GO:0004334
JSON
fumarylacetoacetase activity
Molecular Function
Definition (GO:0004334 GONUTS page)
Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
fumarylacetoacetate hydrolase activity | related |
beta-diketonase activity | related |
4-fumarylacetoacetate fumarylhydrolase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.7.1.2 | |
InterPro | IPR005959 | Fumarylacetoacetase |
InterPro | IPR015377 | Fumarylacetoacetase, N-terminal |
InterPro | IPR036462 | Fumarylacetoacetase, N-terminal domain superfamily |
KEGG_REACTION | R01364 | |
MetaCyc | FUMARYLACETOACETASE-RXN | |
RHEA | 10244 | |
Reactome | R-HSA-71181 | |
UM-BBD_reactionID | r0107 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:13705 | acetoacetate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:29806 | fumarate(2-) |
has_participant | CHEBI | CHEBI:18034 | 4-fumarylacetoacetate(2-) |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004334 based on ALL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fumarylacetoacetase activity
|
11,864.14 | 100.00 | 16,702 | 16,702 |
homogentisate catabolic process
|
11,852.30 | 95.83 | 16,021 | 16,037 |
tyrosine catabolic process
|
3,738.16 | 31.19 | 16,180 | 51,352 |
L-phenylalanine catabolic process
|
2,079.90 | 17.43 | 16,182 | 92,305 |
aromatic amino acid metabolic process
|
1,751.44 | 14.71 | 16,274 | 110,239 |
ureidoglycolate lyase activity
|
127.22 | 0.48 | 144 | 13,429 |
urate catabolic process
|
74.88 | 0.37 | 146 | 23,131 |
acetylpyruvate hydrolase activity
|
24.18 | 0.14 | 80 | 39,259 |
hydrolase activity
|
16.33 | 0.14 | 16,076 | 11,680,370 |
arginine catabolic process
|
16.44 | 0.11 | 82 | 59,176 |
Totals | 104703 | 62833092 |
No co-occurrence statistics for GO:0004334 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fumarylacetoacetase activity
|
12,602.97 | 100.00 | 112 | 112 |
homogentisate catabolic process
|
12,379.91 | 97.37 | 111 | 113 |
L-phenylalanine catabolic process
|
2,525.19 | 19.96 | 110 | 549 |
tyrosine catabolic process
|
2,498.09 | 19.79 | 111 | 560 |
arginine catabolic process
|
237.79 | 0.93 | 2 | 106 |
cell death
|
323.15 | 0.67 | 1 | 39 |
extracellular exosome
|
4.67 | 0.04 | 1 | 2,698 |
extracellular region
|
1.23 | 0.01 | 1 | 10,215 |
cellular_component
|
0.81 | 0.01 | 4 | 62,590 |
biological_process
|
0.38 | 0.00 | 2 | 66,641 |
Totals | 458 | 275036 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). |
2020-10-08 | Deleted | SYNONYM | fumarylacetoacetate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | beta-diketonase activity |
2020-10-08 | Added | SYNONYM | 4-fumarylacetoacetate fumarylhydrolase activity |
2020-10-08 | Added | SYNONYM | fumarylacetoacetate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | 4-fumarylacetoacetate fumarylhydrolase activity |
2020-10-08 | Added | SYNONYM | beta-diketonase activity |
2019-06-20 | Added | XREF | KEGG_REACTION:R01364 |
2019-06-20 | Deleted | XREF | KEGG:R01364 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | fumarylacetoacetase activity |
2002-02-06 | Updated | TERM | fumarylacetoacetase |
2001-04-03 | Updated | TERM | fumarylacetoacetase |
2001-03-30 | Added | TERM | fumarylacetoacetase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). |
2020-10-08 | Deleted | SYNONYM | fumarylacetoacetate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | beta-diketonase activity |
2020-10-08 | Added | SYNONYM | 4-fumarylacetoacetate fumarylhydrolase activity |
2020-10-08 | Added | SYNONYM | fumarylacetoacetate hydrolase activity |
2020-10-08 | Deleted | SYNONYM | 4-fumarylacetoacetate fumarylhydrolase activity |
2020-10-08 | Added | SYNONYM | beta-diketonase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. |
2007-11-08 | Added | SYNONYM | 4-fumarylacetoacetate fumarylhydrolase activity |
2007-09-06 | Added | SYNONYM | fumarylacetoacetate hydrolase activity |
2007-09-06 | Added | SYNONYM | beta-diketonase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016823 (hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R01364 |
2019-06-20 | Deleted | XREF | KEGG:R01364 |
2019-04-01 | Added | XREF | Reactome:R-HSA-71181 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-71181 |
2018-12-11 | Added | XREF | reactome:R-HSA-71181 |
2018-07-13 | Deleted | XREF | RHEA:10247 |
2018-07-13 | Added | XREF | RHEA:10244 |
2011-05-03 | Deleted | XREF | UM-BBD_enzymeID:e0083 |
2011-05-03 | Added | XREF | UM-BBD_reactionID:r0107 |
2010-10-11 | Added | XREF | KEGG:R01364 |
2010-10-11 | Added | XREF | RHEA:10247 |
2003-10-27 | Added | XREF | MetaCyc:FUMARYLACETOACETASE-RXN |
2003-10-27 | Added | XREF | UM-BBD_enzymeID:e0083 |
2001-03-30 | Added | XREF | EC:3.7.1.2 |
Timestamp | Action | Category | Detail |
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