This term is obsolete.
Note that this term has a MetaCyc pathway reference as the pathway only has a single step.

GO:0004354 JSON

glutamate dehydrogenase (NADP+) activity

Molecular Function

Definition (GO:0004354 GONUTS page)

Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.

Comments

Note that this term has a MetaCyc pathway reference as the pathway only has a single step.

25,350 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-glutamic acid dehydrogenase activity related
L-glutamate:NADP+ oxidoreductase (deaminating) related
NAD(P)-glutamate dehydrogenase activity related
NAD(P)H-dependent glutamate dehydrogenase activity related
dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) related
glutamic dehydrogenase activity broad
L-glutamate dehydrogenase broad
glutamic acid dehydrogenase broad

Ancestor Chart

Ancestor chart for GO:0004354
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.4.1.4
MetaCyc GLUTDEHYD-RXN
MetaCyc GLUTSYNIII-PWY
RHEA 11612

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004354 based on ALL annotations
The top 100 of 142 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate dehydrogenase (NADP+) activity
7,705.70 100.00 25,298 25,298
glutamate dehydrogenase [NAD(P)+] activity
4,489.11 54.63 22,708 38,979
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
1,780.69 22.18 21,432 92,744
glutamate biosynthetic process
1,464.95 18.95 24,877 130,854
amino acid metabolic process
359.01 4.66 25,152 539,854
glutamate dehydrogenase (NAD+) activity
474.02 4.34 3,251 52,848
nucleotide binding
83.55 1.08 19,969 1,841,736
glutamate catabolic process
42.71 0.39 335 60,436
oxidoreductase activity
16.32 0.21 25,219 11,906,003
cytosol
13.96 0.18 24,867 13,724,995
Totals 193581 98138915
No co-occurrence statistics for GO:0004354 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate dehydrogenase (NADP+) activity
12,664.70 100.00 102 102
glutamate biosynthetic process
3,240.58 25.32 98 383
glutamate metabolic process
346.98 1.64 4 146
glutamate dehydrogenase complex
12,664.70 0.98 1 1
L-glutamate biosynthetic process
1,407.19 0.91 1 9
sperm storage
791.54 0.85 1 16
guanosine tetraphosphate binding
361.85 0.74 1 35
cellular response to farnesol
287.83 0.69 1 44
NADP+ binding
222.19 0.63 1 57
glutamate binding
143.92 0.53 1 88
Totals 336 530938

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Deleted SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Deleted SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamic acid dehydrogenase activity
Timestamp Action Category Detail
2004-01-07 Updated TERM glutamate dehydrogenase (NADP+) activity
2003-09-06 Updated TERM glutamate dehydrogenase (NADP) activity
2003-03-19 Updated TERM glutamate dehydrogenase (NADP+) activity
2002-02-06 Updated TERM glutamate dehydrogenase (NADP+)
2001-04-03 Updated TERM glutamate dehydrogenase (NADP+)
2001-03-30 Added TERM glutamate dehydrogenase (NADP+)
Timestamp Action Category Detail
2020-10-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2020-10-08 Deleted SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamic acid dehydrogenase activity
2020-10-08 Deleted SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2020-10-08 Deleted SYNONYM NAD(P)-glutamate dehydrogenase activity
2020-10-08 Added SYNONYM L-glutamic acid dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2007-11-08 Added SYNONYM L-glutamate dehydrogenase
2007-11-08 Added SYNONYM L-glutamic acid dehydrogenase activity
2007-11-08 Added SYNONYM dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
2007-11-08 Added SYNONYM glutamic acid dehydrogenase
2007-11-08 Added SYNONYM L-glutamate:NADP+ oxidoreductase (deaminating)
2007-11-08 Added SYNONYM NAD(P)-glutamate dehydrogenase activity
2007-11-08 Added SYNONYM NAD(P)H-dependent glutamate dehydrogenase activity
2007-09-06 Added SYNONYM glutamic dehydrogenase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+.
Timestamp Action Category Detail
2017-07-12 Deleted RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
2017-07-12 Added RELATION is a GO:0004353 (glutamate dehydrogenase [NAD(P)+] activity)
2008-04-01 Updated RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2018-07-13 Added XREF RHEA:11612
2018-07-13 Deleted XREF RHEA:11615
2011-09-16 Added XREF RHEA:11615
2007-07-19 Added XREF MetaCyc:GLUTSYNIII-PWY
2003-10-27 Added XREF MetaCyc:GLUTDEHYD-RXN
2001-03-30 Added XREF EC:1.4.1.4
Timestamp Action Category Detail
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