GO:0004470
JSON
malic enzyme activity
Molecular Function
Definition (GO:0004470 GONUTS page)
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pyruvic-malic carboxylase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004470
Child Term | Relationship to GO:0004470 |
---|---|
malate dehydrogenase (decarboxylating) (NADP+) activity
|
is_a |
malate dehydrogenase (decarboxylating) (NAD+) activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001891 | Malic oxidoreductase |
InterPro | IPR012188 | NAD(P)-dependent malic enzyme |
InterPro | IPR012301 | Malic enzyme, N-terminal domain |
InterPro | IPR037062 | Malic enzyme, N-terminal domain superfamily |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004470 based on ALL annotations
The top 100 of 407 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
malic enzyme activity
|
2,959.35 | 100.00 | 66,959 | 66,959 |
malate metabolic process
|
1,155.81 | 31.43 | 41,292 | 105,724 |
malate dehydrogenase (decarboxylating) (NADP+) activity
|
2,691.68 | 24.00 | 16,462 | 18,099 |
malate dehydrogenase (decarboxylating) (NAD+) activity
|
2,904.74 | 18.76 | 12,606 | 12,843 |
oxaloacetate decarboxylase activity
|
994.33 | 14.77 | 13,965 | 41,563 |
pyruvate metabolic process
|
261.50 | 7.56 | 23,025 | 260,574 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
164.21 | 5.54 | 64,426 | 1,161,093 |
NAD binding
|
160.84 | 5.42 | 64,344 | 1,183,877 |
malolactic enzyme activity
|
2,959.35 | 1.55 | 1,038 | 1,038 |
malolactic fermentation
|
2,959.35 | 1.55 | 1,035 | 1,035 |
Totals | 486653 | 114480015 |
No co-occurrence statistics for GO:0004470 based on MANUAL annotations
The top 41 of 41 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
malic enzyme activity
|
36,193.16 | 100.00 | 39 | 39 |
regulation of NADP metabolic process
|
31,022.71 | 15.00 | 6 | 7 |
malate dehydrogenase (decarboxylating) (NAD+) activity
|
2,513.41 | 5.78 | 10 | 144 |
oxaloacetate decarboxylase activity
|
4,136.36 | 5.71 | 4 | 35 |
malate dehydrogenase (decarboxylating) (NADP+) activity
|
1,779.99 | 4.56 | 15 | 305 |
NADP+ binding
|
2,539.87 | 4.35 | 4 | 57 |
malate metabolic process
|
1,441.49 | 3.97 | 37 | 929 |
pyruvate metabolic process
|
1,115.11 | 3.07 | 35 | 1,136 |
oxygen metabolic process
|
2,262.07 | 1.85 | 1 | 16 |
nucleotide biosynthetic process
|
1,447.73 | 1.59 | 1 | 25 |
Totals | 247 | 531968 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | pyruvic-malic carboxylase activity |
2020-10-08 | Added | SYNONYM | pyruvic-malic carboxylase activity |
2010-10-08 | Deleted | XREF | MetaCyc:MALIC-NADP-RXN |
2010-10-08 | Deleted | XREF | MetaCyc:MALIC-NAD-RXN |
2010-10-08 | Deleted | XREF | MetaCyc:1.1.1.39-RXN |
2009-05-21 | Added | XREF | MetaCyc:MALIC-NADP-RXN |
2009-05-21 | Added | XREF | MetaCyc:MALIC-NAD-RXN |
2009-05-21 | Added | XREF | MetaCyc:1.1.1.39-RXN |
2008-05-13 | Added | DEFINITION | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | malic enzyme activity |
2002-02-06 | Updated | TERM | malic enzyme |
2001-04-03 | Updated | TERM | malic enzyme |
2001-03-30 | Added | TERM | malic enzyme |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | pyruvic-malic carboxylase activity |
2020-10-08 | Added | SYNONYM | pyruvic-malic carboxylase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
2007-09-06 | Added | SYNONYM | pyruvic-malic carboxylase activity |
2002-11-27 | Updated | DEFINITION | Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
2001-08-06 | Added | DEFINITION | The catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016615 (malate dehydrogenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-08 | Deleted | XREF | MetaCyc:MALIC-NADP-RXN |
2010-10-08 | Deleted | XREF | MetaCyc:MALIC-NAD-RXN |
2010-10-08 | Deleted | XREF | MetaCyc:1.1.1.39-RXN |
2009-05-21 | Added | XREF | MetaCyc:MALIC-NADP-RXN |
2009-05-21 | Added | XREF | MetaCyc:MALIC-NAD-RXN |
2009-05-21 | Added | XREF | MetaCyc:1.1.1.39-RXN |
2001-06-21 | Deleted | XREF | EC:1.1.1.37 |
2001-03-30 | Added | XREF | EC:1.1.1.37 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link