GO:0004357
JSON
glutamate-cysteine ligase activity
Molecular Function
Definition (GO:0004357 GONUTS page)
Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
gamma-glutamylcysteinyl synthetase activity | related |
gamma-glutamyl-L-cysteine synthetase activity | related |
L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity | related |
gamma-glutamylcysteine synthetase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004357
Child Term | Relationship to GO:0004357 |
---|---|
positive regulation of glutamate-cysteine ligase activity
|
positively_regulates |
glutamate-cysteine ligase complex
|
capable_of |
glutamate-cysteine ligase regulator activity
|
regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.2.2 | |
InterPro | IPR004308 | Glutamate-cysteine ligase catalytic subunit |
InterPro | IPR006334 | Glutamate--cysteine ligase, monofunctional |
InterPro | IPR006335 | Glutathione biosynthesis bifunctional protein GshAB |
InterPro | IPR006336 | Glutamate--cysteine ligase, GCS2 |
InterPro | IPR007370 | Glutamate--cysteine ligase |
InterPro | IPR011556 | Glutamate--cysteine ligase, plant-type |
InterPro | IPR017809 | Glutamate--cysteine ligase EgtA, Actinobacteria |
InterPro | IPR035434 | Glutamate--cysteine ligase, bacteria and plant |
KEGG_REACTION | R00894 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58173 | L-gamma-glutamyl-L-cysteinate(1-) |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:35235 | L-cysteine zwitterion |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004357 based on ALL annotations
The top 100 of 284 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate-cysteine ligase activity
|
4,165.89 | 100.00 | 47,566 | 47,566 |
modified amino acid biosynthetic process
|
4,165.89 | 42.56 | 20,244 | 20,244 |
glutathione biosynthetic process
|
1,319.22 | 25.33 | 26,575 | 83,920 |
ligase activity, forming carbon-nitrogen bonds
|
643.51 | 13.74 | 26,400 | 170,907 |
glutamate-cysteine ligase complex
|
2,593.01 | 8.82 | 4,433 | 7,122 |
ergothioneine biosynthetic process
|
588.33 | 3.98 | 2,496 | 17,674 |
glutathione synthase activity
|
180.56 | 1.58 | 1,156 | 26,672 |
ligase activity
|
60.39 | 1.45 | 44,491 | 3,069,286 |
regulation of mitochondrial depolarization
|
1,545.83 | 0.37 | 177 | 477 |
blood vessel diameter maintenance
|
87.25 | 0.36 | 204 | 9,740 |
Totals | 236622 | 75192037 |
No co-occurrence statistics for GO:0004357 based on MANUAL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutamate-cysteine ligase activity
|
17,006.42 | 100.00 | 83 | 83 |
glutathione biosynthetic process
|
8,726.98 | 49.68 | 78 | 152 |
glutamate-cysteine ligase complex
|
9,588.73 | 42.74 | 53 | 94 |
cysteine metabolic process
|
4,960.21 | 7.00 | 7 | 24 |
blood vessel diameter maintenance
|
1,700.64 | 4.79 | 7 | 70 |
glutamate binding
|
1,352.78 | 4.27 | 7 | 88 |
glutamate metabolic process
|
901.00 | 3.54 | 8 | 151 |
regulation of mitochondrial depolarization
|
2,834.40 | 3.06 | 3 | 18 |
cellular response to thyroxine stimulus
|
11,337.61 | 2.38 | 2 | 3 |
response to human chorionic gonadotropin
|
2,267.52 | 2.08 | 2 | 15 |
Totals | 434 | 849984 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. |
2020-10-08 | Deleted | SYNONYM | L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamylcysteinyl synthetase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamyl-L-cysteine synthetase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamylcysteine synthetase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamylcysteinyl synthetase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamyl-L-cysteine synthetase activity |
2020-10-08 | Added | SYNONYM | L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity |
2020-10-08 | Added | SYNONYM | gamma-glutamylcysteine synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | glutamate-cysteine ligase activity |
2002-02-06 | Updated | TERM | glutamate-cysteine ligase |
2001-11-07 | Updated | TERM | glutamate-cysteine ligase |
2001-04-03 | Updated | TERM | glutamate--cysteine ligase |
2001-03-30 | Added | TERM | glutamate--cysteine ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. |
2020-10-08 | Deleted | SYNONYM | L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamylcysteinyl synthetase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamyl-L-cysteine synthetase activity |
2020-10-08 | Deleted | SYNONYM | gamma-glutamylcysteine synthetase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamylcysteinyl synthetase activity |
2020-10-08 | Added | SYNONYM | gamma-glutamyl-L-cysteine synthetase activity |
2020-10-08 | Added | SYNONYM | L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity |
2020-10-08 | Added | SYNONYM | gamma-glutamylcysteine synthetase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
2007-12-14 | Added | SYNONYM | L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity |
2007-12-14 | Added | SYNONYM | gamma-glutamylcysteinyl synthetase activity |
2007-09-06 | Added | SYNONYM | gamma-glutamyl-L-cysteine synthetase activity |
2007-08-09 | Added | SYNONYM | gamma-glutamylcysteine synthetase activity |
2007-08-09 | Deleted | SYNONYM | gamma-glutamylcysteine synthetase activity |
2004-08-07 | Added | SYNONYM | gamma-glutamylcysteine synthetase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016881 (acid-amino acid ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R00894 |
2019-06-20 | Added | XREF | KEGG_REACTION:R00894 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5602892 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5602892 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5602892 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5602892 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5602892 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5602892 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5602892 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-174367 |
2019-04-01 | Added | XREF | Reactome:R-HSA-174367 |
2018-12-11 | Added | XREF | reactome:R-HSA-174367 |
2018-07-13 | Added | XREF | RHEA:13285 |
2018-07-13 | Deleted | XREF | RHEA:13288 |
2010-10-11 | Added | XREF | KEGG:R00894 |
2010-10-11 | Added | XREF | RHEA:13288 |
2003-10-27 | Added | XREF | MetaCyc:GLUTCYSLIG-RXN |
2001-03-30 | Added | XREF | EC:6.3.2.2 |
Timestamp | Action | Category | Detail |
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