GO:0004587
JSON
ornithine aminotransferase activity
Molecular Function
Definition (GO:0004587 GONUTS page)
Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ornithine--oxo-acid transaminase activity | related |
ornithine:alpha-oxoglutarate transaminase activity | related |
ornithine delta-transaminase activity | related |
L-ornithine 5-aminotransferase activity | related |
ornithine-oxo-acid aminotransferase activity | exact |
ornithine--ketoglutarate aminotransferase activity | related |
ornithine--keto acid aminotransferase activity | related |
ornithine--2-oxoacid aminotransferase activity | related |
ornithine(lysine) transaminase activity | related |
ornithine-oxo-acid transaminase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.6.1.13 | |
InterPro | IPR010164 | Ornithine aminotransferase |
InterPro | IPR034757 | Ornithine aminotransferase, bacterial type |
MetaCyc | ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN | |
RHEA | 13877 | |
Reactome | R-HSA-70654 | |
Reactome | R-HSA-70666 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:59869 | L-alpha-amino acid zwitterion |
has_participant | CHEBI | CHEBI:58066 | L-glutamic 5-semialdehyde zwitterion |
has_participant | CHEBI | CHEBI:35179 | 2-oxo monocarboxylic acid anion |
has_participant | CHEBI | CHEBI:46911 | L-ornithinium(1+) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0050155 | obsolete ornithine(lysine) transaminase activity | replaced_by GO:0004587 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004587 based on ALL annotations
The top 100 of 135 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ornithine aminotransferase activity
|
12,364.51 | 100.00 | 15,766 | 15,766 |
arginine catabolic process to proline via ornithine
|
12,361.49 | 51.98 | 8,196 | 8,198 |
arginine catabolic process to glutamate
|
4,198.87 | 25.85 | 8,195 | 24,132 |
L-proline biosynthetic process
|
1,161.12 | 9.18 | 12,654 | 134,750 |
identical protein binding
|
431.10 | 3.49 | 15,569 | 446,538 |
transaminase activity
|
161.33 | 1.30 | 15,762 | 1,208,015 |
proline biosynthetic process
|
164.16 | 1.21 | 1,870 | 140,851 |
pyridoxal phosphate binding
|
112.49 | 0.91 | 15,722 | 1,728,166 |
ornithine metabolic process
|
66.85 | 0.38 | 198 | 36,620 |
putrescine--2-oxoglutarate transaminase activity
|
180.57 | 0.21 | 38 | 2,602 |
Totals | 105693 | 108848579 |
No co-occurrence statistics for GO:0004587 based on MANUAL annotations
The top 34 of 34 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ornithine aminotransferase activity
|
11,961.10 | 100.00 | 108 | 108 |
arginine catabolic process to glutamate
|
11,961.10 | 98.15 | 106 | 106 |
arginine catabolic process to proline via ornithine
|
11,737.53 | 95.45 | 105 | 107 |
pyridoxal phosphate binding
|
572.92 | 4.79 | 106 | 2,213 |
ornithine metabolic process
|
2,600.24 | 3.97 | 5 | 23 |
identical protein binding
|
145.77 | 1.22 | 107 | 8,780 |
ornithine catabolic process
|
2,392.22 | 0.89 | 1 | 5 |
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
|
1,329.01 | 0.86 | 1 | 9 |
response to flooding
|
1,087.37 | 0.85 | 1 | 11 |
response to brassinosteroid
|
184.02 | 0.58 | 1 | 65 |
Totals | 680 | 661604 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-07 | Deleted | XREF | MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-06 | Updated | TERM | ornithine aminotransferase activity |
2023-09-06 | Deleted | DEFINITION | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
2023-09-06 | Added | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-06 | Deleted | SYNONYM | ornithine aminotransferase activity |
2023-09-06 | Added | SYNONYM | ornithine-oxo-acid transaminase activity |
2023-09-06 | Added | SYNONYM | ornithine(lysine) transaminase activity |
2023-09-06 | Added | XREF | MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-06 | Updated | TERM | ornithine aminotransferase activity |
2003-09-13 | Updated | TERM | ornithine-oxo-acid transaminase activity |
2003-09-09 | Updated | TERM | ornithine-oxo-acid transminase activity |
2003-03-19 | Updated | TERM | ornithine-oxo-acid aminotransferase activity |
2002-02-06 | Updated | TERM | ornithine-oxo-acid aminotransferase |
2001-11-07 | Updated | TERM | ornithine-oxo-acid aminotransferase |
2001-04-03 | Updated | TERM | ornithine--oxo-acid aminotransferase |
2001-03-30 | Added | TERM | ornithine--oxo-acid aminotransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-06 | Deleted | DEFINITION | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
2023-09-06 | Added | DEFINITION | Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde. |
2023-09-06 | Deleted | SYNONYM | ornithine aminotransferase activity |
2023-09-06 | Added | SYNONYM | ornithine-oxo-acid transaminase activity |
2023-09-06 | Added | SYNONYM | ornithine(lysine) transaminase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--keto acid aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine--alpha-ketoglutarate aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--ketoglutarate aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--oxo acid aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--oxo-acid transaminase activity |
2020-10-08 | Added | SYNONYM | ornithine:alpha-oxoglutarate transaminase activity |
2020-10-08 | Added | SYNONYM | L-ornithine 5-aminotransferase activity |
2020-10-08 | Added | SYNONYM | L-ornithine:alpha-ketoglutarate delta-aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine--oxo-acid transaminase activity |
2020-10-08 | Deleted | SYNONYM | L-ornithine 5-aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | L-ornithine aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine 5-aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine delta-transaminase activity |
