This term is obsolete.

GO:0004340 JSON

glucokinase activity

Molecular Function

Definition (GO:0004340 GONUTS page)

Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.

48,501 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
glucokinase (phosphorylating) related
glucose kinase activity related
ATP:D-glucose 6-phosphotransferase activity related

Ancestor Chart

Ancestor chart for GO:0004340
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004340

Child Term Relationship to
GO:0004340
negative regulation of glucokinase activity
negatively_regulates
positive regulation of glucokinase activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.2
InterPro IPR003836 Glucokinase
InterPro IPR004654 Glucokinase ROK
MetaCyc GLUCOKIN-RXN
RHEA 17825
Reactome R-HSA-5621888
Reactome R-HSA-5621918
Reactome R-HSA-70420

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:4167 D-glucopyranose
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:61548 D-glucopyranose 6-phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004340 based on ALL annotations
The top 100 of 408 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glucokinase activity
4,112.21 100.00 48,187 48,187
D-glucose binding
3,820.07 71.69 36,548 39,343
glucose 6-phosphate metabolic process
1,870.13 45.47 48,178 105,938
intracellular glucose homeostasis
3,581.31 40.13 20,561 23,609
hexokinase activity
3,077.28 37.34 20,579 27,500
fructokinase activity
2,588.25 33.38 20,017 31,803
mannokinase activity
4,107.93 15.95 7,687 7,695
hexose metabolic process
1,161.17 13.21 9,580 33,927
glucose metabolic process
374.35 8.07 19,977 219,446
carbohydrate kinase activity
2,988.79 7.77 3,855 5,304
Totals 491241 93460706
No co-occurrence statistics for GO:0004340 based on MANUAL annotations
The top 100 of 161 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glucokinase activity
3,193.51 100.00 442 442
intracellular glucose homeostasis
2,425.15 70.88 404 532
fructokinase activity
2,028.71 61.29 418 658
glucose 6-phosphate metabolic process
1,786.79 53.53 409 731
glucose metabolic process
754.26 23.13 406 1,719
mannokinase activity
3,159.54 20.99 93 94
glycolytic process
375.87 11.64 405 3,441
hexokinase activity
2,538.43 6.89 31 39
mannose metabolic process
593.48 6.71 42 226
regulation of insulin secretion
244.71 2.93 20 261
Totals 3719 161048

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM glucokinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:D-glucose 6-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:D-glucose 6-phosphotransferase activity
2020-10-08 Added SYNONYM glucose kinase activity
2020-10-08 Deleted SYNONYM glucose kinase activity
2020-10-08 Added SYNONYM glucokinase (phosphorylating)
2019-05-04 Added XREF Reactome:R-HSA-5621918
2019-05-04 Added XREF Reactome:R-HSA-5621888
2019-04-30 Deleted XREF Reactome:R-HSA-5621888
2019-04-30 Deleted XREF Reactome:R-HSA-5621918
Timestamp Action Category Detail
2003-03-19 Updated TERM glucokinase activity
2002-02-06 Updated TERM glucokinase
2001-04-03 Updated TERM glucokinase
2001-03-30 Added TERM glucokinase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM glucokinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:D-glucose 6-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:D-glucose 6-phosphotransferase activity
2020-10-08 Added SYNONYM glucose kinase activity
2020-10-08 Deleted SYNONYM glucose kinase activity
2020-10-08 Added SYNONYM glucokinase (phosphorylating)
2010-09-03 Deleted DEFINITION Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate.
2010-09-03 Added DEFINITION Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate.
2007-11-08 Added SYNONYM ATP:D-glucose 6-phosphotransferase activity
2007-11-08 Added SYNONYM glucokinase (phosphorylating)
2007-09-06 Added SYNONYM glucose kinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate.
Timestamp Action Category Detail
2017-05-01 Added RELATION has part GO:0061621 (canonical glycolysis)
2015-06-13 Added RELATION has part GO:0061705 (sucrose catabolic process to fructose-6-phosphate through glucose and fructose)
2014-05-07 Deleted RELATION has part GO:0061621 (canonical glycolysis)
2014-04-16 Added RELATION has part GO:0061621 (canonical glycolysis)
2010-06-15 Added RELATION part of GO:0051156 (glucose 6-phosphate metabolic process)
2010-06-14 Deleted RELATION part of GO:0051156 (glucose 6-phosphate metabolic process)
2010-06-08 Added RELATION part of GO:0051156 (glucose 6-phosphate metabolic process)
2008-04-01 Updated RELATION is a GO:0004396 (hexokinase activity)
Timestamp Action Category Detail
2019-05-04 Added XREF Reactome:R-HSA-5621918
2019-05-04 Added XREF Reactome:R-HSA-5621888
2019-04-30 Deleted XREF Reactome:R-HSA-5621888
2019-04-30 Deleted XREF Reactome:R-HSA-5621918
2019-04-29 Added XREF Reactome:R-HSA-5621888
2019-04-29 Added XREF Reactome:R-HSA-5621918
2019-04-28 Deleted XREF Reactome:R-HSA-5621888
2019-04-28 Deleted XREF Reactome:R-HSA-5621918
2019-04-27 Added XREF Reactome:R-HSA-5621918
2019-04-27 Added XREF Reactome:R-HSA-5621888
2019-04-23 Deleted XREF Reactome:R-HSA-5621918
2019-04-23 Deleted XREF Reactome:R-HSA-5621888
2019-04-01 Added XREF Reactome:R-HSA-5621888
2019-04-01 Added XREF Reactome:R-HSA-5621918
2019-04-01 Added XREF Reactome:R-HSA-70420
2019-04-01 Deleted XREF reactome:R-HSA-70420
2018-12-11 Added XREF reactome:R-HSA-70420
2018-07-13 Added XREF RHEA:17825
2018-07-13 Deleted XREF RHEA:17828
2011-09-16 Added XREF RHEA:17828
2003-10-27 Added XREF MetaCyc:GLUCOKIN-RXN
2001-03-30 Added XREF EC:2.7.1.2
Timestamp Action Category Detail
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