This term is obsolete.

GO:0004721 JSON

phosphoprotein phosphatase activity

Molecular Function

Definition (GO:0004721 GONUTS page)

Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.

2,115,446 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein phosphatase-2C activity narrow
protein phosphatase activity exact
protein phosphatase-1 activity narrow
phosphoprotein phosphohydrolase activity exact
protein phosphatase-2A activity narrow
protein phosphatase-2B activity narrow

Ancestor Chart

Ancestor chart for GO:0004721
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004721

Child Term Relationship to
GO:0004721
histone phosphatase activity
is_a
[isocitrate dehydrogenase (NADP+)] phosphatase activity
is_a
protein phosphatase regulator activity
regulates
protein serine/threonine phosphatase activity
is_a
protein histidine phosphatase activity
is_a
protein tyrosine/serine/threonine phosphatase activity
is_a
MAP kinase phosphatase activity
is_a
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
is_a
protein tyrosine phosphatase activity
is_a
protein arginine phosphatase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein A0A087QTQ7 9233 A0A087QTQ7_APTFO GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A087VMI5 100784 A0A087VMI5_BALRE GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091CMN8 885580 A0A091CMN8_FUKDA GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091HHI2 9244 A0A091HHI2_CALAN GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091JLW6 188379 A0A091JLW6_EGRGA GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091L9X5 187382 A0A091L9X5_9AVES GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091P439 57397 A0A091P439_APAVI GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091SAD7 54374 A0A091SAD7_9AVES GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A091SQ34 176057 A0A091SQ34_NESNO GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130
IEA Review protein A0A093DPA0 121530 A0A093DPA0_TAUER GO:0016791 To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. IPR000387|IPR016130

Cross-references

Database ID Description
EC 3.1.3.55
InterPro IPR006811 RNA polymerase II subunit A
InterPro IPR008425 Cyclin-dependent kinase inhibitor 3
InterPro IPR011943 HAD-superfamily hydrolase, subfamily IIID
InterPro IPR011947 FCP1-like phosphatase, phosphatase domain
InterPro IPR012008 Serine/threonine-protein phosphatase with EF-hands
InterPro IPR012391 Serine/threonine protein phosphatase, BSU1
InterPro IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
InterPro IPR016660 Kinase associated protein phosphatase
InterPro IPR021766 Phosphate regulon sensor protein PhoR

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0047765 obsolete caldesmon-phosphatase activity consider GO:0004721

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004721 based on ALL annotations
The top 100 of 3,804 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoprotein phosphatase activity
430.19 100.00 460,620 460,620
protein tyrosine phosphatase activity
308.21 26.60 136,960 191,166
protein serine/threonine phosphatase activity
222.86 17.87 98,715 190,548
cellular response to phosphate starvation
349.88 17.58 84,364 103,729
non-membrane spanning protein tyrosine phosphatase activity
333.98 16.01 77,329 99,605
calmodulin-dependent protein phosphatase activity
309.01 14.99 73,374 102,149
MAP kinase serine/threonine phosphatase activity
308.75 14.19 69,205 96,427
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
308.65 14.17 69,130 96,352
RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
308.64 14.17 69,123 96,345
RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
308.64 14.17 69,123 96,345
Totals 2892037 62457710
No co-occurrence statistics for GO:0004721 based on MANUAL annotations
The top 100 of 1,178 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoprotein phosphatase activity
1,237.10 100.00 1,141 1,141
negative regulation of MAPK cascade
201.31 6.97 124 762
endoderm formation
535.15 6.20 77 178
negative regulation of actin filament polymerization
325.08 5.36 72 274
protein dephosphorylation
301.52 5.03 68 279
actin binding
36.76 2.06 72 2,423
protein tyrosine phosphatase activity
36.59 2.01 67 2,265
phosphorelay sensor kinase activity
65.52 1.94 34 642
negative regulation of p38MAPK cascade
327.05 1.91 23 87
Nem1-Spo7 phosphatase complex
394.44 1.85 22 69
Totals 2892 67555

