This term is obsolete.

GO:0004411 JSON

homogentisate 1,2-dioxygenase activity

Molecular Function

Definition (GO:0004411 GONUTS page)

Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.

20,654 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
homogentisate oxidase activity related
homogentisate oxygenase activity related
homogentisate:oxygen 1,2-oxidoreductase (decyclizing) related
homogentisic acid oxidase activity related
homogentisic acid oxygenase activity related
homogentisicase activity related
homogentisate dioxygenase activity related
homogentisic oxygenase activity related

Ancestor Chart

Ancestor chart for GO:0004411
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein D3ZKX9 10116 LOXE3_RAT GO:0016702 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 1.13.11.5
InterPro IPR005708 Homogentisate 1,2-dioxygenase
InterPro IPR022950 Homogentisate 1,2-dioxygenase, bacterial
KEGG_REACTION R02519
MetaCyc HOMOGENTISATE-12-DIOXYGENASE-RXN
RHEA 15449
Reactome R-HSA-71164
UM-BBD_reactionID r0105

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17105 4-maleylacetoacetate
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:16169 homogentisate
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004411 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term PR S% #Together #Compared
homogentisate 1,2-dioxygenase activity
9,655.73 100.00 20,522 20,522
tyrosine metabolic process
7,386.05 61.59 15,591 20,382
L-phenylalanine catabolic process
2,143.18 22.19 20,488 92,305
tyrosine catabolic process
1,218.25 9.91 6,479 51,352
amino acid metabolic process
313.19 3.24 19,023 586,483
dioxygenase activity
271.97 2.81 19,417 689,371
iron ion binding
26.96 0.28 4,853 1,738,058
metal ion binding
9.01 0.09 20,305 21,769,638
cytoplasm
7.65 0.08 20,219 25,503,657
homogentisate catabolic process
10.24 0.05 17 16,037
Totals 148137 80063729
No co-occurrence statistics for GO:0004411 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term PR S% #Together #Compared
homogentisate 1,2-dioxygenase activity
11,962.14 100.00 118 118
L-phenylalanine catabolic process
2,527.52 21.05 116 549
tyrosine catabolic process
106.80 0.74 5 560
homogentisate catabolic process
105.86 0.43 1 113
amino acid metabolic process
54.23 0.41 5 1,103
striated muscle dense body
54.62 0.30 1 219
DNA-binding transcription repressor activity
35.29 0.22 1 339
iron ion binding
22.15 0.17 2 1,080
protein-DNA complex
7.45 0.06 1 1,605
plastid
7.33 0.06 1 1,632
Totals 275 563884

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.
2020-10-08 Added SYNONYM homogentisate oxidase activity
2020-10-08 Deleted SYNONYM homogentisic oxygenase activity
2020-10-08 Deleted SYNONYM homogentisic acid oxygenase activity
2020-10-08 Deleted SYNONYM homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
2020-10-08 Deleted SYNONYM homogentisate oxidase activity
2020-10-08 Deleted SYNONYM homogentisate dioxygenase activity
2020-10-08 Deleted SYNONYM homogentisicase activity
2020-10-08 Deleted SYNONYM homogentisic acid oxidase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM homogentisate 1,2-dioxygenase activity
2002-02-06 Updated TERM homogentisate 1,2-dioxygenase
2001-04-03 Updated TERM homogentisate 1,2-dioxygenase
2001-03-30 Added TERM homogentisate 1,2-dioxygenase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+.
2020-10-08 Added SYNONYM homogentisate oxidase activity
2020-10-08 Deleted SYNONYM homogentisic oxygenase activity
2020-10-08 Deleted SYNONYM homogentisic acid oxygenase activity
2020-10-08 Deleted SYNONYM homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
2020-10-08 Deleted SYNONYM homogentisate oxidase activity
2020-10-08 Deleted SYNONYM homogentisate dioxygenase activity
2020-10-08 Deleted SYNONYM homogentisicase activity
2020-10-08 Deleted SYNONYM homogentisic acid oxidase activity
2020-10-08 Deleted SYNONYM homogentisate oxygenase activity
2020-10-08 Added SYNONYM homogentisicase activity
2020-10-08 Added SYNONYM homogentisic acid oxidase activity
2020-10-08 Added SYNONYM homogentisate oxygenase activity
2020-10-08 Added SYNONYM homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
2020-10-08 Added SYNONYM homogentisic oxygenase activity
2020-10-08 Added SYNONYM homogentisic acid oxygenase activity
2020-10-08 Added SYNONYM homogentisate dioxygenase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate.
2008-05-13 Added DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate.
2007-11-08 Added SYNONYM homogentisic oxygenase activity
2007-11-08 Added SYNONYM homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
2007-11-08 Added SYNONYM homogentisate oxidase activity
2007-11-08 Added SYNONYM homogentisate dioxygenase activity
2007-11-08 Added SYNONYM homogentisic acid oxygenase activity
2007-09-06 Added SYNONYM homogentisate oxygenase activity
2007-09-06 Added SYNONYM homogentisic acid oxidase activity
2007-09-06 Added SYNONYM homogentisicase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
Timestamp Action Category Detail
2019-06-20 Added XREF KEGG_REACTION:R02519
2019-06-20 Deleted XREF KEGG:R02519
2019-04-01 Added XREF Reactome:R-HSA-71164
2019-04-01 Deleted XREF reactome:R-HSA-71164
2018-12-11 Added XREF reactome:R-HSA-71164
2018-07-13 Deleted XREF RHEA:15452
2018-07-13 Added XREF RHEA:15449
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0081
2011-05-03 Added XREF UM-BBD_reactionID:r0105
2010-10-11 Added XREF KEGG:R02519
2010-10-11 Added XREF RHEA:15452
2009-05-21 Deleted XREF MetaCyc:HOMOGENTISATE-1,2-DIOXYGENASE-RXN
2009-05-21 Added XREF MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN
2003-10-27 Added XREF UM-BBD_enzymeID:e0081
2003-10-27 Added XREF MetaCyc:HOMOGENTISATE-1,2-DIOXYGENASE-RXN
2001-03-30 Added XREF EC:1.13.11.5
Timestamp Action Category Detail
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