GO:0004508
JSON
steroid 17-alpha-monooxygenase activity
Molecular Function
Definition (GO:0004508 GONUTS page)
Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cytochrome P-450 (P-45017alpha,lyase) | related |
cytochrome P45017alpha | related |
steroid 17-alpha-hydroxylase-C17-20 lyase activity | exact |
steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) | related |
cytochrome P450 CYP17 | narrow |
steroid 17-alpha-hydroxylase activity | exact |
steroid 17alphahydroxylase/17,20 lyase activity | related |
steroid 17alpha-hydroxylase activity | related |
steroid 17alpha-monooxygenase activity | related |
steroid 17-alpha-hydroxylase/17,20 lyase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0004497 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:58210 | FMN(3-) |
has_participant | CHEBI | CHEBI:61313 | C21-steroid |
has_participant | CHEBI | CHEBI:138141 | 17alpha-hydroxy-C21-steroid |
has_participant | CHEBI | CHEBI:57618 | FMNH2(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0047442 | obsolete 17-alpha-hydroxyprogesterone aldolase activity | replaced_by GO:0004508 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004508 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
steroid 17-alpha-monooxygenase activity
|
27,627.38 | 100.00 | 7,056 | 7,056 |
progesterone metabolic process
|
26,080.19 | 94.27 | 7,046 | 7,464 |
hormone biosynthetic process
|
13,328.42 | 48.21 | 7,045 | 14,603 |
aromatase activity
|
6,567.44 | 14.71 | 1,964 | 8,262 |
hydroperoxy icosatetraenoate dehydratase activity
|
8,947.81 | 4.27 | 331 | 1,022 |
steroid biosynthetic process
|
1,172.71 | 3.80 | 1,871 | 44,078 |
hormone metabolic process
|
4,532.36 | 3.22 | 272 | 1,658 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
909.06 | 3.06 | 2,114 | 64,247 |
steroid binding
|
1,075.35 | 2.87 | 694 | 17,830 |
retinol metabolic process
|
1,134.98 | 2.71 | 521 | 12,682 |
Totals | 77470 | 41418084 |
No co-occurrence statistics for GO:0004508 based on MANUAL annotations
The top 49 of 49 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
steroid 17-alpha-monooxygenase activity
|
22,272.40 | 100.00 | 58 | 58 |
hormone biosynthetic process
|
16,780.57 | 72.37 | 55 | 73 |
progesterone metabolic process
|
9,861.06 | 44.27 | 58 | 131 |
androst-4-ene-3,17-dione biosynthetic process
|
13,363.44 | 5.00 | 3 | 5 |
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
|
5,568.10 | 3.13 | 2 | 8 |
steroid metabolic process
|
722.14 | 3.04 | 19 | 586 |
androgen biosynthetic process
|
1,336.34 | 2.86 | 3 | 50 |
female sex determination
|
2,227.24 | 2.63 | 2 | 20 |
glucocorticoid biosynthetic process
|
941.09 | 2.38 | 3 | 71 |
male sex determination
|
645.58 | 1.60 | 2 | 69 |
Totals | 269 | 109425 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Added | RELATION | is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen) |
2024-11-05 | Deleted | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2024-05-09 | Added | DEFINITION | Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
2024-05-09 | Deleted | DEFINITION | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2024-05-09 | Added | XREF | RHEA:65760 |
2024-05-09 | Added | XREF | EC:1.14.14.32 |
2024-05-09 | Added | XREF | MetaCyc:4.1.2.30-RXN |
2020-10-08 | Deleted | SYNONYM | steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) |
2020-10-08 | Added | SYNONYM | steroid 17alpha-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid 17alphahydroxylase/17,20 lyase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | steroid 17-alpha-monooxygenase activity |
2002-02-06 | Updated | TERM | steroid 17-alpha-monooxygenase |
2001-04-03 | Updated | TERM | steroid 17-alpha-monooxygenase |
2001-03-30 | Added | TERM | steroid 17-alpha-monooxygenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | DEFINITION | Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. |
2024-05-09 | Deleted | DEFINITION | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2020-10-08 | Deleted | SYNONYM | steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) |
2020-10-08 | Added | SYNONYM | steroid 17alpha-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | steroid 17alphahydroxylase/17,20 lyase activity |
2020-10-08 | Deleted | SYNONYM | steroid 17alpha-monooxygenase activity |
2020-10-08 | Deleted | SYNONYM | steroid 17alpha-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | 17alpha-hydroxylase-C17,20 lyase activity |
2020-10-08 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase/17,20 lyase activity |
2020-10-08 | Added | SYNONYM | steroid 17alpha-monooxygenase activity |
2020-10-08 | Added | SYNONYM | steroid 17-alpha-hydroxylase/17,20 lyase activity |
2020-10-08 | Added | SYNONYM | steroid 17alphahydroxylase/17,20 lyase activity |
2020-10-08 | Added | SYNONYM | 17alpha-hydroxylase-C17,20 lyase activity |