Change Log

Timestamp Action Category Detail
2024-09-19 Added XREF EC:3.1.3.55
2023-08-04 Deleted XREF MetaCyc:3.1.3.16-RXN
2022-04-12 Added DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
2022-04-12 Deleted DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2022-02-17 Deleted RELATION part of GO:0006470 (protein dephosphorylation)
2020-09-13 Deleted XREF EC:3.1.3.16
2020-07-19 Added XREF Reactome:R-HSA-9636684
2019-04-01 Deleted XREF reactome:R-HSA-178178
2019-04-01 Added XREF Reactome:R-HSA-69199
2019-04-01 Deleted XREF reactome:R-HSA-1363274
Timestamp Action Category Detail
2004-01-07 Updated TERM phosphoprotein phosphatase activity
2003-03-19 Updated TERM protein phosphatase activity
2002-02-06 Updated TERM protein phosphatase
2001-04-03 Updated TERM protein phosphatase
2001-03-30 Added TERM protein phosphatase
Timestamp Action Category Detail
2022-04-12 Added DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
2022-04-12 Deleted DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2008-05-13 Added DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2007-12-14 Added SYNONYM phosphoprotein phosphohydrolase activity
2007-09-06 Added SYNONYM protein phosphatase-1 activity
2007-09-06 Added SYNONYM protein phosphatase-2A activity
2007-09-06 Added SYNONYM protein phosphatase-2B activity
2007-09-06 Added SYNONYM protein phosphatase-2C activity
2007-08-09 Deleted SYNONYM protein phosphatase activity
2007-08-09 Added SYNONYM protein phosphatase activity
2004-04-19 Added SYNONYM protein phosphatase activity
2004-04-16 Deleted SYNONYM protein phosphatase activity
2004-01-07 Added SYNONYM protein phosphatase activity
2003-03-26 Updated DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2001-08-06 Added DEFINITION Any enzyme that hydrolyzes phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
Timestamp Action Category Detail
2022-02-17 Deleted RELATION part of GO:0006470 (protein dephosphorylation)
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2015-08-13 Added RELATION part of GO:0006470 (protein dephosphorylation)
2008-04-01 Updated RELATION is a GO:0016791 (phosphatase activity)
Timestamp Action Category Detail
2024-09-19 Added XREF EC:3.1.3.55
2023-08-04 Deleted XREF MetaCyc:3.1.3.16-RXN
2020-09-13 Deleted XREF EC:3.1.3.16
2020-07-19 Added XREF Reactome:R-HSA-9636684
2019-04-01 Deleted XREF reactome:R-HSA-178178
2019-04-01 Added XREF Reactome:R-HSA-69199
2019-04-01 Deleted XREF reactome:R-HSA-1363274
2019-04-01 Deleted XREF reactome:R-HSA-2529015
2019-04-01 Added XREF Reactome:R-HSA-170161
2019-04-01 Added XREF Reactome:R-HSA-174110
2019-04-01 Added XREF Reactome:R-HSA-1363274
2019-04-01 Added XREF Reactome:R-HSA-1363276
2019-04-01 Added XREF Reactome:R-HSA-174124
2019-04-01 Added XREF Reactome:R-HSA-178178
2019-04-01 Added XREF Reactome:R-HSA-170153
2019-04-01 Added XREF Reactome:R-HSA-170158
2019-04-01 Deleted XREF reactome:R-HSA-174124
2019-04-01 Deleted XREF reactome:R-HSA-112383
2019-04-01 Deleted XREF reactome:R-HSA-170158
2019-04-01 Deleted XREF reactome:R-HSA-1363276
2019-04-01 Deleted XREF reactome:R-HSA-69199
2019-04-01 Deleted XREF reactome:R-HSA-167072
2019-04-01 Deleted XREF reactome:R-HSA-170161
2019-04-01 Added XREF Reactome:R-HSA-112383
2019-04-01 Added XREF Reactome:R-HSA-113503
2019-04-01 Added XREF Reactome:R-HSA-167072
2019-04-01 Added XREF Reactome:R-HSA-2529015
2019-04-01 Deleted XREF reactome:R-HSA-113503
2019-04-01 Deleted XREF reactome:R-HSA-170153
2019-04-01 Deleted XREF reactome:R-HSA-174110
2018-12-11 Added XREF reactome:R-HSA-112383
2018-12-11 Added XREF reactome:R-HSA-170158
2018-12-11 Added XREF reactome:R-HSA-174124
2018-12-11 Added XREF reactome:R-HSA-170161
2018-12-11 Added XREF reactome:R-HSA-167072
2018-12-11 Added XREF reactome:R-HSA-69199
2018-12-11 Added XREF reactome:R-HSA-1363276
2018-12-11 Added XREF reactome:R-HSA-178178
2018-12-11 Added XREF reactome:R-HSA-174110
2018-12-11 Added XREF reactome:R-HSA-170153
2018-12-11 Added XREF reactome:R-HSA-113503
2018-12-11 Added XREF reactome:R-HSA-2529015
2018-12-11 Added XREF reactome:R-HSA-1363274
2003-10-27 Added XREF MetaCyc:3.1.3.16-RXN
2002-06-12 Deleted XREF EC:3.1.3.-
2002-06-12 Added XREF EC:3.1.3.16
2001-03-30 Added XREF EC:3.1.3.-
Timestamp Action Category Detail
2011-11-05 Deleted SUBSET goslim_candida
2011-08-14 Deleted SUBSET goslim_yeast
2010-12-05 Deleted SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_yeast
2008-06-09 Added SUBSET goslim_candida
2008-06-09 Added SUBSET goslim_generic
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