2020-10-08 | Deleted | SYNONYM | ornithine ketoacid aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine transaminase activity |
2020-10-08 | Added | SYNONYM | ornithine transaminase activity |
2020-10-08 | Added | SYNONYM | L-ornithine:2-oxo-acid aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | L-ornithine:2-oxo-acid aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | L-ornithine:alpha-ketoglutarate delta-aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine:alpha-oxoglutarate transaminase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--2-oxoacid aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--alpha-ketoglutarate aminotransferase activity |
2020-10-08 | Deleted | SYNONYM | ornithine--keto acid transaminase activity |
2020-10-08 | Added | SYNONYM | ornithine--2-oxoacid aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine--ketoglutarate aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine--keto acid aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine--oxo acid aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine delta-transaminase activity |
2020-10-08 | Added | SYNONYM | ornithine--keto acid transaminase activity |
2020-10-08 | Added | SYNONYM | L-ornithine aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine 5-aminotransferase activity |
2020-10-08 | Added | SYNONYM | ornithine ketoacid aminotransferase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
2007-11-08 | Added | SYNONYM | GabT |
2007-11-08 | Added | SYNONYM | L-ornithine:2-oxo-acid aminotransferase activity |
2007-11-08 | Added | SYNONYM | L-ornithine:alpha-ketoglutarate delta-aminotransferase activity |
2007-11-08 | Added | SYNONYM | OAT |
2007-11-08 | Added | SYNONYM | ornithine:alpha-oxoglutarate transaminase activity |
2007-09-06 | Added | SYNONYM | ornithine delta-transaminase activity |
2007-09-06 | Deleted | SYNONYM | L-ornithine 5-aminotransferase |
2007-09-06 | Added | SYNONYM | ornithine 5-aminotransferase activity |
2007-09-06 | Added | SYNONYM | L-ornithine aminotransferase activity |
2007-09-06 | Added | SYNONYM | L-ornithine 5-aminotransferase activity |
2007-09-06 | Added | SYNONYM | ornithine--ketoglutarate aminotransferase activity |
2007-09-06 | Added | SYNONYM | ornithine--oxo acid aminotransferase activity |
2007-09-06 | Deleted | SYNONYM | ornithine--alpha-ketoglutarate aminotransferase |
2007-09-06 | Deleted | SYNONYM | ornithine--2-oxoacid aminotransferase |
2007-09-06 | Added | SYNONYM | ornithine--oxo-acid transaminase activity |
2007-09-06 | Deleted | SYNONYM | ornithine transaminase |
2007-09-06 | Added | SYNONYM | ornithine--keto acid transaminase activity |
2007-09-06 | Added | SYNONYM | ornithine--keto acid aminotransferase activity |
2007-09-06 | Added | SYNONYM | ornithine--alpha-ketoglutarate aminotransferase activity |
2007-09-06 | Added | SYNONYM | ornithine--2-oxoacid aminotransferase activity |
2007-09-06 | Added | SYNONYM | ornithine transaminase activity |
2007-09-06 | Added | SYNONYM | ornithine ketoacid aminotransferase activity |
2007-09-06 | Deleted | SYNONYM | ornithine--keto acid aminotransferase |
2007-09-06 | Deleted | SYNONYM | ornithine--keto acid transaminase |
2007-09-06 | Deleted | SYNONYM | ornithine--ketoglutarate aminotransferase |
2007-09-06 | Deleted | SYNONYM | ornithine ketoacid aminotransferase |
2007-09-06 | Deleted | SYNONYM | ornithine delta-transaminase |
2007-09-06 | Deleted | SYNONYM | ornithine aminotransferase |
2007-09-06 | Deleted | SYNONYM | ornithine 5-aminotransferase |
2007-09-06 | Deleted | SYNONYM | L-ornithine aminotransferase |
2007-09-06 | Added | SYNONYM | ornithine aminotransferase activity |
2007-08-21 | Added | SYNONYM | ornithine--ketoglutarate aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine--keto acid transaminase |
2007-08-21 | Added | SYNONYM | ornithine--keto acid aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine--alpha-ketoglutarate aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine--2-oxoacid aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine ketoacid aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine delta-transaminase |
2007-08-21 | Added | SYNONYM | ornithine aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine 5-aminotransferase |
2007-08-21 | Added | SYNONYM | L-ornithine aminotransferase |
2007-08-21 | Added | SYNONYM | L-ornithine 5-aminotransferase |
2007-08-21 | Added | SYNONYM | ornithine transaminase |
2007-08-09 | Added | SYNONYM | ornithine-oxo-acid aminotransferase activity |
2007-08-09 | Deleted | SYNONYM | ornithine-oxo-acid aminotransferase activity |
2004-04-19 | Added | SYNONYM | ornithine-oxo-acid aminotransferase activity |
2004-04-16 | Deleted | SYNONYM | ornithine-oxo-acid aminotransferase activity |
2003-10-27 | Added | SYNONYM | ornithine-oxo-acid aminotransferase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008483 (transaminase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-07 | Deleted | XREF | MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN |
2023-09-06 | Added | XREF | MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN |
2020-06-22 | Added | XREF | RHEA:13877 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70666 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70666 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70654 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70654 |
2018-12-11 | Added | XREF | reactome:R-HSA-70654 |
2018-12-11 | Added | XREF | reactome:R-HSA-70666 |
2003-10-27 | Added | XREF | MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN |
2001-03-30 | Added | XREF | EC:2.6.1.13 |
Timestamp | Action | Category | Detail |
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