This term is obsolete.

GO:0004300 JSON

enoyl-CoA hydratase activity

Molecular Function

Definition (GO:0004300 GONUTS page)

Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.

Secondary IDs

GO:0016510

100,646 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
beta-hydroxyacyl-CoA dehydrase activity related
2-enoyl-CoA hydratase activity related
enoyl hydrase activity related
(3S)-3-hydroxyacyl-CoA hydro-lyase activity related
3-hydroxy-fatty acyl-CoA dehydratase exact
short-chain enoyl-CoA hydratase activity exact
acyl coenzyme A hydrase activity related
enol-CoA hydratase activity related
2-octenoyl coenzyme A hydrase activity related
unsaturated acyl-CoA hydratase activity related

Ancestor Chart

Ancestor chart for GO:0004300
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004300

Child Term Relationship to
GO:0004300
3-hydroxyacyl-CoA dehydratase activity
is_a
fatty acid beta-oxidation multienzyme complex
capable_of
3-hydroxypropionyl-CoA dehydratase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.2.1.17
InterPro IPR012799 Fatty oxidation complex, alpha subunit FadB
InterPro IPR012802 Fatty oxidation complex, alpha subunit FadJ
InterPro IPR012803 Fatty acid oxidation complex, alpha subunit, mitochondrial
MetaCyc ENOYL-COA-HYDRAT-RXN
MetaCyc RXN-10697
MetaCyc RXN-10704
MetaCyc RXN-10705
RHEA 16105
RHEA 20724

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0102073 obsolete OPC8-trans-2-enoyl-CoA hydratase activity replaced_by GO:0004300
GO:0102074 obsolete OPC6-trans-2-enoyl-CoA hydratase activity replaced_by GO:0004300
GO:0102075 obsolete OPC4-trans-2-enoyl-CoA hydratase activity replaced_by GO:0004300

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004300 based on ALL annotations
The top 100 of 349 co-occurring terms
Co-occurring Term PR S% #Together #Compared
enoyl-CoA hydratase activity
2,280.65 100.00 85,475 85,475
3-hydroxyacyl-CoA dehydrogenase activity
1,402.23 34.00 36,929 60,063
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
2,280.02 33.46 28,601 28,609
fatty acid beta-oxidation
409.88 16.92 63,506 353,360
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
2,259.54 11.26 9,632 9,722
3-hydroxybutyryl-CoA epimerase activity
2,268.49 10.03 8,580 8,626
NAD+ binding
256.75 9.21 28,780 255,642
fatty acid metabolic process
179.11 7.28 42,575 542,123
delta(3)-delta(2)-enoyl-CoA isomerase activity
607.44 6.70 7,027 26,383
fatty acid beta-oxidation multienzyme complex
2,280.15 5.27 4,504 4,505
Totals 535806 81375786
No co-occurrence statistics for GO:0004300 based on MANUAL annotations
The top 100 of 120 co-occurring terms
Co-occurring Term PR S% #Together #Compared
enoyl-CoA hydratase activity
3,999.38 100.00 323 323
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
3,847.02 30.89 101 105
3-hydroxyacyl-CoA dehydrogenase activity
1,544.52 26.82 151 391
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
3,943.05 21.60 70 71
fatty acid beta-oxidation
692.16 17.19 311 1,797
mitochondrial fatty acid beta-oxidation multienzyme complex
1,999.69 11.99 44 88
peroxisome
126.51 3.03 134 4,236
delta(3)-delta(2)-enoyl-CoA isomerase activity
203.67 2.08 11 216
3-hydroxyacyl-CoA dehydratase activity
171.18 1.93 11 257
3-hydroxybutyryl-CoA epimerase activity
3,999.38 1.86 6 6
Totals 1427 109146

