GO:0004740
JSON
pyruvate dehydrogenase (acetyl-transferring) kinase activity
Molecular Function
Definition (GO:0004740 GONUTS page)
Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit].
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pyruvate dehydrogenase kinase activity | related |
PDHK | related |
PDK | related |
PDH kinase activity | related |
pyruvate dehydrogenase kinase (phosphorylating) activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GLD7 | 8355 | A0A1L8GLD7_XENLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A287AG10 | 9823 | A0A287AG10_PIG | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2UNM6 | 9685 | A0A2I2UNM6_FELCA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5VFW3 | 9541 | A0A2K5VFW3_MACFA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765 | |
NOT-qualified manual | protein | A0A3B3IMS5 | 8090 | A0A3B3IMS5_ORYLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.11.2 | |
MetaCyc | 2.7.11.2-RXN | |
RHEA | 23052 | |
Reactome | R-HSA-203946 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:83421 | O-phospho-L-serine(2-) residue |
has_participant | CHEBI | CHEBI:29999 | L-serine residue |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004740 based on ALL annotations
The top 100 of 176 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate dehydrogenase (acetyl-transferring) kinase activity
|
13,668.68 | 100.00 | 14,497 | 14,497 |
regulation of glucose metabolic process
|
12,248.25 | 89.36 | 14,452 | 16,128 |
mitochondrial matrix
|
895.79 | 6.55 | 14,479 | 220,932 |
regulation of acetyl-CoA biosynthetic process from pyruvate
|
11,807.50 | 4.04 | 590 | 683 |
regulation of ketone metabolic process
|
6,387.54 | 1.31 | 193 | 413 |
hypoxia-inducible factor-1alpha signaling pathway
|
7,080.45 | 1.27 | 187 | 361 |
cellular response to fatty acid
|
1,164.78 | 1.20 | 200 | 2,347 |
protein kinase activity
|
103.00 | 0.75 | 14,493 | 1,923,254 |
regulation of mitophagy
|
1,671.28 | 0.73 | 112 | 916 |
regulation of fatty acid biosynthetic process
|
1,351.13 | 0.67 | 103 | 1,042 |
Totals | 105823 | 42300216 |
No co-occurrence statistics for GO:0004740 based on MANUAL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate dehydrogenase (acetyl-transferring) kinase activity
|
5,306.52 | 100.00 | 266 | 266 |
regulation of acetyl-CoA biosynthetic process from pyruvate
|
5,189.03 | 97.43 | 265 | 271 |
regulation of glucose metabolic process
|
3,700.60 | 69.55 | 265 | 380 |
hypoxia-inducible factor-1alpha signaling pathway
|
2,653.26 | 3.27 | 9 | 18 |
cellular response to fatty acid
|
374.18 | 2.68 | 11 | 156 |
insulin receptor signaling pathway
|
167.08 | 2.42 | 25 | 794 |
regulation of ketone metabolic process
|
1,273.56 | 2.11 | 6 | 25 |
peroxisome proliferator activated receptor signaling pathway
|
461.44 | 1.82 | 6 | 69 |
regulation of fatty acid biosynthetic process
|
1,658.29 | 1.81 | 5 | 16 |
regulation of reactive oxygen species metabolic process
|
116.63 | 1.13 | 6 | 273 |
Totals | 1296 | 756289 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-10-25 | Added | RELATION | is a GO:0004674 (protein serine/threonine kinase activity) |
2024-10-25 | Deleted | RELATION | is a GO:0004672 (protein kinase activity) |
2024-10-25 | Added | DEFINITION | Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]. |
2024-10-25 | Deleted | DEFINITION | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
2021-09-04 | Deleted | SYNONYM | ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity |
2021-09-04 | Deleted | SYNONYM | [pyruvate dehydrogenase (lipoamide)] kinase activity |
2021-09-04 | Deleted | SYNONYM | pyruvate dehydrogenase kinase activator protein activity |
2021-09-04 | Deleted | SYNONYM | PDK4 |
2021-09-04 | Deleted | SYNONYM | STK1 |
2021-09-04 | Deleted | SYNONYM | PDK3 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-11-08 | Updated | TERM | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
2003-09-09 | Updated | TERM | [pyruvate dehydrogenase (lipoamide)] kinase activity |
2003-03-19 | Updated | TERM | pyruvate dehydrogenase (lipoamide) kinase activity |
