GO:0004418
JSON
hydroxymethylbilane synthase activity
Molecular Function
Definition (GO:0004418 GONUTS page)
Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) | related |
HMB-synthase activity | related |
uroporphyrinogen I synthetase activity | narrow |
porphobilinogen deaminase activity | related |
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) | related |
uroporphyrinogen synthase activity | related |
uroporphyrinogen I synthase activity | narrow |
uroporphyrinogen synthetase activity | related |
pre-uroporphyrinogen synthase activity | related |
porphobilinogen ammonia-lyase (polymerizing) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.5.1.61 | |
InterPro | IPR000860 | Porphobilinogen deaminase |
InterPro | IPR022417 | Porphobilinogen deaminase, N-terminal |
InterPro | IPR022418 | Porphobilinogen deaminase, C-terminal |
InterPro | IPR022419 | Porphobilinogen deaminase, dipyrromethane cofactor binding site |
InterPro | IPR036803 | Porphobilinogen deaminase, C-terminal domain superfamily |
KEGG_REACTION | R00084 | |
MetaCyc | OHMETHYLBILANESYN-RXN | |
RHEA | 13185 | |
Reactome | R-HSA-189406 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58126 | porphobilinogen(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:57845 | preuroporphyrinogen(8-) |
has_participant | CHEBI | CHEBI:28938 | ammonium |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004418 based on ALL annotations
The top 100 of 306 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
hydroxymethylbilane synthase activity
|
4,704.53 | 100.00 | 42,120 | 42,120 |
tetrapyrrole biosynthetic process
|
1,188.74 | 25.22 | 41,785 | 165,367 |
heme biosynthetic process
|
651.75 | 13.80 | 41,065 | 296,419 |
protoporphyrinogen IX biosynthetic process
|
621.39 | 12.70 | 32,274 | 244,346 |
porphyrin-containing compound biosynthetic process
|
506.12 | 10.73 | 41,255 | 383,474 |
uroporphyrinogen-III synthase activity
|
122.62 | 1.44 | 1,313 | 50,375 |
transferase activity
|
27.13 | 0.58 | 41,029 | 7,114,403 |
siroheme biosynthetic process
|
24.32 | 0.31 | 314 | 60,730 |
uroporphyrin-III C-methyltransferase activity
|
24.25 | 0.27 | 245 | 47,527 |
heme B biosynthetic process
|
90.98 | 0.21 | 99 | 5,119 |
Totals | 284430 | 47678873 |
No co-occurrence statistics for GO:0004418 based on MANUAL annotations
The top 51 of 51 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
hydroxymethylbilane synthase activity
|
9,048.29 | 100.00 | 156 | 156 |
heme biosynthetic process
|
1,639.34 | 18.08 | 154 | 850 |
tetrapyrrole biosynthetic process
|
2,585.23 | 1.24 | 2 | 7 |
heme B biosynthetic process
|
723.86 | 1.12 | 2 | 25 |
heme O biosynthetic process
|
532.25 | 1.06 | 2 | 34 |
uroporphyrinogen-III synthase activity
|
161.58 | 0.75 | 2 | 112 |
amine binding
|
1,292.61 | 0.62 | 1 | 7 |
cellular response to amine stimulus
|
904.83 | 0.61 | 1 | 10 |
cellular response to lead ion
|
822.57 | 0.60 | 1 | 11 |
porphyrin-containing compound metabolic process
|
603.22 | 0.59 | 1 | 15 |
Totals | 526 | 779520 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
2020-10-08 | Deleted | SYNONYM | porphobilinogen deaminase activity |
2020-10-08 | Deleted | SYNONYM | HMB-synthase activity |
2020-10-08 | Deleted | SYNONYM | (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity |
2020-10-08 | Deleted | SYNONYM | pre-uroporphyrinogen synthase activity |
2020-10-08 | Deleted | SYNONYM | uroporphyrinogen synthase activity |
2020-10-08 | Deleted | SYNONYM | uroporphyrinogen synthetase activity |
2020-10-08 | Deleted | SYNONYM | (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2020-10-08 | Deleted | SYNONYM | porphobilinogen ammonia-lyase (polymerizing) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | hydroxymethylbilane synthase activity |
2002-02-06 | Updated | TERM | hydroxymethylbilane synthase |
2001-04-03 | Updated | TERM | hydroxymethylbilane synthase |
2001-03-30 | Added | TERM | hydroxymethylbilane synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
2020-10-08 | Deleted | SYNONYM | porphobilinogen deaminase activity |
2020-10-08 | Deleted | SYNONYM | HMB-synthase activity |
2020-10-08 | Deleted | SYNONYM | (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity |
2020-10-08 | Deleted | SYNONYM | pre-uroporphyrinogen synthase activity |
2020-10-08 | Deleted | SYNONYM | uroporphyrinogen synthase activity |
2020-10-08 | Deleted | SYNONYM | uroporphyrinogen synthetase activity |
2020-10-08 | Deleted | SYNONYM | (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2020-10-08 | Deleted | SYNONYM | porphobilinogen ammonia-lyase (polymerizing) |
2020-10-08 | Deleted | SYNONYM | porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2020-10-08 | Added | SYNONYM | porphobilinogen ammonia-lyase (polymerizing) |
2020-10-08 | Added | SYNONYM | porphobilinogen deaminase activity |
2020-10-08 | Added | SYNONYM | uroporphyrinogen synthase activity |
2020-10-08 | Added | SYNONYM | (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2020-10-08 | Added | SYNONYM | uroporphyrinogen synthetase activity |
2020-10-08 | Added | SYNONYM | porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2020-10-08 | Added | SYNONYM | HMB-synthase activity |
2020-10-08 | Added | SYNONYM | (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity |
2020-10-08 | Added | SYNONYM | pre-uroporphyrinogen synthase activity |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. |
2007-11-08 | Added | SYNONYM | (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2007-11-08 | Added | SYNONYM | porphobilinogen ammonia-lyase (polymerizing) |
2007-11-08 | Added | SYNONYM | porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) |
2007-09-06 | Added | SYNONYM | (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity |
2007-09-06 | Added | SYNONYM | HMB-synthase activity |
2007-09-06 | Added | SYNONYM | porphobilinogen deaminase activity |
2007-09-06 | Added | SYNONYM | pre-uroporphyrinogen synthase activity |
2007-09-06 | Added | SYNONYM | uroporphyrinogen synthetase activity |
2007-09-06 | Added | SYNONYM | uroporphyrinogen I synthetase activity |
2007-09-06 | Added | SYNONYM | uroporphyrinogen I synthase activity |
2007-09-06 | Added | SYNONYM | uroporphyrinogen synthase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 ammonia. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R00084 |
2019-06-20 | Added | XREF | KEGG_REACTION:R00084 |
2019-04-01 | Added | XREF | Reactome:R-HSA-189406 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-189406 |
2018-12-11 | Added | XREF | reactome:R-HSA-189406 |
2018-07-13 | Added | XREF | RHEA:13185 |
2018-07-13 | Deleted | XREF | RHEA:13188 |
2010-10-11 | Added | XREF | RHEA:13188 |
2010-10-11 | Added | XREF | KEGG:R00084 |
2003-10-27 | Added | XREF | MetaCyc:OHMETHYLBILANESYN-RXN |
2003-09-13 | Deleted | XREF | EC:4.3.1.8 |
2003-09-13 | Added | XREF | EC:2.5.1.61 |
2001-03-30 | Added | XREF | EC:4.3.1.8 |
Timestamp | Action | Category | Detail |
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