This term is obsolete.

GO:0004594 JSON

pantothenate kinase activity

Molecular Function

Definition (GO:0004594 GONUTS page)

Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.

54,795 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP:(R)-pantothenate 4'-phosphotransferase activity related
pantothenate kinase (phosphorylating) activity related
pantothenic acid kinase activity related
D-pantothenate kinase activity related
ATP:pantothenate 4'-phosphotransferase activity related

Ancestor Chart

Ancestor chart for GO:0004594
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.33
InterPro IPR004566 Pantothenate kinase
InterPro IPR004567 Type II pantothenate kinase
InterPro IPR004619 Type III pantothenate kinase
InterPro IPR011602 Type II pantothenate kinase, bacterial
InterPro IPR015844 Pantothenate kinase, acetyl-CoA regulated, two-domain type
MetaCyc PANTOTHENATE-KIN-RXN
RHEA 16373
Reactome R-HSA-196857
Reactome R-HSA-199203

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:29032 (R)-pantothenate
has_participant CHEBI CHEBI:10986 (R)-4'-phosphonatopantothenate(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:456216 ADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004594 based on ALL annotations
The top 100 of 355 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pantothenate kinase activity
3,582.12 100.00 54,420 54,420
coenzyme A biosynthetic process
906.45 25.25 53,956 213,224
cation binding
748.89 16.66 24,516 117,266
kinase activity
32.94 0.92 48,004 5,220,332
ATP binding
10.21 0.29 53,751 18,856,705
acetyl-CoA binding
139.46 0.18 105 2,697
cytoplasm
6.02 0.17 42,525 25,285,876
vitamin binding
79.57 0.17 98 4,412
regulation of bile acid metabolic process
1,684.56 0.16 87 185
regulation of triglyceride metabolic process
502.65 0.16 87 620
Totals 325313 115715662
No co-occurrence statistics for GO:0004594 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pantothenate kinase activity
4,127.15 100.00 313 313
coenzyme A biosynthetic process
1,359.69 32.88 311 944
acetyl-CoA binding
1,179.19 3.50 12 42
regulation of bile acid metabolic process
1,289.74 1.54 5 16
regulation of triglyceride metabolic process
543.05 1.45 5 38
vitamin binding
491.33 1.43 5 42
regulation of fatty acid metabolic process
327.55 1.35 5 63
cellular response to gamma radiation
155.74 1.29 6 159
locomotor rhythm
111.04 1.13 6 223
triglyceride homeostasis
96.35 1.06 6 257
Totals 1447 809589

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM D-pantothenate kinase activity
2020-10-08 Deleted SYNONYM D-pantothenate kinase activity
2020-10-08 Deleted SYNONYM pantothenate kinase (phosphorylating) activity
2020-10-08 Deleted SYNONYM pantothenic acid kinase activity
2020-10-08 Deleted SYNONYM ATP:(R)-pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:pantothenate 4'-phosphotransferase activity
2020-10-08 Deleted SYNONYM ATP:pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:(R)-pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM pantothenic acid kinase activity
2020-10-08 Added SYNONYM pantothenate kinase (phosphorylating) activity
Timestamp Action Category Detail
2003-03-19 Updated TERM pantothenate kinase activity
2002-02-06 Updated TERM pantothenate kinase
2001-04-03 Updated TERM pantothenate kinase
2001-03-30 Added TERM pantothenate kinase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM D-pantothenate kinase activity
2020-10-08 Deleted SYNONYM D-pantothenate kinase activity
2020-10-08 Deleted SYNONYM pantothenate kinase (phosphorylating) activity
2020-10-08 Deleted SYNONYM pantothenic acid kinase activity
2020-10-08 Deleted SYNONYM ATP:(R)-pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:pantothenate 4'-phosphotransferase activity
2020-10-08 Deleted SYNONYM ATP:pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM ATP:(R)-pantothenate 4'-phosphotransferase activity
2020-10-08 Added SYNONYM pantothenic acid kinase activity
2020-10-08 Added SYNONYM pantothenate kinase (phosphorylating) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
2007-11-08 Added SYNONYM ATP:(R)-pantothenate 4'-phosphotransferase activity
2007-09-06 Added SYNONYM ATP:pantothenate 4'-phosphotransferase activity
2007-09-06 Added SYNONYM pantothenate kinase (phosphorylating) activity
2007-09-06 Added SYNONYM D-pantothenate kinase activity
2007-09-06 Added SYNONYM pantothenic acid kinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-199203
2019-04-01 Added XREF Reactome:R-HSA-196857
2019-04-01 Deleted XREF reactome:R-HSA-199203
2019-04-01 Deleted XREF reactome:R-HSA-196857
2018-12-11 Added XREF reactome:R-HSA-196857
2018-12-11 Added XREF reactome:R-HSA-199203
2018-07-13 Deleted XREF RHEA:16376
2018-07-13 Added XREF RHEA:16373
2011-09-16 Added XREF RHEA:16376
2003-10-27 Added XREF MetaCyc:PANTOTHENATE-KIN-RXN
2001-03-30 Added XREF EC:2.7.1.33
Timestamp Action Category Detail
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