GO:0004602
JSON
glutathione peroxidase activity
Molecular Function
Definition (GO:0004602 GONUTS page)
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. PMID:36771108
Secondary IDs
GO:0016224
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
GSH peroxidase activity | related |
selenium-glutathione peroxidase activity | related |
non-selenium glutathione peroxidase activity | narrow |
reduced glutathione peroxidase activity | related |
glutathione:hydrogen-peroxide oxidoreductase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004602
Child Term | Relationship to GO:0004602 |
---|---|
regulation of glutathione peroxidase activity
|
regulates |
positive regulation of glutathione peroxidase activity
|
positively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I5Y865 | 10116 | A0A8I5Y865_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J8YB21 | 10116 | A0A8J8YB21_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.11.1.9 | |
InterPro | IPR013376 | Glutathione peroxidase Gpx7, putative |
InterPro | IPR044088 | Glutathione S-transferase kappa |
MetaCyc | GLUTATHIONE-PEROXIDASE-RXN | |
RHEA | 16833 | |
Reactome | R-HSA-2161791 | |
Reactome | R-HSA-2161946 | |
Reactome | R-HSA-2161959 | |
Reactome | R-HSA-2161999 | |
Reactome | R-HSA-3323013 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58297 | glutathione disulfide(2-) |
has_participant | CHEBI | CHEBI:57925 | glutathionate(1-) |
has_participant | CHEBI | CHEBI:16240 | hydrogen peroxide |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004602 based on ALL annotations
The top 100 of 438 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutathione peroxidase activity
|
6,033.20 | 100.00 | 32,311 | 32,311 |
2-hydroxychromene-2-carboxylate isomerase activity
|
5,577.60 | 33.89 | 11,263 | 12,183 |
naphthalene catabolic process
|
5,871.39 | 30.84 | 10,051 | 10,328 |
leukotriene metabolic process
|
5,548.72 | 18.48 | 6,070 | 6,600 |
glutathione transferase activity
|
936.19 | 14.76 | 24,264 | 156,367 |
leukotriene-C4 synthase activity
|
5,863.48 | 8.00 | 2,591 | 2,666 |
leukotriene biosynthetic process
|
3,301.12 | 7.70 | 2,657 | 4,856 |
glutathione metabolic process
|
397.55 | 6.23 | 17,275 | 262,165 |
nuclear envelope
|
292.16 | 4.06 | 6,495 | 134,123 |
cellular oxidant detoxification
|
233.98 | 3.88 | 32,292 | 832,643 |
Totals | 223854 | 22082124 |
No co-occurrence statistics for GO:0004602 based on MANUAL annotations
The top 100 of 308 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
glutathione peroxidase activity
|
2,883.48 | 100.00 | 448 | 448 |
leukotriene-C4 synthase activity
|
2,599.86 | 12.11 | 55 | 61 |
leukotriene biosynthetic process
|
1,651.99 | 11.25 | 55 | 96 |
phospholipid-hydroperoxide glutathione peroxidase activity
|
2,763.34 | 10.22 | 46 | 48 |
glutathione transferase activity
|
241.54 | 8.01 | 289 | 3,450 |
nuclear envelope
|
163.05 | 5.18 | 171 | 3,024 |
response to selenium ion
|
884.27 | 4.60 | 23 | 75 |
lipoxygenase pathway
|
422.42 | 3.95 | 23 | 157 |
selenium binding
|
904.62 | 3.31 | 16 | 51 |
glutathione metabolic process
|
103.99 | 3.26 | 114 | 3,161 |
Totals | 1911 | 63279 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | reduced glutathione peroxidase activity |
2020-10-08 | Deleted | SYNONYM | selenium-glutathione peroxidase activity |
2020-10-08 | Added | SYNONYM | selenium-glutathione peroxidase activity |
2020-10-08 | Added | SYNONYM | glutathione:hydrogen-peroxide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glutathione:hydrogen-peroxide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | GSH peroxidase activity |
2020-10-08 | Added | SYNONYM | GSH peroxidase activity |
2020-10-08 | Added | SYNONYM | reduced glutathione peroxidase activity |
2019-04-01 | Added | XREF | Reactome:R-HSA-71676 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3323013 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | glutathione peroxidase activity |
2002-02-06 | Updated | TERM | glutathione peroxidase |
2001-04-03 | Updated | TERM | glutathione peroxidase |
2001-03-30 | Added | TERM | glutathione peroxidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | reduced glutathione peroxidase activity |
2020-10-08 | Deleted | SYNONYM | selenium-glutathione peroxidase activity |
2020-10-08 | Added | SYNONYM | selenium-glutathione peroxidase activity |
2020-10-08 | Added | SYNONYM | glutathione:hydrogen-peroxide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glutathione:hydrogen-peroxide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | GSH peroxidase activity |
2020-10-08 | Added | SYNONYM | GSH peroxidase activity |
2020-10-08 | Added | SYNONYM | reduced glutathione peroxidase activity |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. |
2007-11-08 | Added | SYNONYM | reduced glutathione peroxidase activity |
2007-11-08 | Added | SYNONYM | GSH peroxidase activity |
2007-11-08 | Added | SYNONYM | glutathione:hydrogen-peroxide oxidoreductase activity |
2007-11-08 | Added | SYNONYM | selenium-glutathione peroxidase activity |
2007-08-09 | Deleted | SYNONYM | non-selenium glutathione peroxidase activity |
2007-08-09 | Added | SYNONYM | non-selenium glutathione peroxidase activity |
2004-11-25 | Added | SYNONYM | non-selenium glutathione peroxidase activity |
2003-10-23 | Updated | DEFINITION | Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004601 (peroxidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-71676 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3323013 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3341277 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161959 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3343700 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161999 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161946 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161791 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161946 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3323013 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161999 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161959 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-71676 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6799695 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3343700 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3341397 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3341277 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3341397 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6799695 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161791 |
2018-12-11 | Added | XREF | reactome:R-HSA-6799695 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161999 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161791 |
2018-12-11 | Added | XREF | reactome:R-HSA-3341397 |
2018-12-11 | Added | XREF | reactome:R-HSA-3323013 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161946 |
2018-12-11 | Added | XREF | reactome:R-HSA-3343700 |
2018-12-11 | Added | XREF | reactome:R-HSA-71676 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161959 |
2018-12-11 | Added | XREF | reactome:R-HSA-3341277 |
2018-07-13 | Added | XREF | RHEA:16833 |
2018-07-13 | Deleted | XREF | RHEA:16836 |
2011-09-16 | Added | XREF | RHEA:16836 |
2003-10-27 | Added | XREF | MetaCyc:GLUTATHIONE-PEROXIDASE-RXN |
2001-03-30 | Added | XREF | EC:1.11.1.9 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-11-25 | Added | SECONDARY | GO:0016224 (non-selenium glutathione peroxidase activity) |
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