This term is obsolete.

GO:0004357 JSON

glutamate-cysteine ligase activity

Molecular Function

Definition (GO:0004357 GONUTS page)

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.

47,681 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
gamma-glutamylcysteinyl synthetase activity related
gamma-glutamyl-L-cysteine synthetase activity related
L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity related
gamma-glutamylcysteine synthetase activity related

Ancestor Chart

Ancestor chart for GO:0004357
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004357

Child Term Relationship to
GO:0004357
positive regulation of glutamate-cysteine ligase activity
positively_regulates
glutamate-cysteine ligase complex
capable_of
glutamate-cysteine ligase regulator activity
regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.2.2
InterPro IPR004308 Glutamate-cysteine ligase catalytic subunit
InterPro IPR006334 Glutamate--cysteine ligase, monofunctional
InterPro IPR006335 Glutathione biosynthesis bifunctional protein GshAB
InterPro IPR006336 Glutamate--cysteine ligase, GCS2
InterPro IPR007370 Glutamate--cysteine ligase
InterPro IPR011556 Glutamate--cysteine ligase, plant-type
InterPro IPR017809 Glutamate--cysteine ligase EgtA, Actinobacteria
InterPro IPR035434 Glutamate--cysteine ligase, bacteria and plant
KEGG_REACTION R00894

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58173 L-gamma-glutamyl-L-cysteinate(1-)
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:35235 L-cysteine zwitterion
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:43474 hydrogenphosphate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004357 based on ALL annotations
The top 100 of 284 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate-cysteine ligase activity
4,165.89 100.00 47,566 47,566
modified amino acid biosynthetic process
4,165.89 42.56 20,244 20,244
glutathione biosynthetic process
1,319.22 25.33 26,575 83,920
ligase activity, forming carbon-nitrogen bonds
643.51 13.74 26,400 170,907
glutamate-cysteine ligase complex
2,593.01 8.82 4,433 7,122
ergothioneine biosynthetic process
588.33 3.98 2,496 17,674
glutathione synthase activity
180.56 1.58 1,156 26,672
ligase activity
60.39 1.45 44,491 3,069,286
regulation of mitochondrial depolarization
1,545.83 0.37 177 477
blood vessel diameter maintenance
87.25 0.36 204 9,740
Totals 236622 75192037
No co-occurrence statistics for GO:0004357 based on MANUAL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutamate-cysteine ligase activity
17,006.42 100.00 83 83
glutathione biosynthetic process
8,726.98 49.68 78 152
glutamate-cysteine ligase complex
9,588.73 42.74 53 94
cysteine metabolic process
4,960.21 7.00 7 24
blood vessel diameter maintenance
1,700.64 4.79 7 70
glutamate binding
1,352.78 4.27 7 88
glutamate metabolic process
901.00 3.54 8 151
regulation of mitochondrial depolarization
2,834.40 3.06 3 18
cellular response to thyroxine stimulus
11,337.61 2.38 2 3
response to human chorionic gonadotropin
2,267.52 2.08 2 15
Totals 434 849984

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.
2020-10-08 Deleted SYNONYM L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
2020-10-08 Deleted SYNONYM gamma-glutamylcysteinyl synthetase activity
2020-10-08 Deleted SYNONYM gamma-glutamyl-L-cysteine synthetase activity
2020-10-08 Deleted SYNONYM gamma-glutamylcysteine synthetase activity
2020-10-08 Added SYNONYM gamma-glutamylcysteinyl synthetase activity
2020-10-08 Added SYNONYM gamma-glutamyl-L-cysteine synthetase activity
2020-10-08 Added SYNONYM L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
2020-10-08 Added SYNONYM gamma-glutamylcysteine synthetase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM glutamate-cysteine ligase activity
2002-02-06 Updated TERM glutamate-cysteine ligase
2001-11-07 Updated TERM glutamate-cysteine ligase
2001-04-03 Updated TERM glutamate--cysteine ligase
2001-03-30 Added TERM glutamate--cysteine ligase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
2022-09-01 Added DEFINITION Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.
2020-10-08 Deleted SYNONYM L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
2020-10-08 Deleted SYNONYM gamma-glutamylcysteinyl synthetase activity
2020-10-08 Deleted SYNONYM gamma-glutamyl-L-cysteine synthetase activity
2020-10-08 Deleted SYNONYM gamma-glutamylcysteine synthetase activity
2020-10-08 Added SYNONYM gamma-glutamylcysteinyl synthetase activity
2020-10-08 Added SYNONYM gamma-glutamyl-L-cysteine synthetase activity
2020-10-08 Added SYNONYM L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
2020-10-08 Added SYNONYM gamma-glutamylcysteine synthetase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
2007-12-14 Added SYNONYM L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
2007-12-14 Added SYNONYM gamma-glutamylcysteinyl synthetase activity
2007-09-06 Added SYNONYM gamma-glutamyl-L-cysteine synthetase activity
2007-08-09 Added SYNONYM gamma-glutamylcysteine synthetase activity
2007-08-09 Deleted SYNONYM gamma-glutamylcysteine synthetase activity
2004-08-07 Added SYNONYM gamma-glutamylcysteine synthetase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016881 (acid-amino acid ligase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R00894
2019-06-20 Added XREF KEGG_REACTION:R00894
2019-05-04 Added XREF Reactome:R-HSA-5602892
2019-04-30 Deleted XREF Reactome:R-HSA-5602892
2019-04-29 Added XREF Reactome:R-HSA-5602892
2019-04-28 Deleted XREF Reactome:R-HSA-5602892
2019-04-27 Added XREF Reactome:R-HSA-5602892
2019-04-23 Deleted XREF Reactome:R-HSA-5602892
2019-04-01 Added XREF Reactome:R-HSA-5602892
2019-04-01 Deleted XREF reactome:R-HSA-174367
2019-04-01 Added XREF Reactome:R-HSA-174367
2018-12-11 Added XREF reactome:R-HSA-174367
2018-07-13 Added XREF RHEA:13285
2018-07-13 Deleted XREF RHEA:13288
2010-10-11 Added XREF KEGG:R00894
2010-10-11 Added XREF RHEA:13288
2003-10-27 Added XREF MetaCyc:GLUTCYSLIG-RXN
2001-03-30 Added XREF EC:6.3.2.2
Timestamp Action Category Detail
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