This term is obsolete.

GO:0004507 JSON

steroid 11-beta-monooxygenase activity

Molecular Function

Definition (GO:0004507 GONUTS page)

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.

633 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cytochrome P450 CYP11B1 narrow
cytochrome P450 CYP11B2 narrow
steroid 11-beta-hydroxylase activity exact
steroid 11beta-hydroxylase activity related
oxygenase, steroid 11beta -mono- related
steroid 11beta/18-hydroxylase activity related
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) related
steroid 11-beta/18-hydroxylase activity related
cytochrome p450 XIB1 activity narrow
steroid 11beta-monooxygenase activity related

Ancestor Chart

Ancestor chart for GO:0004507
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
EC 1.14.15.4
MetaCyc STEROID-11-BETA-MONOOXYGENASE-RXN
RHEA 15629
Reactome R-HSA-193997
Reactome R-HSA-194017
Reactome R-HSA-5580292
Reactome R-HSA-5600598

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:35346 11beta-hydroxy steroid
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:33737 di-mu-sulfido-diiron(2+)
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:35341 steroid
has_participant CHEBI CHEBI:33738 di-mu-sulfido-diiron(1+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004507 based on ALL annotations
The top 54 of 54 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004507
steroid 11-beta-monooxygenase activity
330,258.10 100.00 600 600
GO:0047783
corticosterone 18-monooxygenase activity
330,258.10 95.67 574 574
GO:0032342
aldosterone biosynthetic process
291,195.30 84.79 574 651
GO:0006704
glucocorticoid biosynthetic process
26,801.66 8.09 574 7,073
GO:0034650
cortisol metabolic process
26,739.65 8.06 570 7,040
GO:0071375
cellular response to peptide hormone stimulus
25,493.92 7.69 570 7,384
GO:0034651
cortisol biosynthetic process
68,923.43 3.47 24 115
GO:0002017
regulation of blood volume by renal aldosterone
255,199.45 2.81 17 22
GO:0035865
cellular response to potassium ion
8,989.27 1.62 23 845
GO:0006694
steroid biosynthetic process
3,847.32 1.16 535 45,925
Totals 10021 105492256
No co-occurrence statistics for GO:0004507 based on MANUAL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004507
steroid 11-beta-monooxygenase activity
58,813.88 100.00 24 24
GO:0032342
aldosterone biosynthetic process
54,289.73 92.31 24 26
GO:0047783
corticosterone 18-monooxygenase activity
51,756.21 81.48 22 25
GO:0034650
cortisol metabolic process
17,970.91 29.73 22 72
GO:0006704
glucocorticoid biosynthetic process
13,764.95 22.92 22 94
GO:0071375
cellular response to peptide hormone stimulus
10,693.43 17.89 22 121
GO:0034651
cortisol biosynthetic process
32,674.38 17.86 5 9
GO:0002017
regulation of blood volume by renal aldosterone
29,406.94 11.11 3 6
GO:0001991
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
10,693.43 6.06 2 11
GO:0035865
cellular response to potassium ion
4,056.13 5.13 4 58
Totals 251 84038

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Deleted SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Added SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2020-10-08 Deleted SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM oxygenase, steroid 11beta -mono-
Timestamp Action Category Detail
2003-03-19 Updated TERM steroid 11-beta-monooxygenase activity
2002-02-06 Updated TERM steroid 11-beta-monooxygenase
2001-04-03 Updated TERM steroid 11-beta-monooxygenase
2001-03-30 Added TERM steroid 11-beta-monooxygenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Deleted SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2020-10-08 Added SYNONYM steroid 11beta-monooxygenase activity
2020-10-08 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 11beta/18-hydroxylase activity
2020-10-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2020-10-08 Deleted SYNONYM steroid 11-beta/18-hydroxylase activity
2020-10-08 Deleted SYNONYM oxygenase, steroid 11beta -mono-
2020-10-08 Deleted SYNONYM steroid 11beta-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 11beta-monooxygenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2007-11-08 Added SYNONYM steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
2007-11-08 Added SYNONYM steroid 11beta-hydroxylase activity
2007-11-08 Added SYNONYM oxygenase, steroid 11beta -mono-
2007-11-08 Added SYNONYM steroid 11beta/18-hydroxylase activity
2007-11-08 Added SYNONYM steroid 11beta-monooxygenase activity
2007-09-06 Added SYNONYM steroid 11-beta/18-hydroxylase activity
2007-09-06 Added SYNONYM cytochrome p450 XIB1 activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP11B2
2007-08-09 Deleted SYNONYM steroid 11-beta-hydroxylase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP11B1
2007-08-09 Added SYNONYM cytochrome P450 CYP11B2
2007-08-09 Added SYNONYM steroid 11-beta-hydroxylase activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP11B1
2004-04-19 Added SYNONYM cytochrome P450 CYP11B1
2004-04-19 Added SYNONYM cytochrome P450 CYP11B2
2004-04-19 Added SYNONYM steroid 11-beta-hydroxylase activity
2004-04-16 Deleted SYNONYM cytochrome P450 CYP11B1
2004-04-16 Deleted SYNONYM cytochrome P450 CYP11B2
2003-10-27 Added SYNONYM cytochrome P450 CYP11B1
2003-10-27 Added SYNONYM cytochrome P450 CYP11B2
2003-08-21 Deleted SYNONYM cytochrome P450 CYP11B1
2003-08-21 Deleted SYNONYM cytochrome P450 CYP11B2
2002-11-27 Added DEFINITION Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
2001-03-30 Added SYNONYM cytochrome P450 CYP11B1
2001-03-30 Added SYNONYM cytochrome P450 CYP11B2
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
2008-04-01 Updated RELATION is a GO:0016713 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:15629
2019-05-04 Added XREF Reactome:R-HSA-5580292
2019-05-04 Added XREF Reactome:R-HSA-5600598
2019-04-30 Deleted XREF Reactome:R-HSA-5600598
2019-04-30 Deleted XREF Reactome:R-HSA-5580292
2019-04-29 Added XREF Reactome:R-HSA-5580292
2019-04-29 Added XREF Reactome:R-HSA-5600598
2019-04-28 Deleted XREF Reactome:R-HSA-5580292
2019-04-28 Deleted XREF Reactome:R-HSA-5600598
2019-04-27 Added XREF Reactome:R-HSA-5600598
2019-04-27 Added XREF Reactome:R-HSA-5580292
2019-04-23 Deleted XREF Reactome:R-HSA-5580292
2019-04-23 Deleted XREF Reactome:R-HSA-5600598
2019-04-01 Added XREF Reactome:R-HSA-5580292
2019-04-01 Deleted XREF reactome:R-HSA-193997
2019-04-01 Deleted XREF reactome:R-HSA-194017
2019-04-01 Added XREF Reactome:R-HSA-193997
2019-04-01 Added XREF Reactome:R-HSA-5600598
2019-04-01 Added XREF Reactome:R-HSA-194017
2018-12-11 Added XREF reactome:R-HSA-194017
2018-12-11 Added XREF reactome:R-HSA-193997
2003-10-27 Added XREF MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.15.4
Timestamp Action Category Detail
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