This term is obsolete.

GO:0004529 JSON

DNA exonuclease activity

Molecular Function

Definition (GO:0004529 GONUTS page)

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.

296,188 annotations

Ancestor Chart

Ancestor chart for GO:0004529
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004529

Child Term Relationship to
GO:0004529
GO:0016895
DNA exonuclease activity, producing 5'-phosphomonoesters
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A5X572 7955 A5X572_DANRE GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26269593
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein B2GV68 10116 B2GV68_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P0C5W1 10116 MAP1S_RAT GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR023607 Exodeoxyribonuclease I

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004529 based on ALL annotations
The top 100 of 155 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004529
DNA exonuclease activity
829,099.90 100.00 239 239
GO:1990391
DNA repair complex
28,482.89 3.00 46 1,339
GO:0042771
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
7,117.14 0.84 75 8,737
GO:0010212
response to ionizing radiation
3,515.72 0.42 75 17,687
GO:0019034
viral replication complex
82,909.98 0.40 1 10
GO:0006309
apoptotic DNA fragmentation
3,224.28 0.38 63 16,200
GO:0090592
DNA synthesis involved in DNA replication
34,545.82 0.38 1 24
GO:0032558
adenyl deoxyribonucleotide binding
17,640.42 0.35 1 47
GO:0097281
immune complex formation
17,640.42 0.35 1 47
GO:0002383
immune response in brain or nervous system
17,272.91 0.35 1 48
Totals 2209 16783186
No co-occurrence statistics for GO:0004529 based on MANUAL annotations
The top 100 of 115 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004529
DNA exonuclease activity
13,838.56 100.00 102 102
GO:1990391
DNA repair complex
5,487.70 26.74 46 116
GO:1990238
double-stranded DNA endonuclease activity
741.35 1.94 3 56
GO:0006274
DNA replication termination
3,953.87 1.87 2 7
GO:0006281
DNA repair
230.64 1.66 94 5,640
GO:0006259
DNA metabolic process
485.56 1.27 2 57
GO:0032558
adenyl deoxyribonucleotide binding
4,612.85 0.96 1 3
GO:0097281
immune complex formation
4,612.85 0.96 1 3
GO:0002383
immune response in brain or nervous system
3,459.64 0.95 1 4
GO:0090592
DNA synthesis involved in DNA replication
2,767.71 0.94 1 5
Totals 416 103281

Change Log

Timestamp Action Category Detail
2023-02-28 Deleted RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2022-12-18 Updated TERM DNA exonuclease activity
2015-03-06 Added RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Deleted RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2013-12-18 Added RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2008-05-13 Added DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)
2008-04-01 Updated RELATION is a GO:0004536 (DNA nuclease activity)
2003-03-26 Updated DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
Timestamp Action Category Detail
2022-12-18 Updated TERM DNA exonuclease activity
2003-03-19 Updated TERM exodeoxyribonuclease activity
2002-02-06 Updated TERM exodeoxyribonuclease
2001-04-03 Updated TERM exodeoxyribonuclease
2001-03-30 Added TERM exodeoxyribonuclease
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2003-03-26 Updated DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2001-08-06 Added DEFINITION Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
Timestamp Action Category Detail
2023-02-28 Deleted RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Added RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Deleted RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2013-12-18 Added RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)
2008-04-01 Updated RELATION is a GO:0004536 (DNA nuclease activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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