GO:0004351
JSON
glutamate decarboxylase activity
Molecular Function
Definition (GO:0004351 GONUTS page)
Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-aspartate-alpha-decarboxylase activity | related |
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) | related |
cysteic acid decarboxylase activity | related |
L-glutamate alpha-decarboxylase activity | related |
aspartic alpha-decarboxylase | broad |
L-glutamic decarboxylase activity | related |
L-glutamate 1-carboxy-lyase activity | related |
L-glutamic acid decarboxylase activity | related |
gamma-glutamate decarboxylase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004351
Child Term | Relationship to GO:0004351 |
---|---|
glutamate decarboxylase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q171S0 | 7159 | Q171S0_AEDAE | GO:0004351 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19842059 | |
NOT-qualified manual | protein | Q24062 | 7227 | Q24062_DROME | GO:0004351 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: PMID:19842059 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.1.1.15 | |
InterPro | IPR010107 | Glutamate decarboxylase |
MetaCyc | GLUTDECARBOX-RXN | |
RHEA | 17785 | |
Reactome | R-HSA-888572 | |
Reactome | R-HSA-888577 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:59888 | gamma-aminobutyric acid zwitterion |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004351 based on ALL annotations
The top 100 of 196 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate decarboxylase activity
|
12,863.00 | 100.00 | 15,155 | 15,155 |
glutamate metabolic process
|
9,544.79 | 56.54 | 10,666 | 14,374 |
gamma-aminobutyric acid biosynthetic process
|
12,275.88 | 28.31 | 4,349 | 4,557 |
glutamate catabolic process
|
2,245.43 | 16.22 | 10,550 | 60,436 |
gamma-aminobutyrate shunt
|
10,670.88 | 7.18 | 1,105 | 1,332 |
presynaptic active zone
|
1,298.39 | 6.66 | 2,480 | 24,569 |
aromatic-L-amino-acid decarboxylase activity
|
1,012.45 | 2.82 | 637 | 8,093 |
carboxy-lyase activity
|
271.69 | 2.11 | 14,061 | 665,708 |
presynaptic membrane
|
260.47 | 1.60 | 1,075 | 53,087 |
carboxylic acid metabolic process
|
138.81 | 1.05 | 4,358 | 403,849 |
Totals | 107421 | 82102287 |
No co-occurrence statistics for GO:0004351 based on MANUAL annotations
The top 73 of 73 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate decarboxylase activity
|
4,697.45 | 100.00 | 275 | 275 |
glutamate catabolic process
|
2,132.46 | 40.00 | 212 | 467 |
gamma-aminobutyric acid biosynthetic process
|
3,699.24 | 21.58 | 63 | 80 |
gamma-aminobutyrate shunt
|
4,056.89 | 6.83 | 19 | 22 |
presynaptic active zone
|
235.38 | 3.23 | 23 | 459 |
inhibitory synapse
|
391.45 | 1.76 | 6 | 72 |
aspartate 1-decarboxylase activity
|
521.94 | 1.30 | 4 | 36 |
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
|
1,409.24 | 1.06 | 3 | 10 |
response to caloric restriction
|
408.47 | 0.68 | 2 | 23 |
intracellular pH elevation
|
156.58 | 0.60 | 2 | 60 |
Totals | 997 | 871094 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | L-glutamic acid decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamate 1-carboxy-lyase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamate decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | cysteic acid decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic acid decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate alpha-decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) |
2020-10-08 | Deleted | SYNONYM | L-aspartate-alpha-decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamate alpha-decarboxylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | glutamate decarboxylase activity |
2002-02-06 | Updated | TERM | glutamate decarboxylase |
2001-04-03 | Updated | TERM | glutamate decarboxylase |
2001-03-30 | Added | TERM | glutamate decarboxylase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | L-glutamic acid decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamate 1-carboxy-lyase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamate decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | cysteic acid decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic acid decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate alpha-decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) |
2020-10-08 | Deleted | SYNONYM | L-aspartate-alpha-decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamate alpha-decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) |
2020-10-08 | Added | SYNONYM | cysteic acid decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-aspartate-alpha-decarboxylase activity |
2020-10-08 | Added | SYNONYM | L-glutamic decarboxylase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamate decarboxylase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate 1-carboxy-lyase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
2007-11-08 | Added | SYNONYM | gamma-glutamate decarboxylase activity |
2007-11-08 | Added | SYNONYM | aspartic alpha-decarboxylase |
2007-11-08 | Added | SYNONYM | L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) |
2007-11-08 | Added | SYNONYM | L-glutamic decarboxylase activity |
2007-11-08 | Added | SYNONYM | cysteic acid decarboxylase activity |
2007-11-08 | Added | SYNONYM | L-glutamate alpha-decarboxylase activity |
2007-11-08 | Added | SYNONYM | L-aspartate-alpha-decarboxylase activity |
2007-11-08 | Added | SYNONYM | L-glutamic acid decarboxylase activity |
2007-09-06 | Added | SYNONYM | L-glutamate 1-carboxy-lyase activity |
2003-10-23 | Updated | DEFINITION | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + carbon dioxide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-05-25 | Added | RELATION | has part GO:0006540 (gamma-aminobutyrate shunt) |
2008-04-01 | Updated | RELATION | is a GO:0016831 (carboxy-lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-888577 |
2019-04-01 | Added | XREF | Reactome:R-HSA-888572 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-888577 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-888572 |
2018-12-11 | Added | XREF | reactome:R-HSA-888572 |
2018-12-11 | Added | XREF | reactome:R-HSA-888577 |
2018-07-13 | Deleted | XREF | RHEA:17788 |
2018-07-13 | Added | XREF | RHEA:17785 |
2011-09-16 | Added | XREF | RHEA:17788 |
2003-10-27 | Added | XREF | MetaCyc:GLUTDECARBOX-RXN |
2001-03-30 | Added | XREF | EC:4.1.1.15 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link