GO:0004617
JSON
phosphoglycerate dehydrogenase activity
Molecular Function
Definition (GO:0004617 GONUTS page)
Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
3-phosphoglycerate dehydrogenase activity | related |
PGDH activity | related |
3PHP reductase activity | related |
alpha-KG reductase activity | related |
D- and L-HGA | related |
glycerate-1,3-phosphate dehydrogenase activity | related |
alphaKG reductase activity | related |
SerA 3PG dehydrogenase activity | related |
SerA | related |
phosphoglyceric acid dehydrogenase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.95 | |
InterPro | IPR006236 | D-3-phosphoglycerate dehydrogenase |
MetaCyc | PGLYCDEHYDROG-RXN | |
RHEA | 12641 | |
Reactome | R-HSA-977348 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:18110 | 3-phosphonatooxypyruvate(3-) |
has_participant | CHEBI | CHEBI:58272 | 3-phosphonato-D-glycerate(3-) |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004617 based on ALL annotations
The top 100 of 203 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoglycerate dehydrogenase activity
|
5,181.37 | 100.00 | 37,623 | 37,623 |
L-serine biosynthetic process
|
1,170.35 | 19.79 | 23,148 | 102,481 |
oxidoreductase activity, acting on CH-OH group of donors
|
319.32 | 5.85 | 20,059 | 325,478 |
NAD binding
|
163.44 | 3.15 | 36,650 | 1,161,857 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
70.71 | 1.34 | 15,508 | 1,136,450 |
chloroplast stroma
|
68.20 | 0.90 | 1,051 | 79,851 |
hydroxypyruvate reductase [NAD(P)H] activity
|
59.72 | 0.70 | 669 | 58,048 |
glyoxylate reductase (NADPH) activity
|
57.00 | 0.69 | 675 | 61,354 |
oxidoreductase activity
|
15.82 | 0.31 | 36,353 | 11,906,003 |
carboxylic acid metabolic process
|
16.24 | 0.29 | 1,266 | 403,849 |
Totals | 178524 | 88797821 |
No co-occurrence statistics for GO:0004617 based on MANUAL annotations
The top 58 of 58 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoglycerate dehydrogenase activity
|
3,628.65 | 100.00 | 356 | 356 |
chloroplast stroma
|
110.23 | 2.73 | 75 | 2,469 |
serine family amino acid biosynthetic process
|
2,015.92 | 1.39 | 5 | 9 |
alpha-ketoglutarate reductase activity
|
2,419.10 | 0.56 | 2 | 3 |
taurine metabolic process
|
290.29 | 0.53 | 2 | 25 |
threonine metabolic process
|
213.45 | 0.52 | 2 | 34 |
L-serine metabolic process
|
148.11 | 0.50 | 2 | 49 |
glycine metabolic process
|
145.15 | 0.50 | 2 | 50 |
G1 to G0 transition
|
136.93 | 0.49 | 2 | 53 |
glial cell development
|
113.40 | 0.48 | 2 | 64 |
Totals | 521 | 670420 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | 3-phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | glycerate 3-phosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | 3PHP reductase activity |
2020-10-08 | Added | SYNONYM | phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | phosphoglycerate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glycerate-1,3-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | glycerate 3-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-phosphoglycerate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-KG reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | phosphoglycerate dehydrogenase activity |
2002-02-06 | Updated | TERM | phosphoglycerate dehydrogenase |
2001-04-03 | Updated | TERM | phosphoglycerate dehydrogenase |
2001-03-30 | Added | TERM | phosphoglycerate dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | 3-phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Added | SYNONYM | glycerate 3-phosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | 3PHP reductase activity |
2020-10-08 | Added | SYNONYM | phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | phosphoglycerate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glycerate-1,3-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | glycerate 3-phosphate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-phosphoglycerate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-KG reductase activity |
2020-10-08 | Deleted | SYNONYM | PGDH activity |
2020-10-08 | Deleted | SYNONYM | D-3-phosphoglycerate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | 3PHP reductase activity |
2020-10-08 | Deleted | SYNONYM | 3-phosphoglyceric acid dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | 3-phosphoglycerate dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alphaKG reductase activity |
2020-10-08 | Deleted | SYNONYM | SerA 3PG dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | D-3-phosphoglycerate:NAD+ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-phosphoglycerate:NAD+ 2-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | D-3-phosphoglycerate:NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | D-3-phosphoglycerate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | glycerate-1,3-phosphate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | SerA 3PG dehydrogenase activity |
2020-10-08 | Added | SYNONYM | PGDH activity |
2020-10-08 | Added | SYNONYM | 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 3-phosphoglycerate:NAD+ 2-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 3-phosphoglycerate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | alpha-KG reductase activity |
2020-10-08 | Added | SYNONYM | phosphoglycerate oxidoreductase activity |
2020-10-08 | Added | SYNONYM | alpha-phosphoglycerate dehydrogenase activity |
2020-10-08 | Added | SYNONYM | alphaKG reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
2007-11-08 | Added | SYNONYM | D-3-phosphoglycerate:NAD+ oxidoreductase activity |
2007-11-08 | Added | SYNONYM | 3-phosphoglycerate:NAD+ 2-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | D- and L-HGA |
2007-11-08 | Added | SYNONYM | SerA |
2007-11-08 | Added | SYNONYM | SerA 3PG dehydrogenase activity |
2007-11-08 | Added | SYNONYM | alphaKG reductase activity |
2007-09-06 | Added | SYNONYM | alpha-KG reductase activity |
2007-09-06 | Added | SYNONYM | glycerate-1,3-phosphate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | phosphoglycerate oxidoreductase activity |
2007-09-06 | Added | SYNONYM | phosphoglyceric acid dehydrogenase activity |
2007-09-06 | Added | SYNONYM | alpha-phosphoglycerate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | D-3-phosphoglycerate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | PGDH activity |
2007-09-06 | Added | SYNONYM | 3-phosphoglycerate dehydrogenase activity |
2007-09-06 | Added | SYNONYM | 3-phosphoglyceric acid dehydrogenase activity |
2007-09-06 | Added | SYNONYM | 3PHP reductase activity |
2007-09-06 | Added | SYNONYM | glycerate 3-phosphate dehydrogenase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-977348 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-977348 |
2018-12-11 | Added | XREF | reactome:R-HSA-977348 |
2018-07-13 | Deleted | XREF | RHEA:12644 |
2018-07-13 | Added | XREF | RHEA:12641 |
2012-09-14 | Added | XREF | RHEA:12644 |
2003-10-27 | Added | XREF | MetaCyc:PGLYCDEHYDROG-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.95 |
Timestamp | Action | Category | Detail |
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