This term is obsolete.

GO:0004508 JSON

steroid 17-alpha-monooxygenase activity

Molecular Function

Definition (GO:0004508 GONUTS page)

Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].

7,120 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cytochrome P-450 (P-45017alpha,lyase) related
cytochrome P45017alpha related
steroid 17-alpha-hydroxylase-C17-20 lyase activity exact
steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) related
cytochrome P450 CYP17 narrow
steroid 17-alpha-hydroxylase activity exact
steroid 17alphahydroxylase/17,20 lyase activity related
steroid 17alpha-hydroxylase activity related
steroid 17alpha-monooxygenase activity related
steroid 17-alpha-hydroxylase/17,20 lyase activity related

Ancestor Chart

Ancestor chart for GO:0004508
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
EC 1.14.14.19
EC 1.14.14.32
MetaCyc 4.1.2.30-RXN
MetaCyc STEROID-17-ALPHA-MONOOXYGENASE-RXN
RHEA 65760
Reactome R-HSA-193068
Reactome R-HSA-193070
Reactome R-HSA-193072
Reactome R-HSA-193099
Reactome R-HSA-5601843

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:58210 FMN(3-)
has_participant CHEBI CHEBI:61313 C21-steroid
has_participant CHEBI CHEBI:138141 17alpha-hydroxy-C21-steroid
has_participant CHEBI CHEBI:57618 FMNH2(2-)
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0047442 obsolete 17-alpha-hydroxyprogesterone aldolase activity replaced_by GO:0004508

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004508 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 17-alpha-monooxygenase activity
27,627.38 100.00 7,056 7,056
progesterone metabolic process
26,080.19 94.27 7,046 7,464
hormone biosynthetic process
13,328.42 48.21 7,045 14,603
aromatase activity
6,567.44 14.71 1,964 8,262
hydroperoxy icosatetraenoate dehydratase activity
8,947.81 4.27 331 1,022
steroid biosynthetic process
1,172.71 3.80 1,871 44,078
hormone metabolic process
4,532.36 3.22 272 1,658
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
909.06 3.06 2,114 64,247
steroid binding
1,075.35 2.87 694 17,830
retinol metabolic process
1,134.98 2.71 521 12,682
Totals 77470 41418084
No co-occurrence statistics for GO:0004508 based on MANUAL annotations
The top 49 of 49 co-occurring terms
Co-occurring Term PR S% #Together #Compared
steroid 17-alpha-monooxygenase activity
22,272.40 100.00 58 58
hormone biosynthetic process
16,780.57 72.37 55 73
progesterone metabolic process
9,861.06 44.27 58 131
androst-4-ene-3,17-dione biosynthetic process
13,363.44 5.00 3 5
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
5,568.10 3.13 2 8
steroid metabolic process
722.14 3.04 19 586
androgen biosynthetic process
1,336.34 2.86 3 50
female sex determination
2,227.24 2.63 2 20
glucocorticoid biosynthetic process
941.09 2.38 3 71
male sex determination
645.58 1.60 2 69
Totals 269 109425

