GO:0004455
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ketol-acid reductoisomerase activity
Molecular Function
Definition (GO:0004455 GONUTS page)
Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ketol acid reductoisomerase activity | related |
2-hydroxy-3-keto acid reductoisomerase activity | related |
dihydroxyisovalerate dehydrogenase (isomerizing) activity | related |
alpha-keto-beta-hydroxylacyl reductoisomerase activity | related |
acetohydroxy acid reductoisomerase activity | related |
acetohydroxy acid isomeroreductase activity | related |
isomeroreductase activity | related |
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | related |
acetolactate reductoisomerase activity | related |
dihydroxyisovalerate (isomerizing) dehydrogenase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.86 | |
InterPro | IPR000506 | Ketol-acid reductoisomerase, C-terminal |
InterPro | IPR014359 | Ketol-acid reductoisomerase, prokaryotic |
InterPro | IPR016206 | Ketol-acid reductoisomerase, plant |
InterPro | IPR016207 | Ketol-acid reductoisomerase, fungi |
MetaCyc | ACETOLACTREDUCTOISOM-RXN | |
RHEA | 22068 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58476 | (2S)-2-hydroxy-2-methyl-3-oxobutanoate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:49072 | (R)-2,3-dihydroxy-3-methylbutanoate |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004455 based on ALL annotations
The top 100 of 181 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ketol-acid reductoisomerase activity
|
4,792.83 | 100.00 | 40,673 | 40,673 |
branched-chain amino acid biosynthetic process
|
831.61 | 17.34 | 40,532 | 233,599 |
L-valine biosynthetic process
|
683.18 | 14.24 | 40,431 | 283,644 |
isoleucine biosynthetic process
|
463.28 | 9.66 | 40,431 | 418,276 |
amino acid biosynthetic process
|
242.03 | 5.04 | 39,312 | 778,477 |
NADP binding
|
151.00 | 3.10 | 27,328 | 867,427 |
magnesium ion binding
|
44.89 | 0.93 | 29,530 | 3,152,949 |
isomerase activity
|
43.77 | 0.91 | 29,071 | 3,183,067 |
oxidoreductase activity
|
16.33 | 0.34 | 40,574 | 11,906,003 |
mitochondrial nucleoid
|
35.89 | 0.28 | 181 | 24,170 |
Totals | 403387 | 77710211 |
No co-occurrence statistics for GO:0004455 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ketol-acid reductoisomerase activity
|
9,227.14 | 100.00 | 140 | 140 |
L-valine biosynthetic process
|
2,270.30 | 24.60 | 140 | 569 |
isoleucine biosynthetic process
|
1,715.54 | 18.59 | 140 | 753 |
branched-chain amino acid biosynthetic process
|
136.70 | 0.73 | 2 | 135 |
L-isoleucine biosynthetic process
|
1,153.39 | 0.68 | 1 | 8 |
L-leucine metabolic process
|
768.93 | 0.66 | 1 | 12 |
2-dehydropantoate 2-reductase activity
|
180.92 | 0.53 | 1 | 51 |
mitochondrial genome maintenance
|
37.51 | 0.26 | 1 | 246 |
pantothenate biosynthetic process
|
35.76 | 0.25 | 1 | 258 |
mitochondrial nucleoid
|
16.13 | 0.14 | 1 | 572 |
Totals | 486 | 294967 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | reductoisomerase activity |
2020-10-08 | Added | SYNONYM | alpha-keto-beta-hydroxylacyl reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | ketol acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | isomeroreductase activity |
2020-10-08 | Deleted | SYNONYM | dihydroxyisovalerate (isomerizing) dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | acetolactate reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | acetohydroxy acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-keto acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) |
2020-10-08 | Deleted | SYNONYM | dihydroxyisovalerate dehydrogenase (isomerizing) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | ketol-acid reductoisomerase activity |
2002-02-06 | Updated | TERM | ketol-acid reductoisomerase |
2001-04-03 | Updated | TERM | ketol-acid reductoisomerase |
2001-03-30 | Added | TERM | ketol-acid reductoisomerase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | reductoisomerase activity |
2020-10-08 | Added | SYNONYM | alpha-keto-beta-hydroxylacyl reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | ketol acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | isomeroreductase activity |
2020-10-08 | Deleted | SYNONYM | dihydroxyisovalerate (isomerizing) dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | acetolactate reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | acetohydroxy acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | 2-hydroxy-3-keto acid reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) |
2020-10-08 | Deleted | SYNONYM | dihydroxyisovalerate dehydrogenase (isomerizing) activity |
2020-10-08 | Deleted | SYNONYM | alpha-keto-beta-hydroxylacyl reductoisomerase activity |
2020-10-08 | Deleted | SYNONYM | acetohydroxy acid isomeroreductase activity |
2020-10-08 | Added | SYNONYM | acetolactate reductoisomerase activity |
2020-10-08 | Added | SYNONYM | acetohydroxy acid reductoisomerase activity |
2020-10-08 | Added | SYNONYM | ketol acid reductoisomerase activity |
2020-10-08 | Added | SYNONYM | dihydroxyisovalerate dehydrogenase (isomerizing) activity |
2020-10-08 | Added | SYNONYM | acetohydroxy acid isomeroreductase activity |
2020-10-08 | Added | SYNONYM | isomeroreductase activity |
2020-10-08 | Added | SYNONYM | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) |
2020-10-08 | Added | SYNONYM | dihydroxyisovalerate (isomerizing) dehydrogenase activity |
2020-10-08 | Added | SYNONYM | 2-hydroxy-3-keto acid reductoisomerase activity |
2020-10-08 | Added | SYNONYM | reductoisomerase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. |
2007-11-08 | Added | SYNONYM | acetolactate reductoisomerase activity |
2007-11-08 | Added | SYNONYM | acetohydroxy acid reductoisomerase activity |
2007-11-08 | Added | SYNONYM | 2-hydroxy-3-keto acid reductoisomerase activity |
2007-11-08 | Added | SYNONYM | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) |
2007-11-08 | Added | SYNONYM | dihydroxyisovalerate (isomerizing) dehydrogenase activity |
2007-11-08 | Added | SYNONYM | reductoisomerase activity |
2007-11-08 | Added | SYNONYM | ketol acid reductoisomerase activity |
2007-11-08 | Added | SYNONYM | isomeroreductase activity |
2007-09-06 | Added | SYNONYM | alpha-keto-beta-hydroxylacyl reductoisomerase activity |
2007-09-06 | Added | SYNONYM | dihydroxyisovalerate dehydrogenase (isomerizing) activity |
2007-09-06 | Added | SYNONYM | acetohydroxy acid isomeroreductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-31 | Added | RELATION | has part GO:0009099 (L-valine biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:22068 |
2003-10-27 | Added | XREF | MetaCyc:ACETOLACTREDUCTOISOM-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.86 |
Timestamp | Action | Category | Detail |
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