GO:0004516
JSON
nicotinate phosphoribosyltransferase activity
Molecular Function
Definition (GO:0004516 GONUTS page)
Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. PMID:7503993
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
niacin ribonucleotidase activity | related |
nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity | related |
nicotinic acid mononucleotide glycohydrolase activity | related |
nicotinic acid mononucleotide pyrophosphorylase activity | related |
nicotinic acid phosphoribosyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.4.21 | |
InterPro | IPR006405 | Nicotinate phosphoribosyltransferase pncB-type |
InterPro | IPR006406 | Nicotinate phosphoribosyltransferase |
InterPro | IPR007229 | Nicotinate phosphoribosyltransferase family |
KEGG_REACTION | R01724 | |
MetaCyc | NICOTINATEPRIBOSYLTRANS-RXN | |
RHEA | 36163 | |
Reactome | R-HSA-197186 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:57502 | nicotinate D-ribonucleotide(2-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:58017 | 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:32544 | nicotinate |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004516 based on ALL annotations
The top 100 of 180 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nicotinate phosphoribosyltransferase activity
|
5,459.56 | 100.00 | 36,295 | 36,295 |
NAD salvage
|
5,458.72 | 88.93 | 32,280 | 32,285 |
pyridine nucleotide biosynthetic process
|
792.14 | 14.47 | 35,580 | 245,223 |
NAD biosynthetic process
|
663.77 | 12.15 | 36,143 | 297,281 |
nicotinate-nucleotide diphosphorylase (carboxylating) activity
|
320.45 | 3.28 | 2,518 | 42,900 |
ligase activity
|
63.90 | 1.17 | 35,926 | 3,069,286 |
nicotinamide phosphoribosyltransferase activity
|
408.62 | 1.10 | 460 | 6,146 |
glycosyltransferase activity
|
55.53 | 1.02 | 32,305 | 3,176,052 |
nicotinate nucleotide salvage
|
3,288.70 | 0.56 | 203 | 337 |
rDNA heterochromatin formation
|
197.57 | 0.48 | 202 | 5,582 |
Totals | 248166 | 47909033 |
No co-occurrence statistics for GO:0004516 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nicotinate phosphoribosyltransferase activity
|
8,767.29 | 100.00 | 161 | 161 |
NAD salvage
|
8,501.61 | 96.39 | 160 | 165 |
nicotinate nucleotide salvage
|
2,191.82 | 1.76 | 3 | 12 |
nicotinamide phosphoribosyltransferase activity
|
407.78 | 0.99 | 2 | 43 |
response to host
|
674.41 | 0.58 | 1 | 13 |
cell-abiotic substrate adhesion
|
547.96 | 0.57 | 1 | 16 |
NAD biosynthetic process
|
62.62 | 0.56 | 4 | 560 |
ligase activity, forming carbon-nitrogen bonds
|
282.82 | 0.52 | 1 | 31 |
azurophil granule lumen
|
91.33 | 0.39 | 1 | 96 |
response to oxidative stress
|
31.02 | 0.32 | 6 | 1,696 |
Totals | 521 | 771290 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-23 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. |
2024-12-23 | Added | DEFINITION | Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. |
2021-08-30 | Added | XREF | RHEA:36163 |
2021-08-30 | Deleted | XREF | RHEA:13393 |
2020-10-08 | Added | SYNONYM | nicotinic acid mononucleotide pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | nicotinic acid phosphoribosyltransferase activity |
2020-10-08 | Added | SYNONYM | niacin ribonucleotidase activity |
2020-10-08 | Deleted | SYNONYM | nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | nicotinate phosphoribosyltransferase activity |
2002-02-06 | Updated | TERM | nicotinate phosphoribosyltransferase |
2001-04-03 | Updated | TERM | nicotinate phosphoribosyltransferase |
2001-03-30 | Added | TERM | nicotinate phosphoribosyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-23 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. |
2024-12-23 | Added | DEFINITION | Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. |
2020-10-08 | Added | SYNONYM | nicotinic acid mononucleotide pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | nicotinic acid phosphoribosyltransferase activity |
2020-10-08 | Added | SYNONYM | niacin ribonucleotidase activity |
2020-10-08 | Deleted | SYNONYM | nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | nicotinic acid phosphoribosyltransferase activity |
2020-10-08 | Added | SYNONYM | nicotinic acid mononucleotide glycohydrolase activity |
2020-10-08 | Added | SYNONYM | nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2020-10-08 | Deleted | SYNONYM | niacin ribonucleotidase activity |
2020-10-08 | Deleted | SYNONYM | nicotinic acid mononucleotide glycohydrolase activity |
2020-10-08 | Deleted | SYNONYM | nicotinic acid mononucleotide pyrophosphorylase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
2007-11-08 | Added | SYNONYM | nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity |
2007-09-06 | Added | SYNONYM | niacin ribonucleotidase activity |
2007-09-06 | Added | SYNONYM | nicotinic acid mononucleotide glycohydrolase activity |
2007-09-06 | Added | SYNONYM | nicotinic acid mononucleotide pyrophosphorylase activity |
2007-09-06 | Added | SYNONYM | nicotinic acid phosphoribosyltransferase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-12-25 | Added | RELATION | is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds) |
2017-12-25 | Deleted | RELATION | is a GO:0016763 (pentosyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016763 (pentosyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-08-30 | Added | XREF | RHEA:36163 |
2021-08-30 | Deleted | XREF | RHEA:13393 |
2019-06-20 | Deleted | XREF | KEGG:R01724 |
2019-06-20 | Added | XREF | KEGG_REACTION:R01724 |
2019-04-01 | Added | XREF | Reactome:R-HSA-197186 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-197186 |
2018-12-11 | Added | XREF | reactome:R-HSA-197186 |
2018-07-13 | Deleted | XREF | RHEA:13396 |
2018-07-13 | Added | XREF | RHEA:13393 |
2017-12-25 | Added | XREF | EC:6.3.4.21 |
2017-12-25 | Deleted | XREF | EC:2.4.2.11 |
2010-10-11 | Added | XREF | KEGG:R01724 |
2010-10-11 | Added | XREF | RHEA:13396 |
2003-10-27 | Added | XREF | MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN |
2001-03-30 | Added | XREF | EC:2.4.2.11 |
Timestamp | Action | Category | Detail |
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