-10-08 | Added | SYNONYM | trans-2-enoyl-CoA hydratase activity |
2020-10-08 | Added | SYNONYM | hydratase, enoyl coenzyme A |
2020-10-08 | Added | SYNONYM | beta-hydroxyacyl-CoA dehydrase activity |
2020-10-08 | Added | SYNONYM | enoyl coenzyme A hydrase (L) |
2020-10-08 | Added | SYNONYM | 2-enoyl-CoA hydratase activity |
2020-10-08 | Added | SYNONYM | short chain enoyl coenzyme A hydratase activity |
2020-10-08 | Added | SYNONYM | (3S)-3-hydroxyacyl-CoA hydro-lyase activity |
2020-10-08 | Deleted | SYNONYM | enoyl coenzyme A hydratase activity |
2020-10-08 | Deleted | SYNONYM | enoyl coenzyme A hydrase (L) |
2020-10-08 | Deleted | SYNONYM | enol-CoA hydratase activity |
2020-10-08 | Deleted | SYNONYM | crotonyl hydrase activity |
2020-10-08 | Deleted | SYNONYM | beta-hydroxyacyl-CoA dehydrase activity |
2020-10-08 | Deleted | SYNONYM | beta-hydroxyacid dehydrase activity |
2020-10-08 | Deleted | SYNONYM | acyl coenzyme A hydrase activity |
2020-10-08 | Deleted | SYNONYM | 2-octenoyl coenzyme A hydrase activity |
2020-10-08 | Deleted | SYNONYM | 2-enoyl-CoA hydratase activity |
2020-10-08 | Deleted | SYNONYM | (3S)-3-hydroxyacyl-CoA hydro-lyase activity |
2020-10-08 | Deleted | SYNONYM | trans-2-enoyl-CoA hydratase activity |
2020-10-08 | Deleted | SYNONYM | short chain enoyl coenzyme A hydratase activity |
2020-10-08 | Deleted | SYNONYM | hydratase, enoyl coenzyme A |
2020-10-08 | Added | SYNONYM | crotonyl hydrase activity |
2020-10-08 | Added | SYNONYM | enol-CoA hydratase activity |
2020-10-08 | Added | SYNONYM | acyl coenzyme A hydrase activity |
2020-10-08 | Added | SYNONYM | 2-octenoyl coenzyme A hydrase activity |
2020-10-08 | Added | SYNONYM | unsaturated acyl-CoA hydratase activity |
2020-10-08 | Added | SYNONYM | enoyl coenzyme A hydratase activity |
2020-10-08 | Added | SYNONYM | enoyl hydrase activity |
2020-10-08 | Deleted | SYNONYM | unsaturated acyl-CoA hydratase activity |
2020-10-08 | Deleted | SYNONYM | enoyl hydrase activity |
2020-10-08 | Added | SYNONYM | beta-hydroxyacid dehydrase activity |
2010-09-15 | Deleted | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. |
2010-09-15 | Added | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. |
2007-11-08 | Added | SYNONYM | D-3-hydroxyacyl-CoA dehydratase |
2007-11-08 | Added | SYNONYM | ECH |
2007-11-08 | Added | SYNONYM | acyl coenzyme A hydrase activity |
2007-11-08 | Added | SYNONYM | beta-hydroxyacid dehydrase activity |
2007-11-08 | Added | SYNONYM | beta-hydroxyacyl-CoA dehydrase activity |
2007-11-08 | Added | SYNONYM | crotonyl hydrase activity |
2007-11-08 | Added | SYNONYM | 2-octenoyl coenzyme A hydrase activity |
2007-11-08 | Added | SYNONYM | 2-enoyl-CoA hydratase activity |
2007-11-08 | Added | SYNONYM | (3S)-3-hydroxyacyl-CoA hydro-lyase activity |
2007-11-08 | Added | SYNONYM | enol-CoA hydratase activity |
2007-11-08 | Added | SYNONYM | trans-2-enoyl-CoA hydratase activity |
2007-11-08 | Added | SYNONYM | short chain enoyl coenzyme A hydratase activity |
2007-11-08 | Added | SYNONYM | hydratase, enoyl coenzyme A |
2007-11-08 | Added | SYNONYM | enoyl coenzyme A hydratase activity |
2007-11-08 | Added | SYNONYM | enoyl coenzyme A hydrase (L) |
2007-11-08 | Added | SYNONYM | enoyl coenzyme A hydrase (D) |
2007-09-06 | Added | SYNONYM | enoyl hydrase activity |
2007-09-06 | Added | SYNONYM | unsaturated acyl-CoA hydratase activity |
2007-08-09 | Added | SYNONYM | short-chain enoyl-CoA hydratase activity |
2007-08-09 | Deleted | SYNONYM | short-chain enoyl-CoA hydratase activity |
2004-04-19 | Added | SYNONYM | short-chain enoyl-CoA hydratase activity |
2004-04-16 | Deleted | SYNONYM | short-chain enoyl-CoA hydratase activity |
2003-10-27 | Added | SYNONYM | short-chain enoyl-CoA hydratase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016836 (hydro-lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9916717 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9916717 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9916717 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9916717 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9916717 |
2024-07-16 | Deleted | XREF | UM-BBD_enzymeID:e0014 |
2023-03-14 | Added | XREF | MetaCyc:RXN-10705 |
2023-03-14 | Added | XREF | MetaCyc:RXN-10704 |
2023-03-14 | Added | XREF | MetaCyc:RXN-10697 |
2023-01-28 | Added | XREF | RHEA:20724 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77325 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77256 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77256 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77277 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77301 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77344 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77277 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77314 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70870 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77333 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77301 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70830 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70830 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70870 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77314 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77325 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77333 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77344 |
2018-12-11 | Added | XREF | reactome:R-HSA-77314 |
2018-12-11 | Added | XREF | reactome:R-HSA-77301 |
2018-12-11 | Added | XREF | reactome:R-HSA-77277 |
2018-12-11 | Added | XREF | reactome:R-HSA-70870 |
2018-12-11 | Added | XREF | reactome:R-HSA-77325 |
2018-12-11 | Added | XREF | reactome:R-HSA-77256 |
2018-12-11 | Added | XREF | reactome:R-HSA-77344 |
2018-12-11 | Added | XREF | reactome:R-HSA-77333 |
2018-12-11 | Added | XREF | reactome:R-HSA-70830 |
2018-07-13 | Added | XREF | RHEA:16105 |
2018-07-13 | Deleted | XREF | RHEA:16108 |
2011-09-16 | Added | XREF | RHEA:16108 |
2003-10-27 | Added | XREF | MetaCyc:ENOYL-COA-HYDRAT-RXN |
2003-10-27 | Added | XREF | UM-BBD_enzymeID:e0014 |
2001-03-30 | Added | XREF | EC:4.2.1.17 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-21 | Added | SECONDARY | GO:0016510 (short-chain enoyl-CoA hydratase activity) |
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