This term is obsolete.

GO:0004459 JSON

L-lactate dehydrogenase activity

Molecular Function

Definition (GO:0004459 GONUTS page)

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

55,721 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
L-lactic acid dehydrogenase activity related
L-lactic dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0004459
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004459

Child Term Relationship to
GO:0004459
L-lactate dehydrogenase inhibitor activity
negatively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.27
InterPro IPR011304 L-lactate dehydrogenase
InterPro IPR018177 L-lactate dehydrogenase, active site
MetaCyc L-LACTATE-DEHYDROGENASE-RXN
RHEA 23444
Reactome R-HSA-6807826
Reactome R-HSA-70510
Reactome R-HSA-71849

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:16651 (S)-lactate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15361 pyruvate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004459 based on ALL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3,574.16 100.00 55,441 55,441
2,336.41 57.66 46,030 70,415
1,079.23 16.85 15,300 50,670
583.09 15.54 42,510 260,574
337.50 9.14 41,057 434,793
3,572.11 6.30 3,492 3,494
1,075.98 2.41 1,414 4,697
88.19 2.34 17,383 704,515
73.74 2.01 23,954 1,161,093
57.60 1.50 10,210 633,502
Totals 366728 143239487
No co-occurrence statistics for GO:0004459 based on MANUAL annotations
The top 54 of 54 co-occurring terms
Co-occurring Term PR S% #Together #Compared
4,524.14 100.00 312 312
3,898.16 76.97 274 318
1,087.23 23.23 273 1,136
477.55 4.02 19 180
3,393.11 1.91 6 8
1,428.68 1.85 6 19
405.15 1.61 6 67
2,714.49 0.96 3 5
565.52 0.90 3 24
41.51 0.75 12 1,308
Totals 1171 922496

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM L-lactic dehydrogenase activity
2020-10-08 Deleted SYNONYM L-lactic acid dehydrogenase activity
2020-10-08 Added SYNONYM L-lactic dehydrogenase activity
2020-10-08 Added SYNONYM L-lactic acid dehydrogenase activity
2019-04-01 Deleted XREF reactome:R-HSA-71849
2019-04-01 Deleted XREF reactome:R-HSA-70510
2019-04-01 Added XREF Reactome:R-HSA-70510
2019-04-01 Added XREF Reactome:R-HSA-71849
2019-04-01 Added XREF Reactome:R-HSA-6807826
2019-04-01 Deleted XREF reactome:R-HSA-6807826
Timestamp Action Category Detail
2003-03-19 Updated TERM L-lactate dehydrogenase activity
2002-02-06 Updated TERM L-lactate dehydrogenase
2001-04-03 Updated TERM L-lactate dehydrogenase
2001-03-30 Added TERM L-lactate dehydrogenase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM L-lactic dehydrogenase activity
2020-10-08 Deleted SYNONYM L-lactic acid dehydrogenase activity
2020-10-08 Added SYNONYM L-lactic dehydrogenase activity
2020-10-08 Added SYNONYM L-lactic acid dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
2007-09-06 Added SYNONYM L-lactic dehydrogenase activity
2007-09-06 Added SYNONYM L-lactic acid dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
Timestamp Action Category Detail
2015-08-08 Added RELATION has part GO:0019246 (L(+)-lactate biosynthetic process from pyruvate)
2015-08-08 Deleted RELATION has part GO:0019661 (glucose catabolic process to lactate via pyruvate)
2015-04-24 Added RELATION has part GO:0019661 (glucose catabolic process to lactate via pyruvate)
2015-03-19 Deleted RELATION has part GO:0019661 (glucose catabolic process to lactate via pyruvate)
2013-10-27 Added RELATION has part GO:0019661 (glucose catabolic process to lactate via pyruvate)
2008-04-01 Updated RELATION is a GO:0004457 (lactate dehydrogenase activity)
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-71849
2019-04-01 Deleted XREF reactome:R-HSA-70510
2019-04-01 Added XREF Reactome:R-HSA-70510
2019-04-01 Added XREF Reactome:R-HSA-71849
2019-04-01 Added XREF Reactome:R-HSA-6807826
2019-04-01 Deleted XREF reactome:R-HSA-6807826
2018-12-11 Added XREF reactome:R-HSA-70510
2018-12-11 Added XREF reactome:R-HSA-71849
2018-12-11 Added XREF reactome:R-HSA-6807826
2018-07-13 Deleted XREF RHEA:23447
2018-07-13 Added XREF RHEA:23444
2011-09-16 Added XREF RHEA:23447
2003-10-27 Added XREF MetaCyc:L-LACTATE-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.1.1.27
Timestamp Action Category Detail
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