This term is obsolete.

GO:0004415 JSON

hyalurononglucosaminidase activity

Molecular Function

Definition (GO:0004415 GONUTS page)

Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

9,937 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
hyaluronate 4-glycanohydrolase activity related
hyaluronoglucosidase activity related
hyaluronoglucosaminidase activity exact
chondroitinase I activity related
hyaluronidase activity broad
chondroitinase activity broad

Ancestor Chart

Ancestor chart for GO:0004415
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JZA7 10116 A0A0G2JZA7_RAT GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I0M8 10116 A6I0M8_RAT GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZZ19 10116 D3ZZ19_RAT GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O43820-2 9606 HYAL3_HUMAN GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718
NOT-qualified manual protein O43820-3 9606 HYAL3_HUMAN GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718
NOT-qualified manual protein O43820-4 9606 HYAL3_HUMAN GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q12794-2 9606 HYAL1_HUMAN GO:0004415 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718

Cross-references

Database ID Description
EC 3.2.1.35
InterPro IPR001329 Glycoside hydrolase family 56, bee venom hyaluronidase
InterPro IPR001439 Hyaluronidase PH20/Hyaluronidase-5
InterPro IPR009860 Hyaluronidase, bacterial
InterPro IPR018155 Hyaluronidase
MetaCyc 3.2.1.35-RXN
Reactome R-HSA-1793209
Reactome R-HSA-2160874
Reactome R-HSA-2160892
Reactome R-HSA-2318585

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004415 based on ALL annotations
The top 100 of 218 co-occurring terms
Co-occurring Term PR S% #Together #Compared
hyalurononglucosaminidase activity
19,903.90 100.00 9,794 9,794
hyaluronan catabolic process
18,020.13 66.78 7,031 7,766
hyaluronoglucuronidase activity
19,870.97 12.32 1,207 1,209
acrosomal vesicle
1,917.00 7.22 2,189 22,728
fusion of sperm to egg plasma membrane involved in single fertilization
2,497.39 4.60 664 5,292
cellular response to UV-B
2,829.28 2.48 286 2,012
cellular response to interleukin-1
1,991.09 2.31 286 2,859
single fertilization
646.39 2.29 703 21,647
chondroitin sulfate catabolic process
10,658.22 1.67 166 310
response to virus
526.59 1.41 287 10,848
Totals 59533 11947189
No co-occurrence statistics for GO:0004415 based on MANUAL annotations
The top 100 of 130 co-occurring terms
Co-occurring Term PR S% #Together #Compared
hyalurononglucosaminidase activity
14,514.60 100.00 89 89
hyaluronan catabolic process
5,519.64 36.65 81 213
hyaluronoglucuronidase activity
8,538.00 19.42 20 34
cellular response to UV-B
4,045.05 19.21 34 122
receptor signaling protein tyrosine kinase inhibitor activity
13,708.23 18.89 17 18
negative regulation of protein tyrosine kinase activity
10,281.17 17.71 17 24
hyaluronan metabolic process
9,490.31 17.35 17 26
glycosaminoglycan catabolic process
4,912.63 16.67 22 65
hyaluranon cable
10,885.95 15.96 15 20
virus receptor activity
3,005.98 15.70 35 169
Totals 1209 40844

