This term is obsolete.

GO:0004334 JSON

fumarylacetoacetase activity

Molecular Function

Definition (GO:0004334 GONUTS page)

Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.

16,819 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
fumarylacetoacetate hydrolase activity related
beta-diketonase activity related
4-fumarylacetoacetate fumarylhydrolase activity related

Ancestor Chart

Ancestor chart for GO:0004334
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.7.1.2
InterPro IPR005959 Fumarylacetoacetase
InterPro IPR015377 Fumarylacetoacetase, N-terminal
InterPro IPR036462 Fumarylacetoacetase, N-terminal domain superfamily
KEGG_REACTION R01364
MetaCyc FUMARYLACETOACETASE-RXN
RHEA 10244
Reactome R-HSA-71181
UM-BBD_reactionID r0107

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:13705 acetoacetate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:29806 fumarate(2-)
has_participant CHEBI CHEBI:18034 4-fumarylacetoacetate(2-)
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004334 based on ALL annotations
The top 100 of 185 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fumarylacetoacetase activity
11,864.14 100.00 16,702 16,702
homogentisate catabolic process
11,852.30 95.83 16,021 16,037
tyrosine catabolic process
3,738.16 31.19 16,180 51,352
L-phenylalanine catabolic process
2,079.90 17.43 16,182 92,305
aromatic amino acid metabolic process
1,751.44 14.71 16,274 110,239
ureidoglycolate lyase activity
127.22 0.48 144 13,429
urate catabolic process
74.88 0.37 146 23,131
acetylpyruvate hydrolase activity
24.18 0.14 80 39,259
hydrolase activity
16.33 0.14 16,076 11,680,370
arginine catabolic process
16.44 0.11 82 59,176
Totals 104703 62833092
No co-occurrence statistics for GO:0004334 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fumarylacetoacetase activity
12,602.97 100.00 112 112
homogentisate catabolic process
12,379.91 97.37 111 113
L-phenylalanine catabolic process
2,525.19 19.96 110 549
tyrosine catabolic process
2,498.09 19.79 111 560
arginine catabolic process
237.79 0.93 2 106
cell death
323.15 0.67 1 39
extracellular exosome
4.67 0.04 1 2,698
extracellular region
1.23 0.01 1 10,215
cellular_component
0.81 0.01 4 62,590
biological_process
0.38 0.00 2 66,641
Totals 458 275036

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
2020-10-08 Deleted SYNONYM fumarylacetoacetate hydrolase activity
2020-10-08 Deleted SYNONYM beta-diketonase activity
2020-10-08 Added SYNONYM 4-fumarylacetoacetate fumarylhydrolase activity
2020-10-08 Added SYNONYM fumarylacetoacetate hydrolase activity
2020-10-08 Deleted SYNONYM 4-fumarylacetoacetate fumarylhydrolase activity
2020-10-08 Added SYNONYM beta-diketonase activity
2019-06-20 Added XREF KEGG_REACTION:R01364
2019-06-20 Deleted XREF KEGG:R01364
Timestamp Action Category Detail
2003-03-19 Updated TERM fumarylacetoacetase activity
2002-02-06 Updated TERM fumarylacetoacetase
2001-04-03 Updated TERM fumarylacetoacetase
2001-03-30 Added TERM fumarylacetoacetase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
2020-10-08 Deleted SYNONYM fumarylacetoacetate hydrolase activity
2020-10-08 Deleted SYNONYM beta-diketonase activity
2020-10-08 Added SYNONYM 4-fumarylacetoacetate fumarylhydrolase activity
2020-10-08 Added SYNONYM fumarylacetoacetate hydrolase activity
2020-10-08 Deleted SYNONYM 4-fumarylacetoacetate fumarylhydrolase activity
2020-10-08 Added SYNONYM beta-diketonase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate.
2008-05-13 Added DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate.
2007-11-08 Added SYNONYM 4-fumarylacetoacetate fumarylhydrolase activity
2007-09-06 Added SYNONYM fumarylacetoacetate hydrolase activity
2007-09-06 Added SYNONYM beta-diketonase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016823 (hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R01364
2019-06-20 Deleted XREF KEGG:R01364
2019-04-01 Added XREF Reactome:R-HSA-71181
2019-04-01 Deleted XREF reactome:R-HSA-71181
2018-12-11 Added XREF reactome:R-HSA-71181
2018-07-13 Deleted XREF RHEA:10247
2018-07-13 Added XREF RHEA:10244
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0083
2011-05-03 Added XREF UM-BBD_reactionID:r0107
2010-10-11 Added XREF KEGG:R01364
2010-10-11 Added XREF RHEA:10247
2003-10-27 Added XREF MetaCyc:FUMARYLACETOACETASE-RXN
2003-10-27 Added XREF UM-BBD_enzymeID:e0083
2001-03-30 Added XREF EC:3.7.1.2
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.