Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
GO:0004354
JSON
glutamate dehydrogenase (NADP+) activity
Molecular Function
Definition (GO:0004354 GONUTS page)
Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
Comments
Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-glutamic acid dehydrogenase activity | related |
L-glutamate:NADP+ oxidoreductase (deaminating) | related |
NAD(P)-glutamate dehydrogenase activity | related |
NAD(P)H-dependent glutamate dehydrogenase activity | related |
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) | related |
glutamic dehydrogenase activity | broad |
L-glutamate dehydrogenase | broad |
glutamic acid dehydrogenase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.4.1.4 | |
MetaCyc | GLUTDEHYD-RXN | |
MetaCyc | GLUTSYNIII-PWY | |
RHEA | 11612 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:28938 | ammonium |
has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004354 based on ALL annotations
The top 100 of 142 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate dehydrogenase (NADP+) activity
|
7,705.70 | 100.00 | 25,298 | 25,298 |
glutamate dehydrogenase [NAD(P)+] activity
|
4,489.11 | 54.63 | 22,708 | 38,979 |
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
1,780.69 | 22.18 | 21,432 | 92,744 |
glutamate biosynthetic process
|
1,464.95 | 18.95 | 24,877 | 130,854 |
amino acid metabolic process
|
359.01 | 4.66 | 25,152 | 539,854 |
glutamate dehydrogenase (NAD+) activity
|
474.02 | 4.34 | 3,251 | 52,848 |
nucleotide binding
|
83.55 | 1.08 | 19,969 | 1,841,736 |
glutamate catabolic process
|
42.71 | 0.39 | 335 | 60,436 |
oxidoreductase activity
|
16.32 | 0.21 | 25,219 | 11,906,003 |
cytosol
|
13.96 | 0.18 | 24,867 | 13,724,995 |
Totals | 193581 | 98138915 |
No co-occurrence statistics for GO:0004354 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate dehydrogenase (NADP+) activity
|
12,664.70 | 100.00 | 102 | 102 |
glutamate biosynthetic process
|
3,240.58 | 25.32 | 98 | 383 |
glutamate metabolic process
|
346.98 | 1.64 | 4 | 146 |
glutamate dehydrogenase complex
|
12,664.70 | 0.98 | 1 | 1 |
L-glutamate biosynthetic process
|
1,407.19 | 0.91 | 1 | 9 |
sperm storage
|
791.54 | 0.85 | 1 | 16 |
guanosine tetraphosphate binding
|
361.85 | 0.74 | 1 | 35 |
cellular response to farnesol
|
287.83 | 0.69 | 1 | 44 |
NADP+ binding
|
222.19 | 0.63 | 1 | 57 |
glutamate binding
|
143.92 | 0.53 | 1 | 88 |
Totals | 336 | 530938 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) |
2020-10-08 | Added | SYNONYM | L-glutamate:NADP+ oxidoreductase (deaminating) |
2020-10-08 | Added | SYNONYM | NAD(P)-glutamate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) |
2020-10-08 | Deleted | SYNONYM | NAD(P)H-dependent glutamate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | NAD(P)H-dependent glutamate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate:NADP+ oxidoreductase (deaminating) |
2020-10-08 | Deleted | SYNONYM | NAD(P)-glutamate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-glutamic acid dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | glutamate dehydrogenase (NADP+) activity |
2003-09-06 | Updated | TERM | glutamate dehydrogenase (NADP) activity |
2003-03-19 | Updated | TERM | glutamate dehydrogenase (NADP+) activity |
2002-02-06 | Updated | TERM | glutamate dehydrogenase (NADP+) |
2001-04-03 | Updated | TERM | glutamate dehydrogenase (NADP+) |
2001-03-30 | Added | TERM | glutamate dehydrogenase (NADP+) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) |
2020-10-08 | Added | SYNONYM | L-glutamate:NADP+ oxidoreductase (deaminating) |
2020-10-08 | Added | SYNONYM | NAD(P)-glutamate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) |
2020-10-08 | Deleted | SYNONYM | NAD(P)H-dependent glutamate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | NAD(P)H-dependent glutamate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamic acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-glutamate:NADP+ oxidoreductase (deaminating) |
2020-10-08 | Deleted | SYNONYM | NAD(P)-glutamate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-glutamic acid dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. |
2007-11-08 | Added | SYNONYM | L-glutamate dehydrogenase |
2007-11-08 | Added | SYNONYM | L-glutamic acid dehydrogenase activity |
2007-11-08 | Added | SYNONYM | dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) |
2007-11-08 | Added | SYNONYM | glutamic acid dehydrogenase |
2007-11-08 | Added | SYNONYM | L-glutamate:NADP+ oxidoreductase (deaminating) |
2007-11-08 | Added | SYNONYM | NAD(P)-glutamate dehydrogenase activity |
2007-11-08 | Added | SYNONYM | NAD(P)H-dependent glutamate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | glutamic dehydrogenase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-07-12 | Deleted | RELATION | is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor) |
2017-07-12 | Added | RELATION | is a GO:0004353 (glutamate dehydrogenase [NAD(P)+] activity) |
2008-04-01 | Updated | RELATION | is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Added | XREF | RHEA:11612 |
2018-07-13 | Deleted | XREF | RHEA:11615 |
2011-09-16 | Added | XREF | RHEA:11615 |
2007-07-19 | Added | XREF | MetaCyc:GLUTSYNIII-PWY |
2003-10-27 | Added | XREF | MetaCyc:GLUTDEHYD-RXN |
2001-03-30 | Added | XREF | EC:1.4.1.4 |
Timestamp | Action | Category | Detail |
---|
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