This term is obsolete.

GO:0004602 JSON

glutathione peroxidase activity

Molecular Function

Definition (GO:0004602 GONUTS page)

Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. PMID:36771108

Secondary IDs

GO:0016224

33,179 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
non-selenium glutathione peroxidase activity narrow
glutathione:hydrogen-peroxide oxidoreductase activity related
selenium-glutathione peroxidase activity related
reduced glutathione peroxidase activity related
GSH peroxidase activity related

Ancestor Chart

Ancestor chart for GO:0004602
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004602

Child Term Relationship to
GO:0004602
positive regulation of glutathione peroxidase activity
positively_regulates
regulation of glutathione peroxidase activity
regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5Y865 10116 A0A8I5Y865_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J8YB21 10116 A0A8J8YB21_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
EC 1.11.1.9
InterPro IPR013376 Glutathione peroxidase Gpx7, putative
InterPro IPR044088 Glutathione S-transferase kappa
MetaCyc GLUTATHIONE-PEROXIDASE-RXN
RHEA 16833
Reactome R-HSA-2161791
Reactome R-HSA-2161946
Reactome R-HSA-2161959
Reactome R-HSA-2161999
Reactome R-HSA-3323013

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58297 glutathione disulfide(2-)
has_participant CHEBI CHEBI:57925 glutathionate(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:16240 hydrogen peroxide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004602 based on ALL annotations
The top 100 of 447 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutathione peroxidase activity
6,021.66 100.00 32,907 32,907
2-hydroxychromene-2-carboxylate isomerase activity
5,565.09 33.57 11,360 12,292
naphthalene catabolic process
5,859.59 30.50 10,123 10,403
leukotriene metabolic process
5,565.76 18.78 6,275 6,789
glutathione transferase activity
920.33 14.54 24,657 161,329
leukotriene-C4 synthase activity
5,857.54 8.01 2,641 2,715
leukotriene biosynthetic process
3,307.64 7.71 2,708 4,930
glutathione metabolic process
392.97 6.17 17,482 267,884
nuclear envelope
298.41 4.15 6,702 135,239
cellular oxidant detoxification
234.61 3.90 32,888 844,124
Totals 221770 22593191
No co-occurrence statistics for GO:0004602 based on MANUAL annotations
The top 100 of 315 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glutathione peroxidase activity
2,857.35 100.00 494 494
leukotriene-C4 synthase activity
2,625.68 13.60 68 74
leukotriene biosynthetic process
1,734.82 12.64 68 112
phospholipid-hydroperoxide glutathione peroxidase activity
2,743.06 9.68 48 50
glutathione transferase activity
216.99 7.30 321 4,227
nuclear envelope
172.83 5.54 197 3,257
response to selenium ion
928.64 4.74 26 80
lipoxygenase pathway
359.12 3.52 23 183
selenium binding
737.38 2.96 16 62
glutathione metabolic process
90.56 2.90 125 3,944
Totals 2120 77664

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM selenium-glutathione peroxidase activity
2020-10-08 Added SYNONYM reduced glutathione peroxidase activity
2020-10-08 Added SYNONYM GSH peroxidase activity
2020-10-08 Deleted SYNONYM selenium-glutathione peroxidase activity
2020-10-08 Added SYNONYM glutathione:hydrogen-peroxide oxidoreductase activity
2020-10-08 Deleted SYNONYM GSH peroxidase activity
2020-10-08 Deleted SYNONYM reduced glutathione peroxidase activity
2020-10-08 Deleted SYNONYM glutathione:hydrogen-peroxide oxidoreductase activity
2019-04-01 Added XREF Reactome:R-HSA-71676
2019-04-01 Added XREF Reactome:R-HSA-3323013
Timestamp Action Category Detail
2003-03-19 Updated TERM glutathione peroxidase activity
2002-02-06 Updated TERM glutathione peroxidase
2001-04-03 Updated TERM glutathione peroxidase
2001-03-30 Added TERM glutathione peroxidase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM selenium-glutathione peroxidase activity
2020-10-08 Added SYNONYM reduced glutathione peroxidase activity
2020-10-08 Added SYNONYM GSH peroxidase activity
2020-10-08 Deleted SYNONYM selenium-glutathione peroxidase activity
2020-10-08 Added SYNONYM glutathione:hydrogen-peroxide oxidoreductase activity
2020-10-08 Deleted SYNONYM GSH peroxidase activity
2020-10-08 Deleted SYNONYM reduced glutathione peroxidase activity
2020-10-08 Deleted SYNONYM glutathione:hydrogen-peroxide oxidoreductase activity
2010-09-03 Added DEFINITION Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
2007-11-08 Added SYNONYM selenium-glutathione peroxidase activity
2007-11-08 Added SYNONYM GSH peroxidase activity
2007-11-08 Added SYNONYM glutathione:hydrogen-peroxide oxidoreductase activity
2007-11-08 Added SYNONYM reduced glutathione peroxidase activity
2007-08-09 Deleted SYNONYM non-selenium glutathione peroxidase activity
2007-08-09 Added SYNONYM non-selenium glutathione peroxidase activity
2004-11-25 Added SYNONYM non-selenium glutathione peroxidase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
2002-11-27 Added DEFINITION Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004601 (peroxidase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-71676
2019-04-01 Added XREF Reactome:R-HSA-3323013
2019-04-01 Added XREF Reactome:R-HSA-3341277
2019-04-01 Added XREF Reactome:R-HSA-2161791
2019-04-01 Added XREF Reactome:R-HSA-2161946
2019-04-01 Added XREF Reactome:R-HSA-2161999
2019-04-01 Added XREF Reactome:R-HSA-2161959
2019-04-01 Deleted XREF reactome:R-HSA-2161791
2019-04-01 Deleted XREF reactome:R-HSA-2161946
2019-04-01 Deleted XREF reactome:R-HSA-3323013
2019-04-01 Deleted XREF reactome:R-HSA-2161999
2019-04-01 Deleted XREF reactome:R-HSA-2161959
2019-04-01 Deleted XREF reactome:R-HSA-71676
2019-04-01 Deleted XREF reactome:R-HSA-6799695
2019-04-01 Deleted XREF reactome:R-HSA-3343700
2019-04-01 Deleted XREF reactome:R-HSA-3341397
2019-04-01 Deleted XREF reactome:R-HSA-3341277
2019-04-01 Added XREF Reactome:R-HSA-3343700
2019-04-01 Added XREF Reactome:R-HSA-6799695
2019-04-01 Added XREF Reactome:R-HSA-3341397
2018-12-11 Added XREF reactome:R-HSA-3341277
2018-12-11 Added XREF reactome:R-HSA-2161999
2018-12-11 Added XREF reactome:R-HSA-2161791
2018-12-11 Added XREF reactome:R-HSA-3341397
2018-12-11 Added XREF reactome:R-HSA-3343700
2018-12-11 Added XREF reactome:R-HSA-2161946
2018-12-11 Added XREF reactome:R-HSA-6799695
2018-12-11 Added XREF reactome:R-HSA-71676
2018-12-11 Added XREF reactome:R-HSA-2161959
2018-12-11 Added XREF reactome:R-HSA-3323013
2018-07-13 Added XREF RHEA:16833
2018-07-13 Deleted XREF RHEA:16836
2011-09-16 Added XREF RHEA:16836
2003-10-27 Added XREF MetaCyc:GLUTATHIONE-PEROXIDASE-RXN
2001-03-30 Added XREF EC:1.11.1.9
Timestamp Action Category Detail
2004-11-25 Added SECONDARY GO:0016224 (non-selenium glutathione peroxidase activity)
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