GO:0004415
JSON
hyalurononglucosaminidase activity
Molecular Function
Definition (GO:0004415 GONUTS page)
Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
hyaluronate 4-glycanohydrolase activity | related |
hyaluronoglucosidase activity | related |
hyaluronoglucosaminidase activity | exact |
chondroitinase I activity | related |
hyaluronidase activity | broad |
chondroitinase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JZA7 | 10116 | A0A0G2JZA7_RAT | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I0M8 | 10116 | A6I0M8_RAT | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZZ19 | 10116 | D3ZZ19_RAT | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O43820-2 | 9606 | HYAL3_HUMAN | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718 | |
NOT-qualified manual | protein | O43820-3 | 9606 | HYAL3_HUMAN | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718 | |
NOT-qualified manual | protein | O43820-4 | 9606 | HYAL3_HUMAN | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q12794-2 | 9606 | HYAL1_HUMAN | GO:0004415 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12084718 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.2.1.35 | |
InterPro | IPR001329 | Glycoside hydrolase family 56, bee venom hyaluronidase |
InterPro | IPR001439 | Hyaluronidase PH20/Hyaluronidase-5 |
InterPro | IPR009860 | Hyaluronidase, bacterial |
InterPro | IPR018155 | Hyaluronidase |
MetaCyc | 3.2.1.35-RXN | |
Reactome | R-HSA-1793209 | |
Reactome | R-HSA-2160874 | |
Reactome | R-HSA-2160892 | |
Reactome | R-HSA-2318585 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004415 based on ALL annotations
The top 100 of 218 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
hyalurononglucosaminidase activity
|
19,903.90 | 100.00 | 9,794 | 9,794 |
hyaluronan catabolic process
|
18,020.13 | 66.78 | 7,031 | 7,766 |
hyaluronoglucuronidase activity
|
19,870.97 | 12.32 | 1,207 | 1,209 |
acrosomal vesicle
|
1,917.00 | 7.22 | 2,189 | 22,728 |
fusion of sperm to egg plasma membrane involved in single fertilization
|
2,497.39 | 4.60 | 664 | 5,292 |
cellular response to UV-B
|
2,829.28 | 2.48 | 286 | 2,012 |
cellular response to interleukin-1
|
1,991.09 | 2.31 | 286 | 2,859 |
single fertilization
|
646.39 | 2.29 | 703 | 21,647 |
chondroitin sulfate catabolic process
|
10,658.22 | 1.67 | 166 | 310 |
response to virus
|
526.59 | 1.41 | 287 | 10,848 |
Totals | 59533 | 11947189 |
No co-occurrence statistics for GO:0004415 based on MANUAL annotations
The top 100 of 130 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
hyalurononglucosaminidase activity
|
14,514.60 | 100.00 | 89 | 89 |
hyaluronan catabolic process
|
5,519.64 | 36.65 | 81 | 213 |
hyaluronoglucuronidase activity
|
8,538.00 | 19.42 | 20 | 34 |
cellular response to UV-B
|
4,045.05 | 19.21 | 34 | 122 |
receptor signaling protein tyrosine kinase inhibitor activity
|
13,708.23 | 18.89 | 17 | 18 |
negative regulation of protein tyrosine kinase activity
|
10,281.17 | 17.71 | 17 | 24 |
hyaluronan metabolic process
|
9,490.31 | 17.35 | 17 | 26 |
glycosaminoglycan catabolic process
|
4,912.63 | 16.67 | 22 | 65 |
hyaluranon cable
|
10,885.95 | 15.96 | 15 | 20 |
virus receptor activity
|
3,005.98 | 15.70 | 35 | 169 |
Totals | 1209 | 40844 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | hyaluronoglucosidase activity |
2020-10-08 | Added | SYNONYM | chondroitinase I activity |
2020-10-08 | Added | SYNONYM | hyaluronoglucosidase activity |
2020-10-08 | Added | SYNONYM | hyaluronate 4-glycanohydrolase activity |
2020-10-08 | Deleted | SYNONYM | hyaluronate 4-glycanohydrolase activity |
2020-10-08 | Deleted | SYNONYM | chondroitinase I activity |
2019-05-04 | Added | XREF | Reactome:R-HSA-9036077 |
2019-05-04 | Added | XREF | Reactome:R-HSA-2318585 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-2318585 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9036077 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-09 | Updated | TERM | hyalurononglucosaminidase activity |
2003-03-19 | Updated | TERM | hyaluronoglucosaminidase activity |
2002-02-06 | Updated | TERM | hyaluronoglucosaminidase |
2001-04-03 | Updated | TERM | hyaluronoglucosaminidase |
2001-03-30 | Added | TERM | hyaluronoglucosaminidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | hyaluronoglucosidase activity |
2020-10-08 | Added | SYNONYM | chondroitinase I activity |
2020-10-08 | Added | SYNONYM | hyaluronoglucosidase activity |
2020-10-08 | Added | SYNONYM | hyaluronate 4-glycanohydrolase activity |
2020-10-08 | Deleted | SYNONYM | hyaluronate 4-glycanohydrolase activity |
2020-10-08 | Deleted | SYNONYM | chondroitinase I activity |
2011-10-28 | Deleted | DEFINITION | Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
2011-10-28 | Added | DEFINITION | Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
2008-05-13 | Added | DEFINITION | Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
2007-11-08 | Added | SYNONYM | hyaluronate 4-glycanohydrolase activity |
2007-09-06 | Added | SYNONYM | hyaluronidase activity |
2007-09-06 | Added | SYNONYM | chondroitinase activity |
2007-09-06 | Added | SYNONYM | chondroitinase I activity |
2007-09-06 | Added | SYNONYM | hyaluronoglucosidase activity |
2007-08-09 | Deleted | SYNONYM | hyaluronoglucosaminidase activity |
2007-08-09 | Added | SYNONYM | hyaluronoglucosaminidase activity |
2004-04-19 | Added | SYNONYM | hyaluronoglucosaminidase activity |
2004-04-16 | Deleted | SYNONYM | hyaluronoglucosaminidase activity |
2003-10-27 | Added | SYNONYM | hyaluronoglucosaminidase activity |
2003-08-06 | Updated | DEFINITION | Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0015929 (hexosaminidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-04 | Added | XREF | Reactome:R-HSA-9036077 |
2019-05-04 | Added | XREF | Reactome:R-HSA-2318585 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-2318585 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9036077 |
2019-04-29 | Added | XREF | Reactome:R-HSA-2318585 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9036077 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9036077 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-2318585 |
2019-04-27 | Added | XREF | Reactome:R-HSA-2318585 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9036077 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9036077 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-2318585 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2318585 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9036077 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2160874 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5693356 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2160874 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2160892 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1793209 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1793209 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5693356 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2160892 |
2018-12-11 | Added | XREF | reactome:R-HSA-1793209 |
2018-12-11 | Added | XREF | reactome:R-HSA-2160874 |
2018-12-11 | Added | XREF | reactome:R-HSA-2160892 |
2018-12-11 | Added | XREF | reactome:R-HSA-5693356 |
2003-10-27 | Added | XREF | MetaCyc:3.2.1.35-RXN |
2001-03-30 | Added | XREF | EC:3.2.1.35 |
Timestamp | Action | Category | Detail |
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