GO:0004721
JSON
phosphoprotein phosphatase activity
Molecular Function
Definition (GO:0004721 GONUTS page)
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein phosphatase-2A activity | narrow |
protein phosphatase-2B activity | narrow |
phosphoprotein phosphohydrolase activity | exact |
protein phosphatase-2C activity | narrow |
protein phosphatase activity | exact |
protein phosphatase-1 activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004721
Child Term | Relationship to GO:0004721 |
---|---|
protein arginine phosphatase activity
|
is_a |
[acetyl-CoA carboxylase]-phosphatase activity
|
is_a |
[glycogen-synthase-D] phosphatase activity
|
is_a |
[phosphorylase] phosphatase activity
|
is_a |
protein phosphatase activator activity
|
positively_regulates |
MAP kinase phosphatase activity
|
is_a |
protein histidine phosphatase activity
|
is_a |
protein tyrosine phosphatase activity
|
is_a |
protein phosphatase regulator activity
|
regulates |
myosin-light-chain-phosphatase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | A0A087QTQ7 | 9233 | A0A087QTQ7_APTFO | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A087VMI5 | 100784 | A0A087VMI5_BALRE | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091CMN8 | 885580 | A0A091CMN8_FUKDA | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091HHI2 | 9244 | A0A091HHI2_CALAN | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091JLW6 | 188379 | A0A091JLW6_EGRGA | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091L9X5 | 187382 | A0A091L9X5_9AVES | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091P439 | 57397 | A0A091P439_APAVI | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091SAD7 | 54374 | A0A091SAD7_9AVES | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A091SQ34 | 176057 | A0A091SQ34_NESNO | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
IEA Review | protein | A0A093DPA0 | 121530 | A0A093DPA0_TAUER | GO:0016791 | To remove over-annotation from InterPro entries. These proteins share homology with protein tyrosine phosphatases but do not have enzyme activity. Therefore, they cannot be annotated to phosphatase activity or related GO terms. Reported by InterPro on the 15th of April, 2016. | IPR000387|IPR016130 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.3.55 | |
InterPro | IPR006811 | RNA polymerase II subunit A |
InterPro | IPR008425 | Cyclin-dependent kinase inhibitor 3 |
InterPro | IPR011943 | HAD-superfamily hydrolase, subfamily IIID |
InterPro | IPR011947 | FCP1-like phosphatase, phosphatase domain |
InterPro | IPR012008 | Serine/threonine-protein phosphatase with EF-hands |
InterPro | IPR012391 | Serine/threonine protein phosphatase, BSU1 |
InterPro | IPR012911 | Protein serine/threonine phosphatase 2C, C-terminal |
InterPro | IPR016660 | Kinase associated protein phosphatase |
InterPro | IPR021766 | Phosphate regulon sensor protein PhoR |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0047765 | obsolete caldesmon-phosphatase activity | consider GO:0004721 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004721 based on ALL annotations
The top 100 of 3,897 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoprotein phosphatase activity
|
422.87 | 100.00 | 460,987 | 460,987 |
protein tyrosine phosphatase activity
|
297.09 | 25.40 | 131,226 | 186,783 |
protein serine/threonine phosphatase activity
|
243.63 | 19.59 | 105,505 | 183,126 |
cellular response to phosphate starvation
|
346.33 | 17.33 | 83,048 | 101,403 |
calmodulin-dependent protein phosphatase activity
|
322.08 | 16.04 | 77,830 | 102,186 |
non-membrane spanning protein tyrosine phosphatase activity
|
322.76 | 15.73 | 76,236 | 99,883 |
MAP kinase serine/threonine phosphatase activity
|
322.83 | 15.27 | 73,890 | 96,787 |
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
|
322.75 | 15.25 | 73,809 | 96,706 |
RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
|
322.75 | 15.25 | 73,808 | 96,705 |
RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
|
322.75 | 15.25 | 73,808 | 96,705 |
Totals | 3012616 | 86852516 |
No co-occurrence statistics for GO:0004721 based on MANUAL annotations
The top 100 of 1,167 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoprotein phosphatase activity
|
1,286.65 | 100.00 | 1,004 | 1,004 |
protein dephosphorylation
|
304.37 | 5.42 | 66 | 279 |
negative regulation of actin filament polymerization
|
328.07 | 5.37 | 64 | 251 |
negative regulation of MAPK cascade
|
102.93 | 3.32 | 54 | 675 |
Nem1-Spo7 phosphatase complex
|
428.88 | 2.10 | 22 | 66 |
phosphorelay sensor kinase activity
|
68.26 | 2.07 | 33 | 622 |
actin binding
|
35.99 | 1.98 | 64 | 2,288 |
actin cytoskeleton organization
|
31.58 | 1.88 | 74 | 3,015 |
nuclear envelope organization
|
101.35 | 1.81 | 23 | 292 |
cellular response to phosphate starvation
|
65.98 | 1.75 | 26 | 507 |
Totals | 2354 | 41066 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Added | XREF | EC:3.1.3.55 |
2023-08-04 | Deleted | XREF | MetaCyc:3.1.3.16-RXN |
2022-04-12 | Added | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. |