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM hyaluronoglucosidase activity
2020-10-08 Added SYNONYM chondroitinase I activity
2020-10-08 Added SYNONYM hyaluronoglucosidase activity
2020-10-08 Added SYNONYM hyaluronate 4-glycanohydrolase activity
2020-10-08 Deleted SYNONYM hyaluronate 4-glycanohydrolase activity
2020-10-08 Deleted SYNONYM chondroitinase I activity
2019-05-04 Added XREF Reactome:R-HSA-9036077
2019-05-04 Added XREF Reactome:R-HSA-2318585
2019-04-30 Deleted XREF Reactome:R-HSA-2318585
2019-04-30 Deleted XREF Reactome:R-HSA-9036077
Timestamp Action Category Detail
2003-09-09 Updated TERM hyalurononglucosaminidase activity
2003-03-19 Updated TERM hyaluronoglucosaminidase activity
2002-02-06 Updated TERM hyaluronoglucosaminidase
2001-04-03 Updated TERM hyaluronoglucosaminidase
2001-03-30 Added TERM hyaluronoglucosaminidase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM hyaluronoglucosidase activity
2020-10-08 Added SYNONYM chondroitinase I activity
2020-10-08 Added SYNONYM hyaluronoglucosidase activity
2020-10-08 Added SYNONYM hyaluronate 4-glycanohydrolase activity
2020-10-08 Deleted SYNONYM hyaluronate 4-glycanohydrolase activity
2020-10-08 Deleted SYNONYM chondroitinase I activity
2011-10-28 Deleted DEFINITION Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
2011-10-28 Added DEFINITION Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
2008-05-13 Added DEFINITION Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
2008-05-12 Deleted DEFINITION Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
2007-11-08 Added SYNONYM hyaluronate 4-glycanohydrolase activity
2007-09-06 Added SYNONYM hyaluronidase activity
2007-09-06 Added SYNONYM chondroitinase activity
2007-09-06 Added SYNONYM chondroitinase I activity
2007-09-06 Added SYNONYM hyaluronoglucosidase activity
2007-08-09 Deleted SYNONYM hyaluronoglucosaminidase activity
2007-08-09 Added SYNONYM hyaluronoglucosaminidase activity
2004-04-19 Added SYNONYM hyaluronoglucosaminidase activity
2004-04-16 Deleted SYNONYM hyaluronoglucosaminidase activity
2003-10-27 Added SYNONYM hyaluronoglucosaminidase activity
2003-08-06 Updated DEFINITION Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
2002-11-27 Added DEFINITION Catalysis of the reaction: random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0015929 (hexosaminidase activity)
Timestamp Action Category Detail
2019-05-04 Added XREF Reactome:R-HSA-9036077
2019-05-04 Added XREF Reactome:R-HSA-2318585
2019-04-30 Deleted XREF Reactome:R-HSA-2318585
2019-04-30 Deleted XREF Reactome:R-HSA-9036077
2019-04-29 Added XREF Reactome:R-HSA-2318585
2019-04-29 Added XREF Reactome:R-HSA-9036077
2019-04-28 Deleted XREF Reactome:R-HSA-9036077
2019-04-28 Deleted XREF Reactome:R-HSA-2318585
2019-04-27 Added XREF Reactome:R-HSA-2318585
2019-04-27 Added XREF Reactome:R-HSA-9036077
2019-04-23 Deleted XREF Reactome:R-HSA-9036077
2019-04-23 Deleted XREF Reactome:R-HSA-2318585
2019-04-01 Added XREF Reactome:R-HSA-2318585
2019-04-01 Added XREF Reactome:R-HSA-9036077
2019-04-01 Added XREF Reactome:R-HSA-2160874
2019-04-01 Deleted XREF reactome:R-HSA-5693356
2019-04-01 Deleted XREF reactome:R-HSA-2160874
2019-04-01 Deleted XREF reactome:R-HSA-2160892
2019-04-01 Deleted XREF reactome:R-HSA-1793209
2019-04-01 Added XREF Reactome:R-HSA-1793209
2019-04-01 Added XREF Reactome:R-HSA-5693356
2019-04-01 Added XREF Reactome:R-HSA-2160892
2018-12-11 Added XREF reactome:R-HSA-1793209
2018-12-11 Added XREF reactome:R-HSA-2160874
2018-12-11 Added XREF reactome:R-HSA-2160892
2018-12-11 Added XREF reactome:R-HSA-5693356
2003-10-27 Added XREF MetaCyc:3.2.1.35-RXN
2001-03-30 Added XREF EC:3.2.1.35
Timestamp Action Category Detail
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