GO:0004594
JSON
pantothenate kinase activity
Molecular Function
Definition (GO:0004594 GONUTS page)
Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP:(R)-pantothenate 4'-phosphotransferase activity | related |
pantothenate kinase (phosphorylating) activity | related |
pantothenic acid kinase activity | related |
D-pantothenate kinase activity | related |
ATP:pantothenate 4'-phosphotransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3Q0M1 | 9615 | A0A8I3Q0M1_CANLF | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J0TR01 | 8355 | A0A8J0TR01_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8J0TZJ2 | 8355 | A0A8J0TZJ2_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8M2B232 | 7955 | A0A8M2B232_DANRE | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.1.33 | |
InterPro | IPR004566 | Pantothenate kinase |
InterPro | IPR004567 | Type II pantothenate kinase |
InterPro | IPR004619 | Type III pantothenate kinase |
InterPro | IPR011602 | Type II pantothenate kinase, bacterial |
InterPro | IPR015844 | Pantothenate kinase, acetyl-CoA regulated, two-domain type |
MetaCyc | PANTOTHENATE-KIN-RXN | |
RHEA | 16373 | |
Reactome | R-HSA-196857 | |
Reactome | R-HSA-199203 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:29032 | (R)-pantothenate |
has_participant | CHEBI | CHEBI:10986 | (R)-4'-phosphonatopantothenate(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004594 based on ALL annotations
The top 100 of 355 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pantothenate kinase activity
|
3,582.12 | 100.00 | 54,420 | 54,420 |
coenzyme A biosynthetic process
|
906.45 | 25.25 | 53,956 | 213,224 |
cation binding
|
748.89 | 16.66 | 24,516 | 117,266 |
kinase activity
|
32.94 | 0.92 | 48,004 | 5,220,332 |
ATP binding
|
10.21 | 0.29 | 53,751 | 18,856,705 |
acetyl-CoA binding
|
139.46 | 0.18 | 105 | 2,697 |
cytoplasm
|
6.02 | 0.17 | 42,525 | 25,285,876 |
vitamin binding
|
79.57 | 0.17 | 98 | 4,412 |
regulation of bile acid metabolic process
|
1,684.56 | 0.16 | 87 | 185 |
regulation of triglyceride metabolic process
|
502.65 | 0.16 | 87 | 620 |
Totals | 325313 | 115715662 |
No co-occurrence statistics for GO:0004594 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pantothenate kinase activity
|
4,127.15 | 100.00 | 313 | 313 |
coenzyme A biosynthetic process
|
1,359.69 | 32.88 | 311 | 944 |
acetyl-CoA binding
|
1,179.19 | 3.50 | 12 | 42 |
regulation of bile acid metabolic process
|
1,289.74 | 1.54 | 5 | 16 |
regulation of triglyceride metabolic process
|
543.05 | 1.45 | 5 | 38 |
vitamin binding
|
491.33 | 1.43 | 5 | 42 |
regulation of fatty acid metabolic process
|
327.55 | 1.35 | 5 | 63 |
cellular response to gamma radiation
|
155.74 | 1.29 | 6 | 159 |
locomotor rhythm
|
111.04 | 1.13 | 6 | 223 |
triglyceride homeostasis
|
96.35 | 1.06 | 6 | 257 |
Totals | 1447 | 809589 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | D-pantothenate kinase activity |
2020-10-08 | Deleted | SYNONYM | D-pantothenate kinase activity |
2020-10-08 | Deleted | SYNONYM | pantothenate kinase (phosphorylating) activity |
2020-10-08 | Deleted | SYNONYM | pantothenic acid kinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:(R)-pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | ATP:pantothenate 4'-phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | ATP:pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | ATP:(R)-pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | pantothenic acid kinase activity |
2020-10-08 | Added | SYNONYM | pantothenate kinase (phosphorylating) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | pantothenate kinase activity |
2002-02-06 | Updated | TERM | pantothenate kinase |
2001-04-03 | Updated | TERM | pantothenate kinase |
2001-03-30 | Added | TERM | pantothenate kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | D-pantothenate kinase activity |
2020-10-08 | Deleted | SYNONYM | D-pantothenate kinase activity |
2020-10-08 | Deleted | SYNONYM | pantothenate kinase (phosphorylating) activity |
2020-10-08 | Deleted | SYNONYM | pantothenic acid kinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:(R)-pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | ATP:pantothenate 4'-phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | ATP:pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | ATP:(R)-pantothenate 4'-phosphotransferase activity |
2020-10-08 | Added | SYNONYM | pantothenic acid kinase activity |
2020-10-08 | Added | SYNONYM | pantothenate kinase (phosphorylating) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
2007-11-08 | Added | SYNONYM | ATP:(R)-pantothenate 4'-phosphotransferase activity |
2007-09-06 | Added | SYNONYM | ATP:pantothenate 4'-phosphotransferase activity |
2007-09-06 | Added | SYNONYM | pantothenate kinase (phosphorylating) activity |
2007-09-06 | Added | SYNONYM | D-pantothenate kinase activity |
2007-09-06 | Added | SYNONYM | pantothenic acid kinase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0016301 (kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-199203 |
2019-04-01 | Added | XREF | Reactome:R-HSA-196857 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-199203 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-196857 |
2018-12-11 | Added | XREF | reactome:R-HSA-196857 |
2018-12-11 | Added | XREF | reactome:R-HSA-199203 |
2018-07-13 | Deleted | XREF | RHEA:16376 |
2018-07-13 | Added | XREF | RHEA:16373 |
2011-09-16 | Added | XREF | RHEA:16376 |
2003-10-27 | Added | XREF | MetaCyc:PANTOTHENATE-KIN-RXN |
2001-03-30 | Added | XREF | EC:2.7.1.33 |
Timestamp | Action | Category | Detail |
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