GO:0004620
JSON
phospholipase activity
Molecular Function
Definition (GO:0004620 GONUTS page)
Catalysis of the hydrolysis of a glycerophospholipid.
Ancestor Chart
Ancestor chart for GO:0004620
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004620
Child Term | Relationship to GO:0004620 |
---|---|
phosphatidylserine 1-acylhydrolase activity
|
is_a |
negative regulation of phospholipase activity
|
negatively_regulates |
phospholipase C activity
|
is_a |
cardiolipin hydrolase activity
|
is_a |
positive regulation of phospholipase activity
|
positively_regulates |
sphingomyelin phosphodiesterase activity
|
is_a |
sphingomyelin phosphodiesterase D activity
|
is_a |
phospholipase activator activity
|
positively_regulates |
phospholipase D activity
|
is_a |
phosphatidyl phospholipase B activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A078GW30 | 3708 | A0A078GW30_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078IN56 | 3708 | A0A078IN56_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078IW16 | 3708 | A0A078IW16_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A078J580 | 3708 | A0A078J580_BRANA | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A6JGS1 | 10116 | A6JGS1_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B2RYW5 | 10116 | B2RYW5_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZFS7 | 10116 | D3ZFS7_RAT | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | M4DD04 | 3711 | M4DD04_BRACM | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | M4EQ40 | 3711 | M4EQ40_BRACM | GO:0016298 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002642 | Lysophospholipase, catalytic domain |
InterPro | IPR003187 | Phospholipase A1 |
InterPro | IPR007000 | Phospholipase B-like |
InterPro | IPR016674 | Sphingomyelinase D/Phospholipase D |
InterPro | IPR036541 | Phospholipase A1 superfamily |
InterPro | IPR038885 | Phospholipase B1, membrane-associated |
InterPro | IPR045217 | Patatin-like phospholipase domain containing protein 8-like |
Reactome | R-HSA-6786650 | |
Reactome | R-HSA-6792445 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004620 based on ALL annotations
The top 100 of 1,011 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phospholipase activity
|
2,759.02 | 100.00 | 70,655 | 70,655 |
phospholipase A2 activity
|
854.47 | 15.21 | 16,255 | 52,486 |
phospholipid catabolic process
|
768.78 | 15.01 | 17,348 | 62,259 |
glycerophospholipid catabolic process
|
1,332.67 | 14.46 | 12,091 | 25,032 |
calcium-dependent phospholipase A2 activity
|
1,541.17 | 13.31 | 10,506 | 18,808 |
sphingomyelin phosphodiesterase activity
|
1,798.58 | 13.09 | 9,942 | 15,251 |
phospholipase A1 activity
|
1,000.95 | 9.28 | 7,829 | 21,580 |
lipid catabolic process
|
273.25 | 9.28 | 41,956 | 423,639 |
calcium-independent phospholipase A2 activity
|
898.78 | 7.77 | 6,537 | 20,067 |
phosphatidylserine 1-acylhydrolase activity
|
2,103.87 | 7.48 | 5,411 | 7,096 |
Totals | 402018 | 28232392 |
No co-occurrence statistics for GO:0004620 based on MANUAL annotations
The top 100 of 330 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phospholipase activity
|
809.40 | 100.00 | 1,596 | 1,596 |
monoacylglycerol lipase activity
|
428.73 | 27.15 | 571 | 1,078 |
sphingolipid catabolic process
|
415.01 | 9.21 | 161 | 314 |
cell periphery
|
96.31 | 5.77 | 161 | 1,353 |
ceramide biosynthetic process
|
84.93 | 5.48 | 164 | 1,563 |
phospholipid catabolic process
|
96.84 | 4.92 | 123 | 1,028 |
phosphatidylserine catabolic process
|
468.60 | 4.01 | 66 | 114 |
monoacylglycerol catabolic process
|
375.27 | 3.08 | 51 | 110 |
phospholipid metabolic process
|
58.04 | 2.41 | 56 | 781 |
lipid catabolic process
|
57.45 | 1.67 | 34 | 479 |
Totals | 4228 | 169953 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-04 | Deleted | XREF | EC:3.1.1.- |
2021-01-04 | Added | XREF | EC:3.1.1.- |
2021-01-04 | Deleted | XREF | EC:3.1.1 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6786650 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6792445 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6792445 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6786650 |
2018-12-11 | Added | XREF | reactome:R-HSA-6792445 |
2018-12-11 | Added | XREF | reactome:R-HSA-6786650 |
2016-10-03 | Added | XREF | EC:3.1.1 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | phospholipase activity |
2002-02-06 | Updated | TERM | phospholipase |
2001-04-03 | Updated | TERM | phospholipase |
2001-03-30 | Added | TERM | phospholipase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of a glycerophospholipid. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of a glycerophospholipid. |
2003-08-05 | Updated | DEFINITION | Catalysis of the hydrolysis of a glycerophospholipid. |
2002-11-27 | Added | DEFINITION | Any enzymatic activity that is a lipase and catalyzes the hydrolysis of a glycerophospholipid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016298 (lipase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-04 | Deleted | XREF | EC:3.1.1.- |
2021-01-04 | Added | XREF | EC:3.1.1.- |
2021-01-04 | Deleted | XREF | EC:3.1.1 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6786650 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6792445 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6792445 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6786650 |
2018-12-11 | Added | XREF | reactome:R-HSA-6792445 |
2018-12-11 | Added | XREF | reactome:R-HSA-6786650 |
2016-10-03 | Added | XREF | EC:3.1.1 |
2016-10-03 | Deleted | XREF | EC:3.1.1.- |
2002-03-27 | Added | XREF | EC:3.1.1.- |
2002-03-25 | Deleted | XREF | EC:3.1.1.- |
2001-03-30 | Added | XREF | EC:3.1.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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