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9916717
2024-11-05 Deleted XREF Reactome:R-HSA-9916717
2024-11-03 Added XREF Reactome:R-HSA-9916717
2024-11-02 Deleted XREF Reactome:R-HSA-9916717
2024-11-01 Added XREF Reactome:R-HSA-9916717
2024-10-26 Deleted XREF Reactome:R-HSA-9916717
2024-10-09 Added XREF Reactome:R-HSA-9916717
2024-07-16 Deleted XREF UM-BBD_enzymeID:e0014
2023-03-14 Added XREF MetaCyc:RXN-10705
2023-03-14 Added XREF MetaCyc:RXN-10704
Timestamp Action Category Detail
2003-03-19 Updated TERM enoyl-CoA hydratase activity
2002-02-06 Updated TERM enoyl-CoA hydratase
2001-04-03 Updated TERM enoyl-CoA hydratase
2001-03-30 Added TERM enoyl-CoA hydratase
Timestamp Action Category Detail
2023-03-14 Deleted SYNONYM trans-2-enoyl-CoA hydratase activity
2023-01-28 Deleted SYNONYM hydratase, enoyl coenzyme A
2023-01-28 Deleted SYNONYM enoyl coenzyme A hydrase (L)
2023-01-28 Deleted SYNONYM short chain enoyl coenzyme A hydratase activity
2023-01-28 Added SYNONYM 3-hydroxy-fatty acyl-CoA dehydratase
2023-01-28 Added SYNONYM 3-hydroxyacyl-CoA dehydratase
2023-01-28 Deleted SYNONYM crotonyl hydrase activity
2023-01-28 Deleted SYNONYM enoyl coenzyme A hydratase activity
2023-01-28 Deleted DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
2023-01-28 Added DEFINITION Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.
2023-01-28 Deleted SYNONYM enoyl coenzyme A hydrase (D)
2023-01-28 Deleted SYNONYM ECH
2023-01-28 Deleted SYNONYM D-3-hydroxyacyl-CoA dehydratase
2020-10-08 Added SYNONYM trans-2-enoyl-CoA hydratase activity
2020-10-08 Added SYNONYM hydratase, enoyl coenzyme A
2020-10-08 Added SYNONYM beta-hydroxyacyl-CoA dehydrase activity
2020-10-08 Added SYNONYM enoyl coenzyme A hydrase (L)
2020-10-08 Added SYNONYM 2-enoyl-CoA hydratase activity
2020-10-08 Added SYNONYM short chain enoyl coenzyme A hydratase activity
2020-10-08 Added SYNONYM (3S)-3-hydroxyacyl-CoA hydro-lyase activity
2020-10-08 Deleted SYNONYM enoyl coenzyme A hydratase activity
2020-10-08 Deleted SYNONYM enoyl coenzyme A hydrase (L)
2020-10-08 Deleted SYNONYM enol-CoA hydratase activity
2020-10-08 Deleted SYNONYM crotonyl hydrase activity
2020-10-08 Deleted SYNONYM beta-hydroxyacyl-CoA dehydrase activity
2020-10-08 Deleted SYNONYM beta-hydroxyacid dehydrase activity
2020-10-08 Deleted SYNONYM acyl coenzyme A hydrase activity
2020-10-08 Deleted SYNONYM 2-octenoyl coenzyme A hydrase activity
2020-10-08 Deleted SYNONYM 2-enoyl-CoA hydratase activity
2020-10-08 Deleted SYNONYM (3S)-3-hydroxyacyl-CoA hydro-lyase activity
2020-10-08 Deleted SYNONYM trans-2-enoyl-CoA hydratase activity
2020-10-08 Deleted SYNONYM short chain enoyl coenzyme A hydratase activity
2020-10-08 Deleted SYNONYM hydratase, enoyl coenzyme A
2020-10-08 Added SYNONYM crotonyl hydrase activity
2020-10-08 Added SYNONYM enol-CoA hydratase activity
2020-10-08 Added SYNONYM acyl coenzyme A hydrase activity
2020-10-08 Added SYNONYM 2-octenoyl coenzyme A hydrase activity
2020-10-08 Added SYNONYM unsaturated acyl-CoA hydratase activity
2020-10-08 Added SYNONYM enoyl coenzyme A hydratase activity
2020-10-08 Added SYNONYM enoyl hydrase activity
2020-10-08 Deleted SYNONYM unsaturated acyl-CoA hydratase activity
2020-10-08 Deleted SYNONYM enoyl hydrase activity
2020-10-08 Added SYNONYM beta-hydroxyacid dehydrase activity
2010-09-15 Deleted DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
2010-09-15 Added DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
2007-11-08 Added SYNONYM D-3-hydroxyacyl-CoA dehydratase
