This term is obsolete.

GO:0004529 JSON

DNA exonuclease activity

Molecular Function

Definition (GO:0004529 GONUTS page)

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.

290,529 annotations

Ancestor Chart

Ancestor chart for GO:0004529
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004529

Child Term Relationship to
GO:0004529
DNA exonuclease activity, producing 5'-phosphomonoesters
is_a
regulation of exodeoxyribonuclease activity
regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A5X572 7955 A5X572_DANRE GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26269593
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein B2GV68 10116 B2GV68_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P0C5W1 10116 MAP1S_RAT GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR023607 Exodeoxyribonuclease I

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004529 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA exonuclease activity
1,015,306.20 100.00 192 192
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
8,949.11 0.87 75 8,509
viral replication complex
101,530.62 0.50 1 10
DNA synthesis involved in DNA replication
42,304.43 0.47 1 24
response to ionizing radiation
4,395.01 0.43 75 17,326
apoptotic DNA fragmentation
4,071.57 0.40 63 15,710
single-stranded DNA endodeoxyribonuclease activity
2,048.32 0.20 65 32,219
DNA end binding
2,027.72 0.19 7 3,505
RNA polymerase I complex
1,506.32 0.15 62 41,790
DNA repair complex
1,607.77 0.14 2 1,263
Totals 2569 198623964
No co-occurrence statistics for GO:0004529 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA exonuclease activity
23,067.84 100.00 56 56
DNA replication termination
6,590.81 3.28 2 7
double-stranded DNA endonuclease activity
1,384.07 2.91 3 50
DNA synthesis involved in DNA replication
4,613.57 1.67 1 5
viral replication complex
3,844.64 1.64 1 6
DNA repair complex
649.80 1.60 2 71
late viral transcription
1,281.55 1.37 1 18
DNA repair
236.62 1.02 49 4,777
DNA endonuclease activity
250.74 0.91 3 276
DNA metabolic process
404.70 0.89 1 57
Totals 218 468773

Change Log

Timestamp Action Category Detail
2023-02-28 Deleted RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2022-12-18 Updated TERM DNA exonuclease activity
2015-03-06 Deleted RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Added RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2013-12-18 Added RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2008-05-13 Added DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)
2008-04-01 Updated RELATION is a GO:0004536 (DNA nuclease activity)
2003-03-26 Updated DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
Timestamp Action Category Detail
2022-12-18 Updated TERM DNA exonuclease activity
2003-03-19 Updated TERM exodeoxyribonuclease activity
2002-02-06 Updated TERM exodeoxyribonuclease
2001-04-03 Updated TERM exodeoxyribonuclease
2001-03-30 Added TERM exodeoxyribonuclease
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2003-03-26 Updated DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
2001-08-06 Added DEFINITION Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
Timestamp Action Category Detail
2023-02-28 Deleted RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Deleted RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2015-03-06 Added RELATION has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2013-12-18 Added RELATION part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic)
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)
2008-04-01 Updated RELATION is a GO:0004536 (DNA nuclease activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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