This term is obsolete.

GO:0004673 JSON

protein histidine kinase activity

Molecular Function

Definition (GO:0004673 GONUTS page)

Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.

Secondary IDs

GO:0008896

1,510,593 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
histidine protein kinase activity related
protein kinase (histidine) related
ATP:protein-L-histidine N-phosphotransferase activity related
protein-histidine kinase activity exact
histidine kinase activity exact

Ancestor Chart

Ancestor chart for GO:0004673
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004673

Child Term Relationship to
GO:0004673
phosphorelay sensor kinase activity
is_a
protein histidine kinase complex
capable_of
regulation of protein histidine kinase activity
regulates
transmembrane receptor histidine kinase activity
is_a
protein histidine tele-kinase activity
is_a
protein histidine pros-kinase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A0G2QC55 10116 A0A0G2QC55_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A4D6K026 7227 A0A4D6K026_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A0A6M3Q8Y2 7227 A0A6M3Q8Y2_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5ZTU0 10116 A0A8I5ZTU0_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 2.7.13.3
InterPro IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal
InterPro IPR004105 Histidine kinase CheA-like, homodimeric domain
InterPro IPR006290 Heavy metal sensor kinase
InterPro IPR008358 Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB
InterPro IPR010808 Chemotaxis protein CheA, P2 response regulator-binding
InterPro IPR011102 Signal transduction histidine kinase, HWE region
InterPro IPR011620 Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region
InterPro IPR014302 Signal transduction histidine kinase, TMAO sensor TorS
InterPro IPR014310 Signal transduction histidine kinase, phosphate regulon sensor PhoR

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004673 based on ALL annotations
The top 100 of 414 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein histidine kinase activity
5,310.53 100.00 36,708 36,708
cellular hyperosmotic response
2,179.48 8.88 3,738 9,108
cytokinin-activated signaling pathway
863.26 7.80 4,791 29,473
photoreceptor activity
508.93 6.89 7,221 75,349
detection of visible light
309.92 2.26 1,307 22,396
phosphorelay sensor kinase activity
73.65 1.37 20,432 1,473,219
protein-glutamate methylesterase activity
113.31 1.19 968 45,367
circadian rhythm
139.65 1.03 608 23,121
cellular response to phosphate starvation
72.38 1.01 1,382 101,403
nitrogen fixation
62.66 0.86 1,143 96,875
Totals 214838 160873517
No co-occurrence statistics for GO:0004673 based on MANUAL annotations
The top 100 of 163 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein histidine kinase activity
25,329.39 100.00 51 51
transmembrane histidine kinase cytokinin receptor activity
25,329.39 7.84 4 4
cellular hyperosmotic response
2,244.38 7.18 14 158
cytokinin receptor activity
25,329.39 5.88 3 3
secondary growth
18,997.04 5.77 3 4
regulation of meristem development
5,427.73 4.84 3 14
regulation of shoot system development
4,749.26 4.69 3 16
negative regulation of ethylene-activated signaling pathway
4,469.89 4.62 3 17
phosphotransferase activity, carboxyl group as acceptor
25,329.39 3.92 2 2
regulation of chlorophyll catabolic process
12,664.70 3.77 2 4
Totals 261 11229

