This term is obsolete.

GO:0004587 JSON

ornithine aminotransferase activity

Molecular Function

Definition (GO:0004587 GONUTS page)

Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.

15,887 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ornithine--oxo-acid transaminase activity related
ornithine:alpha-oxoglutarate transaminase activity related
ornithine delta-transaminase activity related
L-ornithine 5-aminotransferase activity related
ornithine-oxo-acid aminotransferase activity exact
ornithine--ketoglutarate aminotransferase activity related
ornithine--keto acid aminotransferase activity related
ornithine--2-oxoacid aminotransferase activity related
ornithine(lysine) transaminase activity related
ornithine-oxo-acid transaminase activity related

Ancestor Chart

Ancestor chart for GO:0004587
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.6.1.13
InterPro IPR010164 Ornithine aminotransferase
InterPro IPR034757 Ornithine aminotransferase, bacterial type
MetaCyc ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
RHEA 13877
Reactome R-HSA-70654
Reactome R-HSA-70666

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:59869 L-alpha-amino acid zwitterion
has_participant CHEBI CHEBI:58066 L-glutamic 5-semialdehyde zwitterion
has_participant CHEBI CHEBI:35179 2-oxo monocarboxylic acid anion
has_participant CHEBI CHEBI:46911 L-ornithinium(1+)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0050155 obsolete ornithine(lysine) transaminase activity replaced_by GO:0004587

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004587 based on ALL annotations
The top 100 of 135 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ornithine aminotransferase activity
12,364.51 100.00 15,766 15,766
arginine catabolic process to proline via ornithine
12,361.49 51.98 8,196 8,198
arginine catabolic process to glutamate
4,198.87 25.85 8,195 24,132
L-proline biosynthetic process
1,161.12 9.18 12,654 134,750
identical protein binding
431.10 3.49 15,569 446,538
transaminase activity
161.33 1.30 15,762 1,208,015
proline biosynthetic process
164.16 1.21 1,870 140,851
pyridoxal phosphate binding
112.49 0.91 15,722 1,728,166
ornithine metabolic process
66.85 0.38 198 36,620
putrescine--2-oxoglutarate transaminase activity
180.57 0.21 38 2,602
Totals 105693 108848579
No co-occurrence statistics for GO:0004587 based on MANUAL annotations
The top 34 of 34 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ornithine aminotransferase activity
11,961.10 100.00 108 108
arginine catabolic process to glutamate
11,961.10 98.15 106 106
arginine catabolic process to proline via ornithine
11,737.53 95.45 105 107
pyridoxal phosphate binding
572.92 4.79 106 2,213
ornithine metabolic process
2,600.24 3.97 5 23
identical protein binding
145.77 1.22 107 8,780
ornithine catabolic process
2,392.22 0.89 1 5
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
1,329.01 0.86 1 9
response to flooding
1,087.37 0.85 1 11
response to brassinosteroid
184.02 0.58 1 65
Totals 680 661604

