GO:0004350
JSON
glutamate-5-semialdehyde dehydrogenase activity
Molecular Function
Definition (GO:0004350 GONUTS page)
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.
Secondary IDs
GO:0001513
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
glutamate semialdehyde dehydrogenase activity | related |
gamma-glutamyl phosphate reductase activity | related |
gamma-glutamylphosphate reductase activity | related |
L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | related |
beta-glutamylphosphate reductase activity | related |
glutamate-phosphate reductase activity | exact |
glutamate-gamma-semialdehyde dehydrogenase activity | related |
glutamyl-gamma-semialdehyde dehydrogenase activity | related |
glutamylphosphate reductase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.2.1.41 | |
InterPro | IPR000965 | GPR domain |
InterPro | IPR012134 | Glutamate-5-semialdehyde dehydrogenase |
InterPro | IPR020593 | Gamma-glutamyl phosphate reductase GPR, conserved site |
KEGG_REACTION | R03313 | |
MetaCyc | GLUTSEMIALDEHYDROG-RXN | |
RHEA | 19541 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58066 | L-glutamic 5-semialdehyde zwitterion |
has_participant | CHEBI | CHEBI:58274 | L-gamma-glutamyl phosphate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004350 based on ALL annotations
The top 100 of 210 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate-5-semialdehyde dehydrogenase activity
|
4,523.89 | 100.00 | 43,091 | 43,091 |
proline biosynthetic process
|
1,291.70 | 27.98 | 40,217 | 140,851 |
L-proline biosynthetic process
|
1,270.31 | 27.03 | 37,838 | 134,750 |
amino acid biosynthetic process
|
214.22 | 4.70 | 36,863 | 778,477 |
glutamate 5-kinase activity
|
401.33 | 4.53 | 3,652 | 41,166 |
NADP binding
|
178.76 | 3.91 | 34,276 | 867,427 |
glutamine family amino acid biosynthetic process
|
3,068.18 | 2.82 | 1,233 | 1,818 |
oxidoreductase activity
|
16.34 | 0.36 | 43,014 | 11,906,003 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
|
11.66 | 0.24 | 1,157 | 448,711 |
glutamate metabolic process
|
32.42 | 0.18 | 103 | 14,374 |
Totals | 288800 | 93368265 |
No co-occurrence statistics for GO:0004350 based on MANUAL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate-5-semialdehyde dehydrogenase activity
|
7,298.30 | 100.00 | 177 | 177 |
proline biosynthetic process
|
793.29 | 3.86 | 10 | 92 |
glutamate 5-kinase activity
|
706.29 | 2.58 | 6 | 62 |
glutamate metabolic process
|
249.94 | 1.57 | 5 | 146 |
citrulline biosynthetic process
|
218.51 | 1.47 | 5 | 167 |
ornithine biosynthetic process
|
124.40 | 0.86 | 3 | 176 |
response to temperature stimulus
|
108.12 | 0.65 | 2 | 135 |
amino acid biosynthetic process
|
561.41 | 0.53 | 1 | 13 |
L-proline biosynthetic process
|
60.07 | 0.48 | 2 | 243 |
mitochondrial membrane
|
13.33 | 0.16 | 2 | 1,095 |
Totals | 270 | 791488 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. |
2020-10-08 | Deleted | SYNONYM | gamma-glutamyl phosphate reductase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | glutamate-gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamyl phosphate reductase activity |
2020-10-08 | Added | SYNONYM | glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | glutamate-gamma-semialdehyde dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | glutamate-5-semialdehyde dehydrogenase activity |
2002-02-06 | Updated | TERM | glutamate-5-semialdehyde dehydrogenase |
2001-04-03 | Updated | TERM | glutamate-5-semialdehyde dehydrogenase |
2001-03-30 | Added | TERM | glutamate-5-semialdehyde dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. |
2020-10-08 | Deleted | SYNONYM | gamma-glutamyl phosphate reductase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | glutamate-gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamyl phosphate reductase activity |
2020-10-08 | Added | SYNONYM | glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | glutamate-gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | beta-glutamylphosphate reductase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamylphosphate reductase activity |
2020-10-08 | Added | SYNONYM | glutamyl-gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | glutamyl-gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamylphosphate reductase activity |
2020-10-08 | Deleted | SYNONYM | beta-glutamylphosphate reductase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. |
2007-11-08 | Added | SYNONYM | glutamate-gamma-semialdehyde dehydrogenase activity |
2007-11-08 | Added | SYNONYM | gamma-glutamyl phosphate reductase activity |
2007-11-08 | Added | SYNONYM | L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2007-11-08 | Added | SYNONYM | glutamate semialdehyde dehydrogenase activity |
2007-09-06 | Added | SYNONYM | glutamyl-gamma-semialdehyde dehydrogenase activity |
2007-09-06 | Added | SYNONYM | gamma-glutamylphosphate reductase activity |
2007-09-06 | Added | SYNONYM | beta-glutamylphosphate reductase activity |
2007-08-09 | Added | SYNONYM | glutamate-phosphate reductase activity |
2007-08-09 | Added | SYNONYM | glutamylphosphate reductase activity |
2007-08-09 | Deleted | SYNONYM | glutamate-phosphate reductase activity |
2007-08-09 | Deleted | SYNONYM | glutamylphosphate reductase activity |
2004-04-19 | Added | SYNONYM | glutamate-phosphate reductase activity |
2004-04-19 | Added | SYNONYM | glutamylphosphate reductase activity |
2004-04-16 | Deleted | SYNONYM | glutamate-phosphate reductase activity |
2004-04-16 | Deleted | SYNONYM | glutamylphosphate reductase activity |
2003-10-27 | Added | SYNONYM | glutamate-phosphate reductase activity |
2003-10-27 | Added | SYNONYM | glutamylphosphate reductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R03313 |
2019-06-20 | Added | XREF | KEGG_REACTION:R03313 |
2018-07-13 | Deleted | XREF | RHEA:19544 |
2018-07-13 | Added | XREF | RHEA:19541 |
2010-10-11 | Added | XREF | KEGG:R03313 |
2010-10-11 | Added | XREF | RHEA:19544 |
2003-10-27 | Added | XREF | MetaCyc:GLUTSEMIALDEHYDROG-RXN |
2001-03-30 | Added | XREF | EC:1.2.1.41 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-20 | Added | SECONDARY | GO:0001513 (glutamate phosphate reductase activity) |
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