This term is obsolete.

GO:0004516 JSON

nicotinate phosphoribosyltransferase activity

Molecular Function

Definition (GO:0004516 GONUTS page)

Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. PMID:7503993

36,467 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
niacin ribonucleotidase activity related
nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity related
nicotinic acid mononucleotide glycohydrolase activity related
nicotinic acid mononucleotide pyrophosphorylase activity related
nicotinic acid phosphoribosyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0004516
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.4.21
InterPro IPR006405 Nicotinate phosphoribosyltransferase pncB-type
InterPro IPR006406 Nicotinate phosphoribosyltransferase
InterPro IPR007229 Nicotinate phosphoribosyltransferase family
KEGG_REACTION R01724
MetaCyc NICOTINATEPRIBOSYLTRANS-RXN
RHEA 36163
Reactome R-HSA-197186

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:57502 nicotinate D-ribonucleotide(2-)
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:58017 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:32544 nicotinate
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004516 based on ALL annotations
The top 100 of 180 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nicotinate phosphoribosyltransferase activity
5,459.56 100.00 36,295 36,295
NAD salvage
5,458.72 88.93 32,280 32,285
pyridine nucleotide biosynthetic process
792.14 14.47 35,580 245,223
NAD biosynthetic process
663.77 12.15 36,143 297,281
nicotinate-nucleotide diphosphorylase (carboxylating) activity
320.45 3.28 2,518 42,900
ligase activity
63.90 1.17 35,926 3,069,286
nicotinamide phosphoribosyltransferase activity
408.62 1.10 460 6,146
glycosyltransferase activity
55.53 1.02 32,305 3,176,052
nicotinate nucleotide salvage
3,288.70 0.56 203 337
rDNA heterochromatin formation
197.57 0.48 202 5,582
Totals 248166 47909033
No co-occurrence statistics for GO:0004516 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nicotinate phosphoribosyltransferase activity
8,767.29 100.00 161 161
NAD salvage
8,501.61 96.39 160 165
nicotinate nucleotide salvage
2,191.82 1.76 3 12
nicotinamide phosphoribosyltransferase activity
407.78 0.99 2 43
response to host
674.41 0.58 1 13
cell-abiotic substrate adhesion
547.96 0.57 1 16
NAD biosynthetic process
62.62 0.56 4 560
ligase activity, forming carbon-nitrogen bonds
282.82 0.52 1 31
azurophil granule lumen
91.33 0.39 1 96
response to oxidative stress
31.02 0.32 6 1,696
Totals 521 771290

Change Log

Timestamp Action Category Detail
2024-12-23 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.
2024-12-23 Added DEFINITION Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
2022-09-01 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.
2021-08-30 Added XREF RHEA:36163
2021-08-30 Deleted XREF RHEA:13393
2020-10-08 Added SYNONYM nicotinic acid mononucleotide pyrophosphorylase activity
2020-10-08 Added SYNONYM nicotinic acid phosphoribosyltransferase activity
2020-10-08 Added SYNONYM niacin ribonucleotidase activity
2020-10-08 Deleted SYNONYM nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM nicotinate phosphoribosyltransferase activity
2002-02-06 Updated TERM nicotinate phosphoribosyltransferase
2001-04-03 Updated TERM nicotinate phosphoribosyltransferase
2001-03-30 Added TERM nicotinate phosphoribosyltransferase
Timestamp Action Category Detail
2024-12-23 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.
2024-12-23 Added DEFINITION Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
2022-09-01 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate.
2020-10-08 Added SYNONYM nicotinic acid mononucleotide pyrophosphorylase activity
2020-10-08 Added SYNONYM nicotinic acid phosphoribosyltransferase activity
2020-10-08 Added SYNONYM niacin ribonucleotidase activity
2020-10-08 Deleted SYNONYM nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2020-10-08 Deleted SYNONYM nicotinic acid phosphoribosyltransferase activity
2020-10-08 Added SYNONYM nicotinic acid mononucleotide glycohydrolase activity
2020-10-08 Added SYNONYM nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2020-10-08 Deleted SYNONYM niacin ribonucleotidase activity
2020-10-08 Deleted SYNONYM nicotinic acid mononucleotide glycohydrolase activity
2020-10-08 Deleted SYNONYM nicotinic acid mononucleotide pyrophosphorylase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
2008-05-13 Added DEFINITION Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
2007-11-08 Added SYNONYM nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity
2007-09-06 Added SYNONYM niacin ribonucleotidase activity
2007-09-06 Added SYNONYM nicotinic acid mononucleotide glycohydrolase activity
2007-09-06 Added SYNONYM nicotinic acid mononucleotide pyrophosphorylase activity
2007-09-06 Added SYNONYM nicotinic acid phosphoribosyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Timestamp Action Category Detail
2017-12-25 Added RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
2017-12-25 Deleted RELATION is a GO:0016763 (pentosyltransferase activity)
2008-04-01 Updated RELATION is a GO:0016763 (pentosyltransferase activity)
Timestamp Action Category Detail
2021-08-30 Added XREF RHEA:36163
2021-08-30 Deleted XREF RHEA:13393
2019-06-20 Deleted XREF KEGG:R01724
2019-06-20 Added XREF KEGG_REACTION:R01724
2019-04-01 Added XREF Reactome:R-HSA-197186
2019-04-01 Deleted XREF reactome:R-HSA-197186
2018-12-11 Added XREF reactome:R-HSA-197186
2018-07-13 Deleted XREF RHEA:13396
2018-07-13 Added XREF RHEA:13393
2017-12-25 Added XREF EC:6.3.4.21
2017-12-25 Deleted XREF EC:2.4.2.11
2010-10-11 Added XREF KEGG:R01724
2010-10-11 Added XREF RHEA:13396
2003-10-27 Added XREF MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN
2001-03-30 Added XREF EC:2.4.2.11
Timestamp Action Category Detail
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