GO:0004411
JSON
homogentisate 1,2-dioxygenase activity
Molecular Function
Definition (GO:0004411 GONUTS page)
Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
homogentisate oxidase activity | related |
homogentisate oxygenase activity | related |
homogentisate:oxygen 1,2-oxidoreductase (decyclizing) | related |
homogentisic acid oxidase activity | related |
homogentisic acid oxygenase activity | related |
homogentisicase activity | related |
homogentisate dioxygenase activity | related |
homogentisic oxygenase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | D3ZKX9 | 10116 | LOXE3_RAT | GO:0016702 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.13.11.5 | |
InterPro | IPR005708 | Homogentisate 1,2-dioxygenase |
InterPro | IPR022950 | Homogentisate 1,2-dioxygenase, bacterial |
KEGG_REACTION | R02519 | |
MetaCyc | HOMOGENTISATE-12-DIOXYGENASE-RXN | |
RHEA | 15449 | |
Reactome | R-HSA-71164 | |
UM-BBD_reactionID | r0105 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17105 | 4-maleylacetoacetate |
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:16169 | homogentisate |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004411 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
homogentisate 1,2-dioxygenase activity
|
9,655.73 | 100.00 | 20,522 | 20,522 |
tyrosine metabolic process
|
7,386.05 | 61.59 | 15,591 | 20,382 |
L-phenylalanine catabolic process
|
2,143.18 | 22.19 | 20,488 | 92,305 |
tyrosine catabolic process
|
1,218.25 | 9.91 | 6,479 | 51,352 |
amino acid metabolic process
|
313.19 | 3.24 | 19,023 | 586,483 |
dioxygenase activity
|
271.97 | 2.81 | 19,417 | 689,371 |
iron ion binding
|
26.96 | 0.28 | 4,853 | 1,738,058 |
metal ion binding
|
9.01 | 0.09 | 20,305 | 21,769,638 |
cytoplasm
|
7.65 | 0.08 | 20,219 | 25,503,657 |
homogentisate catabolic process
|
10.24 | 0.05 | 17 | 16,037 |
Totals | 148137 | 80063729 |
No co-occurrence statistics for GO:0004411 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
homogentisate 1,2-dioxygenase activity
|
11,962.14 | 100.00 | 118 | 118 |
L-phenylalanine catabolic process
|
2,527.52 | 21.05 | 116 | 549 |
tyrosine catabolic process
|
106.80 | 0.74 | 5 | 560 |
homogentisate catabolic process
|
105.86 | 0.43 | 1 | 113 |
amino acid metabolic process
|
54.23 | 0.41 | 5 | 1,103 |
striated muscle dense body
|
54.62 | 0.30 | 1 | 219 |
DNA-binding transcription repressor activity
|
35.29 | 0.22 | 1 | 339 |
iron ion binding
|
22.15 | 0.17 | 2 | 1,080 |
protein-DNA complex
|
7.45 | 0.06 | 1 | 1,605 |
plastid
|
7.33 | 0.06 | 1 | 1,632 |
Totals | 275 | 563884 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+. |
2020-10-08 | Added | SYNONYM | homogentisate oxidase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic oxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic acid oxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisate:oxygen 1,2-oxidoreductase (decyclizing) |
2020-10-08 | Deleted | SYNONYM | homogentisate oxidase activity |
2020-10-08 | Deleted | SYNONYM | homogentisate dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisicase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic acid oxidase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | homogentisate 1,2-dioxygenase activity |
2002-02-06 | Updated | TERM | homogentisate 1,2-dioxygenase |
2001-04-03 | Updated | TERM | homogentisate 1,2-dioxygenase |
2001-03-30 | Added | TERM | homogentisate 1,2-dioxygenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+. |
2020-10-08 | Added | SYNONYM | homogentisate oxidase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic oxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic acid oxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisate:oxygen 1,2-oxidoreductase (decyclizing) |
2020-10-08 | Deleted | SYNONYM | homogentisate oxidase activity |
2020-10-08 | Deleted | SYNONYM | homogentisate dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | homogentisicase activity |
2020-10-08 | Deleted | SYNONYM | homogentisic acid oxidase activity |
2020-10-08 | Deleted | SYNONYM | homogentisate oxygenase activity |
2020-10-08 | Added | SYNONYM | homogentisicase activity |
2020-10-08 | Added | SYNONYM | homogentisic acid oxidase activity |
2020-10-08 | Added | SYNONYM | homogentisate oxygenase activity |
2020-10-08 | Added | SYNONYM | homogentisate:oxygen 1,2-oxidoreductase (decyclizing) |
2020-10-08 | Added | SYNONYM | homogentisic oxygenase activity |
2020-10-08 | Added | SYNONYM | homogentisic acid oxygenase activity |
2020-10-08 | Added | SYNONYM | homogentisate dioxygenase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. |
2007-11-08 | Added | SYNONYM | homogentisic oxygenase activity |
2007-11-08 | Added | SYNONYM | homogentisate:oxygen 1,2-oxidoreductase (decyclizing) |
2007-11-08 | Added | SYNONYM | homogentisate oxidase activity |
2007-11-08 | Added | SYNONYM | homogentisate dioxygenase activity |
2007-11-08 | Added | SYNONYM | homogentisic acid oxygenase activity |
2007-09-06 | Added | SYNONYM | homogentisate oxygenase activity |
2007-09-06 | Added | SYNONYM | homogentisic acid oxidase activity |
2007-09-06 | Added | SYNONYM | homogentisicase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Added | XREF | KEGG_REACTION:R02519 |
2019-06-20 | Deleted | XREF | KEGG:R02519 |
2019-04-01 | Added | XREF | Reactome:R-HSA-71164 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-71164 |
2018-12-11 | Added | XREF | reactome:R-HSA-71164 |
2018-07-13 | Deleted | XREF | RHEA:15452 |
2018-07-13 | Added | XREF | RHEA:15449 |
2011-05-03 | Deleted | XREF | UM-BBD_enzymeID:e0081 |
2011-05-03 | Added | XREF | UM-BBD_reactionID:r0105 |
2010-10-11 | Added | XREF | KEGG:R02519 |
2010-10-11 | Added | XREF | RHEA:15452 |
2009-05-21 | Deleted | XREF | MetaCyc:HOMOGENTISATE-1,2-DIOXYGENASE-RXN |
2009-05-21 | Added | XREF | MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN |
2003-10-27 | Added | XREF | UM-BBD_enzymeID:e0081 |
2003-10-27 | Added | XREF | MetaCyc:HOMOGENTISATE-1,2-DIOXYGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.13.11.5 |
Timestamp | Action | Category | Detail |
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