GO:0004661
JSON
protein geranylgeranyltransferase activity
Molecular Function
Definition (GO:0004661 GONUTS page)
Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. PMID:8621375
Secondary IDs
GO:0018224
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein-cysteine geranylgeranyltransferase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004661
Child Term | Relationship to GO:0004661 |
---|---|
CAAX-protein geranylgeranyltransferase activity
|
is_a |
Rab geranylgeranyltransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR041960 | Geranylgeranyl transferase type-1 subunit beta |
RHEA | 21240 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57533 | geranylgeranyl diphosphate(3-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:86021 | S-geranylgeranyl-L-cysteine residue |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004661 based on ALL annotations
The top 100 of 123 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein geranylgeranyltransferase activity
|
53,393.26 | 100.00 | 3,651 | 3,651 |
CAAX-protein geranylgeranyltransferase complex
|
11,857.95 | 18.17 | 1,826 | 8,222 |
CAAX-protein geranylgeranyltransferase activity
|
11,660.45 | 17.80 | 1,791 | 8,201 |
Rab geranylgeranyltransferase activity
|
11,102.10 | 17.36 | 1,872 | 9,003 |
Rab-protein geranylgeranyltransferase complex
|
7,366.82 | 12.12 | 1,824 | 13,220 |
peptide pheromone maturation
|
16,495.48 | 2.92 | 114 | 369 |
positive regulation of tubulin deacetylation
|
48,835.30 | 2.05 | 75 | 82 |
protein farnesyltransferase activity
|
1,194.10 | 1.62 | 203 | 9,077 |
protein farnesyltransferase complex
|
1,191.63 | 1.62 | 202 | 9,051 |
prenyltransferase activity
|
758.49 | 1.42 | 3,618 | 254,687 |
Totals | 18818 | 84283219 |
No co-occurrence statistics for GO:0004661 based on MANUAL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein geranylgeranyltransferase activity
|
71,766.61 | 100.00 | 18 | 18 |
protein farnesylation
|
32,893.03 | 35.48 | 11 | 24 |
protein geranylgeranylation
|
26,096.95 | 34.78 | 16 | 44 |
positive regulation of tubulin deacetylation
|
20,504.75 | 8.70 | 2 | 7 |
obsolete negative regulation of nitric-oxide synthase biosynthetic process
|
14,353.32 | 7.69 | 2 | 10 |
CAAX-protein geranylgeranyltransferase complex
|
4,667.75 | 6.45 | 16 | 246 |
protein prenyltransferase activity
|
71,766.61 | 5.56 | 1 | 1 |
CAAX-protein geranylgeranyltransferase activity
|
3,761.96 | 5.14 | 13 | 248 |
positive regulation of deacetylase activity
|
23,922.21 | 5.00 | 1 | 3 |
positive regulation of skeletal muscle acetylcholine-gated channel clustering
|
4,630.10 | 4.26 | 2 | 31 |
Totals | 182 | 555927 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-01-30 | Added | XREF | RHEA:21240 |
2019-06-29 | Deleted | XREF | EC:2.5.1 |
2016-10-03 | Deleted | XREF | EC:2.5.1.- |
2016-10-03 | Added | XREF | EC:2.5.1 |
2008-05-13 | Added | DEFINITION | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
2008-04-01 | Updated | RELATION | is a GO:0008318 (protein prenyltransferase activity) |
2007-08-09 | Deleted | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
2007-08-09 | Added | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
2004-09-10 | Added | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | protein geranylgeranyltransferase activity |
2002-02-06 | Updated | TERM | protein geranylgeranyltransferase |
2001-04-03 | Updated | TERM | protein geranylgeranyltransferase |
2001-03-30 | Added | TERM | protein geranylgeranyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
2007-08-09 | Deleted | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
2007-08-09 | Added | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
2004-09-10 | Added | SYNONYM | protein-cysteine geranylgeranyltransferase activity |
2004-09-08 | Added | DEFINITION | Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008318 (protein prenyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-01-30 | Added | XREF | RHEA:21240 |
2019-06-29 | Deleted | XREF | EC:2.5.1 |
2016-10-03 | Deleted | XREF | EC:2.5.1.- |
2016-10-03 | Added | XREF | EC:2.5.1 |
2001-03-30 | Added | XREF | EC:2.5.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-09-10 | Added | SECONDARY | GO:0018224 (protein-cysteine geranylgeranyltransferase activity) |
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