This term is obsolete.

GO:0004418 JSON

hydroxymethylbilane synthase activity

Molecular Function

Definition (GO:0004418 GONUTS page)

Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.

42,302 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) related
HMB-synthase activity related
uroporphyrinogen I synthetase activity narrow
porphobilinogen deaminase activity related
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) related
uroporphyrinogen synthase activity related
uroporphyrinogen I synthase activity narrow
uroporphyrinogen synthetase activity related
pre-uroporphyrinogen synthase activity related
porphobilinogen ammonia-lyase (polymerizing) related

Ancestor Chart

Ancestor chart for GO:0004418
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.5.1.61
InterPro IPR000860 Porphobilinogen deaminase
InterPro IPR022417 Porphobilinogen deaminase, N-terminal
InterPro IPR022418 Porphobilinogen deaminase, C-terminal
InterPro IPR022419 Porphobilinogen deaminase, dipyrromethane cofactor binding site
InterPro IPR036803 Porphobilinogen deaminase, C-terminal domain superfamily
KEGG_REACTION R00084
MetaCyc OHMETHYLBILANESYN-RXN
RHEA 13185
Reactome R-HSA-189406

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58126 porphobilinogen(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:57845 preuroporphyrinogen(8-)
has_participant CHEBI CHEBI:28938 ammonium

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004418 based on ALL annotations
The top 100 of 306 co-occurring terms
Co-occurring Term PR S% #Together #Compared
hydroxymethylbilane synthase activity
4,704.53 100.00 42,120 42,120
tetrapyrrole biosynthetic process
1,188.74 25.22 41,785 165,367
heme biosynthetic process
651.75 13.80 41,065 296,419
protoporphyrinogen IX biosynthetic process
621.39 12.70 32,274 244,346
porphyrin-containing compound biosynthetic process
506.12 10.73 41,255 383,474
uroporphyrinogen-III synthase activity
122.62 1.44 1,313 50,375
transferase activity
27.13 0.58 41,029 7,114,403
siroheme biosynthetic process
24.32 0.31 314 60,730
uroporphyrin-III C-methyltransferase activity
24.25 0.27 245 47,527
heme B biosynthetic process
90.98 0.21 99 5,119
Totals 284430 47678873
No co-occurrence statistics for GO:0004418 based on MANUAL annotations
The top 51 of 51 co-occurring terms
Co-occurring Term PR S% #Together #Compared
hydroxymethylbilane synthase activity
9,048.29 100.00 156 156
heme biosynthetic process
1,639.34 18.08 154 850
tetrapyrrole biosynthetic process
2,585.23 1.24 2 7
heme B biosynthetic process
723.86 1.12 2 25
heme O biosynthetic process
532.25 1.06 2 34
uroporphyrinogen-III synthase activity
161.58 0.75 2 112
amine binding
1,292.61 0.62 1 7
cellular response to amine stimulus
904.83 0.61 1 10
cellular response to lead ion
822.57 0.60 1 11
porphyrin-containing compound metabolic process
603.22 0.59 1 15
Totals 526 779520

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
2020-10-08 Deleted SYNONYM porphobilinogen deaminase activity
2020-10-08 Deleted SYNONYM HMB-synthase activity
2020-10-08 Deleted SYNONYM (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
2020-10-08 Deleted SYNONYM pre-uroporphyrinogen synthase activity
2020-10-08 Deleted SYNONYM uroporphyrinogen synthase activity
2020-10-08 Deleted SYNONYM uroporphyrinogen synthetase activity
2020-10-08 Deleted SYNONYM (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2020-10-08 Deleted SYNONYM porphobilinogen ammonia-lyase (polymerizing)
Timestamp Action Category Detail
2003-03-19 Updated TERM hydroxymethylbilane synthase activity
2002-02-06 Updated TERM hydroxymethylbilane synthase
2001-04-03 Updated TERM hydroxymethylbilane synthase
2001-03-30 Added TERM hydroxymethylbilane synthase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
2020-10-08 Deleted SYNONYM porphobilinogen deaminase activity
2020-10-08 Deleted SYNONYM HMB-synthase activity
2020-10-08 Deleted SYNONYM (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
2020-10-08 Deleted SYNONYM pre-uroporphyrinogen synthase activity
2020-10-08 Deleted SYNONYM uroporphyrinogen synthase activity
2020-10-08 Deleted SYNONYM uroporphyrinogen synthetase activity
2020-10-08 Deleted SYNONYM (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2020-10-08 Deleted SYNONYM porphobilinogen ammonia-lyase (polymerizing)
2020-10-08 Deleted SYNONYM porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2020-10-08 Added SYNONYM porphobilinogen ammonia-lyase (polymerizing)
2020-10-08 Added SYNONYM porphobilinogen deaminase activity
2020-10-08 Added SYNONYM uroporphyrinogen synthase activity
2020-10-08 Added SYNONYM (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2020-10-08 Added SYNONYM uroporphyrinogen synthetase activity
2020-10-08 Added SYNONYM porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2020-10-08 Added SYNONYM HMB-synthase activity
2020-10-08 Added SYNONYM (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
2020-10-08 Added SYNONYM pre-uroporphyrinogen synthase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.
2008-05-13 Added DEFINITION Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.
2007-11-08 Added SYNONYM (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2007-11-08 Added SYNONYM porphobilinogen ammonia-lyase (polymerizing)
2007-11-08 Added SYNONYM porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
2007-09-06 Added SYNONYM (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity
2007-09-06 Added SYNONYM HMB-synthase activity
2007-09-06 Added SYNONYM porphobilinogen deaminase activity
2007-09-06 Added SYNONYM pre-uroporphyrinogen synthase activity
2007-09-06 Added SYNONYM uroporphyrinogen synthetase activity
2007-09-06 Added SYNONYM uroporphyrinogen I synthetase activity
2007-09-06 Added SYNONYM uroporphyrinogen I synthase activity
2007-09-06 Added SYNONYM uroporphyrinogen synthase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.
2002-11-27 Added DEFINITION Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 ammonia.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R00084
2019-06-20 Added XREF KEGG_REACTION:R00084
2019-04-01 Added XREF Reactome:R-HSA-189406
2019-04-01 Deleted XREF reactome:R-HSA-189406
2018-12-11 Added XREF reactome:R-HSA-189406
2018-07-13 Added XREF RHEA:13185
2018-07-13 Deleted XREF RHEA:13188
2010-10-11 Added XREF RHEA:13188
2010-10-11 Added XREF KEGG:R00084
2003-10-27 Added XREF MetaCyc:OHMETHYLBILANESYN-RXN
2003-09-13 Deleted XREF EC:4.3.1.8
2003-09-13 Added XREF EC:2.5.1.61
2001-03-30 Added XREF EC:4.3.1.8
Timestamp Action Category Detail
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