GO:0004312
JSON
fatty acid synthase activity
Molecular Function
Definition (GO:0004312 GONUTS page)
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) | related |
fatty-acid synthase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.3.1.85 | |
InterPro | IPR003965 | Fatty acid synthase |
InterPro | IPR023102 | Fatty acid synthase, domain 2 |
InterPro | IPR026025 | Fatty acid synthase alpha subunit, yeast |
MetaCyc | FATTY-ACID-SYNTHASE-RXN | |
RHEA | 14993 | |
Reactome | R-HSA-75872 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004312 based on ALL annotations
The top 100 of 608 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fatty acid synthase activity
|
1,690.15 | 100.00 | 115,338 | 115,338 |
phosphopantetheine binding
|
470.66 | 22.08 | 59,547 | 213,836 |
3-oxoacyl-[acyl-carrier-protein] synthase activity
|
412.66 | 20.22 | 62,354 | 255,384 |
DIM/DIP cell wall layer assembly
|
1,336.91 | 17.04 | 20,581 | 26,019 |
fatty acid synthase complex
|
1,688.40 | 15.04 | 17,349 | 17,367 |
fatty acid biosynthetic process
|
191.81 | 11.34 | 114,733 | 1,010,957 |
antibiotic biosynthetic process
|
269.70 | 9.25 | 20,784 | 130,248 |
small molecule biosynthetic process
|
384.44 | 8.98 | 14,898 | 65,498 |
secondary metabolite biosynthetic process
|
178.05 | 7.70 | 25,630 | 243,292 |
macrolide biosynthetic process
|
1,672.72 | 5.49 | 6,334 | 6,400 |
Totals | 776035 | 123072224 |
No co-occurrence statistics for GO:0004312 based on MANUAL annotations
The top 100 of 123 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fatty acid synthase activity
|
5,980.55 | 100.00 | 216 | 216 |
secondary metabolite biosynthetic process
|
1,436.67 | 17.62 | 86 | 358 |
fatty acid biosynthetic process
|
726.26 | 12.12 | 213 | 1,754 |
DIM/DIP cell wall layer assembly
|
3,289.30 | 9.40 | 22 | 40 |
[acyl-carrier-protein] S-acetyltransferase activity
|
5,232.98 | 3.23 | 7 | 8 |
fatty acid synthase complex
|
951.45 | 2.77 | 7 | 44 |
cellular response to sucrose stimulus
|
1,380.13 | 2.54 | 6 | 26 |
secondary metabolic process
|
170.87 | 2.35 | 25 | 875 |
polyketide synthase complex
|
1,495.14 | 2.16 | 5 | 20 |
phenolic phthiocerol biosynthetic process
|
1,993.52 | 1.79 | 4 | 12 |
Totals | 754 | 16235 |
Change Log
- All changes
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-11-03 | Added | XREF | Reactome:R-HSA-163756 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-11-01 | Added | XREF | Reactome:R-HSA-163756 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-10-09 | Added | XREF | Reactome:R-HSA-163756 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-21 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-19 | Added | XREF | Reactome:R-HSA-163756 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Updated | TERM | fatty acid synthase activity |
2003-03-19 | Updated | TERM | fatty-acid synthase activity |
2002-02-06 | Updated | TERM | fatty-acid synthase |
2001-04-03 | Updated | TERM | fatty-acid synthase |
2001-03-30 | Added | TERM | fatty-acid synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) |
2020-10-08 | Added | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) |
2010-05-13 | Added | SYNONYM | fatty-acid synthase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
2007-11-08 | Added | SYNONYM | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) |
2006-02-04 | Updated | DEFINITION | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
2003-10-24 | Updated | DEFINITION | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-07-31 | Deleted | RELATION | is a GO:0008415 (acyltransferase activity) |
2011-07-31 | Added | RELATION | is a GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups) |
2008-04-01 | Updated | RELATION | is a GO:0008415 (acyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-11-03 | Added | XREF | Reactome:R-HSA-163756 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-11-01 | Added | XREF | Reactome:R-HSA-163756 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-10-09 | Added | XREF | Reactome:R-HSA-163756 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-21 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-19 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-10 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-07 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-09-05 | Added | XREF | Reactome:R-HSA-163756 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-08-20 | Added | XREF | Reactome:R-HSA-163756 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-08-15 | Added | XREF | Reactome:R-HSA-163756 |
2024-08-08 | Added | XREF | Reactome:R-HSA-163756 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-08-05 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-27 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-25 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-19 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-18 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-14 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-11 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-10 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-09 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-06 | Added | XREF | Reactome:R-HSA-163756 |
2024-07-04 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-07-03 | Added | XREF | Reactome:R-HSA-163756 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-06-29 | Added | XREF | Reactome:R-HSA-163756 |
2024-06-28 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-06-27 | Added | XREF | Reactome:R-HSA-163756 |
2024-06-26 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-06-23 | Added | XREF | Reactome:R-HSA-163756 |
2024-06-20 | Deleted | XREF | Reactome:R-HSA-163756 |
2024-06-19 | Added | XREF | Reactome:R-HSA-163756 |
2020-06-22 | Added | XREF | RHEA:14993 |
2019-04-01 | Added | XREF | Reactome:R-HSA-75872 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-75872 |
2018-12-11 | Added | XREF | reactome:R-HSA-75872 |
2003-10-27 | Added | XREF | MetaCyc:FATTY-ACID-SYNTHASE-RXN |
2001-03-30 | Added | XREF | EC:2.3.1.85 |
Timestamp | Action | Category | Detail |
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