GO:0004540
JSON
RNA nuclease activity
Molecular Function
Definition (GO:0004540 GONUTS page)
Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ribonuclease activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004540
Child Term | Relationship to GO:0004540 |
---|---|
ribonuclease activator activity
|
positively_regulates |
ribonuclease T1 activity
|
is_a |
ribonuclease inhibitor activity
|
negatively_regulates |
ribonuclease H2 complex
|
capable_of |
double-stranded RNA-specific ribonuclease activity
|
is_a |
RNA exonuclease activity
|
is_a |
rRNA endonuclease activity
|
is_a |
RNA endonuclease activity
|
is_a |
5'-hydroxyl dinucleotide hydrolase activity
|
is_a |
negative regulation of ribonuclease activity
|
negatively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JWR1 | 10116 | A6JWR1_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | D3Z898 | 10116 | D3Z898_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A2W9 | 10116 | D4A2W9_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001900 | Ribonuclease II/R |
InterPro | IPR004025 | Fungal ribotoxin |
InterPro | IPR004476 | Ribonuclease II/ribonuclease R |
InterPro | IPR004659 | Ribonuclease E/G |
InterPro | IPR005987 | Ribonuclease T |
InterPro | IPR008201 | Ribonuclease HepT-like |
InterPro | IPR010513 | KEN domain |
InterPro | IPR016191 | Ribonuclease/ribotoxin |
InterPro | IPR021139 | NYN domain |
InterPro | IPR021679 | Toxin endonuclease, YhaV |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004540 based on ALL annotations
The top 100 of 1,470 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA nuclease activity
|
756.59 | 100.00 | 257,653 | 257,653 |
modulation of process of another organism
|
395.32 | 16.39 | 49,683 | 95,087 |
toxin activity
|
382.47 | 16.22 | 49,683 | 98,282 |
mRNA catabolic process
|
208.78 | 14.56 | 60,683 | 219,909 |
nuclease activity
|
112.53 | 11.18 | 80,018 | 537,985 |
exoribonuclease II activity
|
690.93 | 11.13 | 28,978 | 31,732 |
toxin-antitoxin complex
|
586.84 | 9.95 | 26,405 | 34,043 |
RNA metabolic process
|
256.37 | 9.15 | 28,690 | 84,670 |
exonuclease activity
|
50.46 | 5.18 | 48,402 | 725,769 |
3'-5'-RNA exonuclease activity
|
86.26 | 5.00 | 21,061 | 184,729 |
Totals | 1678147 | 123557486 |
No co-occurrence statistics for GO:0004540 based on MANUAL annotations
The top 100 of 384 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA nuclease activity
|
3,032.39 | 100.00 | 426 | 426 |
defense response to Gram-positive bacterium
|
316.48 | 8.62 | 141 | 1,351 |
tRNA-specific ribonuclease activity
|
1,937.36 | 5.24 | 23 | 36 |
negative regulation of translation in response to stress
|
1,962.14 | 5.02 | 22 | 34 |
angiogenin-PRI complex
|
1,419.42 | 4.88 | 22 | 47 |
antibacterial humoral response
|
235.07 | 4.43 | 40 | 516 |
rRNA transcription
|
601.01 | 4.27 | 22 | 111 |
hematopoietic stem cell proliferation
|
454.86 | 4.27 | 24 | 160 |
negative regulation of smooth muscle cell proliferation
|
438.90 | 3.96 | 22 | 152 |
signaling
|
349.28 | 3.70 | 22 | 191 |
Totals | 1933 | 63703 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-23 | Deleted | SYNONYM | https://github.com/geneontology/go-ontology/issues/24408 |
2023-05-20 | Deleted | RELATION | part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis) |
2023-03-06 | Updated | TERM | RNA nuclease activity |
2023-03-06 | Added | SYNONYM | ribonuclease activity |
2023-03-06 | Added | SYNONYM | https://github.com/geneontology/go-ontology/issues/24408 |
2017-09-19 | Added | RELATION | is a GO:0140098 (catalytic activity, acting on RNA) |
2013-12-18 | Added | RELATION | part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis) |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
2008-04-01 | Updated | RELATION | is a GO:0004518 (nuclease activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-03-06 | Updated | TERM | RNA nuclease activity |
2003-03-19 | Updated | TERM | ribonuclease activity |
2002-02-06 | Updated | TERM | ribonuclease |
2001-04-03 | Updated | TERM | ribonuclease |
2001-03-30 | Added | TERM | ribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-23 | Deleted | SYNONYM | https://github.com/geneontology/go-ontology/issues/24408 |
2023-03-06 | Added | SYNONYM | ribonuclease activity |
2023-03-06 | Added | SYNONYM | https://github.com/geneontology/go-ontology/issues/24408 |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
2003-03-26 | Updated | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. |
2001-08-06 | Added | DEFINITION | Any of a group of nuclease enzymes that cleave phosphodiester bonds in chains of RNA. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-20 | Deleted | RELATION | part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis) |
2017-09-19 | Added | RELATION | is a GO:0140098 (catalytic activity, acting on RNA) |
2013-12-18 | Added | RELATION | part of GO:0090501 (obsolete RNA phosphodiester bond hydrolysis) |
2008-04-01 | Updated | RELATION | is a GO:0004518 (nuclease activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link