This term is obsolete.

GO:0004507 JSON

steroid 11-beta-monooxygenase activity

Molecular Function

Definition (GO:0004507 GONUTS page)

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.

623 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
steroid 11-beta-hydroxylase activity exact
cytochrome P450 CYP11B1 narrow
cytochrome P450 CYP11B2 narrow
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) related
steroid 11beta/18-hydroxylase activity related
oxygenase, steroid 11beta -mono- related
steroid 11beta-hydroxylase activity related
steroid 11-beta/18-hydroxylase activity related
steroid 11beta-monooxygenase activity related
cytochrome p450 XIB1 activity narrow

Ancestor Chart

Ancestor chart for GO:0004507
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
EC 1.14.15.4
MetaCyc STEROID-11-BETA-MONOOXYGENASE-RXN
RHEA 15629
Reactome R-HSA-193997
Reactome R-HSA-194017
Reactome R-HSA-5580292
Reactome R-HSA-5600598

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:33737 di-mu-sulfido-diiron(2+)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:35341 steroid
has_participant CHEBI CHEBI:35346 11beta-hydroxy steroid
has_participant CHEBI CHEBI:33738 di-mu-sulfido-diiron(1+)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004507 based on ALL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 11-beta-monooxygenase activity
329,845.66 100.00 591 591
corticosterone 18-monooxygenase activity
329,845.66 95.43 564 564
aldosterone biosynthetic process
290,099.00 84.13 562 639
glucocorticoid biosynthetic process
26,918.39 8.13 564 6,911
cortisol metabolic process
26,855.71 8.11 560 6,878
cellular response to peptide hormone stimulus
25,569.43 7.72 560 7,224
cortisol biosynthetic process
68,837.35 3.52 24 115
regulation of blood volume by renal aldosterone
254,880.73 2.85 17 22
cellular response to potassium ion
8,967.44 1.63 23 846
steroid biosynthetic process
3,981.08 1.21 532 44,078
Totals 10348 105307742
No co-occurrence statistics for GO:0004507 based on MANUAL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 11-beta-monooxygenase activity
56,165.18 100.00 23 23
aldosterone biosynthetic process
51,671.96 92.00 23 25
corticosterone 18-monooxygenase activity
49,144.53 80.77 21 24
cortisol metabolic process
24,572.27 42.00 21 48
glucocorticoid biosynthetic process
16,612.23 28.77 21 71
cellular response to peptide hormone stimulus
11,913.82 20.79 21 99
cortisol biosynthetic process
31,202.87 18.52 5 9
regulation of blood volume by renal aldosterone
28,082.59 11.54 3 6
C21-steroid hormone biosynthetic process
5,616.52 6.78 4 40
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
10,211.85 6.25 2 11
Totals 243 78969

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Deleted SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Deleted SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2020-10-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
Timestamp Action Category Detail
2003-03-19 Updated TERM steroid 11-beta-monooxygenase activity
2002-02-06 Updated TERM steroid 11-beta-monooxygenase
2001-04-03 Updated TERM steroid 11-beta-monooxygenase
2001-03-30 Added TERM steroid 11-beta-monooxygenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Deleted SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Deleted SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2020-10-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Deleted SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM oxygenase, steroid 11beta -mono-
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2007-11-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2007-11-08 Added SYNONYM steroid 11beta-monooxygenase activity
2007-11-08 Added SYNONYM steroid 11beta-hydroxylase activity
2007-11-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2007-11-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2007-09-06 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2007-09-06 Added SYNONYM cytochrome p450 XIB1 activity
2007-08-09 Added SYNONYM steroid 11-beta-hydroxylase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP11B2
2007-08-09 Added SYNONYM cytochrome P450 CYP11B1
2007-08-09 Deleted SYNONYM cytochrome P450 CYP11B1
2007-08-09 Deleted SYNONYM steroid 11-beta-hydroxylase activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP11B2
2004-04-19 Added SYNONYM cytochrome P450 CYP11B2
2004-04-19 Added SYNONYM cytochrome P450 CYP11B1
2004-04-19 Added SYNONYM steroid 11-beta-hydroxylase activity
2004-04-16 Deleted SYNONYM cytochrome P450 CYP11B2
2004-04-16 Deleted SYNONYM cytochrome P450 CYP11B1
2003-10-27 Added SYNONYM cytochrome P450 CYP11B1
2003-10-27 Added SYNONYM cytochrome P450 CYP11B2
2003-08-21 Deleted SYNONYM cytochrome P450 CYP11B2
2003-08-21 Deleted SYNONYM cytochrome P450 CYP11B1
2002-11-27 Added DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2001-03-30 Added SYNONYM cytochrome P450 CYP11B1
2001-03-30 Added SYNONYM cytochrome P450 CYP11B2
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
2008-04-01 Updated RELATION is a GO:0016713 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:15629
2019-05-04 Added XREF Reactome:R-HSA-5600598
2019-05-04 Added XREF Reactome:R-HSA-5580292
2019-04-30 Deleted XREF Reactome:R-HSA-5580292
2019-04-30 Deleted XREF Reactome:R-HSA-5600598
2019-04-29 Added XREF Reactome:R-HSA-5580292
2019-04-29 Added XREF Reactome:R-HSA-5600598
2019-04-28 Deleted XREF Reactome:R-HSA-5600598
2019-04-28 Deleted XREF Reactome:R-HSA-5580292
2019-04-27 Added XREF Reactome:R-HSA-5600598
2019-04-27 Added XREF Reactome:R-HSA-5580292
2019-04-23 Deleted XREF Reactome:R-HSA-5600598
2019-04-23 Deleted XREF Reactome:R-HSA-5580292
2019-04-01 Added XREF Reactome:R-HSA-194017
2019-04-01 Added XREF Reactome:R-HSA-193997
2019-04-01 Deleted XREF reactome:R-HSA-194017
2019-04-01 Added XREF Reactome:R-HSA-5600598
2019-04-01 Deleted XREF reactome:R-HSA-193997
2019-04-01 Added XREF Reactome:R-HSA-5580292
2018-12-11 Added XREF reactome:R-HSA-193997
2018-12-11 Added XREF reactome:R-HSA-194017
2003-10-27 Added XREF MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.15.4
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.