Change Log

Timestamp Action Category Detail
2024-08-07 Deleted XREF MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
2023-09-23 Added DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-23 Deleted DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-06 Updated TERM ornithine aminotransferase activity
2023-09-06 Deleted DEFINITION Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
2023-09-06 Added DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-06 Deleted SYNONYM ornithine aminotransferase activity
2023-09-06 Added SYNONYM ornithine-oxo-acid transaminase activity
2023-09-06 Added SYNONYM ornithine(lysine) transaminase activity
2023-09-06 Added XREF MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
Timestamp Action Category Detail
2023-09-06 Updated TERM ornithine aminotransferase activity
2003-09-13 Updated TERM ornithine-oxo-acid transaminase activity
2003-09-09 Updated TERM ornithine-oxo-acid transminase activity
2003-03-19 Updated TERM ornithine-oxo-acid aminotransferase activity
2002-02-06 Updated TERM ornithine-oxo-acid aminotransferase
2001-11-07 Updated TERM ornithine-oxo-acid aminotransferase
2001-04-03 Updated TERM ornithine--oxo-acid aminotransferase
2001-03-30 Added TERM ornithine--oxo-acid aminotransferase
Timestamp Action Category Detail
2023-09-23 Added DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-23 Deleted DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-06 Deleted DEFINITION Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
2023-09-06 Added DEFINITION Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde.
2023-09-06 Deleted SYNONYM ornithine aminotransferase activity
2023-09-06 Added SYNONYM ornithine-oxo-acid transaminase activity
2023-09-06 Added SYNONYM ornithine(lysine) transaminase activity
2020-10-08 Deleted SYNONYM ornithine--keto acid aminotransferase activity
2020-10-08 Added SYNONYM ornithine--alpha-ketoglutarate aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine--ketoglutarate aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine--oxo acid aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine--oxo-acid transaminase activity
2020-10-08 Added SYNONYM ornithine:alpha-oxoglutarate transaminase activity
2020-10-08 Added SYNONYM L-ornithine 5-aminotransferase activity
2020-10-08 Added SYNONYM L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
2020-10-08 Added SYNONYM ornithine--oxo-acid transaminase activity
2020-10-08 Deleted SYNONYM L-ornithine 5-aminotransferase activity
2020-10-08 Deleted SYNONYM L-ornithine aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine 5-aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine delta-transaminase activity
2020-10-08 Deleted SYNONYM ornithine ketoacid aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine transaminase activity
2020-10-08 Added SYNONYM ornithine transaminase activity
2020-10-08 Added SYNONYM L-ornithine:2-oxo-acid aminotransferase activity
2020-10-08 Deleted SYNONYM L-ornithine:2-oxo-acid aminotransferase activity
2020-10-08 Deleted SYNONYM L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine:alpha-oxoglutarate transaminase activity
2020-10-08 Deleted SYNONYM ornithine--2-oxoacid aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine--alpha-ketoglutarate aminotransferase activity
2020-10-08 Deleted SYNONYM ornithine--keto acid transaminase activity
2020-10-08 Added SYNONYM ornithine--2-oxoacid aminotransferase activity
2020-10-08 Added SYNONYM ornithine--ketoglutarate aminotransferase activity
2020-10-08 Added SYNONYM ornithine--keto acid aminotransferase activity
2020-10-08 Added SYNONYM ornithine aminotransferase activity
2020-10-08 Added SYNONYM ornithine--oxo acid aminotransferase activity
2020-10-08 Added SYNONYM ornithine delta-transaminase activity
2020-10-08 Added SYNONYM ornithine--keto acid transaminase activity
2020-10-08 Added SYNONYM L-ornithine aminotransferase activity
2020-10-08 Added SYNONYM ornithine 5-aminotransferase activity
2020-10-08 Added SYNONYM ornithine ketoacid aminotransferase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
2007-11-08 Added SYNONYM GabT
2007-11-08 Added SYNONYM L-ornithine:2-oxo-acid aminotransferase activity
2007-11-08 Added SYNONYM L-ornithine:alpha-ketoglutarate delta-aminotransferase activity
2007-11-08 Added SYNONYM OAT
2007-11-08 Added SYNONYM ornithine:alpha-oxoglutarate transaminase activity
2007-09-06 Added SYNONYM ornithine delta-transaminase activity
2007-09-06 Deleted SYNONYM L-ornithine 5-aminotransferase
2007-09-06 Added SYNONYM ornithine 5-aminotransferase activity
2007-09-06 Added SYNONYM L-ornithine aminotransferase activity
2007-09-06 Added SYNONYM L-ornithine 5-aminotransferase activity
2007-09-06 Added SYNONYM ornithine--ketoglutarate aminotransferase activity
2007-09-06 Added SYNONYM ornithine--oxo acid aminotransferase activity
2007-09-06 Deleted SYNONYM ornithine--alpha-ketoglutarate aminotransferase
2007-09-06 Deleted SYNONYM ornithine--2-oxoacid aminotransferase
2007-09-06 Added SYNONYM ornithine--oxo-acid transaminase activity
2007-09-06 Deleted SYNONYM ornithine transaminase
2007-09-06 Added SYNONYM ornithine--keto acid transaminase activity
2007-09-06 Added SYNONYM ornithine--keto acid aminotransferase activity
2007-09-06 Added SYNONYM ornithine--alpha-ketoglutarate aminotransferase activity
2007-09-06 Added SYNONYM ornithine--2-oxoacid aminotransferase activity
2007-09-06 Added SYNONYM ornithine transaminase activity
2007-09-06 Added SYNONYM ornithine ketoacid aminotransferase activity
2007-09-06 Deleted SYNONYM ornithine--keto acid aminotransferase
2007-09-06 Deleted SYNONYM ornithine--keto acid transaminase
2007-09-06 Deleted SYNONYM ornithine--ketoglutarate aminotransferase
2007-09-06 Deleted SYNONYM ornithine ketoacid aminotransferase
2007-09-06 Deleted SYNONYM ornithine delta-transaminase
2007-09-06 Deleted SYNONYM ornithine aminotransferase
2007-09-06 Deleted SYNONYM ornithine 5-aminotransferase
2007-09-06 Deleted SYNONYM L-ornithine aminotransferase
2007-09-06 Added SYNONYM ornithine aminotransferase activity
2007-08-21 Added SYNONYM ornithine--ketoglutarate aminotransferase
2007-08-21 Added SYNONYM ornithine--keto acid transaminase
2007-08-21 Added SYNONYM ornithine--keto acid aminotransferase
2007-08-21 Added SYNONYM ornithine--alpha-ketoglutarate aminotransferase
2007-08-21 Added SYNONYM ornithine--2-oxoacid aminotransferase
2007-08-21 Added SYNONYM ornithine ketoacid aminotransferase
2007-08-21 Added SYNONYM ornithine delta-transaminase
2007-08-21 Added SYNONYM ornithine aminotransferase
2007-08-21 Added SYNONYM ornithine 5-aminotransferase
2007-08-21 Added SYNONYM L-ornithine aminotransferase
2007-08-21 Added SYNONYM L-ornithine 5-aminotransferase
2007-08-21 Added SYNONYM ornithine transaminase
2007-08-09 Added SYNONYM ornithine-oxo-acid aminotransferase activity
2007-08-09 Deleted SYNONYM ornithine-oxo-acid aminotransferase activity
2004-04-19 Added SYNONYM ornithine-oxo-acid aminotransferase activity
2004-04-16 Deleted SYNONYM ornithine-oxo-acid aminotransferase activity
2003-10-27 Added SYNONYM ornithine-oxo-acid aminotransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008483 (transaminase activity)
Timestamp Action Category Detail
2024-08-07 Deleted XREF MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
2023-09-06 Added XREF MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
2020-06-22 Added XREF RHEA:13877
2019-04-01 Added XREF Reactome:R-HSA-70666
2019-04-01 Deleted XREF reactome:R-HSA-70666
2019-04-01 Deleted XREF reactome:R-HSA-70654
2019-04-01 Added XREF Reactome:R-HSA-70654
2018-12-11 Added XREF reactome:R-HSA-70654
2018-12-11 Added XREF reactome:R-HSA-70666
2003-10-27 Added XREF MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
2001-03-30 Added XREF EC:2.6.1.13
Timestamp Action Category Detail
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