2007-11-08 Added SYNONYM ECH
2007-11-08 Added SYNONYM acyl coenzyme A hydrase activity
2007-11-08 Added SYNONYM beta-hydroxyacid dehydrase activity
2007-11-08 Added SYNONYM beta-hydroxyacyl-CoA dehydrase activity
2007-11-08 Added SYNONYM crotonyl hydrase activity
2007-11-08 Added SYNONYM 2-octenoyl coenzyme A hydrase activity
2007-11-08 Added SYNONYM 2-enoyl-CoA hydratase activity
2007-11-08 Added SYNONYM (3S)-3-hydroxyacyl-CoA hydro-lyase activity
2007-11-08 Added SYNONYM enol-CoA hydratase activity
2007-11-08 Added SYNONYM trans-2-enoyl-CoA hydratase activity
2007-11-08 Added SYNONYM short chain enoyl coenzyme A hydratase activity
2007-11-08 Added SYNONYM hydratase, enoyl coenzyme A
2007-11-08 Added SYNONYM enoyl coenzyme A hydratase activity
2007-11-08 Added SYNONYM enoyl coenzyme A hydrase (L)
2007-11-08 Added SYNONYM enoyl coenzyme A hydrase (D)
2007-09-06 Added SYNONYM enoyl hydrase activity
2007-09-06 Added SYNONYM unsaturated acyl-CoA hydratase activity
2007-08-09 Added SYNONYM short-chain enoyl-CoA hydratase activity
2007-08-09 Deleted SYNONYM short-chain enoyl-CoA hydratase activity
2004-04-19 Added SYNONYM short-chain enoyl-CoA hydratase activity
2004-04-16 Deleted SYNONYM short-chain enoyl-CoA hydratase activity
2003-10-27 Added SYNONYM short-chain enoyl-CoA hydratase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016836 (hydro-lyase activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9916717
2024-11-05 Deleted XREF Reactome:R-HSA-9916717
2024-11-03 Added XREF Reactome:R-HSA-9916717
2024-11-02 Deleted XREF Reactome:R-HSA-9916717
2024-11-01 Added XREF Reactome:R-HSA-9916717
2024-10-26 Deleted XREF Reactome:R-HSA-9916717
2024-10-09 Added XREF Reactome:R-HSA-9916717
2024-07-16 Deleted XREF UM-BBD_enzymeID:e0014
2023-03-14 Added XREF MetaCyc:RXN-10705
2023-03-14 Added XREF MetaCyc:RXN-10704
2023-03-14 Added XREF MetaCyc:RXN-10697
2023-01-28 Added XREF RHEA:20724
2019-04-01 Added XREF Reactome:R-HSA-77325
2019-04-01 Added XREF Reactome:R-HSA-77256
2019-04-01 Deleted XREF reactome:R-HSA-77256
2019-04-01 Deleted XREF reactome:R-HSA-77277
2019-04-01 Deleted XREF reactome:R-HSA-77301
2019-04-01 Added XREF Reactome:R-HSA-77344
2019-04-01 Added XREF Reactome:R-HSA-77277
2019-04-01 Added XREF Reactome:R-HSA-77314
2019-04-01 Added XREF Reactome:R-HSA-70870
2019-04-01 Added XREF Reactome:R-HSA-77333
2019-04-01 Added XREF Reactome:R-HSA-77301
2019-04-01 Added XREF Reactome:R-HSA-70830
2019-04-01 Deleted XREF reactome:R-HSA-70830
2019-04-01 Deleted XREF reactome:R-HSA-70870
2019-04-01 Deleted XREF reactome:R-HSA-77314
2019-04-01 Deleted XREF reactome:R-HSA-77325
2019-04-01 Deleted XREF reactome:R-HSA-77333
2019-04-01 Deleted XREF reactome:R-HSA-77344
2018-12-11 Added XREF reactome:R-HSA-77314
2018-12-11 Added XREF reactome:R-HSA-77301
2018-12-11 Added XREF reactome:R-HSA-77277
2018-12-11 Added XREF reactome:R-HSA-70870
2018-12-11 Added XREF reactome:R-HSA-77325
2018-12-11 Added XREF reactome:R-HSA-77256
2018-12-11 Added XREF reactome:R-HSA-77344
2018-12-11 Added XREF reactome:R-HSA-77333
2018-12-11 Added XREF reactome:R-HSA-70830
2018-07-13 Added XREF RHEA:16105
2018-07-13 Deleted XREF RHEA:16108
2011-09-16 Added XREF RHEA:16108
2003-10-27 Added XREF MetaCyc:ENOYL-COA-HYDRAT-RXN
2003-10-27 Added XREF UM-BBD_enzymeID:e0014
2001-03-30 Added XREF EC:4.2.1.17
Timestamp Action Category Detail
2003-08-21 Added SECONDARY GO:0016510 (short-chain enoyl-CoA hydratase activity)
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