The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.
GO:0004660
JSON
protein farnesyltransferase activity
Molecular Function
Definition (GO:0004660 GONUTS page)
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. PMID:8621375
Comments
The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.
Secondary IDs
GO:0018223
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
FTase activity | related |
farnesyl-diphosphate:protein-cysteine farnesyltransferase activity | related |
protein-cysteine farnesyltransferase activity | exact |
CAAX farnesyltransferase activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004660
Child Term | Relationship to GO:0004660 |
---|---|
protein farnesyltransferase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.5.1.58 | |
MetaCyc | RXN-17573 | |
RHEA | 13345 | |
Reactome | R-HSA-2530501 | |
Reactome | R-HSA-9647978 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:175763 | 2-trans,6-trans-farnesyl diphosphate(3-) |
has_participant | CHEBI | CHEBI:86019 | S-[(2E,6E)-farnesyl]-L-cysteine residue |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004660 based on ALL annotations
The top 100 of 189 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein farnesyltransferase activity
|
21,476.13 | 100.00 | 9,077 | 9,077 |
protein farnesyltransferase complex
|
21,435.79 | 99.34 | 9,034 | 9,051 |
protein prenyltransferase activity
|
10,123.35 | 46.95 | 9,000 | 19,093 |
CAAX-protein geranylgeranyltransferase complex
|
12,064.98 | 36.43 | 4,619 | 8,222 |
CAAX-protein geranylgeranyltransferase activity
|
12,077.54 | 36.41 | 4,612 | 8,201 |
prenylation
|
10,001.80 | 25.85 | 3,335 | 7,161 |
prenyltransferase activity
|
753.09 | 3.50 | 8,931 | 254,687 |
peptide pheromone maturation
|
14,142.81 | 2.64 | 243 | 369 |
protein geranylgeranyltransferase activity
|
1,194.10 | 1.62 | 203 | 3,651 |
positive regulation of tubulin deacetylation
|
19,642.80 | 0.83 | 75 | 82 |
Totals | 61553 | 58605228 |
No co-occurrence statistics for GO:0004660 based on MANUAL annotations
The top 63 of 63 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein farnesyltransferase activity
|
4,784.44 | 100.00 | 270 | 270 |
protein farnesyltransferase complex
|
4,784.44 | 98.89 | 267 | 267 |
peptide pheromone maturation
|
4,144.66 | 50.85 | 149 | 172 |
CAAX-protein geranylgeranyltransferase complex
|
2,975.69 | 42.15 | 153 | 246 |
CAAX-protein geranylgeranyltransferase activity
|
2,874.52 | 40.38 | 149 | 248 |
negative regulation of abscisic acid-activated signaling pathway
|
1,215.51 | 11.52 | 47 | 185 |
protein farnesylation
|
4,186.39 | 7.69 | 21 | 24 |
protein geranylgeranyltransferase activity
|
2,923.82 | 3.97 | 11 | 18 |
protein geranylgeranylation
|
1,087.37 | 3.29 | 10 | 44 |
protein prenylation
|
1,275.85 | 1.42 | 4 | 15 |
Totals | 1341 | 557847 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:RXN-17573 |
2023-08-11 | Deleted | XREF | MetaCyc:2.5.1.58-RXN |
2020-10-08 | Deleted | SYNONYM | farnesyl-diphosphate:protein-cysteine farnesyltransferase activity |
2020-10-08 | Deleted | SYNONYM | FTase activity |
2020-10-08 | Added | SYNONYM | farnesyl-diphosphate:protein-cysteine farnesyltransferase activity |
2020-10-08 | Added | SYNONYM | FTase activity |
2020-07-19 | Added | XREF | Reactome:R-HSA-9647978 |
2020-06-22 | Added | XREF | RHEA:13345 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2530501 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2530501 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | protein farnesyltransferase activity |
2002-02-06 | Updated | TERM | protein farnesyltransferase |
2001-04-03 | Updated | TERM | protein farnesyltransferase |
2001-03-30 | Added | TERM | protein farnesyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | farnesyl-diphosphate:protein-cysteine farnesyltransferase activity |
2020-10-08 | Deleted | SYNONYM | FTase activity |
2020-10-08 | Added | SYNONYM | farnesyl-diphosphate:protein-cysteine farnesyltransferase activity |
2020-10-08 | Added | SYNONYM | FTase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
2007-11-08 | Added | SYNONYM | farnesyl-diphosphate:protein-cysteine farnesyltransferase activity |
2007-09-06 | Added | SYNONYM | CAAX farnesyltransferase activity |
2007-09-06 | Added | SYNONYM | FTase activity |
2007-08-09 | Deleted | SYNONYM | protein-cysteine farnesyltransferase activity |
2007-08-09 | Added | SYNONYM | protein-cysteine farnesyltransferase activity |
2005-08-27 | Updated | DEFINITION | Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
2004-09-10 | Added | SYNONYM | protein-cysteine farnesyltransferase activity |
2004-09-08 | Added | DEFINITION | Catalysis of the covalent addition of a farnesyl (15-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008318 (protein prenyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:RXN-17573 |
2023-08-11 | Deleted | XREF | MetaCyc:2.5.1.58-RXN |
2020-07-19 | Added | XREF | Reactome:R-HSA-9647978 |
2020-06-22 | Added | XREF | RHEA:13345 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2530501 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2530501 |
2018-12-11 | Added | XREF | reactome:R-HSA-2530501 |
2009-05-21 | Added | XREF | MetaCyc:2.5.1.58-RXN |
2005-08-29 | Deleted | XREF | EC:2.5.1.- |
2005-08-29 | Added | XREF | EC:2.5.1.58 |
2001-03-30 | Added | XREF | EC:2.5.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-09-10 | Added | SECONDARY | GO:0018223 (protein-cysteine farnesyltransferase activity) |
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