This term is obsolete.

GO:0004549 JSON

tRNA-specific ribonuclease activity

Molecular Function

Definition (GO:0004549 GONUTS page)

Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.

210,154 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
tRNA-specific RNase activity exact

Ancestor Chart

Ancestor chart for GO:0004549
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004549

Child Term Relationship to
GO:0004549
tRNA-intron endonuclease activity
is_a
ribonuclease P activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JWR1 10116 A6JWR1_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein D3Z898 10116 D3Z898_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A2W9 10116 D4A2W9_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR033806 CDI toxin, Bp1026b-like
Reactome R-HSA-5696813
Reactome R-HSA-5696815
Reactome R-HSA-6785722
Reactome R-HSA-6786854

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004549 based on ALL annotations
The top 100 of 121 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA-specific ribonuclease activity
345,636.16 100.00 564 564
angiogenin-PRI complex
99,041.94 7.14 49 171
negative regulation of translation in response to stress
71,321.74 6.81 52 252
negative regulation of smooth muscle cell proliferation
8,334.73 1.92 49 2,032
hematopoietic stem cell proliferation
8,059.68 1.90 52 2,230
positive regulation of protein secretion
4,764.04 1.20 49 3,555
tRNA destabilization
345,636.16 0.89 5 5
positive regulation of phosphorylation
2,287.20 0.60 34 5,138
antibacterial humoral response
1,930.47 0.53 47 8,415
positive regulation of endothelial cell proliferation
1,610.82 0.44 49 10,514
Totals 3629 75538841
No co-occurrence statistics for GO:0004549 based on MANUAL annotations
The top 85 of 85 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA-specific ribonuclease activity
35,883.31 100.00 36 36
negative regulation of translation in response to stress
23,218.61 45.83 22 34
angiogenin-PRI complex
15,269.49 31.75 20 47
rRNA transcription
6,465.46 15.75 20 111
hematopoietic stem cell proliferation
4,933.95 12.64 22 160
negative regulation of smooth muscle cell proliferation
4,721.49 11.90 20 152
tRNA destabilization
35,883.31 11.11 4 4
signaling
3,757.41 9.66 20 191
tRNA decay
7,176.66 7.69 4 20
positive regulation of protein secretion
2,345.31 6.21 20 306
Totals 714 815929

Change Log

Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-6785722
2019-04-01 Added XREF Reactome:R-HSA-5696815
2019-04-01 Deleted XREF reactome:R-HSA-5696815
2019-04-01 Added XREF Reactome:R-HSA-5696813
2019-04-01 Deleted XREF reactome:R-HSA-5696813
2019-04-01 Deleted XREF reactome:R-HSA-6786854
2019-04-01 Added XREF Reactome:R-HSA-6786854
2019-04-01 Deleted XREF reactome:R-HSA-6785722
2018-12-11 Added XREF reactome:R-HSA-5696813
2018-12-11 Added XREF reactome:R-HSA-6785722
Timestamp Action Category Detail
2003-03-19 Updated TERM tRNA-specific ribonuclease activity
2002-02-06 Updated TERM tRNA-specific ribonuclease
2001-04-03 Updated TERM tRNA-specific ribonuclease
2001-03-30 Added TERM tRNA-specific ribonuclease
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
2007-11-16 Added SYNONYM tRNA-specific RNase activity
2005-10-11 Added DEFINITION Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140101 (catalytic activity, acting on a tRNA)
2008-04-01 Updated RELATION is a GO:0004540 (RNA nuclease activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-6785722
2019-04-01 Added XREF Reactome:R-HSA-5696815
2019-04-01 Deleted XREF reactome:R-HSA-5696815
2019-04-01 Added XREF Reactome:R-HSA-5696813
2019-04-01 Deleted XREF reactome:R-HSA-5696813
2019-04-01 Deleted XREF reactome:R-HSA-6786854
2019-04-01 Added XREF Reactome:R-HSA-6786854
2019-04-01 Deleted XREF reactome:R-HSA-6785722
2018-12-11 Added XREF reactome:R-HSA-5696813
2018-12-11 Added XREF reactome:R-HSA-6785722
2018-12-11 Added XREF reactome:R-HSA-6786854
2018-12-11 Added XREF reactome:R-HSA-5696815
Timestamp Action Category Detail
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