GO:0004459
JSON
L-lactate dehydrogenase activity
Molecular Function
Definition (GO:0004459 GONUTS page)
Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
L-lactic acid dehydrogenase activity | related |
L-lactic dehydrogenase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004459
Child Term | Relationship to GO:0004459 |
---|---|
L-lactate dehydrogenase inhibitor activity
|
negatively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.27 | |
InterPro | IPR011304 | L-lactate dehydrogenase |
InterPro | IPR018177 | L-lactate dehydrogenase, active site |
MetaCyc | L-LACTATE-DEHYDROGENASE-RXN | |
RHEA | 23444 | |
Reactome | R-HSA-6807826 | |
Reactome | R-HSA-70510 | |
Reactome | R-HSA-71849 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:16651 | (S)-lactate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:15361 | pyruvate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004459 based on ALL annotations
The top 100 of 249 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
|
3,574.16 | 100.00 | 55,441 | 55,441 |
|
2,336.41 | 57.66 | 46,030 | 70,415 |
|
1,079.23 | 16.85 | 15,300 | 50,670 |
|
583.09 | 15.54 | 42,510 | 260,574 |
|
337.50 | 9.14 | 41,057 | 434,793 |
|
3,572.11 | 6.30 | 3,492 | 3,494 |
|
1,075.98 | 2.41 | 1,414 | 4,697 |
|
88.19 | 2.34 | 17,383 | 704,515 |
|
73.74 | 2.01 | 23,954 | 1,161,093 |
|
57.60 | 1.50 | 10,210 | 633,502 |
Totals | 366728 | 143239487 |
No co-occurrence statistics for GO:0004459 based on MANUAL annotations
The top 54 of 54 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
|
4,524.14 | 100.00 | 312 | 312 |
|
3,898.16 | 76.97 | 274 | 318 |
|
1,087.23 | 23.23 | 273 | 1,136 |
|
477.55 | 4.02 | 19 | 180 |
|
3,393.11 | 1.91 | 6 | 8 |
|
1,428.68 | 1.85 | 6 | 19 |
|
405.15 | 1.61 | 6 | 67 |
|
2,714.49 | 0.96 | 3 | 5 |
|
565.52 | 0.90 | 3 | 24 |
|
41.51 | 0.75 | 12 | 1,308 |
Totals | 1171 | 922496 |
Change Log
- All changes
- All changes
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | L-lactic dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-lactic acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-lactic dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-lactic acid dehydrogenase activity |
2019-04-01 | Deleted | XREF | reactome:R-HSA-71849 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70510 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70510 |
2019-04-01 | Added | XREF | Reactome:R-HSA-71849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6807826 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6807826 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | L-lactate dehydrogenase activity |
2002-02-06 | Updated | TERM | L-lactate dehydrogenase |
2001-04-03 | Updated | TERM | L-lactate dehydrogenase |
2001-03-30 | Added | TERM | L-lactate dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | L-lactic dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | L-lactic acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-lactic dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-lactic acid dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
2007-09-06 | Added | SYNONYM | L-lactic dehydrogenase activity |
2007-09-06 | Added | SYNONYM | L-lactic acid dehydrogenase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-08-08 | Added | RELATION | has part GO:0019246 (L(+)-lactate biosynthetic process from pyruvate) |
2015-08-08 | Deleted | RELATION | has part GO:0019661 (glucose catabolic process to lactate via pyruvate) |
2015-04-24 | Added | RELATION | has part GO:0019661 (glucose catabolic process to lactate via pyruvate) |
2015-03-19 | Deleted | RELATION | has part GO:0019661 (glucose catabolic process to lactate via pyruvate) |
2013-10-27 | Added | RELATION | has part GO:0019661 (glucose catabolic process to lactate via pyruvate) |
2008-04-01 | Updated | RELATION | is a GO:0004457 (lactate dehydrogenase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-71849 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70510 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70510 |
2019-04-01 | Added | XREF | Reactome:R-HSA-71849 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6807826 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6807826 |
2018-12-11 | Added | XREF | reactome:R-HSA-70510 |
2018-12-11 | Added | XREF | reactome:R-HSA-71849 |
2018-12-11 | Added | XREF | reactome:R-HSA-6807826 |
2018-07-13 | Deleted | XREF | RHEA:23447 |
2018-07-13 | Added | XREF | RHEA:23444 |
2011-09-16 | Added | XREF | RHEA:23447 |
2003-10-27 | Added | XREF | MetaCyc:L-LACTATE-DEHYDROGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.27 |
Timestamp | Action | Category | Detail |
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