This term is obsolete.

GO:0004351 JSON

glutamate decarboxylase activity

Molecular Function

Definition (GO:0004351 GONUTS page)

Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.

15,411 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-aspartate-alpha-decarboxylase activity related
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) related
cysteic acid decarboxylase activity related
L-glutamate alpha-decarboxylase activity related
aspartic alpha-decarboxylase broad
L-glutamic decarboxylase activity related
L-glutamate 1-carboxy-lyase activity related
L-glutamic acid decarboxylase activity related
gamma-glutamate decarboxylase activity related

Ancestor Chart

Ancestor chart for GO:0004351
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004351

Child Term Relationship to
GO:0004351
glutamate decarboxylase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q171S0 7159 Q171S0_AEDAE GO:0004351 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19842059
NOT-qualified manual protein Q24062 7227 Q24062_DROME GO:0004351 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: PMID:19842059
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.1.1.15
InterPro IPR010107 Glutamate decarboxylase
MetaCyc GLUTDECARBOX-RXN
RHEA 17785
Reactome R-HSA-888572
Reactome R-HSA-888577

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:59888 gamma-aminobutyric acid zwitterion
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:16526 carbon dioxide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004351 based on ALL annotations
The top 100 of 196 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate decarboxylase activity
12,863.00 100.00 15,155 15,155
glutamate metabolic process
9,544.79 56.54 10,666 14,374
gamma-aminobutyric acid biosynthetic process
12,275.88 28.31 4,349 4,557
glutamate catabolic process
2,245.43 16.22 10,550 60,436
gamma-aminobutyrate shunt
10,670.88 7.18 1,105 1,332
presynaptic active zone
1,298.39 6.66 2,480 24,569
aromatic-L-amino-acid decarboxylase activity
1,012.45 2.82 637 8,093
carboxy-lyase activity
271.69 2.11 14,061 665,708
presynaptic membrane
260.47 1.60 1,075 53,087
carboxylic acid metabolic process
138.81 1.05 4,358 403,849
Totals 107421 82102287
No co-occurrence statistics for GO:0004351 based on MANUAL annotations
The top 73 of 73 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate decarboxylase activity
4,697.45 100.00 275 275
glutamate catabolic process
2,132.46 40.00 212 467
gamma-aminobutyric acid biosynthetic process
3,699.24 21.58 63 80
gamma-aminobutyrate shunt
4,056.89 6.83 19 22
presynaptic active zone
235.38 3.23 23 459
inhibitory synapse
391.45 1.76 6 72
aspartate 1-decarboxylase activity
521.94 1.30 4 36
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
1,409.24 1.06 3 10
response to caloric restriction
408.47 0.68 2 23
intracellular pH elevation
156.58 0.60 2 60
Totals 997 871094

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM L-glutamic acid decarboxylase activity
2020-10-08 Added SYNONYM L-glutamate 1-carboxy-lyase activity
2020-10-08 Deleted SYNONYM gamma-glutamate decarboxylase activity
2020-10-08 Deleted SYNONYM cysteic acid decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamic decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamic acid decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamate alpha-decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
2020-10-08 Deleted SYNONYM L-aspartate-alpha-decarboxylase activity
2020-10-08 Added SYNONYM L-glutamate alpha-decarboxylase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM glutamate decarboxylase activity
2002-02-06 Updated TERM glutamate decarboxylase
2001-04-03 Updated TERM glutamate decarboxylase
2001-03-30 Added TERM glutamate decarboxylase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM L-glutamic acid decarboxylase activity
2020-10-08 Added SYNONYM L-glutamate 1-carboxy-lyase activity
2020-10-08 Deleted SYNONYM gamma-glutamate decarboxylase activity
2020-10-08 Deleted SYNONYM cysteic acid decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamic decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamic acid decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamate alpha-decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
2020-10-08 Deleted SYNONYM L-aspartate-alpha-decarboxylase activity
2020-10-08 Added SYNONYM L-glutamate alpha-decarboxylase activity
2020-10-08 Added SYNONYM L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
2020-10-08 Added SYNONYM cysteic acid decarboxylase activity
2020-10-08 Added SYNONYM L-aspartate-alpha-decarboxylase activity
2020-10-08 Added SYNONYM L-glutamic decarboxylase activity
2020-10-08 Added SYNONYM gamma-glutamate decarboxylase activity
2020-10-08 Deleted SYNONYM L-glutamate 1-carboxy-lyase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
2007-11-08 Added SYNONYM gamma-glutamate decarboxylase activity
2007-11-08 Added SYNONYM aspartic alpha-decarboxylase
2007-11-08 Added SYNONYM L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
2007-11-08 Added SYNONYM L-glutamic decarboxylase activity
2007-11-08 Added SYNONYM cysteic acid decarboxylase activity
2007-11-08 Added SYNONYM L-glutamate alpha-decarboxylase activity
2007-11-08 Added SYNONYM L-aspartate-alpha-decarboxylase activity
2007-11-08 Added SYNONYM L-glutamic acid decarboxylase activity
2007-09-06 Added SYNONYM L-glutamate 1-carboxy-lyase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate = 4-aminobutanoate + carbon dioxide.
Timestamp Action Category Detail
2012-05-25 Added RELATION has part GO:0006540 (gamma-aminobutyrate shunt)
2008-04-01 Updated RELATION is a GO:0016831 (carboxy-lyase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-888577
2019-04-01 Added XREF Reactome:R-HSA-888572
2019-04-01 Deleted XREF reactome:R-HSA-888577
2019-04-01 Deleted XREF reactome:R-HSA-888572
2018-12-11 Added XREF reactome:R-HSA-888572
2018-12-11 Added XREF reactome:R-HSA-888577
2018-07-13 Deleted XREF RHEA:17788
2018-07-13 Added XREF RHEA:17785
2011-09-16 Added XREF RHEA:17788
2003-10-27 Added XREF MetaCyc:GLUTDECARBOX-RXN
2001-03-30 Added XREF EC:4.1.1.15
Timestamp Action Category Detail
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