2022-04-12 | Deleted | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2022-02-17 | Deleted | RELATION | part of GO:0006470 (protein dephosphorylation) |
2020-09-13 | Deleted | XREF | EC:3.1.3.16 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9636684 |
2019-04-01 | Added | XREF | Reactome:R-HSA-69199 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-174124 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-112383 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | phosphoprotein phosphatase activity |
2003-03-19 | Updated | TERM | protein phosphatase activity |
2002-02-06 | Updated | TERM | protein phosphatase |
2001-04-03 | Updated | TERM | protein phosphatase |
2001-03-30 | Added | TERM | protein phosphatase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-12 | Added | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. |
2022-04-12 | Deleted | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2007-12-14 | Added | SYNONYM | phosphoprotein phosphohydrolase activity |
2007-09-06 | Added | SYNONYM | protein phosphatase-2A activity |
2007-09-06 | Added | SYNONYM | protein phosphatase-2B activity |
2007-09-06 | Added | SYNONYM | protein phosphatase-2C activity |
2007-09-06 | Added | SYNONYM | protein phosphatase-1 activity |
2007-08-09 | Added | SYNONYM | protein phosphatase activity |
2007-08-09 | Deleted | SYNONYM | protein phosphatase activity |
2004-04-19 | Added | SYNONYM | protein phosphatase activity |
2004-04-16 | Deleted | SYNONYM | protein phosphatase activity |
2004-01-07 | Added | SYNONYM | protein phosphatase activity |
2003-03-26 | Updated | DEFINITION | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2002-11-27 | Updated | DEFINITION | Catalysis of the hydrolysis of phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
2001-08-06 | Added | DEFINITION | Any enzyme that hydrolyzes phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | RELATION | part of GO:0006470 (protein dephosphorylation) |
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2015-08-13 | Added | RELATION | part of GO:0006470 (protein dephosphorylation) |
2008-04-01 | Updated | RELATION | is a GO:0016791 (phosphatase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-19 | Added | XREF | EC:3.1.3.55 |
2023-08-04 | Deleted | XREF | MetaCyc:3.1.3.16-RXN |
2020-09-13 | Deleted | XREF | EC:3.1.3.16 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9636684 |
2019-04-01 | Added | XREF | Reactome:R-HSA-69199 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-174124 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-112383 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-170158 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1363276 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-69199 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-167072 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-170161 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1363274 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2529015 |
2019-04-01 | Added | XREF | Reactome:R-HSA-170161 |
2019-04-01 | Added | XREF | Reactome:R-HSA-174110 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1363274 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1363276 |
2019-04-01 | Added | XREF | Reactome:R-HSA-174124 |
2019-04-01 | Added | XREF | Reactome:R-HSA-178178 |
2019-04-01 | Added | XREF | Reactome:R-HSA-170153 |
2019-04-01 | Added | XREF | Reactome:R-HSA-170158 |
2019-04-01 | Added | XREF | Reactome:R-HSA-112383 |
2019-04-01 | Added | XREF | Reactome:R-HSA-113503 |
2019-04-01 | Added | XREF | Reactome:R-HSA-167072 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2529015 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-113503 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-170153 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-174110 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-178178 |
2018-12-11 | Added | XREF | reactome:R-HSA-1363276 |
2018-12-11 | Added | XREF | reactome:R-HSA-167072 |
2018-12-11 | Added | XREF | reactome:R-HSA-178178 |
2018-12-11 | Added | XREF | reactome:R-HSA-69199 |
2018-12-11 | Added | XREF | reactome:R-HSA-170161 |
2018-12-11 | Added | XREF | reactome:R-HSA-174124 |
2018-12-11 | Added | XREF | reactome:R-HSA-1363274 |
2018-12-11 | Added | XREF | reactome:R-HSA-112383 |
2018-12-11 | Added | XREF | reactome:R-HSA-174110 |
2018-12-11 | Added | XREF | reactome:R-HSA-170153 |
2018-12-11 | Added | XREF | reactome:R-HSA-113503 |
2018-12-11 | Added | XREF | reactome:R-HSA-2529015 |
2018-12-11 | Added | XREF | reactome:R-HSA-170158 |
2003-10-27 | Added | XREF | MetaCyc:3.1.3.16-RXN |
2002-06-12 | Deleted | XREF | EC:3.1.3.- |
2002-06-12 | Added | XREF | EC:3.1.3.16 |
2001-03-30 | Added | XREF | EC:3.1.3.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-11-05 | Deleted | SUBSET | goslim_candida |
2011-08-14 | Deleted | SUBSET | goslim_yeast |
2010-12-05 | Deleted | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_yeast |
2008-06-09 | Added | SUBSET | goslim_candida |
2008-06-09 | Added | SUBSET | goslim_generic |
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