This term is obsolete.

GO:0004661 JSON

protein geranylgeranyltransferase activity

Molecular Function

Definition (GO:0004661 GONUTS page)

Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. PMID:8621375

Secondary IDs

GO:0018224

22,000 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein-cysteine geranylgeranyltransferase activity exact

Ancestor Chart

Ancestor chart for GO:0004661
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004661

Child Term Relationship to
GO:0004661
CAAX-protein geranylgeranyltransferase activity
is_a
Rab geranylgeranyltransferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR041960 Geranylgeranyl transferase type-1 subunit beta
RHEA 21240

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57533 geranylgeranyl diphosphate(3-)
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:86021 S-geranylgeranyl-L-cysteine residue
has_participant CHEBI CHEBI:33019 diphosphate(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004661 based on ALL annotations
The top 100 of 120 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein geranylgeranyltransferase activity
53,324.77 100.00 3,716 3,716
CAAX-protein geranylgeranyltransferase complex
11,818.23 18.30 1,904 8,591
CAAX-protein geranylgeranyltransferase activity
11,630.20 17.95 1,870 8,574
Rab geranylgeranyltransferase activity
10,637.49 16.63 1,859 9,319
Rab-protein geranylgeranyltransferase complex
7,033.08 11.58 1,811 13,731
peptide pheromone maturation
16,266.18 2.89 115 377
protein farnesyltransferase activity
1,145.25 1.57 203 9,452
protein farnesyltransferase complex
1,143.00 1.56 202 9,424
prenyltransferase activity
727.81 1.36 3,680 269,624
positive regulation of skeletal muscle acetylcholine-gated channel clustering
5,252.55 1.11 46 467
Totals 19007 96943682
No co-occurrence statistics for GO:0004661 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein geranylgeranyltransferase activity
78,418.50 100.00 18 18
protein farnesylation
35,941.81 35.48 11 24
protein geranylgeranylation
28,515.82 34.78 16 44
CAAX-protein geranylgeranyltransferase complex
4,863.16 6.15 16 258
protein prenyltransferase activity
78,418.50 5.56 1 1
CAAX-protein geranylgeranyltransferase activity
3,905.90 4.89 13 261
positive regulation of skeletal muscle acetylcholine-gated channel clustering
5,059.26 4.26 2 31
protein farnesyltransferase activity
2,995.15 3.73 11 288
peptide pheromone maturation
3,049.61 3.66 7 180
protein farnesyltransferase complex
2,761.22 3.42 10 284
Totals 175 585964

Change Log

Timestamp Action Category Detail
2024-01-30 Added XREF RHEA:21240
2019-06-29 Deleted XREF EC:2.5.1
2016-10-03 Deleted XREF EC:2.5.1.-
2016-10-03 Added XREF EC:2.5.1
2008-05-13 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
2008-05-12 Deleted DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
2008-04-01 Updated RELATION is a GO:0008318 (protein prenyltransferase activity)
2007-08-09 Deleted SYNONYM protein-cysteine geranylgeranyltransferase activity
2007-08-09 Added SYNONYM protein-cysteine geranylgeranyltransferase activity
2004-09-10 Added SYNONYM protein-cysteine geranylgeranyltransferase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM protein geranylgeranyltransferase activity
2002-02-06 Updated TERM protein geranylgeranyltransferase
2001-04-03 Updated TERM protein geranylgeranyltransferase
2001-03-30 Added TERM protein geranylgeranyltransferase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
2008-05-12 Deleted DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
2007-08-09 Deleted SYNONYM protein-cysteine geranylgeranyltransferase activity
2007-08-09 Added SYNONYM protein-cysteine geranylgeranyltransferase activity
2004-09-10 Added SYNONYM protein-cysteine geranylgeranyltransferase activity
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008318 (protein prenyltransferase activity)
Timestamp Action Category Detail
2024-01-30 Added XREF RHEA:21240
2019-06-29 Deleted XREF EC:2.5.1
2016-10-03 Deleted XREF EC:2.5.1.-
2016-10-03 Added XREF EC:2.5.1
2001-03-30 Added XREF EC:2.5.1.-
Timestamp Action Category Detail
2004-09-10 Added SECONDARY GO:0018224 (protein-cysteine geranylgeranyltransferase activity)
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