This term is obsolete.

GO:0004508 JSON

steroid 17-alpha-monooxygenase activity

Molecular Function

Definition (GO:0004508 GONUTS page)

Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].

7,263 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
steroid 17alpha-monooxygenase activity related
steroid 17alpha-hydroxylase activity related
steroid 17-alpha-hydroxylase/17,20 lyase activity related
steroid 17alphahydroxylase/17,20 lyase activity related
steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) related
cytochrome P450 CYP17 narrow
steroid 17-alpha-hydroxylase activity exact
17alpha-hydroxylase-C17,20 lyase activity related
cytochrome p450 XVIIA1 activity narrow
cytochrome P-450 (P-45017alpha,lyase) related

Ancestor Chart

Ancestor chart for GO:0004508
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004508

Child Term Relationship to
GO:0004508
androst-4-ene-3,17-dione monooxygenase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
EC 1.14.14.19
EC 1.14.14.32
MetaCyc 4.1.2.30-RXN
MetaCyc STEROID-17-ALPHA-MONOOXYGENASE-RXN
RHEA 65760
Reactome R-HSA-193068
Reactome R-HSA-193070
Reactome R-HSA-193072
Reactome R-HSA-193099
Reactome R-HSA-5601843

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58210 FMN(3-)
has_participant CHEBI CHEBI:57618 FMNH2(2-)
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:61313 C21-steroid
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:138141 17alpha-hydroxy-C21-steroid

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0047442 obsolete 17-alpha-hydroxyprogesterone aldolase activity replaced_by GO:0004508

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004508 based on ALL annotations
The top 100 of 190 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 17-alpha-monooxygenase activity
27,559.79 100.00 7,190 7,190
progesterone metabolic process
25,981.84 94.14 7,179 7,615
hormone biosynthetic process
14,906.50 54.04 7,178 13,271
aromatase activity
6,477.56 14.55 1,987 8,454
hormone metabolic process
6,014.97 4.61 397 1,819
hydroperoxy icosatetraenoate dehydratase activity
8,969.16 4.19 330 1,014
steroid biosynthetic process
1,079.59 3.51 1,799 45,925
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
920.25 3.10 2,142 64,149
steroid binding
1,047.66 2.79 683 17,967
estrogen 16-alpha-hydroxylase activity
9,900.58 2.75 208 579
Totals 79066 41447414
No co-occurrence statistics for GO:0004508 based on MANUAL annotations
The top 49 of 49 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 17-alpha-monooxygenase activity
17,426.33 100.00 81 81
hormone biosynthetic process
14,158.90 78.79 78 96
progesterone metabolic process
8,206.59 47.09 81 172
androst-4-ene-3,17-dione biosynthetic process
10,455.80 3.61 3 5
steroid metabolic process
529.76 2.77 19 625
androgen biosynthetic process
1,005.37 2.31 3 52
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity
4,356.58 2.30 2 8
female sex determination
1,742.63 2.02 2 20
glucocorticoid biosynthetic process
556.16 1.74 3 94
steroid biosynthetic process
304.39 1.31 4 229
Totals 340 118055

