GO:0004507
JSON
steroid 11-beta-monooxygenase activity
Molecular Function
Definition (GO:0004507 GONUTS page)
Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
steroid 11-beta-hydroxylase activity | exact |
cytochrome P450 CYP11B1 | narrow |
cytochrome P450 CYP11B2 | narrow |
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) | related |
steroid 11beta/18-hydroxylase activity | related |
oxygenase, steroid 11beta -mono- | related |
steroid 11beta-hydroxylase activity | related |
steroid 11-beta/18-hydroxylase activity | related |
steroid 11beta-monooxygenase activity | related |
cytochrome p450 XIB1 activity | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0004497 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.14.15.4 | |
MetaCyc | STEROID-11-BETA-MONOOXYGENASE-RXN | |
RHEA | 15629 | |
Reactome | R-HSA-193997 | |
Reactome | R-HSA-194017 | |
Reactome | R-HSA-5580292 | |
Reactome | R-HSA-5600598 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:33737 | di-mu-sulfido-diiron(2+) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:35341 | steroid |
has_participant | CHEBI | CHEBI:35346 | 11beta-hydroxy steroid |
has_participant | CHEBI | CHEBI:33738 | di-mu-sulfido-diiron(1+) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004507 based on ALL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
steroid 11-beta-monooxygenase activity
|
329,845.66 | 100.00 | 591 | 591 |
corticosterone 18-monooxygenase activity
|
329,845.66 | 95.43 | 564 | 564 |
aldosterone biosynthetic process
|
290,099.00 | 84.13 | 562 | 639 |
glucocorticoid biosynthetic process
|
26,918.39 | 8.13 | 564 | 6,911 |
cortisol metabolic process
|
26,855.71 | 8.11 | 560 | 6,878 |
cellular response to peptide hormone stimulus
|
25,569.43 | 7.72 | 560 | 7,224 |
cortisol biosynthetic process
|
68,837.35 | 3.52 | 24 | 115 |
regulation of blood volume by renal aldosterone
|
254,880.73 | 2.85 | 17 | 22 |
cellular response to potassium ion
|
8,967.44 | 1.63 | 23 | 846 |
steroid biosynthetic process
|
3,981.08 | 1.21 | 532 | 44,078 |
Totals | 10348 | 105307742 |
No co-occurrence statistics for GO:0004507 based on MANUAL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
steroid 11-beta-monooxygenase activity
|
56,165.18 | 100.00 | 23 | 23 |
aldosterone biosynthetic process
|
51,671.96 | 92.00 | 23 | 25 |
corticosterone 18-monooxygenase activity
|
49,144.53 | 80.77 | 21 | 24 |
cortisol metabolic process
|
24,572.27 | 42.00 | 21 | 48 |
glucocorticoid biosynthetic process
|
16,612.23 | 28.77 | 21 | 71 |
cellular response to peptide hormone stimulus
|
11,913.82 | 20.79 | 21 | 99 |
cortisol biosynthetic process
|
31,202.87 | 18.52 | 5 | 9 |
regulation of blood volume by renal aldosterone
|
28,082.59 | 11.54 | 3 | 6 |
C21-steroid hormone biosynthetic process
|
5,616.52 | 6.78 | 4 | 40 |
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
|
10,211.85 | 6.25 | 2 | 11 |
Totals | 243 | 78969 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | steroid 11beta-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11-beta/18-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) |
2020-10-08 | Deleted | SYNONYM | steroid 11beta/18-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid 11beta-monooxygenase activity |
2020-10-08 | Deleted | SYNONYM | steroid 11beta-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11beta/18-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11beta-monooxygenase activity |
2020-10-08 | Added | SYNONYM | oxygenase, steroid 11beta -mono- |
2020-10-08 | Added | SYNONYM | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | steroid 11-beta-monooxygenase activity |
2002-02-06 | Updated | TERM | steroid 11-beta-monooxygenase |
2001-04-03 | Updated | TERM | steroid 11-beta-monooxygenase |
2001-03-30 | Added | TERM | steroid 11-beta-monooxygenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | steroid 11beta-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11-beta/18-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) |
2020-10-08 | Deleted | SYNONYM | steroid 11beta/18-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid 11beta-monooxygenase activity |
2020-10-08 | Deleted | SYNONYM | steroid 11beta-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11beta/18-hydroxylase activity |
2020-10-08 | Added | SYNONYM | steroid 11beta-monooxygenase activity |
2020-10-08 | Added | SYNONYM | oxygenase, steroid 11beta -mono- |
2020-10-08 | Added | SYNONYM | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) |
2020-10-08 | Deleted | SYNONYM | steroid 11-beta/18-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | oxygenase, steroid 11beta -mono- |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
2007-11-08 | Added | SYNONYM | oxygenase, steroid 11beta -mono- |
2007-11-08 | Added | SYNONYM | steroid 11beta-monooxygenase activity |
2007-11-08 | Added | SYNONYM | steroid 11beta-hydroxylase activity |
2007-11-08 | Added | SYNONYM | steroid 11beta/18-hydroxylase activity |
2007-11-08 | Added | SYNONYM | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) |
2007-09-06 | Added | SYNONYM | steroid 11-beta/18-hydroxylase activity |
2007-09-06 | Added | SYNONYM | cytochrome p450 XIB1 activity |
2007-08-09 | Added | SYNONYM | steroid 11-beta-hydroxylase activity |
2007-08-09 | Added | SYNONYM | cytochrome P450 CYP11B2 |
2007-08-09 | Added | SYNONYM | cytochrome P450 CYP11B1 |
2007-08-09 | Deleted | SYNONYM | cytochrome P450 CYP11B1 |
2007-08-09 | Deleted | SYNONYM | steroid 11-beta-hydroxylase activity |
2007-08-09 | Deleted | SYNONYM | cytochrome P450 CYP11B2 |
2004-04-19 | Added | SYNONYM | cytochrome P450 CYP11B2 |
2004-04-19 | Added | SYNONYM | cytochrome P450 CYP11B1 |
2004-04-19 | Added | SYNONYM | steroid 11-beta-hydroxylase activity |
2004-04-16 | Deleted | SYNONYM | cytochrome P450 CYP11B2 |
2004-04-16 | Deleted | SYNONYM | cytochrome P450 CYP11B1 |
2003-10-27 | Added | SYNONYM | cytochrome P450 CYP11B1 |
2003-10-27 | Added | SYNONYM | cytochrome P450 CYP11B2 |
2003-08-21 | Deleted | SYNONYM | cytochrome P450 CYP11B2 |
2003-08-21 | Deleted | SYNONYM | cytochrome P450 CYP11B1 |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
2001-03-30 | Added | SYNONYM | cytochrome P450 CYP11B1 |
2001-03-30 | Added | SYNONYM | cytochrome P450 CYP11B2 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008395 (steroid hydroxylase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016713 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:15629 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5600598 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5580292 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5580292 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5600598 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5580292 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5600598 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5600598 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5580292 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5600598 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5580292 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5600598 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5580292 |
2019-04-01 | Added | XREF | Reactome:R-HSA-194017 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193997 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-194017 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5600598 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-193997 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5580292 |
2018-12-11 | Added | XREF | reactome:R-HSA-193997 |
2018-12-11 | Added | XREF | reactome:R-HSA-194017 |
2003-10-27 | Added | XREF | MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.14.15.4 |
Timestamp | Action | Category | Detail |
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