GO:0004529
JSON
DNA exonuclease activity
Molecular Function
Definition (GO:0004529 GONUTS page)
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule.
Ancestor Chart
Ancestor chart for GO:0004529
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004529
Child Term | Relationship to GO:0004529 |
---|---|
DNA exonuclease activity, producing 5'-phosphomonoesters
|
is_a |
regulation of exodeoxyribonuclease activity
|
regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004527 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A5X572 | 7955 | A5X572_DANRE | GO:0004527 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26269593 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004527 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | B2GV68 | 10116 | B2GV68_RAT | GO:0004527 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P0C5W1 | 10116 | MAP1S_RAT | GO:0004536 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR023607 | Exodeoxyribonuclease I |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004529 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA exonuclease activity
|
1,015,306.20 | 100.00 | 192 | 192 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
|
8,949.11 | 0.87 | 75 | 8,509 |
viral replication complex
|
101,530.62 | 0.50 | 1 | 10 |
DNA synthesis involved in DNA replication
|
42,304.43 | 0.47 | 1 | 24 |
response to ionizing radiation
|
4,395.01 | 0.43 | 75 | 17,326 |
apoptotic DNA fragmentation
|
4,071.57 | 0.40 | 63 | 15,710 |
single-stranded DNA endodeoxyribonuclease activity
|
2,048.32 | 0.20 | 65 | 32,219 |
DNA end binding
|
2,027.72 | 0.19 | 7 | 3,505 |
RNA polymerase I complex
|
1,506.32 | 0.15 | 62 | 41,790 |
DNA repair complex
|
1,607.77 | 0.14 | 2 | 1,263 |
Totals | 2569 | 198623964 |
No co-occurrence statistics for GO:0004529 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA exonuclease activity
|
23,067.84 | 100.00 | 56 | 56 |
DNA replication termination
|
6,590.81 | 3.28 | 2 | 7 |
double-stranded DNA endonuclease activity
|
1,384.07 | 2.91 | 3 | 50 |
DNA synthesis involved in DNA replication
|
4,613.57 | 1.67 | 1 | 5 |
viral replication complex
|
3,844.64 | 1.64 | 1 | 6 |
DNA repair complex
|
649.80 | 1.60 | 2 | 71 |
late viral transcription
|
1,281.55 | 1.37 | 1 | 18 |
DNA repair
|
236.62 | 1.02 | 49 | 4,777 |
DNA endonuclease activity
|
250.74 | 0.91 | 3 | 276 |
DNA metabolic process
|
404.70 | 0.89 | 1 | 57 |
Totals | 218 | 468773 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-02-28 | Deleted | RELATION | has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2022-12-18 | Updated | TERM | DNA exonuclease activity |
2015-03-06 | Deleted | RELATION | part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2015-03-06 | Added | RELATION | has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2013-12-18 | Added | RELATION | part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2008-05-13 | Added | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
2008-04-01 | Updated | RELATION | is a GO:0004527 (exonuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0004536 (DNA nuclease activity) |
2003-03-26 | Updated | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Updated | TERM | DNA exonuclease activity |
2003-03-19 | Updated | TERM | exodeoxyribonuclease activity |
2002-02-06 | Updated | TERM | exodeoxyribonuclease |
2001-04-03 | Updated | TERM | exodeoxyribonuclease |
2001-03-30 | Added | TERM | exodeoxyribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
2003-03-26 | Updated | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
2001-08-06 | Added | DEFINITION | Deoxyribonuclease that catalyzes sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-02-28 | Deleted | RELATION | has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2015-03-06 | Deleted | RELATION | part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2015-03-06 | Added | RELATION | has part GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2013-12-18 | Added | RELATION | part of GO:0000738 (obsolete DNA catabolic process, exonucleolytic) |
2008-04-01 | Updated | RELATION | is a GO:0004527 (exonuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0004536 (DNA nuclease activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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