This term is obsolete.
Note that this term has a MetaCyc pathway reference as the pathway only has a single step.

GO:0004354 JSON

glutamate dehydrogenase (NADP+) activity

Molecular Function

Definition (GO:0004354 GONUTS page)

Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.

Comments

Note that this term has a MetaCyc pathway reference as the pathway only has a single step.

25,699 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
glutamic dehydrogenase activity broad
NAD(P)H-dependent glutamate dehydrogenase activity related
L-glutamate dehydrogenase broad
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) related
NAD(P)-glutamate dehydrogenase activity related
L-glutamate:NADP+ oxidoreductase (deaminating) related
L-glutamic acid dehydrogenase activity related
glutamic acid dehydrogenase broad

Ancestor Chart

Ancestor chart for GO:0004354
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.4.1.4
MetaCyc GLUTDEHYD-RXN
MetaCyc GLUTSYNIII-PWY
RHEA 11612

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004354 based on ALL annotations
The top 100 of 147 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate dehydrogenase (NADP+) activity
7,726.54 100.00 25,646 25,646
glutamate dehydrogenase [NAD(P)+] activity
4,502.47 54.64 23,023 39,509
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
1,770.86 22.01 21,715 94,746
glutamate biosynthetic process
1,459.03 18.82 25,226 133,589
amino acid metabolic process
335.89 4.35 25,496 586,483
glutamate dehydrogenase (NAD+) activity
460.00 4.20 3,201 53,767
nucleotide binding
79.66 1.03 19,856 1,925,949
glutamate catabolic process
41.61 0.38 334 62,019
oxidoreductase activity
16.01 0.21 25,563 12,339,325
cytosol
13.93 0.18 25,216 13,989,509
Totals 195694 55888698
No co-occurrence statistics for GO:0004354 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate dehydrogenase (NADP+) activity
12,716.51 100.00 111 111
glutamate biosynthetic process
3,334.97 25.97 107 408
glutamate metabolic process
336.86 1.55 4 151
glutamate dehydrogenase complex
12,716.51 0.90 1 1
L-glutamate biosynthetic process
1,412.95 0.84 1 9
sperm storage
794.78 0.79 1 16
guanosine tetraphosphate binding
363.33 0.69 1 35
cellular response to farnesol
289.01 0.65 1 44
NADP+ binding
223.10 0.60 1 57
glutamate binding
144.51 0.51 1 88
Totals 362 572322

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Deleted SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
Timestamp Action Category Detail
2004-01-07 Updated TERM glutamate dehydrogenase (NADP+) activity
2003-09-06 Updated TERM glutamate dehydrogenase (NADP) activity
2003-03-19 Updated TERM glutamate dehydrogenase (NADP+) activity
2002-02-06 Updated TERM glutamate dehydrogenase (NADP+)
2001-04-03 Updated TERM glutamate dehydrogenase (NADP+)
2001-03-30 Added TERM glutamate dehydrogenase (NADP+)
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Deleted SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2007-11-08 Added SYNONYM L-glutamate dehydrogenase
2007-11-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2007-11-08 Added SYNONYM glutamic acid dehydrogenase
2007-11-08 Added SYNONYM L-glutamic acid dehydrogenase activity
2007-11-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2007-11-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2007-11-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2007-09-06 Added SYNONYM glutamic dehydrogenase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+.
Timestamp Action Category Detail
2017-07-12 Added RELATION is a GO:0004353 (glutamate dehydrogenase [NAD(P)+] activity)
2017-07-12 Deleted RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2018-07-13 Added XREF RHEA:11612
2018-07-13 Deleted XREF RHEA:11615
2011-09-16 Added XREF RHEA:11615
2007-07-19 Added XREF MetaCyc:GLUTSYNIII-PWY
2003-10-27 Added XREF MetaCyc:GLUTDEHYD-RXN
2001-03-30 Added XREF EC:1.4.1.4
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.