2002-02-06 | Updated | TERM | pyruvate dehydrogenase (lipoamide) kinase |
2001-04-03 | Updated | TERM | pyruvate dehydrogenase (lipoamide) kinase |
2001-03-30 | Added | TERM | pyruvate dehydrogenase (lipoamide) kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-10-25 | Added | DEFINITION | Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]. |
2024-10-25 | Deleted | DEFINITION | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
2021-09-04 | Deleted | SYNONYM | ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity |
2021-09-04 | Deleted | SYNONYM | [pyruvate dehydrogenase (lipoamide)] kinase activity |
2021-09-04 | Deleted | SYNONYM | pyruvate dehydrogenase kinase activator protein activity |
2021-09-04 | Deleted | SYNONYM | PDK4 |
2021-09-04 | Deleted | SYNONYM | STK1 |
2021-09-04 | Deleted | SYNONYM | PDK3 |
2021-09-04 | Deleted | SYNONYM | PDK2 |
2021-09-04 | Deleted | SYNONYM | PDK1 |
2021-09-04 | Deleted | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2020-10-08 | Added | SYNONYM | pyruvate dehydrogenase kinase (phosphorylating) activity |
2020-10-08 | Deleted | SYNONYM | pyruvate dehydrogenase kinase (phosphorylating) activity |
2020-10-08 | Deleted | SYNONYM | PDH kinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity |
2020-10-08 | Added | SYNONYM | PDH kinase activity |
2020-10-08 | Added | SYNONYM | ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity |
2020-10-08 | Added | SYNONYM | pyruvate dehydrogenase kinase activity |
2020-10-08 | Deleted | SYNONYM | pyruvate dehydrogenase kinase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
2008-04-01 | Deleted | SYNONYM | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
2007-11-08 | Added | SYNONYM | pyruvate dehydrogenase kinase activity |
2007-11-08 | Added | SYNONYM | pyruvate dehydrogenase kinase (phosphorylating) activity |
2007-11-08 | Added | SYNONYM | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
2007-11-08 | Added | SYNONYM | [pyruvate dehydrogenase (lipoamide)] kinase activity |
2007-11-08 | Added | SYNONYM | STK1 |
2007-11-08 | Added | SYNONYM | PDK4 |
2007-11-08 | Added | SYNONYM | PDK3 |
2007-11-08 | Added | SYNONYM | PDK2 |
2007-11-08 | Added | SYNONYM | PDK1 |
2007-11-08 | Added | SYNONYM | PDK |
2007-11-08 | Added | SYNONYM | PDHK |
2007-11-08 | Added | SYNONYM | PDH kinase activity |
2007-11-08 | Added | SYNONYM | ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity |
2007-11-08 | Added | SYNONYM | pyruvate dehydrogenase kinase activator protein activity |
2007-10-25 | Updated | DEFINITION | Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. |
2007-08-09 | Deleted | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2007-08-09 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2004-04-19 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2004-04-16 | Deleted | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2003-10-27 | Added | SYNONYM | pyruvate dehydrogenase (lipoamide) kinase activity |
2003-04-24 | Updated | DEFINITION | Catalysis of the reaction: ATP + (pyruvate dehydrogenase (lipoamide)) = ADP + (pyruvate dehydrogenase (lipoamide)) phosphate. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + [pyruvate dehydrogenase (lipoamide)] = ADP + [pyruvate dehydrogenase (lipoamide)] phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-10-25 | Added | RELATION | is a GO:0004674 (protein serine/threonine kinase activity) |
2024-10-25 | Deleted | RELATION | is a GO:0004672 (protein kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004672 (protein kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:23052 |
2019-04-01 | Added | XREF | Reactome:R-HSA-203946 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-203946 |
2018-12-11 | Added | XREF | reactome:R-HSA-203946 |
2007-09-26 | Added | XREF | EC:2.7.11.2 |
2007-09-26 | Deleted | XREF | EC:2.7.1.99 |
2007-09-26 | Deleted | XREF | MetaCyc:2.7.1.99-RXN |
2007-09-26 | Added | XREF | MetaCyc:2.7.11.2-RXN |
2003-10-27 | Added | XREF | MetaCyc:2.7.1.99-RXN |
2001-03-30 | Added | XREF | EC:2.7.1.99 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link