GO:0004460
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L-lactate dehydrogenase (cytochrome) activity
Molecular Function
Definition (GO:0004460 GONUTS page)
Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cytochrome b2 (flavin-free derivative of flavocytochrome b2) | related |
flavocytochrome b2 | related |
dehydrogenase, lactate (cytochrome) | related |
L-lactate cytochrome c reductase activity | related |
lactate dehydrogenase (cytochrome) | related |
L(+)-lactate:cytochrome c oxidoreductase activity | related |
L-lactate ferricytochrome c oxidoreductase activity | related |
(S)-lactate:ferricytochrome-c 2-oxidoreductase activity | related |
lactic cytochrome c reductase activity | related |
lactic acid dehydrogenase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.2.3 | |
MetaCyc | L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN | |
RHEA | 19909 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:29033 | iron(2+) |
has_participant | CHEBI | CHEBI:15361 | pyruvate |
has_participant | CHEBI | CHEBI:29034 | iron(3+) |
has_participant | CHEBI | CHEBI:16651 | (S)-lactate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004460 based on ALL annotations
The top 76 of 76 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-lactate dehydrogenase (cytochrome) activity
|
41,494.00 | 100.00 | 4,698 | 4,698 |
lactate metabolic process
|
1,532.79 | 3.58 | 2,552 | 69,085 |
lactate dehydrogenase activity
|
3,064.62 | 3.21 | 252 | 3,412 |
L-lactate dehydrogenase activity
|
1,087.99 | 2.47 | 1,432 | 54,614 |
(S)-mandelate dehydrogenase activity
|
2,585.30 | 0.40 | 20 | 321 |
FMN binding
|
128.53 | 0.31 | 2,335 | 753,797 |
(S)-2-hydroxy-acid oxidase activity
|
107.27 | 0.16 | 21 | 8,123 |
lactate 2-monooxygenase activity
|
669.26 | 0.12 | 6 | 372 |
aerobic respiration
|
26.72 | 0.06 | 1,432 | 2,223,967 |
heme binding
|
21.53 | 0.05 | 1,864 | 3,591,635 |
Totals | 23137 | 305842769 |
No co-occurrence statistics for GO:0004460 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-lactate dehydrogenase (cytochrome) activity
|
86,119.94 | 100.00 | 15 | 15 |
lactate metabolic process
|
4,364.19 | 5.07 | 15 | 296 |
mitochondrial intermembrane space
|
61.56 | 0.07 | 1 | 1,399 |
carbohydrate transport
|
40.34 | 0.05 | 1 | 2,135 |
mitochondrial inner membrane
|
12.31 | 0.01 | 1 | 6,995 |
mitochondrion
|
1.88 | 0.00 | 1 | 45,791 |
cytosol
|
1.02 | 0.00 | 1 | 84,217 |
nucleus
|
0.45 | 0.00 | 1 | 192,276 |
Totals | 36 | 333124 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-04 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. |
2021-06-04 | Deleted | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
2020-10-08 | Added | SYNONYM | (S)-lactate:ferricytochrome-c 2-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | dehydrogenase, lactate (cytochrome) |
2020-10-08 | Added | SYNONYM | lactic cytochrome c reductase activity |
2020-10-08 | Added | SYNONYM | L-lactate cytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | L(+)-lactate:cytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | L-lactate cytochrome c reductase activity |
2020-10-08 | Deleted | SYNONYM | (S)-lactate:ferricytochrome-c 2-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L(+)-lactate:cytochrome c oxidoreductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | L-lactate dehydrogenase (cytochrome) activity |
2002-02-06 | Updated | TERM | L-lactate dehydrogenase (cytochrome) |
2001-04-03 | Updated | TERM | L-lactate dehydrogenase (cytochrome) |
2001-03-30 | Added | TERM | L-lactate dehydrogenase (cytochrome) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-04 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. |
2021-06-04 | Deleted | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
2020-10-08 | Added | SYNONYM | (S)-lactate:ferricytochrome-c 2-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | dehydrogenase, lactate (cytochrome) |
2020-10-08 | Added | SYNONYM | lactic cytochrome c reductase activity |
2020-10-08 | Added | SYNONYM | L-lactate cytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | L(+)-lactate:cytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | L-lactate cytochrome c reductase activity |
2020-10-08 | Deleted | SYNONYM | (S)-lactate:ferricytochrome-c 2-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L(+)-lactate:cytochrome c oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-lactate cytochrome c oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-lactate cytochrome c reductase activity |
2020-10-08 | Deleted | SYNONYM | L-lactate ferricytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | L-lactate ferricytochrome c oxidoreductase activity |
2020-10-08 | Added | SYNONYM | lactate dehydrogenase (cytochrome) |
2020-10-08 | Deleted | SYNONYM | lactic cytochrome c reductase activity |
2020-10-08 | Deleted | SYNONYM | lactate dehydrogenase (cytochrome) |
2020-10-08 | Deleted | SYNONYM | dehydrogenase, lactate (cytochrome) |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
2007-11-08 | Added | SYNONYM | lactic cytochrome c reductase activity |
2007-11-08 | Added | SYNONYM | lactate dehydrogenase (cytochrome) |
2007-11-08 | Added | SYNONYM | flavocytochrome b2 |
2007-11-08 | Added | SYNONYM | cytochrome b2 (flavin-free derivative of flavocytochrome b2) |
2007-11-08 | Added | SYNONYM | L-lactate cytochrome c reductase activity |
2007-11-08 | Added | SYNONYM | L-lactate cytochrome c oxidoreductase activity |
2007-11-08 | Added | SYNONYM | L(+)-lactate:cytochrome c oxidoreductase activity |
2007-11-08 | Added | SYNONYM | (S)-lactate:ferricytochrome-c 2-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | dehydrogenase, lactate (cytochrome) |
2007-09-06 | Added | SYNONYM | L-lactate ferricytochrome c oxidoreductase activity |
2007-09-06 | Added | SYNONYM | lactic acid dehydrogenase activity |
2007-08-09 | Added | SYNONYM | cytochrome b2 |
2007-08-09 | Deleted | SYNONYM | cytochrome b2 |
2004-04-19 | Added | SYNONYM | cytochrome b2 |
2004-04-05 | Deleted | SYNONYM | cytochrome b2 |
2003-10-27 | Added | SYNONYM | cytochrome b2 |
2003-08-21 | Deleted | SYNONYM | cytochrome b2 |
2003-03-19 | Deleted | SYNONYM | cytochrome-b2 |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. |
2002-01-08 | Added | SYNONYM | cytochrome b2 |
2001-03-30 | Added | SYNONYM | cytochrome-b2 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004457 (lactate dehydrogenase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016898 (oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:19909 |
2009-05-21 | Added | XREF | MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN |
2009-05-21 | Deleted | XREF | MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN |
2003-10-27 | Added | XREF | MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN |
2001-03-30 | Added | XREF | EC:1.1.2.3 |
Timestamp | Action | Category | Detail |
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