This term is obsolete.

GO:0004620 JSON

phospholipase activity

Molecular Function

Definition (GO:0004620 GONUTS page)

Catalysis of the hydrolysis of a glycerophospholipid.

397,917 annotations

Ancestor Chart

Ancestor chart for GO:0004620
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004620

Child Term Relationship to
GO:0004620
phosphatidylserine 1-acylhydrolase activity
is_a
negative regulation of phospholipase activity
negatively_regulates
phospholipase C activity
is_a
cardiolipin hydrolase activity
is_a
positive regulation of phospholipase activity
positively_regulates
sphingomyelin phosphodiesterase activity
is_a
sphingomyelin phosphodiesterase D activity
is_a
phospholipase activator activity
positively_regulates
phospholipase D activity
is_a
phosphatidyl phospholipase B activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A078GW30 3708 A0A078GW30_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078IN56 3708 A0A078IN56_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078IW16 3708 A0A078IW16_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A078J580 3708 A0A078J580_BRANA GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A6JGS1 10116 A6JGS1_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B2RYW5 10116 B2RYW5_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZFS7 10116 D3ZFS7_RAT GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein M4DD04 3711 M4DD04_BRACM GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein M4EQ40 3711 M4EQ40_BRACM GO:0016298 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR002642 Lysophospholipase, catalytic domain
InterPro IPR003187 Phospholipase A1
InterPro IPR007000 Phospholipase B-like
InterPro IPR016674 Sphingomyelinase D/Phospholipase D
InterPro IPR036541 Phospholipase A1 superfamily
InterPro IPR038885 Phospholipase B1, membrane-associated
InterPro IPR045217 Patatin-like phospholipase domain containing protein 8-like
Reactome R-HSA-6786650
Reactome R-HSA-6792445

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004620 based on ALL annotations
The top 100 of 1,011 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phospholipase activity
2,759.02 100.00 70,655 70,655
phospholipase A2 activity
854.47 15.21 16,255 52,486
phospholipid catabolic process
768.78 15.01 17,348 62,259
glycerophospholipid catabolic process
1,332.67 14.46 12,091 25,032
calcium-dependent phospholipase A2 activity
1,541.17 13.31 10,506 18,808
sphingomyelin phosphodiesterase activity
1,798.58 13.09 9,942 15,251
phospholipase A1 activity
1,000.95 9.28 7,829 21,580
lipid catabolic process
273.25 9.28 41,956 423,639
calcium-independent phospholipase A2 activity
898.78 7.77 6,537 20,067
phosphatidylserine 1-acylhydrolase activity
2,103.87 7.48 5,411 7,096
Totals 402018 28232392
No co-occurrence statistics for GO:0004620 based on MANUAL annotations
The top 100 of 330 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phospholipase activity
809.40 100.00 1,596 1,596
monoacylglycerol lipase activity
428.73 27.15 571 1,078
sphingolipid catabolic process
415.01 9.21 161 314
cell periphery
96.31 5.77 161 1,353
ceramide biosynthetic process
84.93 5.48 164 1,563
phospholipid catabolic process
96.84 4.92 123 1,028
phosphatidylserine catabolic process
468.60 4.01 66 114
monoacylglycerol catabolic process
375.27 3.08 51 110
phospholipid metabolic process
58.04 2.41 56 781
lipid catabolic process
57.45 1.67 34 479
Totals 4228 169953

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2022-09-04 Deleted XREF EC:3.1.1.-
2021-01-04 Added XREF EC:3.1.1.-
2021-01-04 Deleted XREF EC:3.1.1
2019-04-01 Added XREF Reactome:R-HSA-6786650
2019-04-01 Added XREF Reactome:R-HSA-6792445
2019-04-01 Deleted XREF reactome:R-HSA-6792445
2019-04-01 Deleted XREF reactome:R-HSA-6786650
2018-12-11 Added XREF reactome:R-HSA-6792445
2018-12-11 Added XREF reactome:R-HSA-6786650
2016-10-03 Added XREF EC:3.1.1
Timestamp Action Category Detail
2003-03-19 Updated TERM phospholipase activity
2002-02-06 Updated TERM phospholipase
2001-04-03 Updated TERM phospholipase
2001-03-30 Added TERM phospholipase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of a glycerophospholipid.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of a glycerophospholipid.
2003-08-05 Updated DEFINITION Catalysis of the hydrolysis of a glycerophospholipid.
2002-11-27 Added DEFINITION Any enzymatic activity that is a lipase and catalyzes the hydrolysis of a glycerophospholipid.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016298 (lipase activity)
Timestamp Action Category Detail
2022-09-04 Deleted XREF EC:3.1.1.-
2021-01-04 Added XREF EC:3.1.1.-
2021-01-04 Deleted XREF EC:3.1.1
2019-04-01 Added XREF Reactome:R-HSA-6786650
2019-04-01 Added XREF Reactome:R-HSA-6792445
2019-04-01 Deleted XREF reactome:R-HSA-6792445
2019-04-01 Deleted XREF reactome:R-HSA-6786650
2018-12-11 Added XREF reactome:R-HSA-6792445
2018-12-11 Added XREF reactome:R-HSA-6786650
2016-10-03 Added XREF EC:3.1.1
2016-10-03 Deleted XREF EC:3.1.1.-
2002-03-27 Added XREF EC:3.1.1.-
2002-03-25 Deleted XREF EC:3.1.1.-
2001-03-30 Added XREF EC:3.1.1.-
Timestamp Action Category Detail
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
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