This term is obsolete.

GO:0004764 JSON

shikimate 3-dehydrogenase (NADP+) activity

Molecular Function

Definition (GO:0004764 GONUTS page)

Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.

63,667 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
dehydroshikimic reductase activity broad
shikimate oxidoreductase activity broad
DHS reductase activity broad
5-dehydroshikimic reductase activity related
shikimate:NADP(+) 5-oxidoreductase activity related
shikimate:NADP(+) oxidoreductase activity broad
5-dehydroshikimate reductase activity related

Ancestor Chart

Ancestor chart for GO:0004764
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.25
EC 1.1.1.282
InterPro IPR008289 Pentafunctional AroM protein
InterPro IPR010110 Shikimate dehydrogenase, AroM-type
InterPro IPR011342 Shikimate dehydrogenase
InterPro IPR013708 Shikimate dehydrogenase substrate binding, N-terminal
InterPro IPR022872 Quinate/Shikimate dehydrogenase
InterPro IPR022893 Shikimate dehydrogenase family
KEGG_REACTION R02413
MetaCyc SHIKIMATE-5-DEHYDROGENASE-RXN

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:16630 3-dehydroshikimate
has_participant CHEBI CHEBI:36208 shikimate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57783 NADPH(4-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0033706 obsolete quinate/shikimate dehydrogenase activity consider GO:0004764

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004764 based on ALL annotations
The top 100 of 317 co-occurring terms
Co-occurring Term PR S% #Together #Compared
shikimate 3-dehydrogenase (NADP+) activity
3,071.50 100.00 63,467 63,467
shikimate metabolic process
3,067.50 94.25 59,892 59,970
chorismate biosynthetic process
642.92 20.89 62,841 300,220
aromatic amino acid family biosynthetic process
345.12 10.63 41,977 373,587
3-dehydroquinate dehydratase activity
411.08 6.47 7,072 52,840
NADP binding
183.02 5.88 51,686 867,427
amino acid biosynthetic process
161.12 5.10 40,835 778,477
shikimate kinase activity
183.69 2.68 2,941 49,176
3-phosphoshikimate 1-carboxyvinyltransferase activity
179.83 2.63 2,886 49,293
3-dehydroquinate synthase activity
101.59 1.51 1,709 51,669
Totals 443851 121322720
No co-occurrence statistics for GO:0004764 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term PR S% #Together #Compared
shikimate 3-dehydrogenase (NADP+) activity
6,728.12 100.00 192 192
shikimate metabolic process
6,352.44 91.63 186 197
chorismate biosynthetic process
2,866.24 42.41 190 446
NADP binding
449.19 5.51 46 689
3-dehydroquinate dehydratase activity
841.01 3.23 8 64
3-phosphoshikimate 1-carboxyvinyltransferase activity
258.77 1.58 5 130
shikimate kinase activity
252.94 1.56 5 133
quinate 3-dehydrogenase (NAD+) activity
2,691.25 1.03 2 5
3-dehydroquinate synthase activity
133.23 0.69 2 101
shikimate 3-dehydrogenase (NAD+) activity
6,728.12 0.52 1 1
Totals 703 534748

Change Log

Timestamp Action Category Detail
2024-06-16 Deleted XREF KEGG_REACTION:R06847
2024-06-16 Added XREF KEGG_REACTION:R02413
2020-10-08 Added SYNONYM shikimate:NADP(+) 5-oxidoreductase activity
2020-10-08 Deleted SYNONYM 5-dehydroshikimic reductase activity
2020-10-08 Deleted SYNONYM 5-dehydroshikimate reductase activity
2020-10-08 Deleted SYNONYM shikimate:NADP(+) 5-oxidoreductase activity
2020-10-08 Added SYNONYM 5-dehydroshikimate reductase activity
2020-10-08 Added SYNONYM 5-dehydroshikimic reductase activity
2019-06-20 Added XREF KEGG_REACTION:R06847
2019-06-20 Deleted XREF KEGG:R06847
Timestamp Action Category Detail
2011-08-19 Updated TERM shikimate 3-dehydrogenase (NADP+) activity
2003-03-19 Updated TERM shikimate 5-dehydrogenase activity
2002-02-06 Updated TERM shikimate 5-dehydrogenase
2001-04-03 Updated TERM shikimate 5-dehydrogenase
2001-03-30 Added TERM shikimate 5-dehydrogenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM shikimate:NADP(+) 5-oxidoreductase activity
2020-10-08 Deleted SYNONYM 5-dehydroshikimic reductase activity
2020-10-08 Deleted SYNONYM 5-dehydroshikimate reductase activity
2020-10-08 Deleted SYNONYM shikimate:NADP(+) 5-oxidoreductase activity
2020-10-08 Added SYNONYM 5-dehydroshikimate reductase activity
2020-10-08 Added SYNONYM 5-dehydroshikimic reductase activity
2011-08-19 Deleted SYNONYM shikimate oxidoreductase activity
2011-08-19 Deleted SYNONYM DHS reductase activity
2011-08-19 Added DEFINITION Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.
2011-08-19 Deleted DEFINITION Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+.
2011-08-19 Added SYNONYM DHS reductase activity
2011-08-19 Added SYNONYM shikimate oxidoreductase activity
2011-08-19 Added SYNONYM dehydroshikimic reductase activity
2011-08-19 Added SYNONYM shikimate:NADP(+) oxidoreductase activity
2011-08-19 Deleted SYNONYM shikimate:NADP(+) oxidoreductase activity
2011-08-19 Deleted SYNONYM dehydroshikimic reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+.
2008-04-01 Deleted SYNONYM shikimate 5-dehydrogenase activity
2007-10-01 Added SYNONYM shikimate 5-dehydrogenase activity
2007-09-26 Deleted SYNONYM shikimate 5-dehydrogenase activity
2007-09-06 Added SYNONYM shikimate:NADP(+) oxidoreductase activity
2007-09-06 Added SYNONYM shikimate:NADP(+) 5-oxidoreductase activity
2007-09-06 Added SYNONYM shikimate oxidoreductase activity
2007-09-06 Added SYNONYM shikimate 5-dehydrogenase activity
2007-09-06 Added SYNONYM DHS reductase activity
2007-09-06 Added SYNONYM 5-dehydroshikimic reductase activity
2007-09-06 Added SYNONYM 5-dehydroshikimate reductase activity
2007-09-06 Added SYNONYM dehydroshikimic reductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2024-06-16 Deleted XREF KEGG_REACTION:R06847
2024-06-16 Added XREF KEGG_REACTION:R02413
2019-06-20 Added XREF KEGG_REACTION:R06847
2019-06-20 Deleted XREF KEGG:R06847
2018-07-13 Deleted XREF RHEA:17740
2018-07-13 Added XREF RHEA:17737
2011-08-19 Added XREF EC:1.1.1.282
2011-08-19 Added XREF KEGG:R06847
2011-08-19 Added XREF RHEA:17740
2003-10-27 Added XREF MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.1.1.25
Timestamp Action Category Detail
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