This term is obsolete.

GO:0004312 JSON

fatty acid synthase activity

Molecular Function

Definition (GO:0004312 GONUTS page)

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.

115,419 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) related
fatty-acid synthase activity exact

Ancestor Chart

Ancestor chart for GO:0004312
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.3.1.85
InterPro IPR003965 Fatty acid synthase
InterPro IPR023102 Fatty acid synthase, domain 2
InterPro IPR026025 Fatty acid synthase alpha subunit, yeast
MetaCyc FATTY-ACID-SYNTHASE-RXN
RHEA 14993
Reactome R-HSA-75872

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004312 based on ALL annotations
The top 100 of 608 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fatty acid synthase activity
1,690.15 100.00 115,338 115,338
phosphopantetheine binding
470.66 22.08 59,547 213,836
3-oxoacyl-[acyl-carrier-protein] synthase activity
412.66 20.22 62,354 255,384
DIM/DIP cell wall layer assembly
1,336.91 17.04 20,581 26,019
fatty acid synthase complex
1,688.40 15.04 17,349 17,367
fatty acid biosynthetic process
191.81 11.34 114,733 1,010,957
antibiotic biosynthetic process
269.70 9.25 20,784 130,248
small molecule biosynthetic process
384.44 8.98 14,898 65,498
secondary metabolite biosynthetic process
178.05 7.70 25,630 243,292
macrolide biosynthetic process
1,672.72 5.49 6,334 6,400
Totals 776035 123072224
No co-occurrence statistics for GO:0004312 based on MANUAL annotations
The top 100 of 123 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fatty acid synthase activity
5,980.55 100.00 216 216
secondary metabolite biosynthetic process
1,436.67 17.62 86 358
fatty acid biosynthetic process
726.26 12.12 213 1,754
DIM/DIP cell wall layer assembly
3,289.30 9.40 22 40
[acyl-carrier-protein] S-acetyltransferase activity
5,232.98 3.23 7 8
fatty acid synthase complex
951.45 2.77 7 44
cellular response to sucrose stimulus
1,380.13 2.54 6 26
secondary metabolic process
170.87 2.35 25 875
polyketide synthase complex
1,495.14 2.16 5 20
phenolic phthiocerol biosynthetic process
1,993.52 1.79 4 12
Totals 754 16235

Change Log

Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-163756
2024-11-03 Added XREF Reactome:R-HSA-163756
2024-11-02 Deleted XREF Reactome:R-HSA-163756
2024-11-01 Added XREF Reactome:R-HSA-163756
2024-10-26 Deleted XREF Reactome:R-HSA-163756
2024-10-09 Added XREF Reactome:R-HSA-163756
2024-10-08 Deleted XREF Reactome:R-HSA-163756
2024-09-21 Added XREF Reactome:R-HSA-163756
2024-09-20 Deleted XREF Reactome:R-HSA-163756
2024-09-19 Added XREF Reactome:R-HSA-163756
Timestamp Action Category Detail
2010-05-13 Updated TERM fatty acid synthase activity
2003-03-19 Updated TERM fatty-acid synthase activity
2002-02-06 Updated TERM fatty-acid synthase
2001-04-03 Updated TERM fatty-acid synthase
2001-03-30 Added TERM fatty-acid synthase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2020-10-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2010-05-13 Added SYNONYM fatty-acid synthase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2007-11-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2003-10-24 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2002-11-27 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
Timestamp Action Category Detail
2011-07-31 Deleted RELATION is a GO:0008415 (acyltransferase activity)
2011-07-31 Added RELATION is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
2008-04-01 Updated RELATION is a GO:0008415 (acyltransferase activity)
Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-163756
2024-11-03 Added XREF Reactome:R-HSA-163756
2024-11-02 Deleted XREF Reactome:R-HSA-163756
2024-11-01 Added XREF Reactome:R-HSA-163756
2024-10-26 Deleted XREF Reactome:R-HSA-163756
2024-10-09 Added XREF Reactome:R-HSA-163756
2024-10-08 Deleted XREF Reactome:R-HSA-163756
2024-09-21 Added XREF Reactome:R-HSA-163756
2024-09-20 Deleted XREF Reactome:R-HSA-163756
2024-09-19 Added XREF Reactome:R-HSA-163756
2024-09-13 Deleted XREF Reactome:R-HSA-163756
2024-09-10 Added XREF Reactome:R-HSA-163756
2024-09-08 Deleted XREF Reactome:R-HSA-163756
2024-09-07 Added XREF Reactome:R-HSA-163756
2024-09-06 Deleted XREF Reactome:R-HSA-163756
2024-09-05 Added XREF Reactome:R-HSA-163756
2024-09-02 Deleted XREF Reactome:R-HSA-163756
2024-08-20 Added XREF Reactome:R-HSA-163756
2024-08-16 Deleted XREF Reactome:R-HSA-163756
2024-08-15 Added XREF Reactome:R-HSA-163756
2024-08-08 Added XREF Reactome:R-HSA-163756
2024-08-08 Deleted XREF Reactome:R-HSA-163756
2024-08-06 Deleted XREF Reactome:R-HSA-163756
2024-08-05 Added XREF Reactome:R-HSA-163756
2024-07-28 Deleted XREF Reactome:R-HSA-163756
2024-07-27 Added XREF Reactome:R-HSA-163756
2024-07-26 Deleted XREF Reactome:R-HSA-163756
2024-07-25 Added XREF Reactome:R-HSA-163756
2024-07-20 Deleted XREF Reactome:R-HSA-163756
2024-07-19 Added XREF Reactome:R-HSA-163756
2024-07-18 Deleted XREF Reactome:R-HSA-163756
2024-07-14 Added XREF Reactome:R-HSA-163756
2024-07-11 Deleted XREF Reactome:R-HSA-163756
2024-07-10 Added XREF Reactome:R-HSA-163756
2024-07-09 Deleted XREF Reactome:R-HSA-163756
2024-07-06 Added XREF Reactome:R-HSA-163756
2024-07-04 Deleted XREF Reactome:R-HSA-163756
2024-07-03 Added XREF Reactome:R-HSA-163756
2024-06-30 Deleted XREF Reactome:R-HSA-163756
2024-06-29 Added XREF Reactome:R-HSA-163756
2024-06-28 Deleted XREF Reactome:R-HSA-163756
2024-06-27 Added XREF Reactome:R-HSA-163756
2024-06-26 Deleted XREF Reactome:R-HSA-163756
2024-06-23 Added XREF Reactome:R-HSA-163756
2024-06-20 Deleted XREF Reactome:R-HSA-163756
2024-06-19 Added XREF Reactome:R-HSA-163756
2020-06-22 Added XREF RHEA:14993
2019-04-01 Added XREF Reactome:R-HSA-75872
2019-04-01 Deleted XREF reactome:R-HSA-75872
2018-12-11 Added XREF reactome:R-HSA-75872
2003-10-27 Added XREF MetaCyc:FATTY-ACID-SYNTHASE-RXN
2001-03-30 Added XREF EC:2.3.1.85
Timestamp Action Category Detail
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