This term is obsolete.

GO:0004740 JSON

pyruvate dehydrogenase (acetyl-transferring) kinase activity

Molecular Function

Definition (GO:0004740 GONUTS page)

Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit].

14,660 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pyruvate dehydrogenase kinase activity related
PDHK related
PDK related
PDH kinase activity related
pyruvate dehydrogenase kinase (phosphorylating) activity related

Ancestor Chart

Ancestor chart for GO:0004740
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GLD7 8355 A0A1L8GLD7_XENLA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A287AG10 9823 A0A287AG10_PIG GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2UNM6 9685 A0A2I2UNM6_FELCA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5VFW3 9541 A0A2K5VFW3_MACFA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765
NOT-qualified manual protein A0A3B3IMS5 8090 A0A3B3IMS5_ORYLA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.11.2
MetaCyc 2.7.11.2-RXN
RHEA 23052
Reactome R-HSA-203946

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:83421 O-phospho-L-serine(2-) residue
has_participant CHEBI CHEBI:29999 L-serine residue
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:30616 ATP(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004740 based on ALL annotations
The top 100 of 176 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) kinase activity
13,668.68 100.00 14,497 14,497
regulation of glucose metabolic process
12,248.25 89.36 14,452 16,128
mitochondrial matrix
895.79 6.55 14,479 220,932
regulation of acetyl-CoA biosynthetic process from pyruvate
11,807.50 4.04 590 683
regulation of ketone metabolic process
6,387.54 1.31 193 413
hypoxia-inducible factor-1alpha signaling pathway
7,080.45 1.27 187 361
cellular response to fatty acid
1,164.78 1.20 200 2,347
protein kinase activity
103.00 0.75 14,493 1,923,254
regulation of mitophagy
1,671.28 0.73 112 916
regulation of fatty acid biosynthetic process
1,351.13 0.67 103 1,042
Totals 105823 42300216
No co-occurrence statistics for GO:0004740 based on MANUAL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate dehydrogenase (acetyl-transferring) kinase activity
5,306.52 100.00 266 266
regulation of acetyl-CoA biosynthetic process from pyruvate
5,189.03 97.43 265 271
regulation of glucose metabolic process
3,700.60 69.55 265 380
hypoxia-inducible factor-1alpha signaling pathway
2,653.26 3.27 9 18
cellular response to fatty acid
374.18 2.68 11 156
insulin receptor signaling pathway
167.08 2.42 25 794
regulation of ketone metabolic process
1,273.56 2.11 6 25
peroxisome proliferator activated receptor signaling pathway
461.44 1.82 6 69
regulation of fatty acid biosynthetic process
1,658.29 1.81 5 16
regulation of reactive oxygen species metabolic process
116.63 1.13 6 273
Totals 1296 756289

