This term is obsolete.

GO:0004617 JSON

phosphoglycerate dehydrogenase activity

Molecular Function

Definition (GO:0004617 GONUTS page)

Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

37,781 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
3-phosphoglycerate dehydrogenase activity related
PGDH activity related
3PHP reductase activity related
alpha-KG reductase activity related
D- and L-HGA related
glycerate-1,3-phosphate dehydrogenase activity related
alphaKG reductase activity related
SerA 3PG dehydrogenase activity related
SerA related
phosphoglyceric acid dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0004617
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.95
InterPro IPR006236 D-3-phosphoglycerate dehydrogenase
MetaCyc PGLYCDEHYDROG-RXN
RHEA 12641
Reactome R-HSA-977348

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:18110 3-phosphonatooxypyruvate(3-)
has_participant CHEBI CHEBI:58272 3-phosphonato-D-glycerate(3-)
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57540 NAD(1-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004617 based on ALL annotations
The top 100 of 203 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoglycerate dehydrogenase activity
5,181.37 100.00 37,623 37,623
L-serine biosynthetic process
1,170.35 19.79 23,148 102,481
oxidoreductase activity, acting on CH-OH group of donors
319.32 5.85 20,059 325,478
NAD binding
163.44 3.15 36,650 1,161,857
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
70.71 1.34 15,508 1,136,450
chloroplast stroma
68.20 0.90 1,051 79,851
hydroxypyruvate reductase [NAD(P)H] activity
59.72 0.70 669 58,048
glyoxylate reductase (NADPH) activity
57.00 0.69 675 61,354
oxidoreductase activity
15.82 0.31 36,353 11,906,003
carboxylic acid metabolic process
16.24 0.29 1,266 403,849
Totals 178524 88797821
No co-occurrence statistics for GO:0004617 based on MANUAL annotations
The top 58 of 58 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoglycerate dehydrogenase activity
3,628.65 100.00 356 356
chloroplast stroma
110.23 2.73 75 2,469
serine family amino acid biosynthetic process
2,015.92 1.39 5 9
alpha-ketoglutarate reductase activity
2,419.10 0.56 2 3
taurine metabolic process
290.29 0.53 2 25
threonine metabolic process
213.45 0.52 2 34
L-serine metabolic process
148.11 0.50 2 49
glycine metabolic process
145.15 0.50 2 50
G1 to G0 transition
136.93 0.49 2 53
glial cell development
113.40 0.48 2 64
Totals 521 670420

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM 3-phosphoglyceric acid dehydrogenase activity
2020-10-08 Added SYNONYM glycerate 3-phosphate dehydrogenase activity
2020-10-08 Added SYNONYM 3PHP reductase activity
2020-10-08 Added SYNONYM phosphoglyceric acid dehydrogenase activity
2020-10-08 Deleted SYNONYM phosphoglyceric acid dehydrogenase activity
2020-10-08 Deleted SYNONYM phosphoglycerate oxidoreductase activity
2020-10-08 Deleted SYNONYM glycerate-1,3-phosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM glycerate 3-phosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-phosphoglycerate dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-KG reductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM phosphoglycerate dehydrogenase activity
2002-02-06 Updated TERM phosphoglycerate dehydrogenase
2001-04-03 Updated TERM phosphoglycerate dehydrogenase
2001-03-30 Added TERM phosphoglycerate dehydrogenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM 3-phosphoglyceric acid dehydrogenase activity
2020-10-08 Added SYNONYM glycerate 3-phosphate dehydrogenase activity
2020-10-08 Added SYNONYM 3PHP reductase activity
2020-10-08 Added SYNONYM phosphoglyceric acid dehydrogenase activity
2020-10-08 Deleted SYNONYM phosphoglyceric acid dehydrogenase activity
2020-10-08 Deleted SYNONYM phosphoglycerate oxidoreductase activity
2020-10-08 Deleted SYNONYM glycerate-1,3-phosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM glycerate 3-phosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-phosphoglycerate dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-KG reductase activity
2020-10-08 Deleted SYNONYM PGDH activity
2020-10-08 Deleted SYNONYM D-3-phosphoglycerate dehydrogenase activity
2020-10-08 Deleted SYNONYM 3PHP reductase activity
2020-10-08 Deleted SYNONYM 3-phosphoglyceric acid dehydrogenase activity
2020-10-08 Deleted SYNONYM 3-phosphoglycerate dehydrogenase activity
2020-10-08 Deleted SYNONYM alphaKG reductase activity
2020-10-08 Deleted SYNONYM SerA 3PG dehydrogenase activity
2020-10-08 Deleted SYNONYM D-3-phosphoglycerate:NAD+ oxidoreductase activity
2020-10-08 Deleted SYNONYM 3-phosphoglycerate:NAD+ 2-oxidoreductase activity
2020-10-08 Deleted SYNONYM 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
2020-10-08 Added SYNONYM D-3-phosphoglycerate:NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM D-3-phosphoglycerate dehydrogenase activity
2020-10-08 Added SYNONYM glycerate-1,3-phosphate dehydrogenase activity
2020-10-08 Added SYNONYM SerA 3PG dehydrogenase activity
2020-10-08 Added SYNONYM PGDH activity
2020-10-08 Added SYNONYM 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
2020-10-08 Added SYNONYM 3-phosphoglycerate:NAD+ 2-oxidoreductase activity
2020-10-08 Added SYNONYM 3-phosphoglycerate dehydrogenase activity
2020-10-08 Added SYNONYM alpha-KG reductase activity
2020-10-08 Added SYNONYM phosphoglycerate oxidoreductase activity
2020-10-08 Added SYNONYM alpha-phosphoglycerate dehydrogenase activity
2020-10-08 Added SYNONYM alphaKG reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
2007-11-08 Added SYNONYM D-3-phosphoglycerate:NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM 3-phosphoglycerate:NAD+ 2-oxidoreductase activity
2007-11-08 Added SYNONYM 3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity
2007-11-08 Added SYNONYM D- and L-HGA
2007-11-08 Added SYNONYM SerA
2007-11-08 Added SYNONYM SerA 3PG dehydrogenase activity
2007-11-08 Added SYNONYM alphaKG reductase activity
2007-09-06 Added SYNONYM alpha-KG reductase activity
2007-09-06 Added SYNONYM glycerate-1,3-phosphate dehydrogenase activity
2007-09-06 Added SYNONYM phosphoglycerate oxidoreductase activity
2007-09-06 Added SYNONYM phosphoglyceric acid dehydrogenase activity
2007-09-06 Added SYNONYM alpha-phosphoglycerate dehydrogenase activity
2007-09-06 Added SYNONYM D-3-phosphoglycerate dehydrogenase activity
2007-09-06 Added SYNONYM PGDH activity
2007-09-06 Added SYNONYM 3-phosphoglycerate dehydrogenase activity
2007-09-06 Added SYNONYM 3-phosphoglyceric acid dehydrogenase activity
2007-09-06 Added SYNONYM 3PHP reductase activity
2007-09-06 Added SYNONYM glycerate 3-phosphate dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-977348
2019-04-01 Deleted XREF reactome:R-HSA-977348
2018-12-11 Added XREF reactome:R-HSA-977348
2018-07-13 Deleted XREF RHEA:12644
2018-07-13 Added XREF RHEA:12641
2012-09-14 Added XREF RHEA:12644
2003-10-27 Added XREF MetaCyc:PGLYCDEHYDROG-RXN
2001-03-30 Added XREF EC:1.1.1.95
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.