GO:0004536
JSON
DNA nuclease activity
Molecular Function
Definition (GO:0004536 GONUTS page)
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
Secondary IDs
GO:0004537
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
caspase-activated deoxyribonuclease activity | narrow |
deoxyribonuclease activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004536
Child Term | Relationship to GO:0004536 |
---|---|
positive regulation of deoxyribonuclease activity
|
positively_regulates |
DNA endonuclease activity
|
is_a |
deoxyribonuclease inhibitor activity
|
negatively_regulates |
DNA exonuclease activity
|
is_a |
regulation of deoxyribonuclease activity
|
regulates |
negative regulation of deoxyribonuclease activity
|
negatively_regulates |
oligodeoxyribonucleotidase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P0C5W1 | 10116 | MAP1S_RAT | GO:0004536 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q10103 | 284812 | CHP1_SCHPO | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22081013 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q66K74 | 9606 | MAP1S_HUMAN | GO:0004536 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15907802 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR011578 | T7 endonuclease I-like |
InterPro | IPR015991 | Hydrolase TatD/YcfH-like |
InterPro | IPR016202 | Deoxyribonuclease I |
Reactome | R-HSA-211247 | |
Reactome | R-HSA-5685994 | |
Reactome | R-HSA-6785986 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004536 based on ALL annotations
The top 100 of 410 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA nuclease activity
|
4,201.00 | 100.00 | 46,403 | 46,403 |
deoxyribonuclease I activity
|
2,143.93 | 9.17 | 4,665 | 9,141 |
DNA metabolic process
|
281.95 | 6.62 | 38,709 | 576,758 |
DNA catabolic process
|
238.06 | 4.12 | 6,070 | 107,116 |
apoptotic DNA fragmentation
|
519.84 | 3.23 | 1,944 | 15,710 |
zymogen granule
|
3,669.27 | 2.09 | 973 | 1,114 |
DNA endonuclease activity
|
121.39 | 1.52 | 1,439 | 49,802 |
programmed cell death involved in cell development
|
3,201.23 | 1.39 | 650 | 853 |
D-aminoacyl-tRNA deacylase activity
|
72.81 | 0.81 | 701 | 40,444 |
D-amino acid catabolic process
|
56.92 | 0.72 | 701 | 51,733 |
Totals | 226971 | 96141723 |
No co-occurrence statistics for GO:0004536 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA nuclease activity
|
22,272.40 | 100.00 | 58 | 58 |
apoptotic DNA fragmentation
|
2,440.81 | 10.06 | 32 | 292 |
mitochondrial DNA catabolic process
|
7,424.13 | 4.69 | 3 | 9 |
meiotic drive
|
2,474.71 | 4.44 | 4 | 36 |
DNA metabolic process
|
1,562.98 | 3.60 | 4 | 57 |
regulation of neutrophil mediated cytotoxicity
|
3,181.77 | 2.86 | 2 | 14 |
positive regulation of hydrogen peroxide-mediated programmed cell death
|
2,784.05 | 2.78 | 2 | 16 |
positive regulation of apoptotic DNA fragmentation
|
2,474.71 | 2.70 | 2 | 18 |
negative regulation of apoptotic DNA fragmentation
|
2,344.46 | 2.67 | 2 | 19 |
regulation of acute inflammatory response
|
2,344.46 | 2.67 | 2 | 19 |
Totals | 281 | 53692 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-06 | Added | SYNONYM | deoxyribonuclease activity |
2023-03-06 | Updated | TERM | DNA nuclease activity |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5685994 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6785986 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5685994 |
2019-04-01 | Added | XREF | Reactome:R-HSA-211247 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6785986 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-211247 |
2018-12-11 | Added | XREF | reactome:R-HSA-211247 |
2018-12-11 | Added | XREF | reactome:R-HSA-6785986 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-06 | Updated | TERM | DNA nuclease activity |
2003-03-19 | Updated | TERM | deoxyribonuclease activity |
2002-02-06 | Updated | TERM | deoxyribonuclease |
2001-04-03 | Updated | TERM | deoxyribonuclease |
2001-03-30 | Added | TERM | deoxyribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-06 | Added | SYNONYM | deoxyribonuclease activity |
2010-10-07 | Added | SYNONYM | caspase-activated deoxyribonuclease activity |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
2002-11-27 | Updated | DEFINITION | Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
2001-08-06 | Added | DEFINITION | An enzyme that catalyzes the hydrolysis of ester linkages within deoxyribonucleic acid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Added | RELATION | is a GO:0140097 (catalytic activity, acting on DNA) |
2015-03-06 | Deleted | RELATION | part of GO:0006308 (DNA catabolic process) |
2015-03-06 | Added | RELATION | part of GO:0006259 (DNA metabolic process) |
2015-03-06 | Added | RELATION | has part GO:0006308 (DNA catabolic process) |
2013-12-18 | Added | RELATION | part of GO:0006308 (DNA catabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0004518 (nuclease activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-5685994 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6785986 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5685994 |
2019-04-01 | Added | XREF | Reactome:R-HSA-211247 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6785986 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-211247 |
2018-12-11 | Added | XREF | reactome:R-HSA-211247 |
2018-12-11 | Added | XREF | reactome:R-HSA-6785986 |
2018-12-11 | Added | XREF | reactome:R-HSA-5685994 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-07 | Added | SECONDARY | GO:0004537 (caspase-activated deoxyribonuclease activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link