GO:0004739
JSON
pyruvate dehydrogenase (acetyl-transferring) activity
Molecular Function
Definition (GO:0004739 GONUTS page)
Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pyruvate dehydrogenase complex activity | related |
pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) | related |
pyruvate dehydrogenase (lipoamide) activity | exact |
MtPDC (mitochondrial pyruvate dehydogenase complex) activity | narrow |
PDH | related |
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O06159 | 83332 | BKDC_MYCTU | GO:0004739 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16045627 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.2.4.1 | |
InterPro | IPR017597 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y |
InterPro | IPR027110 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type |
MetaCyc | RXN0-1134 | |
RHEA | 19189 | |
Reactome | R-HSA-9861734 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:15361 | pyruvate |
has_participant | CHEBI | CHEBI:83099 | N(6)-[(R)-lipoyl]-L-lysine residue |
has_participant | CHEBI | CHEBI:83111 | N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysine residue |
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004739 based on ALL annotations
The top 100 of 387 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate dehydrogenase (acetyl-transferring) activity
|
2,552.02 | 100.00 | 76,386 | 76,386 |
acetyl-CoA biosynthetic process from pyruvate
|
1,217.47 | 35.43 | 44,246 | 92,747 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
583.24 | 14.99 | 23,178 | 101,417 |
branched-chain amino acid catabolic process
|
233.41 | 4.43 | 6,049 | 66,139 |
intracellular membrane-bounded organelle
|
53.41 | 1.95 | 17,019 | 813,169 |
glucose metabolic process
|
30.43 | 0.89 | 2,553 | 214,123 |
pyruvate dehydrogenase complex
|
53.83 | 0.68 | 764 | 36,220 |
pyruvate metabolic process
|
21.07 | 0.65 | 2,191 | 265,404 |
oxidoreductase activity
|
15.78 | 0.62 | 73,609 | 11,906,003 |
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
|
114.28 | 0.56 | 481 | 10,741 |
Totals | 287840 | 64806245 |
No co-occurrence statistics for GO:0004739 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate dehydrogenase (acetyl-transferring) activity
|
2,578.44 | 100.00 | 501 | 501 |
acetyl-CoA biosynthetic process from pyruvate
|
2,101.90 | 80.59 | 494 | 606 |
pyruvate dehydrogenase complex
|
1,250.62 | 24.07 | 162 | 334 |
pyruvate dehydrogenase (NAD+) activity
|
1,031.38 | 1.94 | 10 | 25 |
dihydrolipoyllysine-residue acetyltransferase activity
|
60.81 | 0.71 | 5 | 212 |
pyruvate dehydrogenase activity
|
773.53 | 0.59 | 3 | 10 |
pyruvate catabolic process
|
407.12 | 0.58 | 3 | 19 |
dihydrolipoyl dehydrogenase activity
|
34.84 | 0.50 | 4 | 296 |
catalytic complex
|
77.35 | 0.50 | 3 | 100 |
acetyltransferase complex
|
859.48 | 0.40 | 2 | 6 |
Totals | 1281 | 749803 |
Change Log
- All changes
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9861734 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9861734 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9861734 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9861734 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-21 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-9861734 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | pyruvate dehydrogenase (acetyl-transferring) activity |
2003-03-19 | Updated | TERM | pyruvate dehydrogenase (lipoamide) activity |
2002-02-06 | Updated | TERM | pyruvate dehydrogenase (lipoamide) |
2001-04-03 | Updated | TERM | pyruvate dehydrogenase (lipoamide) |
2001-03-30 | Added | TERM | pyruvate dehydrogenase (lipoamide) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) |
2020-10-08 | Deleted | SYNONYM | pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity |
2020-10-08 | Deleted | SYNONYM | pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) |
2020-10-08 | Added | SYNONYM | pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
2007-11-08 | Added | SYNONYM | pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) |
2007-11-08 | Added | SYNONYM | PDH |
2007-09-06 | Added | SYNONYM | pyruvate dehydrogenase complex activity |
2007-09-06 | Added | SYNONYM | pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity |
2007-09-06 | Added | SYNONYM | MtPDC (mitochondrial pyruvate dehydogenase complex) activity |
2007-08-09 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) activity |
2007-08-09 | Deleted | SYNONYM | pyruvate dehydrogenase (lipoamide) activity |
2004-04-19 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) activity |
2004-04-16 | Deleted | SYNONYM | pyruvate dehydrogenase (lipoamide) activity |
2004-01-07 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) activity |
2003-10-23 | Updated | DEFINITION | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + carbon dioxide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-08-16 | Added | RELATION | has part GO:0034604 (pyruvate dehydrogenase (NAD+) activity) |
2008-04-01 | Updated | RELATION | is a GO:0004738 (pyruvate dehydrogenase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016624 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9861734 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9861734 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9861734 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9861734 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-21 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-19 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-10 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-07 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-09-05 | Added | XREF | Reactome:R-HSA-9861734 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-08-20 | Added | XREF | Reactome:R-HSA-9861734 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-08-15 | Added | XREF | Reactome:R-HSA-9861734 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-08-08 | Added | XREF | Reactome:R-HSA-9861734 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-08-05 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-27 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-25 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-19 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-18 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-14 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-11 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-10 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-09 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-06 | Added | XREF | Reactome:R-HSA-9861734 |
2024-07-04 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-07-03 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-29 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-28 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-27 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-26 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-23 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-20 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-19 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-14 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-13 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-12 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-11 | Added | XREF | Reactome:R-HSA-9861734 |
2024-06-07 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-06-01 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-31 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-30 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-29 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-25 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-24 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-23 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-22 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-16 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-15 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-14 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-11 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-09 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-09 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-08 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-05 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-03 | Added | XREF | Reactome:R-HSA-9861734 |
2024-05-02 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-05-01 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-25 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-24 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-21 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-19 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-18 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-14 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-13 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-12 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-11 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-09 | Added | XREF | Reactome:R-HSA-9861734 |
2024-04-07 | Deleted | XREF | Reactome:R-HSA-9861734 |
2024-04-06 | Added | XREF | Reactome:R-HSA-9861734 |
2024-01-15 | Added | XREF | MetaCyc:RXN0-1134 |
2020-06-22 | Added | XREF | RHEA:19189 |
2009-05-21 | Deleted | XREF | MetaCyc:PYRUVATEDECARB-RXN |
2003-10-27 | Added | XREF | MetaCyc:PYRUVATEDECARB-RXN |
2001-03-30 | Added | XREF | EC:1.2.4.1 |
Timestamp | Action | Category | Detail |
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