This term is obsolete.

GO:0004333 JSON

fumarate hydratase activity

Molecular Function

Definition (GO:0004333 GONUTS page)

Catalysis of the reaction: (S)-malate = fumarate + H2O.

59,562 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
(S)-malate hydro-lyase activity related
(S)-malate hydro-lyase (fumarate-forming) related
fumarase activity related
L-malate hydro-lyase activity related

Ancestor Chart

Ancestor chart for GO:0004333
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.2.1.2
InterPro IPR005677 Fumarate hydratase, class II
InterPro IPR011167 Iron-dependent fumarate hydratase
KEGG_REACTION R01082
MetaCyc FUMHYDR-RXN
RHEA 12460
Reactome R-HSA-70982

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29806 fumarate(2-)
has_participant CHEBI CHEBI:15589 (S)-malate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004333 based on ALL annotations
The top 100 of 265 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fumarate hydratase activity
3,339.09 100.00 59,344 59,344
fumarate metabolic process
3,111.71 59.57 36,963 39,664
generation of precursor metabolites and energy
2,540.61 27.04 17,535 23,046
malate metabolic process
817.21 18.59 25,875 105,724
tricarboxylic acid cycle
214.80 6.31 45,321 704,515
aspartate ammonia-lyase activity
192.09 1.34 1,017 17,678
lyase activity
42.30 1.27 57,302 4,523,172
aspartate metabolic process
159.63 1.16 893 18,680
4 iron, 4 sulfur cluster binding
28.16 0.83 20,272 2,404,018
hydro-lyase activity
13.28 0.33 1,155 290,423
Totals 321770 96606509
No co-occurrence statistics for GO:0004333 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fumarate hydratase activity
7,165.14 100.00 197 197
fumarate metabolic process
6,898.12 76.35 155 161
malate metabolic process
1,180.05 15.72 153 929
tricarboxylic acid cycle
525.04 7.29 184 2,511
arginine metabolic process
265.38 1.09 3 81
urea cycle
152.45 1.05 4 188
protein tetramerization
135.19 0.66 2 106
homeostasis of number of cells within a tissue
86.85 0.56 2 165
single-species biofilm formation
81.42 0.54 2 176
tartrate metabolic process
7,165.14 0.51 1 1
Totals 949 784564

Change Log

Timestamp Action Category Detail
2024-11-06 Deleted XREF Reactome:R-HSA-451033
2024-11-05 Added XREF Reactome:R-HSA-451033
2024-11-03 Deleted XREF Reactome:R-HSA-451033
2024-11-02 Added XREF Reactome:R-HSA-451033
2024-11-01 Deleted XREF Reactome:R-HSA-451033
2024-10-26 Added XREF Reactome:R-HSA-451033
2024-10-09 Deleted XREF Reactome:R-HSA-451033
2024-10-08 Added XREF Reactome:R-HSA-451033
2024-09-21 Deleted XREF Reactome:R-HSA-451033
2024-09-20 Added XREF Reactome:R-HSA-451033
Timestamp Action Category Detail
2003-03-19 Updated TERM fumarate hydratase activity
2002-02-06 Updated TERM fumarate hydratase
2001-04-03 Updated TERM fumarate hydratase
2001-03-30 Added TERM fumarate hydratase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
2022-09-01 Added DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H2O.
2020-10-08 Added SYNONYM (S)-malate hydro-lyase activity
2020-10-08 Added SYNONYM (S)-malate hydro-lyase (fumarate-forming)
2020-10-08 Added SYNONYM fumarase activity
2020-10-08 Added SYNONYM L-malate hydro-lyase activity
2020-10-08 Deleted SYNONYM L-malate hydro-lyase activity
2020-10-08 Deleted SYNONYM (S)-malate hydro-lyase activity
2020-10-08 Deleted SYNONYM (S)-malate hydro-lyase (fumarate-forming)
2020-10-08 Deleted SYNONYM fumarase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H(2)O.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H2O.
2007-11-08 Added SYNONYM (S)-malate hydro-lyase activity
2007-11-08 Added SYNONYM L-malate hydro-lyase activity
2007-11-08 Added SYNONYM (S)-malate hydro-lyase (fumarate-forming)
2007-09-06 Added SYNONYM fumarase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (S)-malate = fumarate + H2O.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016836 (hydro-lyase activity)
Timestamp Action Category Detail
2024-11-06 Deleted XREF Reactome:R-HSA-451033
2024-11-05 Added XREF Reactome:R-HSA-451033
2024-11-03 Deleted XREF Reactome:R-HSA-451033
2024-11-02 Added XREF Reactome:R-HSA-451033
2024-11-01 Deleted XREF Reactome:R-HSA-451033
2024-10-26 Added XREF Reactome:R-HSA-451033
2024-10-09 Deleted XREF Reactome:R-HSA-451033
2024-10-08 Added XREF Reactome:R-HSA-451033
2024-09-21 Deleted XREF Reactome:R-HSA-451033
2024-09-20 Added XREF Reactome:R-HSA-451033
2024-09-19 Deleted XREF Reactome:R-HSA-451033
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2024-05-14 Deleted XREF Reactome:R-HSA-451033
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2024-05-03 Deleted XREF Reactome:R-HSA-451033
2024-05-02 Added XREF Reactome:R-HSA-451033
2024-05-01 Deleted XREF Reactome:R-HSA-451033
2024-04-25 Added XREF Reactome:R-HSA-451033
2024-04-24 Deleted XREF Reactome:R-HSA-451033
2024-04-21 Added XREF Reactome:R-HSA-451033
2024-04-19 Deleted XREF Reactome:R-HSA-451033
2024-04-18 Added XREF Reactome:R-HSA-451033
2024-04-14 Deleted XREF Reactome:R-HSA-451033
2024-04-13 Added XREF Reactome:R-HSA-451033
2024-04-12 Deleted XREF Reactome:R-HSA-451033
2024-04-11 Added XREF Reactome:R-HSA-451033
2024-04-09 Deleted XREF Reactome:R-HSA-451033
2024-04-07 Added XREF Reactome:R-HSA-451033
2024-04-06 Deleted XREF Reactome:R-HSA-451033
2019-06-20 Added XREF KEGG_REACTION:R01082
2019-06-20 Deleted XREF KEGG:R01082
2019-04-01 Added XREF Reactome:R-HSA-70982
2019-04-01 Added XREF Reactome:R-HSA-451033
2019-04-01 Deleted XREF reactome:R-HSA-70982
2019-04-01 Deleted XREF reactome:R-HSA-451033
2018-12-11 Added XREF reactome:R-HSA-70982
2018-12-11 Added XREF reactome:R-HSA-451033
2018-07-13 Added XREF RHEA:12460
2018-07-13 Deleted XREF RHEA:12463
2010-10-11 Added XREF KEGG:R01082
2010-10-11 Added XREF RHEA:12463
2003-10-27 Added XREF MetaCyc:FUMHYDR-RXN
2001-03-30 Added XREF EC:4.2.1.2
Timestamp Action Category Detail
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