Change Log

Timestamp Action Category Detail
2024-11-05 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2024-11-05 Added RELATION is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
2024-05-09 Added XREF MetaCyc:4.1.2.30-RXN
2024-05-09 Added DEFINITION Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2024-05-09 Added XREF RHEA:65760
2024-05-09 Added XREF EC:1.14.14.32
2024-05-09 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2020-10-08 Deleted SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 17alpha-monooxygenase activity
2020-10-08 Deleted SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM steroid 17-alpha-monooxygenase activity
2002-02-06 Updated TERM steroid 17-alpha-monooxygenase
2001-04-03 Updated TERM steroid 17-alpha-monooxygenase
2001-03-30 Added TERM steroid 17-alpha-monooxygenase
Timestamp Action Category Detail
2024-05-09 Added DEFINITION Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2024-05-09 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2020-10-08 Deleted SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 17alpha-monooxygenase activity
2020-10-08 Deleted SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2020-10-08 Deleted SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2020-10-08 Deleted SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2020-10-08 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2020-10-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2020-10-08 Deleted SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2007-11-08 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-11-08 Added SYNONYM cytochrome P45017alpha
2007-11-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2007-11-08 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase activity
2007-11-08 Added SYNONYM cytochrome P-450 (P-45017alpha,lyase)
2007-11-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2007-11-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2007-11-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2007-11-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2007-09-06 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2007-09-06 Added SYNONYM cytochrome p450 XVIIA1 activity
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-08-09 Deleted SYNONYM cytochrome P450 CYP17
2007-08-09 Added SYNONYM cytochrome P450 CYP17
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2005-03-22 Updated DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2004-04-19 Added SYNONYM cytochrome P450 CYP17
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase activity
2004-04-16 Deleted SYNONYM cytochrome P450 CYP17
2004-04-16 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added SYNONYM cytochrome P450 CYP17
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2003-08-21 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-08-21 Deleted SYNONYM cytochrome P450 CYP17
2003-03-19 Deleted SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2002-12-06 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.
2001-03-30 Added SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2001-03-30 Added SYNONYM cytochrome P450 CYP17
Timestamp Action Category Detail
2024-11-05 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2024-11-05 Added RELATION is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
Timestamp Action Category Detail
2024-05-09 Added XREF MetaCyc:4.1.2.30-RXN
2024-05-09 Added XREF RHEA:65760
2024-05-09 Added XREF EC:1.14.14.32
2019-09-25 Deleted XREF EC:1.14.99.9
2019-09-25 Added XREF EC:1.14.14.19
2019-05-04 Added XREF Reactome:R-HSA-5601843
2019-05-04 Added XREF Reactome:R-HSA-9035954
2019-05-04 Added XREF Reactome:R-HSA-9035956
2019-04-30 Deleted XREF Reactome:R-HSA-5601843
2019-04-30 Deleted XREF Reactome:R-HSA-9035954
2019-04-30 Deleted XREF Reactome:R-HSA-9035956
2019-04-29 Added XREF Reactome:R-HSA-5601843
2019-04-29 Added XREF Reactome:R-HSA-9035954
2019-04-29 Added XREF Reactome:R-HSA-9035956
2019-04-28 Deleted XREF Reactome:R-HSA-9035954
2019-04-28 Deleted XREF Reactome:R-HSA-9035956
2019-04-28 Deleted XREF Reactome:R-HSA-5601843
2019-04-27 Added XREF Reactome:R-HSA-9035954
2019-04-27 Added XREF Reactome:R-HSA-9035956
2019-04-27 Added XREF Reactome:R-HSA-5601843
2019-04-23 Deleted XREF Reactome:R-HSA-9035954
2019-04-23 Deleted XREF Reactome:R-HSA-5601843
2019-04-23 Deleted XREF Reactome:R-HSA-9035956
2019-04-01 Added XREF Reactome:R-HSA-193070
2019-04-01 Added XREF Reactome:R-HSA-5601843
2019-04-01 Added XREF Reactome:R-HSA-193099
2019-04-01 Added XREF Reactome:R-HSA-193068
2019-04-01 Added XREF Reactome:R-HSA-9035956
2019-04-01 Added XREF Reactome:R-HSA-9035954
2019-04-01 Deleted XREF reactome:R-HSA-193068
2019-04-01 Deleted XREF reactome:R-HSA-193072
2019-04-01 Deleted XREF reactome:R-HSA-193099
2019-04-01 Deleted XREF reactome:R-HSA-193070
2019-04-01 Added XREF Reactome:R-HSA-193072
2018-12-11 Added XREF reactome:R-HSA-193068
2018-12-11 Added XREF reactome:R-HSA-193070
2018-12-11 Added XREF reactome:R-HSA-193072
2018-12-11 Added XREF reactome:R-HSA-193099
2003-10-27 Added XREF MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.99.9
Timestamp Action Category Detail
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