This term is obsolete.

GO:0004455 JSON

ketol-acid reductoisomerase activity

Molecular Function

Definition (GO:0004455 GONUTS page)

Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.

40,811 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ketol acid reductoisomerase activity related
2-hydroxy-3-keto acid reductoisomerase activity related
dihydroxyisovalerate dehydrogenase (isomerizing) activity related
alpha-keto-beta-hydroxylacyl reductoisomerase activity related
acetohydroxy acid reductoisomerase activity related
acetohydroxy acid isomeroreductase activity related
isomeroreductase activity related
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) related
acetolactate reductoisomerase activity related
dihydroxyisovalerate (isomerizing) dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0004455
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.86
InterPro IPR000506 Ketol-acid reductoisomerase, C-terminal
InterPro IPR014359 Ketol-acid reductoisomerase, prokaryotic
InterPro IPR016206 Ketol-acid reductoisomerase, plant
InterPro IPR016207 Ketol-acid reductoisomerase, fungi
MetaCyc ACETOLACTREDUCTOISOM-RXN
RHEA 22068

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58476 (2S)-2-hydroxy-2-methyl-3-oxobutanoate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:49072 (R)-2,3-dihydroxy-3-methylbutanoate
has_participant CHEBI CHEBI:58349 NADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004455 based on ALL annotations
The top 100 of 181 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ketol-acid reductoisomerase activity
4,792.83 100.00 40,673 40,673
branched-chain amino acid biosynthetic process
831.61 17.34 40,532 233,599
L-valine biosynthetic process
683.18 14.24 40,431 283,644
isoleucine biosynthetic process
463.28 9.66 40,431 418,276
amino acid biosynthetic process
242.03 5.04 39,312 778,477
NADP binding
151.00 3.10 27,328 867,427
magnesium ion binding
44.89 0.93 29,530 3,152,949
isomerase activity
43.77 0.91 29,071 3,183,067
oxidoreductase activity
16.33 0.34 40,574 11,906,003
mitochondrial nucleoid
35.89 0.28 181 24,170
Totals 403387 77710211
No co-occurrence statistics for GO:0004455 based on MANUAL annotations
The top 21 of 21 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ketol-acid reductoisomerase activity
9,227.14 100.00 140 140
L-valine biosynthetic process
2,270.30 24.60 140 569
isoleucine biosynthetic process
1,715.54 18.59 140 753
branched-chain amino acid biosynthetic process
136.70 0.73 2 135
L-isoleucine biosynthetic process
1,153.39 0.68 1 8
L-leucine metabolic process
768.93 0.66 1 12
2-dehydropantoate 2-reductase activity
180.92 0.53 1 51
mitochondrial genome maintenance
37.51 0.26 1 246
pantothenate biosynthetic process
35.76 0.25 1 258
mitochondrial nucleoid
16.13 0.14 1 572
Totals 486 294967

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM reductoisomerase activity
2020-10-08 Added SYNONYM alpha-keto-beta-hydroxylacyl reductoisomerase activity
2020-10-08 Deleted SYNONYM ketol acid reductoisomerase activity
2020-10-08 Deleted SYNONYM isomeroreductase activity
2020-10-08 Deleted SYNONYM dihydroxyisovalerate (isomerizing) dehydrogenase activity
2020-10-08 Deleted SYNONYM acetolactate reductoisomerase activity
2020-10-08 Deleted SYNONYM acetohydroxy acid reductoisomerase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-keto acid reductoisomerase activity
2020-10-08 Deleted SYNONYM (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2020-10-08 Deleted SYNONYM dihydroxyisovalerate dehydrogenase (isomerizing) activity
Timestamp Action Category Detail
2003-03-19 Updated TERM ketol-acid reductoisomerase activity
2002-02-06 Updated TERM ketol-acid reductoisomerase
2001-04-03 Updated TERM ketol-acid reductoisomerase
2001-03-30 Added TERM ketol-acid reductoisomerase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM reductoisomerase activity
2020-10-08 Added SYNONYM alpha-keto-beta-hydroxylacyl reductoisomerase activity
2020-10-08 Deleted SYNONYM ketol acid reductoisomerase activity
2020-10-08 Deleted SYNONYM isomeroreductase activity
2020-10-08 Deleted SYNONYM dihydroxyisovalerate (isomerizing) dehydrogenase activity
2020-10-08 Deleted SYNONYM acetolactate reductoisomerase activity
2020-10-08 Deleted SYNONYM acetohydroxy acid reductoisomerase activity
2020-10-08 Deleted SYNONYM 2-hydroxy-3-keto acid reductoisomerase activity
2020-10-08 Deleted SYNONYM (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2020-10-08 Deleted SYNONYM dihydroxyisovalerate dehydrogenase (isomerizing) activity
2020-10-08 Deleted SYNONYM alpha-keto-beta-hydroxylacyl reductoisomerase activity
2020-10-08 Deleted SYNONYM acetohydroxy acid isomeroreductase activity
2020-10-08 Added SYNONYM acetolactate reductoisomerase activity
2020-10-08 Added SYNONYM acetohydroxy acid reductoisomerase activity
2020-10-08 Added SYNONYM ketol acid reductoisomerase activity
2020-10-08 Added SYNONYM dihydroxyisovalerate dehydrogenase (isomerizing) activity
2020-10-08 Added SYNONYM acetohydroxy acid isomeroreductase activity
2020-10-08 Added SYNONYM isomeroreductase activity
2020-10-08 Added SYNONYM (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2020-10-08 Added SYNONYM dihydroxyisovalerate (isomerizing) dehydrogenase activity
2020-10-08 Added SYNONYM 2-hydroxy-3-keto acid reductoisomerase activity
2020-10-08 Added SYNONYM reductoisomerase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
2007-11-08 Added SYNONYM acetolactate reductoisomerase activity
2007-11-08 Added SYNONYM acetohydroxy acid reductoisomerase activity
2007-11-08 Added SYNONYM 2-hydroxy-3-keto acid reductoisomerase activity
2007-11-08 Added SYNONYM (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
2007-11-08 Added SYNONYM dihydroxyisovalerate (isomerizing) dehydrogenase activity
2007-11-08 Added SYNONYM reductoisomerase activity
2007-11-08 Added SYNONYM ketol acid reductoisomerase activity
2007-11-08 Added SYNONYM isomeroreductase activity
2007-09-06 Added SYNONYM alpha-keto-beta-hydroxylacyl reductoisomerase activity
2007-09-06 Added SYNONYM dihydroxyisovalerate dehydrogenase (isomerizing) activity
2007-09-06 Added SYNONYM acetohydroxy acid isomeroreductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
Timestamp Action Category Detail
2018-03-31 Added RELATION has part GO:0009099 (L-valine biosynthetic process)
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:22068
2003-10-27 Added XREF MetaCyc:ACETOLACTREDUCTOISOM-RXN
2001-03-30 Added XREF EC:1.1.1.86
Timestamp Action Category Detail
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