Change Log

Timestamp Action Category Detail
2024-10-25 Added RELATION is a GO:0004674 (protein serine/threonine kinase activity)
2024-10-25 Deleted RELATION is a GO:0004672 (protein kinase activity)
2024-10-25 Added DEFINITION Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit].
2024-10-25 Deleted DEFINITION Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
2021-09-04 Deleted SYNONYM ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity
2021-09-04 Deleted SYNONYM [pyruvate dehydrogenase (lipoamide)] kinase activity
2021-09-04 Deleted SYNONYM pyruvate dehydrogenase kinase activator protein activity
2021-09-04 Deleted SYNONYM PDK4
2021-09-04 Deleted SYNONYM STK1
2021-09-04 Deleted SYNONYM PDK3
Timestamp Action Category Detail
2007-11-08 Updated TERM pyruvate dehydrogenase (acetyl-transferring) kinase activity
2003-09-09 Updated TERM [pyruvate dehydrogenase (lipoamide)] kinase activity
2003-03-19 Updated TERM pyruvate dehydrogenase (lipoamide) kinase activity
2002-02-06 Updated TERM pyruvate dehydrogenase (lipoamide) kinase
2001-04-03 Updated TERM pyruvate dehydrogenase (lipoamide) kinase
2001-03-30 Added TERM pyruvate dehydrogenase (lipoamide) kinase
Timestamp Action Category Detail
2024-10-25 Added DEFINITION Catalysis of the reaction: ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = ADP + H+ + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit].
2024-10-25 Deleted DEFINITION Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
2021-09-04 Deleted SYNONYM ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity
2021-09-04 Deleted SYNONYM [pyruvate dehydrogenase (lipoamide)] kinase activity
2021-09-04 Deleted SYNONYM pyruvate dehydrogenase kinase activator protein activity
2021-09-04 Deleted SYNONYM PDK4
2021-09-04 Deleted SYNONYM STK1
2021-09-04 Deleted SYNONYM PDK3
2021-09-04 Deleted SYNONYM PDK2
2021-09-04 Deleted SYNONYM PDK1
2021-09-04 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2020-10-08 Added SYNONYM pyruvate dehydrogenase kinase (phosphorylating) activity
2020-10-08 Deleted SYNONYM pyruvate dehydrogenase kinase (phosphorylating) activity
2020-10-08 Deleted SYNONYM PDH kinase activity
2020-10-08 Deleted SYNONYM ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity
2020-10-08 Added SYNONYM PDH kinase activity
2020-10-08 Added SYNONYM ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity
2020-10-08 Added SYNONYM pyruvate dehydrogenase kinase activity
2020-10-08 Deleted SYNONYM pyruvate dehydrogenase kinase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
2008-04-01 Deleted SYNONYM pyruvate dehydrogenase (acetyl-transferring) kinase activity
2007-11-08 Added SYNONYM pyruvate dehydrogenase kinase activity
2007-11-08 Added SYNONYM pyruvate dehydrogenase kinase (phosphorylating) activity
2007-11-08 Added SYNONYM pyruvate dehydrogenase (acetyl-transferring) kinase activity
2007-11-08 Added SYNONYM [pyruvate dehydrogenase (lipoamide)] kinase activity
2007-11-08 Added SYNONYM STK1
2007-11-08 Added SYNONYM PDK4
2007-11-08 Added SYNONYM PDK3
2007-11-08 Added SYNONYM PDK2
2007-11-08 Added SYNONYM PDK1
2007-11-08 Added SYNONYM PDK
2007-11-08 Added SYNONYM PDHK
2007-11-08 Added SYNONYM PDH kinase activity
2007-11-08 Added SYNONYM ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity
2007-11-08 Added SYNONYM pyruvate dehydrogenase kinase activator protein activity
2007-10-25 Updated DEFINITION Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2007-08-09 Added SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2004-04-19 Added SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2003-10-27 Added SYNONYM pyruvate dehydrogenase (lipoamide) kinase activity
2003-04-24 Updated DEFINITION Catalysis of the reaction: ATP + (pyruvate dehydrogenase (lipoamide)) = ADP + (pyruvate dehydrogenase (lipoamide)) phosphate.
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + [pyruvate dehydrogenase (lipoamide)] = ADP + [pyruvate dehydrogenase (lipoamide)] phosphate.
Timestamp Action Category Detail
2024-10-25 Added RELATION is a GO:0004674 (protein serine/threonine kinase activity)
2024-10-25 Deleted RELATION is a GO:0004672 (protein kinase activity)
2008-04-01 Updated RELATION is a GO:0004672 (protein kinase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:23052
2019-04-01 Added XREF Reactome:R-HSA-203946
2019-04-01 Deleted XREF reactome:R-HSA-203946
2018-12-11 Added XREF reactome:R-HSA-203946
2007-09-26 Added XREF EC:2.7.11.2
2007-09-26 Deleted XREF EC:2.7.1.99
2007-09-26 Deleted XREF MetaCyc:2.7.1.99-RXN
2007-09-26 Added XREF MetaCyc:2.7.11.2-RXN
2003-10-27 Added XREF MetaCyc:2.7.1.99-RXN
2001-03-30 Added XREF EC:2.7.1.99
Timestamp Action Category Detail
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