This term is obsolete.

GO:0004470 JSON

malic enzyme activity

Molecular Function

Definition (GO:0004470 GONUTS page)

Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.

98,060 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pyruvic-malic carboxylase activity related

Ancestor Chart

Ancestor chart for GO:0004470
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004470

Child Term Relationship to
GO:0004470
malate dehydrogenase (decarboxylating) (NADP+) activity
is_a
malate dehydrogenase (decarboxylating) (NAD+) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR001891 Malic oxidoreductase
InterPro IPR012188 NAD(P)-dependent malic enzyme
InterPro IPR012301 Malic enzyme, N-terminal domain
InterPro IPR037062 Malic enzyme, N-terminal domain superfamily

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004470 based on ALL annotations
The top 100 of 407 co-occurring terms
Co-occurring Term PR S% #Together #Compared
malic enzyme activity
2,959.35 100.00 66,959 66,959
malate metabolic process
1,155.81 31.43 41,292 105,724
malate dehydrogenase (decarboxylating) (NADP+) activity
2,691.68 24.00 16,462 18,099
malate dehydrogenase (decarboxylating) (NAD+) activity
2,904.74 18.76 12,606 12,843
oxaloacetate decarboxylase activity
994.33 14.77 13,965 41,563
pyruvate metabolic process
261.50 7.56 23,025 260,574
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
164.21 5.54 64,426 1,161,093
NAD binding
160.84 5.42 64,344 1,183,877
malolactic enzyme activity
2,959.35 1.55 1,038 1,038
malolactic fermentation
2,959.35 1.55 1,035 1,035
Totals 486653 114480015
No co-occurrence statistics for GO:0004470 based on MANUAL annotations
The top 41 of 41 co-occurring terms
Co-occurring Term PR S% #Together #Compared
malic enzyme activity
36,193.16 100.00 39 39
regulation of NADP metabolic process
31,022.71 15.00 6 7
malate dehydrogenase (decarboxylating) (NAD+) activity
2,513.41 5.78 10 144
oxaloacetate decarboxylase activity
4,136.36 5.71 4 35
malate dehydrogenase (decarboxylating) (NADP+) activity
1,779.99 4.56 15 305
NADP+ binding
2,539.87 4.35 4 57
malate metabolic process
1,441.49 3.97 37 929
pyruvate metabolic process
1,115.11 3.07 35 1,136
oxygen metabolic process
2,262.07 1.85 1 16
nucleotide biosynthetic process
1,447.73 1.59 1 25
Totals 247 531968

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM pyruvic-malic carboxylase activity
2020-10-08 Added SYNONYM pyruvic-malic carboxylase activity
2010-10-08 Deleted XREF MetaCyc:MALIC-NADP-RXN
2010-10-08 Deleted XREF MetaCyc:MALIC-NAD-RXN
2010-10-08 Deleted XREF MetaCyc:1.1.1.39-RXN
2009-05-21 Added XREF MetaCyc:MALIC-NADP-RXN
2009-05-21 Added XREF MetaCyc:MALIC-NAD-RXN
2009-05-21 Added XREF MetaCyc:1.1.1.39-RXN
2008-05-13 Added DEFINITION Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
2008-05-12 Deleted DEFINITION Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
Timestamp Action Category Detail
2003-03-19 Updated TERM malic enzyme activity
2002-02-06 Updated TERM malic enzyme
2001-04-03 Updated TERM malic enzyme
2001-03-30 Added TERM malic enzyme
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM pyruvic-malic carboxylase activity
2020-10-08 Added SYNONYM pyruvic-malic carboxylase activity
2008-05-13 Added DEFINITION Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
2008-05-12 Deleted DEFINITION Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
2007-09-06 Added SYNONYM pyruvic-malic carboxylase activity
2002-11-27 Updated DEFINITION Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
2001-08-06 Added DEFINITION The catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016615 (malate dehydrogenase activity)
Timestamp Action Category Detail
2010-10-08 Deleted XREF MetaCyc:MALIC-NADP-RXN
2010-10-08 Deleted XREF MetaCyc:MALIC-NAD-RXN
2010-10-08 Deleted XREF MetaCyc:1.1.1.39-RXN
2009-05-21 Added XREF MetaCyc:MALIC-NADP-RXN
2009-05-21 Added XREF MetaCyc:MALIC-NAD-RXN
2009-05-21 Added XREF MetaCyc:1.1.1.39-RXN
2001-06-21 Deleted XREF EC:1.1.1.37
2001-03-30 Added XREF EC:1.1.1.37
Timestamp Action Category Detail
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