This term is obsolete.

GO:0004536 JSON

DNA nuclease activity

Molecular Function

Definition (GO:0004536 GONUTS page)

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.

Secondary IDs

GO:0004537

821,297 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
caspase-activated deoxyribonuclease activity narrow
deoxyribonuclease activity exact

Ancestor Chart

Ancestor chart for GO:0004536
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004536

Child Term Relationship to
GO:0004536
positive regulation of deoxyribonuclease activity
positively_regulates
DNA endonuclease activity
is_a
deoxyribonuclease inhibitor activity
negatively_regulates
DNA exonuclease activity
is_a
regulation of deoxyribonuclease activity
regulates
negative regulation of deoxyribonuclease activity
negatively_regulates
oligodeoxyribonucleotidase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P0C5W1 10116 MAP1S_RAT GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q10103 284812 CHP1_SCHPO GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22081013
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q66K74 9606 MAP1S_HUMAN GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15907802

Cross-references

Database ID Description
InterPro IPR011578 T7 endonuclease I-like
InterPro IPR015991 Hydrolase TatD/YcfH-like
InterPro IPR016202 Deoxyribonuclease I
Reactome R-HSA-211247
Reactome R-HSA-5685994
Reactome R-HSA-6785986

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004536 based on ALL annotations
The top 100 of 410 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA nuclease activity
4,201.00 100.00 46,403 46,403
deoxyribonuclease I activity
2,143.93 9.17 4,665 9,141
DNA metabolic process
281.95 6.62 38,709 576,758
DNA catabolic process
238.06 4.12 6,070 107,116
apoptotic DNA fragmentation
519.84 3.23 1,944 15,710
zymogen granule
3,669.27 2.09 973 1,114
DNA endonuclease activity
121.39 1.52 1,439 49,802
programmed cell death involved in cell development
3,201.23 1.39 650 853
D-aminoacyl-tRNA deacylase activity
72.81 0.81 701 40,444
D-amino acid catabolic process
56.92 0.72 701 51,733
Totals 226971 96141723
No co-occurrence statistics for GO:0004536 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA nuclease activity
22,272.40 100.00 58 58
apoptotic DNA fragmentation
2,440.81 10.06 32 292
mitochondrial DNA catabolic process
7,424.13 4.69 3 9
meiotic drive
2,474.71 4.44 4 36
DNA metabolic process
1,562.98 3.60 4 57
regulation of neutrophil mediated cytotoxicity
3,181.77 2.86 2 14
positive regulation of hydrogen peroxide-mediated programmed cell death
2,784.05 2.78 2 16
positive regulation of apoptotic DNA fragmentation
2,474.71 2.70 2 18
negative regulation of apoptotic DNA fragmentation
2,344.46 2.67 2 19
regulation of acute inflammatory response
2,344.46 2.67 2 19
Totals 281 53692

Change Log

Timestamp Action Category Detail
2023-03-06 Added SYNONYM deoxyribonuclease activity
2023-03-06 Updated TERM DNA nuclease activity
2019-04-01 Deleted XREF reactome:R-HSA-5685994
2019-04-01 Added XREF Reactome:R-HSA-6785986
2019-04-01 Added XREF Reactome:R-HSA-5685994
2019-04-01 Added XREF Reactome:R-HSA-211247
2019-04-01 Deleted XREF reactome:R-HSA-6785986
2019-04-01 Deleted XREF reactome:R-HSA-211247
2018-12-11 Added XREF reactome:R-HSA-211247
2018-12-11 Added XREF reactome:R-HSA-6785986
Timestamp Action Category Detail
2023-03-06 Updated TERM DNA nuclease activity
2003-03-19 Updated TERM deoxyribonuclease activity
2002-02-06 Updated TERM deoxyribonuclease
2001-04-03 Updated TERM deoxyribonuclease
2001-03-30 Added TERM deoxyribonuclease
Timestamp Action Category Detail
2023-03-06 Added SYNONYM deoxyribonuclease activity
2010-10-07 Added SYNONYM caspase-activated deoxyribonuclease activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
2001-08-06 Added DEFINITION An enzyme that catalyzes the hydrolysis of ester linkages within deoxyribonucleic acid.
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2015-03-06 Deleted RELATION part of GO:0006308 (DNA catabolic process)
2015-03-06 Added RELATION part of GO:0006259 (DNA metabolic process)
2015-03-06 Added RELATION has part GO:0006308 (DNA catabolic process)
2013-12-18 Added RELATION part of GO:0006308 (DNA catabolic process)
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-5685994
2019-04-01 Added XREF Reactome:R-HSA-6785986
2019-04-01 Added XREF Reactome:R-HSA-5685994
2019-04-01 Added XREF Reactome:R-HSA-211247
2019-04-01 Deleted XREF reactome:R-HSA-6785986
2019-04-01 Deleted XREF reactome:R-HSA-211247
2018-12-11 Added XREF reactome:R-HSA-211247
2018-12-11 Added XREF reactome:R-HSA-6785986
2018-12-11 Added XREF reactome:R-HSA-5685994
Timestamp Action Category Detail
2010-10-07 Added SECONDARY GO:0004537 (caspase-activated deoxyribonuclease activity)
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