2020-10-08 | Added | SYNONYM | steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2007-11-08 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2007-11-08 | Added | SYNONYM | steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) |
2007-11-08 | Added | SYNONYM | cytochrome P-450 (P-45017alpha,lyase) |
2007-11-08 | Added | SYNONYM | 17alpha-hydroxylase-C17,20 lyase activity |
2007-11-08 | Added | SYNONYM | steroid 17alphahydroxylase/17,20 lyase activity |
2007-11-08 | Added | SYNONYM | steroid 17alpha-monooxygenase activity |
2007-11-08 | Added | SYNONYM | steroid 17alpha-hydroxylase activity |
2007-11-08 | Added | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase activity |
2007-11-08 | Added | SYNONYM | cytochrome P45017alpha |
2007-09-06 | Added | SYNONYM | cytochrome p450 XVIIA1 activity |
2007-09-06 | Added | SYNONYM | steroid 17-alpha-hydroxylase/17,20 lyase activity |
2007-08-09 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2007-08-09 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase activity |
2007-08-09 | Deleted | SYNONYM | cytochrome P450 CYP17 |
2007-08-09 | Added | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2007-08-09 | Added | SYNONYM | steroid 17-alpha-hydroxylase activity |
2007-08-09 | Added | SYNONYM | cytochrome P450 CYP17 |
2005-03-22 | Updated | DEFINITION | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
2004-04-19 | Added | SYNONYM | steroid 17-alpha-hydroxylase activity |
2004-04-19 | Added | SYNONYM | cytochrome P450 CYP17 |
2004-04-19 | Added | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2004-04-16 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2004-04-16 | Deleted | SYNONYM | cytochrome P450 CYP17 |
2003-10-27 | Added | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2003-10-27 | Added | SYNONYM | cytochrome P450 CYP17 |
2003-08-22 | Updated | DEFINITION | Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. |
2003-08-21 | Deleted | SYNONYM | cytochrome P450 CYP17 |
2003-08-21 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2003-03-19 | Deleted | SYNONYM | steroid 17-alpha-hydroxylase/C17-20 lyase |
2002-12-06 | Added | SYNONYM | steroid 17-alpha-hydroxylase-C17-20 lyase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O. |
2001-03-30 | Added | SYNONYM | cytochrome P450 CYP17 |
2001-03-30 | Added | SYNONYM | steroid 17-alpha-hydroxylase/C17-20 lyase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Added | RELATION | is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen) |
2024-11-05 | Deleted | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0008395 (steroid hydroxylase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | XREF | RHEA:65760 |
2024-05-09 | Added | XREF | EC:1.14.14.32 |
2024-05-09 | Added | XREF | MetaCyc:4.1.2.30-RXN |
2019-09-25 | Added | XREF | EC:1.14.14.19 |
2019-09-25 | Deleted | XREF | EC:1.14.99.9 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5601843 |
2019-05-04 | Added | XREF | Reactome:R-HSA-9035956 |
2019-05-04 | Added | XREF | Reactome:R-HSA-9035954 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5601843 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9035954 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9035956 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5601843 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9035956 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9035954 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9035956 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5601843 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9035954 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5601843 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9035956 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9035954 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9035956 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9035954 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5601843 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193072 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9035956 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193068 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193099 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5601843 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-193072 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9035954 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-193068 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-193070 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-193099 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193070 |
2018-12-11 | Added | XREF | reactome:R-HSA-193072 |
2018-12-11 | Added | XREF | reactome:R-HSA-193099 |
2018-12-11 | Added | XREF | reactome:R-HSA-193070 |
2018-12-11 | Added | XREF | reactome:R-HSA-193068 |
2003-10-27 | Added | XREF | MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.14.99.9 |
Timestamp | Action | Category | Detail |
---|
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