GO:0004549
JSON
tRNA-specific ribonuclease activity
Molecular Function
Definition (GO:0004549 GONUTS page)
Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
tRNA-specific RNase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004549
Child Term | Relationship to GO:0004549 |
---|---|
tRNA-intron endonuclease activity
|
is_a |
ribonuclease P activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JWR1 | 10116 | A6JWR1_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | D3Z898 | 10116 | D3Z898_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A2W9 | 10116 | D4A2W9_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR033806 | CDI toxin, Bp1026b-like |
Reactome | R-HSA-5696813 | |
Reactome | R-HSA-5696815 | |
Reactome | R-HSA-6785722 | |
Reactome | R-HSA-6786854 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004549 based on ALL annotations
The top 100 of 121 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA-specific ribonuclease activity
|
345,636.16 | 100.00 | 564 | 564 |
angiogenin-PRI complex
|
99,041.94 | 7.14 | 49 | 171 |
negative regulation of translation in response to stress
|
71,321.74 | 6.81 | 52 | 252 |
negative regulation of smooth muscle cell proliferation
|
8,334.73 | 1.92 | 49 | 2,032 |
hematopoietic stem cell proliferation
|
8,059.68 | 1.90 | 52 | 2,230 |
positive regulation of protein secretion
|
4,764.04 | 1.20 | 49 | 3,555 |
tRNA destabilization
|
345,636.16 | 0.89 | 5 | 5 |
positive regulation of phosphorylation
|
2,287.20 | 0.60 | 34 | 5,138 |
antibacterial humoral response
|
1,930.47 | 0.53 | 47 | 8,415 |
positive regulation of endothelial cell proliferation
|
1,610.82 | 0.44 | 49 | 10,514 |
Totals | 3629 | 75538841 |
No co-occurrence statistics for GO:0004549 based on MANUAL annotations
The top 85 of 85 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA-specific ribonuclease activity
|
35,883.31 | 100.00 | 36 | 36 |
negative regulation of translation in response to stress
|
23,218.61 | 45.83 | 22 | 34 |
angiogenin-PRI complex
|
15,269.49 | 31.75 | 20 | 47 |
rRNA transcription
|
6,465.46 | 15.75 | 20 | 111 |
hematopoietic stem cell proliferation
|
4,933.95 | 12.64 | 22 | 160 |
negative regulation of smooth muscle cell proliferation
|
4,721.49 | 11.90 | 20 | 152 |
tRNA destabilization
|
35,883.31 | 11.11 | 4 | 4 |
signaling
|
3,757.41 | 9.66 | 20 | 191 |
tRNA decay
|
7,176.66 | 7.69 | 4 | 20 |
positive regulation of protein secretion
|
2,345.31 | 6.21 | 20 | 306 |
Totals | 714 | 815929 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-6785722 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5696815 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696815 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5696813 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696813 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6786854 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6786854 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6785722 |
2018-12-11 | Added | XREF | reactome:R-HSA-5696813 |
2018-12-11 | Added | XREF | reactome:R-HSA-6785722 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | tRNA-specific ribonuclease activity |
2002-02-06 | Updated | TERM | tRNA-specific ribonuclease |
2001-04-03 | Updated | TERM | tRNA-specific ribonuclease |
2001-03-30 | Added | TERM | tRNA-specific ribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. |
2007-11-16 | Added | SYNONYM | tRNA-specific RNase activity |
2005-10-11 | Added | DEFINITION | Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Added | RELATION | is a GO:0140101 (catalytic activity, acting on a tRNA) |
2008-04-01 | Updated | RELATION | is a GO:0004540 (RNA nuclease activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-6785722 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5696815 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696815 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5696813 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5696813 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6786854 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6786854 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6785722 |
2018-12-11 | Added | XREF | reactome:R-HSA-5696813 |
2018-12-11 | Added | XREF | reactome:R-HSA-6785722 |
2018-12-11 | Added | XREF | reactome:R-HSA-6786854 |
2018-12-11 | Added | XREF | reactome:R-HSA-5696815 |
Timestamp | Action | Category | Detail |
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