This term is obsolete.
The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.

GO:0004660 JSON

protein farnesyltransferase activity

Molecular Function

Definition (GO:0004660 GONUTS page)

Catalysis of the reaction: L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate. PMID:8621375

Comments

The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.

Secondary IDs

GO:0018223

9,637 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
farnesyl-diphosphate:protein-cysteine farnesyltransferase activity related
FTase activity related
protein-cysteine farnesyltransferase activity exact
CAAX farnesyltransferase activity narrow

Ancestor Chart

Ancestor chart for GO:0004660
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004660

Child Term Relationship to
GO:0004660
protein farnesyltransferase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.5.1.58
MetaCyc RXN-17573
RHEA 13345
Reactome R-HSA-2530501
Reactome R-HSA-9647978

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:175763 2-trans,6-trans-farnesyl diphosphate(3-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:86019 S-[(2E,6E)-farnesyl]-L-cysteine residue

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004660 based on ALL annotations
The top 100 of 179 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein farnesyltransferase activity
20,964.33 100.00 9,452 9,452
protein farnesyltransferase complex
20,926.51 99.35 9,407 9,424
protein prenyltransferase activity
9,938.12 47.21 9,371 19,768
CAAX-protein geranylgeranyltransferase complex
11,840.18 36.78 4,852 8,591
CAAX-protein geranylgeranyltransferase activity
11,848.98 36.77 4,846 8,574
prenylation
9,654.77 25.59 3,454 7,500
prenyltransferase activity
723.66 3.45 9,307 269,624
peptide pheromone maturation
13,957.69 2.62 251 377
protein geranylgeranyltransferase activity
1,145.25 1.57 203 3,716
negative regulation of abscisic acid-activated signaling pathway
303.94 0.54 80 5,518
Totals 64066 60136879
No co-occurrence statistics for GO:0004660 based on MANUAL annotations
The top 58 of 58 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein farnesyltransferase activity
4,901.16 100.00 288 288
protein farnesyltransferase complex
4,901.16 98.61 284 284
peptide pheromone maturation
4,274.90 50.48 157 180
CAAX-protein geranylgeranyltransferase complex
3,058.47 41.82 161 258
CAAX-protein geranylgeranyltransferase activity
2,948.21 40.05 157 261
negative regulation of abscisic acid-activated signaling pathway
1,274.30 11.93 52 200
protein farnesylation
4,288.51 7.22 21 24
protein geranylgeranyltransferase activity
2,995.15 3.73 11 18
protein geranylgeranylation
1,113.90 3.11 10 44
protein prenylation
1,306.98 1.34 4 15
Totals 1408 585080

Change Log

Timestamp Action Category Detail
2024-12-03 Added DEFINITION Catalysis of the reaction: L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.
2024-12-03 Deleted DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2023-08-11 Added XREF MetaCyc:RXN-17573
2023-08-11 Deleted XREF MetaCyc:2.5.1.58-RXN
2020-10-08 Added SYNONYM FTase activity
2020-10-08 Added SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2020-10-08 Deleted SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2020-10-08 Deleted SYNONYM FTase activity
2020-07-19 Added XREF Reactome:R-HSA-9647978
2020-06-22 Added XREF RHEA:13345
Timestamp Action Category Detail
2003-03-19 Updated TERM protein farnesyltransferase activity
2002-02-06 Updated TERM protein farnesyltransferase
2001-04-03 Updated TERM protein farnesyltransferase
2001-03-30 Added TERM protein farnesyltransferase
Timestamp Action Category Detail
2024-12-03 Added DEFINITION Catalysis of the reaction: L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.
2024-12-03 Deleted DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2020-10-08 Added SYNONYM FTase activity
2020-10-08 Added SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2020-10-08 Deleted SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2020-10-08 Deleted SYNONYM FTase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2007-11-08 Added SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2007-09-06 Added SYNONYM CAAX farnesyltransferase activity
2007-09-06 Added SYNONYM FTase activity
2007-08-09 Added SYNONYM protein-cysteine farnesyltransferase activity
2007-08-09 Deleted SYNONYM protein-cysteine farnesyltransferase activity
2005-08-27 Updated DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2004-09-10 Added SYNONYM protein-cysteine farnesyltransferase activity
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a farnesyl (15-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008318 (protein prenyltransferase activity)
Timestamp Action Category Detail
2023-08-11 Added XREF MetaCyc:RXN-17573
2023-08-11 Deleted XREF MetaCyc:2.5.1.58-RXN
2020-07-19 Added XREF Reactome:R-HSA-9647978
2020-06-22 Added XREF RHEA:13345
2019-04-01 Added XREF Reactome:R-HSA-2530501
2019-04-01 Deleted XREF reactome:R-HSA-2530501
2018-12-11 Added XREF reactome:R-HSA-2530501
2009-05-21 Added XREF MetaCyc:2.5.1.58-RXN
2005-08-29 Added XREF EC:2.5.1.58
2005-08-29 Deleted XREF EC:2.5.1.-
2001-03-30 Added XREF EC:2.5.1.-
Timestamp Action Category Detail
2004-09-10 Added SECONDARY GO:0018223 (protein-cysteine farnesyltransferase activity)
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