This term is obsolete.

GO:0004739 JSON

pyruvate dehydrogenase (acetyl-transferring) activity

Molecular Function

Definition (GO:0004739 GONUTS page)

Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.

74,597 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pyruvate dehydrogenase complex activity related
MtPDC (mitochondrial pyruvate dehydogenase complex) activity narrow
pyruvate dehydrogenase (lipoamide) activity exact
pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) related
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity related
PDH related

Ancestor Chart

Ancestor chart for GO:0004739
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O06159 83332 BKDC_MYCTU GO:0004739 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16045627

Cross-references

Database ID Description
EC 1.2.4.1
InterPro IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
InterPro IPR027110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type
MetaCyc RXN0-1134
RHEA 19189
Reactome R-HSA-9861734

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:16526 carbon dioxide
has_participant CHEBI CHEBI:83111 N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysine residue
has_participant CHEBI CHEBI:83099 N(6)-[(R)-lipoyl]-L-lysine residue
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15361 pyruvate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004739 based on ALL annotations
The top 100 of 377 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) activity
2,674.99 100.00 74,077 74,077
pyruvate decarboxylation to acetyl-CoA
1,278.34 36.56 45,101 94,376
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
604.81 15.18 23,416 103,565
branched-chain amino acid catabolic process
241.84 4.52 6,146 67,981
intracellular membrane-bounded organelle
55.91 1.96 17,389 831,948
glucose metabolic process
31.95 0.90 2,621 219,446
pyruvate dehydrogenase complex
56.25 0.71 778 36,995
oxidoreductase activity
15.93 0.60 73,489 12,339,325
sulfur compound biosynthetic process
28.18 0.55 844 80,121
organic acid metabolic process
26.41 0.53 843 85,381
Totals 274311 59374540
No co-occurrence statistics for GO:0004739 based on MANUAL annotations
The top 45 of 45 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) activity
2,529.63 100.00 558 558
pyruvate decarboxylation to acetyl-CoA
2,079.67 81.24 550 669
pyruvate dehydrogenase complex
1,230.07 23.76 177 364
pyruvate dehydrogenase (NAD+) activity
1,011.85 1.75 10 25
dihydrolipoyllysine-residue acetyltransferase activity
56.21 0.64 5 225
pyruvate dehydrogenase activity
843.21 0.53 3 9
pyruvate catabolic process
399.42 0.52 3 19
dihydrolipoyl dehydrogenase activity
32.22 0.46 4 314
catalytic complex
75.89 0.46 3 100
acetyltransferase complex
843.21 0.36 2 6
Totals 1407 800998

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9861734
2024-11-05 Deleted XREF Reactome:R-HSA-9861734
2024-11-03 Added XREF Reactome:R-HSA-9861734
2024-11-02 Deleted XREF Reactome:R-HSA-9861734
2024-11-01 Added XREF Reactome:R-HSA-9861734
2024-10-26 Deleted XREF Reactome:R-HSA-9861734
2024-10-09 Added XREF Reactome:R-HSA-9861734
2024-10-08 Deleted XREF Reactome:R-HSA-9861734
2024-09-21 Added XREF Reactome:R-HSA-9861734
2024-09-20 Deleted XREF Reactome:R-HSA-9861734
Timestamp Action Category Detail
2004-01-07 Updated TERM pyruvate dehydrogenase (acetyl-transferring) activity
2003-03-19 Updated TERM pyruvate dehydrogenase (lipoamide) activity
2002-02-06 Updated TERM pyruvate dehydrogenase (lipoamide)
2001-04-03 Updated TERM pyruvate dehydrogenase (lipoamide)
2001-03-30 Added TERM pyruvate dehydrogenase (lipoamide)
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2020-10-08 Added SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2020-10-08 Added SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2020-10-08 Deleted SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2008-05-13 Added DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2007-11-08 Added SYNONYM PDH
2007-11-08 Added SYNONYM pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
2007-09-06 Added SYNONYM pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
2007-09-06 Added SYNONYM pyruvate dehydrogenase complex activity
2007-09-06 Added SYNONYM MtPDC (mitochondrial pyruvate dehydogenase complex) activity
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) activity
2007-08-09 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-04-19 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) activity
2004-01-07 Added SYNONYM pyruvate dehydrogenase (lipoamide) activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
2002-11-27 Added DEFINITION Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + carbon dioxide.
Timestamp Action Category Detail
2015-08-16 Added RELATION has part GO:0034604 (pyruvate dehydrogenase (NAD+) activity)
2008-04-01 Updated RELATION is a GO:0004738 (pyruvate dehydrogenase activity)
2008-04-01 Updated RELATION is a GO:0016624 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9861734
2024-11-05 Deleted XREF Reactome:R-HSA-9861734
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2024-04-07 Deleted XREF Reactome:R-HSA-9861734
2024-04-06 Added XREF Reactome:R-HSA-9861734
2024-01-15 Added XREF MetaCyc:RXN0-1134
2020-06-22 Added XREF RHEA:19189
2009-05-21 Deleted XREF MetaCyc:PYRUVATEDECARB-RXN
2003-10-27 Added XREF MetaCyc:PYRUVATEDECARB-RXN
2001-03-30 Added XREF EC:1.2.4.1
Timestamp Action Category Detail
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