This term is obsolete.

GO:0004540 JSON

RNA nuclease activity

Molecular Function

Definition (GO:0004540 GONUTS page)

Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.

1,699,008 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ribonuclease activity exact

Ancestor Chart

Ancestor chart for GO:0004540
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004540

Child Term Relationship to
GO:0004540
ribonuclease activator activity
positively_regulates
ribonuclease T1 activity
is_a
ribonuclease inhibitor activity
negatively_regulates
ribonuclease H2 complex
capable_of
double-stranded RNA-specific ribonuclease activity
is_a
RNA exonuclease activity
is_a
rRNA endonuclease activity
is_a
RNA endonuclease activity
is_a
5'-hydroxyl dinucleotide hydrolase activity
is_a
negative regulation of ribonuclease activity
negatively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JWR1 10116 A6JWR1_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein D3Z898 10116 D3Z898_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A2W9 10116 D4A2W9_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR001900 Ribonuclease II/R
InterPro IPR004025 Fungal ribotoxin
InterPro IPR004476 Ribonuclease II/ribonuclease R
InterPro IPR004659 Ribonuclease E/G
InterPro IPR005987 Ribonuclease T
InterPro IPR008201 Ribonuclease HepT-like
InterPro IPR010513 KEN domain
InterPro IPR016191 Ribonuclease/ribotoxin
InterPro IPR021139 NYN domain
InterPro IPR021679 Toxin endonuclease, YhaV

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004540 based on ALL annotations
The top 100 of 1,470 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA nuclease activity
756.59 100.00 257,653 257,653
modulation of process of another organism
395.32 16.39 49,683 95,087
toxin activity
382.47 16.22 49,683 98,282
mRNA catabolic process
208.78 14.56 60,683 219,909
nuclease activity
112.53 11.18 80,018 537,985
exoribonuclease II activity
690.93 11.13 28,978 31,732
toxin-antitoxin complex
586.84 9.95 26,405 34,043
RNA metabolic process
256.37 9.15 28,690 84,670
exonuclease activity
50.46 5.18 48,402 725,769
3'-5'-RNA exonuclease activity
86.26 5.00 21,061 184,729
Totals 1678147 123557486
No co-occurrence statistics for GO:0004540 based on MANUAL annotations
The top 100 of 384 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA nuclease activity
3,032.39 100.00 426 426
defense response to Gram-positive bacterium
316.48 8.62 141 1,351
tRNA-specific ribonuclease activity
1,937.36 5.24 23 36
negative regulation of translation in response to stress
1,962.14 5.02 22 34
angiogenin-PRI complex
1,419.42 4.88 22 47
antibacterial humoral response
235.07 4.43 40 516
rRNA transcription
601.01 4.27 22 111
hematopoietic stem cell proliferation
454.86 4.27 24 160
negative regulation of smooth muscle cell proliferation
438.90 3.96 22 152
signaling
349.28 3.70 22 191
Totals 1933 63703

Change Log

Timestamp Action Category Detail
2023-10-23 Deleted SYNONYM https://github.com/geneontology/go-ontology/issues/24408
2023-05-20 Deleted RELATION part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis)
2023-03-06 Updated TERM RNA nuclease activity
2023-03-06 Added SYNONYM ribonuclease activity
2023-03-06 Added SYNONYM https://github.com/geneontology/go-ontology/issues/24408
2017-09-19 Added RELATION is a GO:0140098 (catalytic activity, acting on RNA)
2013-12-18 Added RELATION part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis)
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
Timestamp Action Category Detail
2023-03-06 Updated TERM RNA nuclease activity
2003-03-19 Updated TERM ribonuclease activity
2002-02-06 Updated TERM ribonuclease
2001-04-03 Updated TERM ribonuclease
2001-03-30 Added TERM ribonuclease
Timestamp Action Category Detail
2023-10-23 Deleted SYNONYM https://github.com/geneontology/go-ontology/issues/24408
2023-03-06 Added SYNONYM ribonuclease activity
2023-03-06 Added SYNONYM https://github.com/geneontology/go-ontology/issues/24408
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
2001-08-06 Added DEFINITION Any of a group of nuclease enzymes that cleave phosphodiester bonds in chains of RNA.
Timestamp Action Category Detail
2023-05-20 Deleted RELATION part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis)
2017-09-19 Added RELATION is a GO:0140098 (catalytic activity, acting on RNA)
2013-12-18 Added RELATION part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis)
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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