This term is obsolete.

GO:0004739 JSON

pyruvate dehydrogenase (acetyl-transferring) activity

Molecular Function

Definition (GO:0004739 GONUTS page)

Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.

76,860 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pyruvate dehydrogenase complex activity related
pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) related
pyruvate dehydrogenase (lipoamide) activity exact
MtPDC (mitochondrial pyruvate dehydogenase complex) activity narrow
PDH related
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity related

Ancestor Chart

Ancestor chart for GO:0004739
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O06159 83332 BKDC_MYCTU GO:0004739 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16045627

Cross-references

Database ID Description
EC 1.2.4.1
InterPro IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
InterPro IPR027110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type
MetaCyc RXN0-1134
RHEA 19189
Reactome R-HSA-9861734

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15361 pyruvate
has_participant CHEBI CHEBI:83099 N(6)-[(R)-lipoyl]-L-lysine residue
has_participant CHEBI CHEBI:83111 N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysine residue
has_participant CHEBI CHEBI:16526 carbon dioxide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004739 based on ALL annotations
The top 100 of 387 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) activity
2,552.02 100.00 76,386 76,386
acetyl-CoA biosynthetic process from pyruvate
1,217.47 35.43 44,246 92,747
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
583.24 14.99 23,178 101,417
branched-chain amino acid catabolic process
233.41 4.43 6,049 66,139
intracellular membrane-bounded organelle
53.41 1.95 17,019 813,169
glucose metabolic process
30.43 0.89 2,553 214,123
pyruvate dehydrogenase complex
53.83 0.68 764 36,220
pyruvate metabolic process
21.07 0.65 2,191 265,404
oxidoreductase activity
15.78 0.62 73,609 11,906,003
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
114.28 0.56 481 10,741
Totals 287840 64806245
No co-occurrence statistics for GO:0004739 based on MANUAL annotations
The top 46 of 46 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) activity
2,578.44 100.00 501 501
acetyl-CoA biosynthetic process from pyruvate
2,101.90 80.59 494 606
pyruvate dehydrogenase complex
1,250.62 24.07 162 334
pyruvate dehydrogenase (NAD+) activity
1,031.38 1.94 10 25
dihydrolipoyllysine-residue acetyltransferase activity
60.81 0.71 5 212
pyruvate dehydrogenase activity
773.53 0.59 3 10
pyruvate catabolic process
407.12 0.58 3 19
dihydrolipoyl dehydrogenase activity
34.84 0.50 4 296
catalytic complex
77.35 0.50 3 100
acetyltransferase complex
859.48 0.40 2 6
Totals 1281 749803

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9861734
2024-11-05 Deleted XREF Reactome:R-HSA-9861734
2024-11-03 Added XREF Reactome:R-HSA-9861734
2024-11-02 Deleted XREF Reactome:R-HSA-9861734
2024-11-01 Added XREF Reactome:R-HSA-9861734
2024-10-26 Deleted XREF Reactome:R-HSA-9861734
2024-10-09 Added XREF Reactome:R-HSA-9861734
2024-10-08 Deleted XREF Reactome:R-HSA-9861734
2024-09-21 Added XREF Reactome:R-HSA-9861734
2024-09-20 Deleted XREF Reactome:R-HSA-9861734
Timestamp Action Category Detail
2004-01-07 Updated TERM pyruvate dehydrogenase (acetyl-transferring) activity
2003-03-19 Updated TERM pyruvate dehydrogenase (lipoamide) activity
2002-02-06 Updated TERM pyruvate dehydrogenase (lipoamide)
2001-04-03 Updated TERM pyruvate dehydrogenase (lipoamide)
2001-03-30 Added TERM pyruvate dehydrogenase (lipoamide)
Timestamp Action Category Detail
2020-10-08 Added SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2020-10-08 Deleted SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2020-10-08 Deleted SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2020-10-08 Added SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2007-11-08 Added SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2007-11-08 Added SYNONYM PDH
2007-09-06 Added SYNONYM pyruvate dehydrogenase complex activity
2007-09-06 Added SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2007-09-06 Added SYNONYM MtPDC (mitochondrial pyruvate dehydogenase complex) activity
2007-08-09 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-04-19 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-01-07 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2002-11-27 Added DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + carbon dioxide.
Timestamp Action Category Detail
2015-08-16 Added RELATION has part GO:0034604 (pyruvate dehydrogenase (NAD+) activity)
2008-04-01 Updated RELATION is a GO:0004738 (pyruvate dehydrogenase activity)
2008-04-01 Updated RELATION is a GO:0016624 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9861734
2024-11-05 Deleted XREF Reactome:R-HSA-9861734
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2024-04-07 Deleted XREF Reactome:R-HSA-9861734
2024-04-06 Added XREF Reactome:R-HSA-9861734
2024-01-15 Added XREF MetaCyc:RXN0-1134
2020-06-22 Added XREF RHEA:19189
2009-05-21 Deleted XREF MetaCyc:PYRUVATEDECARB-RXN
2003-10-27 Added XREF MetaCyc:PYRUVATEDECARB-RXN
2001-03-30 Added XREF EC:1.2.4.1
Timestamp Action Category Detail
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