Change Log

Timestamp Action Category Detail
2022-07-24 Deleted SYNONYM histidine kinase (ambiguous)
2022-07-24 Deleted SYNONYM EnvZ
2022-07-24 Deleted SYNONYM histidine protein kinase (ambiguous)
2022-07-24 Deleted SYNONYM HP165
2022-07-24 Deleted SYNONYM protein kinase (histidine) (ambiguous)
2022-07-24 Deleted SYNONYM Sln1p
2022-07-24 Deleted SYNONYM protein histidine kinase (ambiguous)
2022-07-24 Deleted SYNONYM HK1
2020-10-08 Added SYNONYM protein kinase (histidine)
2020-10-08 Added SYNONYM protein histidine kinase (ambiguous)
Timestamp Action Category Detail
2005-07-25 Updated TERM protein histidine kinase activity
2003-09-09 Updated TERM protein-histidine kinase activity
2003-03-19 Updated TERM protein histidine kinase activity
2002-02-06 Updated TERM protein histidine kinase
2001-04-03 Updated TERM protein histidine kinase
2001-03-30 Added TERM protein histidine kinase
Timestamp Action Category Detail
2022-07-24 Deleted SYNONYM histidine kinase (ambiguous)
2022-07-24 Deleted SYNONYM EnvZ
2022-07-24 Deleted SYNONYM histidine protein kinase (ambiguous)
2022-07-24 Deleted SYNONYM HP165
2022-07-24 Deleted SYNONYM protein kinase (histidine) (ambiguous)
2022-07-24 Deleted SYNONYM Sln1p
2022-07-24 Deleted SYNONYM protein histidine kinase (ambiguous)
2022-07-24 Deleted SYNONYM HK1
2020-10-08 Added SYNONYM protein kinase (histidine)
2020-10-08 Added SYNONYM protein histidine kinase (ambiguous)
2020-10-08 Added SYNONYM histidine protein kinase (ambiguous)
2020-10-08 Added SYNONYM histidine kinase (ambiguous)
2020-10-08 Added SYNONYM ATP:protein-L-histidine N-phosphotransferase activity
2020-10-08 Added SYNONYM protein kinase (histidine) (ambiguous)
2020-10-08 Added SYNONYM histidine protein kinase activity
2020-10-08 Deleted SYNONYM histidine protein kinase (ambiguous)
2020-10-08 Deleted SYNONYM histidine kinase (ambiguous)
2020-10-08 Deleted SYNONYM protein kinase (histidine) (ambiguous)
2020-10-08 Deleted SYNONYM protein histidine kinase (ambiguous)
2020-10-08 Deleted SYNONYM ATP:protein-L-histidine N-phosphotransferase activity
2020-10-08 Deleted SYNONYM protein kinase (histidine)
2020-10-08 Deleted SYNONYM histidine protein kinase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
2007-11-08 Added SYNONYM histidine protein kinase activity
2007-11-08 Added SYNONYM histidine kinase activity
2007-11-08 Added SYNONYM protein kinase (histidine)
2007-11-08 Added SYNONYM ATP:protein-L-histidine N-phosphotransferase activity
2007-11-08 Deleted SYNONYM histidine kinase
2007-09-26 Added SYNONYM EnvZ
2007-09-26 Added SYNONYM histidine kinase (ambiguous)
2007-09-26 Added SYNONYM Sln1p
2007-09-26 Added SYNONYM HP165
2007-09-26 Added SYNONYM protein kinase (histidine) (ambiguous)
2007-09-26 Added SYNONYM histidine protein kinase (ambiguous)
2007-09-26 Added SYNONYM HK1
2007-09-26 Added SYNONYM protein histidine kinase (ambiguous)
2007-08-09 Added SYNONYM histidine kinase
2007-08-09 Deleted SYNONYM protein-histidine kinase activity
2007-08-09 Deleted SYNONYM histidine kinase
2007-08-09 Added SYNONYM protein-histidine kinase activity
2005-07-25 Deleted SYNONYM protein histidine kinase activity
2005-07-25 Added SYNONYM protein-histidine kinase activity
2004-09-23 Added SYNONYM protein histidine kinase activity
2004-09-11 Added DEFINITION Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
2004-04-19 Added SYNONYM histidine kinase
2004-04-16 Deleted SYNONYM histidine kinase
2003-02-28 Added SYNONYM histidine kinase
Timestamp Action Category Detail
2013-12-07 Added RELATION has part GO:0038200 (ethylene receptor histidine kinase activity)
2013-10-10 Added RELATION part of GO:0018106 (peptidyl-histidine phosphorylation)
2008-04-01 Updated RELATION is a GO:0004672 (protein kinase activity)
2008-04-01 Updated RELATION is a GO:0016775 (phosphotransferase activity, nitrogenous group as acceptor)
Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.7.13.3-RXN
2007-09-26 Added XREF EC:2.7.13.3
2007-09-26 Deleted XREF EC:2.7.3.-
2001-03-30 Added XREF EC:2.7.3.-
Timestamp Action Category Detail
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