Change Log

Timestamp Action Category Detail
2024-11-05 Added RELATION is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
2024-11-05 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2024-05-09 Added DEFINITION Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2024-05-09 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2024-05-09 Added XREF RHEA:65760
2024-05-09 Added XREF EC:1.14.14.32
2024-05-09 Added XREF MetaCyc:4.1.2.30-RXN
2020-10-08 Deleted SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2020-10-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM steroid 17-alpha-monooxygenase activity
2002-02-06 Updated TERM steroid 17-alpha-monooxygenase
2001-04-03 Updated TERM steroid 17-alpha-monooxygenase
2001-03-30 Added TERM steroid 17-alpha-monooxygenase
Timestamp Action Category Detail
2024-05-09 Added DEFINITION Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
2024-05-09 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2020-10-08 Deleted SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2020-10-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Deleted SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2020-10-08 Deleted SYNONYM steroid 17alpha-monooxygenase activity
2020-10-08 Deleted SYNONYM steroid 17alpha-hydroxylase activity
2020-10-08 Deleted SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2020-10-08 Deleted SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2020-10-08 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2020-10-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2020-10-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2007-11-08 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-11-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2007-11-08 Added SYNONYM cytochrome P-450 (P-45017alpha,lyase)
2007-11-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2007-11-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2007-11-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2007-11-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2007-11-08 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase activity
2007-11-08 Added SYNONYM cytochrome P45017alpha
2007-09-06 Added SYNONYM cytochrome p450 XVIIA1 activity
2007-09-06 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP17
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP17
2005-03-22 Updated DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase activity
2004-04-19 Added SYNONYM cytochrome P450 CYP17
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2004-04-16 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2004-04-16 Deleted SYNONYM cytochrome P450 CYP17
2003-10-27 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added SYNONYM cytochrome P450 CYP17
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2003-08-21 Deleted SYNONYM cytochrome P450 CYP17
2003-08-21 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-03-19 Deleted SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2002-12-06 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.
2001-03-30 Added SYNONYM cytochrome P450 CYP17
2001-03-30 Added SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
Timestamp Action Category Detail
2024-11-05 Added RELATION is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
2024-11-05 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
Timestamp Action Category Detail
2024-05-09 Added XREF RHEA:65760
2024-05-09 Added XREF EC:1.14.14.32
2024-05-09 Added XREF MetaCyc:4.1.2.30-RXN
2019-09-25 Added XREF EC:1.14.14.19
2019-09-25 Deleted XREF EC:1.14.99.9
2019-05-04 Added XREF Reactome:R-HSA-5601843
2019-05-04 Added XREF Reactome:R-HSA-9035956
2019-05-04 Added XREF Reactome:R-HSA-9035954
2019-04-30 Deleted XREF Reactome:R-HSA-5601843
2019-04-30 Deleted XREF Reactome:R-HSA-9035954
2019-04-30 Deleted XREF Reactome:R-HSA-9035956
2019-04-29 Added XREF Reactome:R-HSA-5601843
2019-04-29 Added XREF Reactome:R-HSA-9035956
2019-04-29 Added XREF Reactome:R-HSA-9035954
2019-04-28 Deleted XREF Reactome:R-HSA-9035956
2019-04-28 Deleted XREF Reactome:R-HSA-5601843
2019-04-28 Deleted XREF Reactome:R-HSA-9035954
2019-04-27 Added XREF Reactome:R-HSA-5601843
2019-04-27 Added XREF Reactome:R-HSA-9035956
2019-04-27 Added XREF Reactome:R-HSA-9035954
2019-04-23 Deleted XREF Reactome:R-HSA-9035956
2019-04-23 Deleted XREF Reactome:R-HSA-9035954
2019-04-23 Deleted XREF Reactome:R-HSA-5601843
2019-04-01 Added XREF Reactome:R-HSA-193072
2019-04-01 Added XREF Reactome:R-HSA-9035956
2019-04-01 Added XREF Reactome:R-HSA-193068
2019-04-01 Added XREF Reactome:R-HSA-193099
2019-04-01 Added XREF Reactome:R-HSA-5601843
2019-04-01 Deleted XREF reactome:R-HSA-193072
2019-04-01 Added XREF Reactome:R-HSA-9035954
2019-04-01 Deleted XREF reactome:R-HSA-193068
2019-04-01 Deleted XREF reactome:R-HSA-193070
2019-04-01 Deleted XREF reactome:R-HSA-193099
2019-04-01 Added XREF Reactome:R-HSA-193070
2018-12-11 Added XREF reactome:R-HSA-193072
2018-12-11 Added XREF reactome:R-HSA-193099
2018-12-11 Added XREF reactome:R-HSA-193070
2018-12-11 Added XREF reactome:R-HSA-193068
2003-10-27 Added XREF MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.99.9
Timestamp Action Category Detail
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