This term is obsolete.

GO:0004350 JSON

glutamate-5-semialdehyde dehydrogenase activity

Molecular Function

Definition (GO:0004350 GONUTS page)

Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.

Secondary IDs

GO:0001513

43,273 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
glutamate semialdehyde dehydrogenase activity related
gamma-glutamyl phosphate reductase activity related
gamma-glutamylphosphate reductase activity related
L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) related
beta-glutamylphosphate reductase activity related
glutamate-phosphate reductase activity exact
glutamate-gamma-semialdehyde dehydrogenase activity related
glutamyl-gamma-semialdehyde dehydrogenase activity related
glutamylphosphate reductase activity exact

Ancestor Chart

Ancestor chart for GO:0004350
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.2.1.41
InterPro IPR000965 GPR domain
InterPro IPR012134 Glutamate-5-semialdehyde dehydrogenase
InterPro IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site
KEGG_REACTION R03313
MetaCyc GLUTSEMIALDEHYDROG-RXN
RHEA 19541

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58066 L-glutamic 5-semialdehyde zwitterion
has_participant CHEBI CHEBI:58274 L-gamma-glutamyl phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:43474 hydrogenphosphate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004350 based on ALL annotations
The top 100 of 210 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate-5-semialdehyde dehydrogenase activity
4,523.89 100.00 43,091 43,091
proline biosynthetic process
1,291.70 27.98 40,217 140,851
L-proline biosynthetic process
1,270.31 27.03 37,838 134,750
amino acid biosynthetic process
214.22 4.70 36,863 778,477
glutamate 5-kinase activity
401.33 4.53 3,652 41,166
NADP binding
178.76 3.91 34,276 867,427
glutamine family amino acid biosynthetic process
3,068.18 2.82 1,233 1,818
oxidoreductase activity
16.34 0.36 43,014 11,906,003
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
11.66 0.24 1,157 448,711
glutamate metabolic process
32.42 0.18 103 14,374
Totals 288800 93368265
No co-occurrence statistics for GO:0004350 based on MANUAL annotations
The top 23 of 23 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate-5-semialdehyde dehydrogenase activity
7,298.30 100.00 177 177
proline biosynthetic process
793.29 3.86 10 92
glutamate 5-kinase activity
706.29 2.58 6 62
glutamate metabolic process
249.94 1.57 5 146
citrulline biosynthetic process
218.51 1.47 5 167
ornithine biosynthetic process
124.40 0.86 3 176
response to temperature stimulus
108.12 0.65 2 135
amino acid biosynthetic process
561.41 0.53 1 13
L-proline biosynthetic process
60.07 0.48 2 243
mitochondrial membrane
13.33 0.16 2 1,095
Totals 270 791488

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.
2020-10-08 Deleted SYNONYM gamma-glutamyl phosphate reductase activity
2020-10-08 Deleted SYNONYM L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Deleted SYNONYM glutamate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM glutamate-gamma-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM gamma-glutamyl phosphate reductase activity
2020-10-08 Added SYNONYM glutamate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM glutamate-gamma-semialdehyde dehydrogenase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM glutamate-5-semialdehyde dehydrogenase activity
2002-02-06 Updated TERM glutamate-5-semialdehyde dehydrogenase
2001-04-03 Updated TERM glutamate-5-semialdehyde dehydrogenase
2001-03-30 Added TERM glutamate-5-semialdehyde dehydrogenase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.
2020-10-08 Deleted SYNONYM gamma-glutamyl phosphate reductase activity
2020-10-08 Deleted SYNONYM L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Deleted SYNONYM glutamate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM glutamate-gamma-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM gamma-glutamyl phosphate reductase activity
2020-10-08 Added SYNONYM glutamate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM glutamate-gamma-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM beta-glutamylphosphate reductase activity
2020-10-08 Added SYNONYM gamma-glutamylphosphate reductase activity
2020-10-08 Added SYNONYM glutamyl-gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM glutamyl-gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM gamma-glutamylphosphate reductase activity
2020-10-08 Deleted SYNONYM beta-glutamylphosphate reductase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+.
2007-11-08 Added SYNONYM glutamate-gamma-semialdehyde dehydrogenase activity
2007-11-08 Added SYNONYM gamma-glutamyl phosphate reductase activity
2007-11-08 Added SYNONYM L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2007-11-08 Added SYNONYM glutamate semialdehyde dehydrogenase activity
2007-09-06 Added SYNONYM glutamyl-gamma-semialdehyde dehydrogenase activity
2007-09-06 Added SYNONYM gamma-glutamylphosphate reductase activity
2007-09-06 Added SYNONYM beta-glutamylphosphate reductase activity
2007-08-09 Added SYNONYM glutamate-phosphate reductase activity
2007-08-09 Added SYNONYM glutamylphosphate reductase activity
2007-08-09 Deleted SYNONYM glutamate-phosphate reductase activity
2007-08-09 Deleted SYNONYM glutamylphosphate reductase activity
2004-04-19 Added SYNONYM glutamate-phosphate reductase activity
2004-04-19 Added SYNONYM glutamylphosphate reductase activity
2004-04-16 Deleted SYNONYM glutamate-phosphate reductase activity
2004-04-16 Deleted SYNONYM glutamylphosphate reductase activity
2003-10-27 Added SYNONYM glutamate-phosphate reductase activity
2003-10-27 Added SYNONYM glutamylphosphate reductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R03313
2019-06-20 Added XREF KEGG_REACTION:R03313
2018-07-13 Deleted XREF RHEA:19544
2018-07-13 Added XREF RHEA:19541
2010-10-11 Added XREF KEGG:R03313
2010-10-11 Added XREF RHEA:19544
2003-10-27 Added XREF MetaCyc:GLUTSEMIALDEHYDROG-RXN
2001-03-30 Added XREF EC:1.2.1.41
Timestamp Action Category Detail
2003-09-20 Added SECONDARY GO:0001513 (glutamate phosphate reductase activity)
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