This term is obsolete.

GO:0004460 JSON

L-lactate dehydrogenase (cytochrome) activity

Molecular Function

Definition (GO:0004460 GONUTS page)

Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.

4,702 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cytochrome b2 (flavin-free derivative of flavocytochrome b2) related
flavocytochrome b2 related
dehydrogenase, lactate (cytochrome) related
L-lactate cytochrome c reductase activity related
lactate dehydrogenase (cytochrome) related
L(+)-lactate:cytochrome c oxidoreductase activity related
L-lactate ferricytochrome c oxidoreductase activity related
(S)-lactate:ferricytochrome-c 2-oxidoreductase activity related
lactic cytochrome c reductase activity related
lactic acid dehydrogenase activity broad

Ancestor Chart

Ancestor chart for GO:0004460
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.1.2.3
MetaCyc L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
RHEA 19909

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:29033 iron(2+)
has_participant CHEBI CHEBI:15361 pyruvate
has_participant CHEBI CHEBI:29034 iron(3+)
has_participant CHEBI CHEBI:16651 (S)-lactate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004460 based on ALL annotations
The top 76 of 76 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-lactate dehydrogenase (cytochrome) activity
41,494.00 100.00 4,698 4,698
lactate metabolic process
1,532.79 3.58 2,552 69,085
lactate dehydrogenase activity
3,064.62 3.21 252 3,412
L-lactate dehydrogenase activity
1,087.99 2.47 1,432 54,614
(S)-mandelate dehydrogenase activity
2,585.30 0.40 20 321
FMN binding
128.53 0.31 2,335 753,797
(S)-2-hydroxy-acid oxidase activity
107.27 0.16 21 8,123
lactate 2-monooxygenase activity
669.26 0.12 6 372
aerobic respiration
26.72 0.06 1,432 2,223,967
heme binding
21.53 0.05 1,864 3,591,635
Totals 23137 305842769
No co-occurrence statistics for GO:0004460 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-lactate dehydrogenase (cytochrome) activity
86,119.94 100.00 15 15
lactate metabolic process
4,364.19 5.07 15 296
mitochondrial intermembrane space
61.56 0.07 1 1,399
carbohydrate transport
40.34 0.05 1 2,135
mitochondrial inner membrane
12.31 0.01 1 6,995
mitochondrion
1.88 0.00 1 45,791
cytosol
1.02 0.00 1 84,217
nucleus
0.45 0.00 1 192,276
Totals 36 333124

Change Log

Timestamp Action Category Detail
2021-06-04 Added DEFINITION Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
2021-06-04 Deleted DEFINITION Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
2020-10-08 Added SYNONYM (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
2020-10-08 Added SYNONYM dehydrogenase, lactate (cytochrome)
2020-10-08 Added SYNONYM lactic cytochrome c reductase activity
2020-10-08 Added SYNONYM L-lactate cytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM L(+)-lactate:cytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM L-lactate cytochrome c reductase activity
2020-10-08 Deleted SYNONYM (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
2020-10-08 Deleted SYNONYM L(+)-lactate:cytochrome c oxidoreductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM L-lactate dehydrogenase (cytochrome) activity
2002-02-06 Updated TERM L-lactate dehydrogenase (cytochrome)
2001-04-03 Updated TERM L-lactate dehydrogenase (cytochrome)
2001-03-30 Added TERM L-lactate dehydrogenase (cytochrome)
Timestamp Action Category Detail
2021-06-04 Added DEFINITION Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
2021-06-04 Deleted DEFINITION Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
2020-10-08 Added SYNONYM (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
2020-10-08 Added SYNONYM dehydrogenase, lactate (cytochrome)
2020-10-08 Added SYNONYM lactic cytochrome c reductase activity
2020-10-08 Added SYNONYM L-lactate cytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM L(+)-lactate:cytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM L-lactate cytochrome c reductase activity
2020-10-08 Deleted SYNONYM (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
2020-10-08 Deleted SYNONYM L(+)-lactate:cytochrome c oxidoreductase activity
2020-10-08 Deleted SYNONYM L-lactate cytochrome c oxidoreductase activity
2020-10-08 Deleted SYNONYM L-lactate cytochrome c reductase activity
2020-10-08 Deleted SYNONYM L-lactate ferricytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM L-lactate ferricytochrome c oxidoreductase activity
2020-10-08 Added SYNONYM lactate dehydrogenase (cytochrome)
2020-10-08 Deleted SYNONYM lactic cytochrome c reductase activity
2020-10-08 Deleted SYNONYM lactate dehydrogenase (cytochrome)
2020-10-08 Deleted SYNONYM dehydrogenase, lactate (cytochrome)
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
2007-11-08 Added SYNONYM lactic cytochrome c reductase activity
2007-11-08 Added SYNONYM lactate dehydrogenase (cytochrome)
2007-11-08 Added SYNONYM flavocytochrome b2
2007-11-08 Added SYNONYM cytochrome b2 (flavin-free derivative of flavocytochrome b2)
2007-11-08 Added SYNONYM L-lactate cytochrome c reductase activity
2007-11-08 Added SYNONYM L-lactate cytochrome c oxidoreductase activity
2007-11-08 Added SYNONYM L(+)-lactate:cytochrome c oxidoreductase activity
2007-11-08 Added SYNONYM (S)-lactate:ferricytochrome-c 2-oxidoreductase activity
2007-11-08 Added SYNONYM dehydrogenase, lactate (cytochrome)
2007-09-06 Added SYNONYM L-lactate ferricytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM lactic acid dehydrogenase activity
2007-08-09 Added SYNONYM cytochrome b2
2007-08-09 Deleted SYNONYM cytochrome b2
2004-04-19 Added SYNONYM cytochrome b2
2004-04-05 Deleted SYNONYM cytochrome b2
2003-10-27 Added SYNONYM cytochrome b2
2003-08-21 Deleted SYNONYM cytochrome b2
2003-03-19 Deleted SYNONYM cytochrome-b2
2002-11-27 Added DEFINITION Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.
2002-01-08 Added SYNONYM cytochrome b2
2001-03-30 Added SYNONYM cytochrome-b2
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004457 (lactate dehydrogenase activity)
2008-04-01 Updated RELATION is a GO:0016898 (oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:19909
2009-05-21 Added XREF MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
2009-05-21 Deleted XREF MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN
2003-10-27 Added XREF MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN
2001-03-30 Added XREF EC:1.1.2.3
Timestamp Action Category Detail
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