GO:0004764
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shikimate 3-dehydrogenase (NADP+) activity
Molecular Function
Definition (GO:0004764 GONUTS page)
Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
dehydroshikimic reductase activity | broad |
shikimate oxidoreductase activity | broad |
DHS reductase activity | broad |
5-dehydroshikimic reductase activity | related |
shikimate:NADP(+) 5-oxidoreductase activity | related |
shikimate:NADP(+) oxidoreductase activity | broad |
5-dehydroshikimate reductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.25 | |
EC | 1.1.1.282 | |
InterPro | IPR008289 | Pentafunctional AroM protein |
InterPro | IPR010110 | Shikimate dehydrogenase, AroM-type |
InterPro | IPR011342 | Shikimate dehydrogenase |
InterPro | IPR013708 | Shikimate dehydrogenase substrate binding, N-terminal |
InterPro | IPR022872 | Quinate/Shikimate dehydrogenase |
InterPro | IPR022893 | Shikimate dehydrogenase family |
KEGG_REACTION | R02413 | |
MetaCyc | SHIKIMATE-5-DEHYDROGENASE-RXN |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:16630 | 3-dehydroshikimate |
has_participant | CHEBI | CHEBI:36208 | shikimate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0033706 | obsolete quinate/shikimate dehydrogenase activity | consider GO:0004764 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004764 based on ALL annotations
The top 100 of 317 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
shikimate 3-dehydrogenase (NADP+) activity
|
3,071.50 | 100.00 | 63,467 | 63,467 |
shikimate metabolic process
|
3,067.50 | 94.25 | 59,892 | 59,970 |
chorismate biosynthetic process
|
642.92 | 20.89 | 62,841 | 300,220 |
aromatic amino acid family biosynthetic process
|
345.12 | 10.63 | 41,977 | 373,587 |
3-dehydroquinate dehydratase activity
|
411.08 | 6.47 | 7,072 | 52,840 |
NADP binding
|
183.02 | 5.88 | 51,686 | 867,427 |
amino acid biosynthetic process
|
161.12 | 5.10 | 40,835 | 778,477 |
shikimate kinase activity
|
183.69 | 2.68 | 2,941 | 49,176 |
3-phosphoshikimate 1-carboxyvinyltransferase activity
|
179.83 | 2.63 | 2,886 | 49,293 |
3-dehydroquinate synthase activity
|
101.59 | 1.51 | 1,709 | 51,669 |
Totals | 443851 | 121322720 |
No co-occurrence statistics for GO:0004764 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
shikimate 3-dehydrogenase (NADP+) activity
|
6,728.12 | 100.00 | 192 | 192 |
shikimate metabolic process
|
6,352.44 | 91.63 | 186 | 197 |
chorismate biosynthetic process
|
2,866.24 | 42.41 | 190 | 446 |
NADP binding
|
449.19 | 5.51 | 46 | 689 |
3-dehydroquinate dehydratase activity
|
841.01 | 3.23 | 8 | 64 |
3-phosphoshikimate 1-carboxyvinyltransferase activity
|
258.77 | 1.58 | 5 | 130 |
shikimate kinase activity
|
252.94 | 1.56 | 5 | 133 |
quinate 3-dehydrogenase (NAD+) activity
|
2,691.25 | 1.03 | 2 | 5 |
3-dehydroquinate synthase activity
|
133.23 | 0.69 | 2 | 101 |
shikimate 3-dehydrogenase (NAD+) activity
|
6,728.12 | 0.52 | 1 | 1 |
Totals | 703 | 534748 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-16 | Deleted | XREF | KEGG_REACTION:R06847 |
2024-06-16 | Added | XREF | KEGG_REACTION:R02413 |
2020-10-08 | Added | SYNONYM | shikimate:NADP(+) 5-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 5-dehydroshikimic reductase activity |
2020-10-08 | Deleted | SYNONYM | 5-dehydroshikimate reductase activity |
2020-10-08 | Deleted | SYNONYM | shikimate:NADP(+) 5-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 5-dehydroshikimate reductase activity |
2020-10-08 | Added | SYNONYM | 5-dehydroshikimic reductase activity |
2019-06-20 | Added | XREF | KEGG_REACTION:R06847 |
2019-06-20 | Deleted | XREF | KEGG:R06847 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-19 | Updated | TERM | shikimate 3-dehydrogenase (NADP+) activity |
2003-03-19 | Updated | TERM | shikimate 5-dehydrogenase activity |
2002-02-06 | Updated | TERM | shikimate 5-dehydrogenase |
2001-04-03 | Updated | TERM | shikimate 5-dehydrogenase |
2001-03-30 | Added | TERM | shikimate 5-dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | shikimate:NADP(+) 5-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 5-dehydroshikimic reductase activity |
2020-10-08 | Deleted | SYNONYM | 5-dehydroshikimate reductase activity |
2020-10-08 | Deleted | SYNONYM | shikimate:NADP(+) 5-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 5-dehydroshikimate reductase activity |
2020-10-08 | Added | SYNONYM | 5-dehydroshikimic reductase activity |
2011-08-19 | Deleted | SYNONYM | shikimate oxidoreductase activity |
2011-08-19 | Deleted | SYNONYM | DHS reductase activity |
2011-08-19 | Added | DEFINITION | Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. |
2011-08-19 | Deleted | DEFINITION | Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. |
2011-08-19 | Added | SYNONYM | DHS reductase activity |
2011-08-19 | Added | SYNONYM | shikimate oxidoreductase activity |
2011-08-19 | Added | SYNONYM | dehydroshikimic reductase activity |
2011-08-19 | Added | SYNONYM | shikimate:NADP(+) oxidoreductase activity |
2011-08-19 | Deleted | SYNONYM | shikimate:NADP(+) oxidoreductase activity |
2011-08-19 | Deleted | SYNONYM | dehydroshikimic reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. |
2008-04-01 | Deleted | SYNONYM | shikimate 5-dehydrogenase activity |
2007-10-01 | Added | SYNONYM | shikimate 5-dehydrogenase activity |
2007-09-26 | Deleted | SYNONYM | shikimate 5-dehydrogenase activity |
2007-09-06 | Added | SYNONYM | shikimate:NADP(+) oxidoreductase activity |
2007-09-06 | Added | SYNONYM | shikimate:NADP(+) 5-oxidoreductase activity |
2007-09-06 | Added | SYNONYM | shikimate oxidoreductase activity |
2007-09-06 | Added | SYNONYM | shikimate 5-dehydrogenase activity |
2007-09-06 | Added | SYNONYM | DHS reductase activity |
2007-09-06 | Added | SYNONYM | 5-dehydroshikimic reductase activity |
2007-09-06 | Added | SYNONYM | 5-dehydroshikimate reductase activity |
2007-09-06 | Added | SYNONYM | dehydroshikimic reductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-16 | Deleted | XREF | KEGG_REACTION:R06847 |
2024-06-16 | Added | XREF | KEGG_REACTION:R02413 |
2019-06-20 | Added | XREF | KEGG_REACTION:R06847 |
2019-06-20 | Deleted | XREF | KEGG:R06847 |
2018-07-13 | Deleted | XREF | RHEA:17740 |
2018-07-13 | Added | XREF | RHEA:17737 |
2011-08-19 | Added | XREF | EC:1.1.1.282 |
2011-08-19 | Added | XREF | KEGG:R06847 |
2011-08-19 | Added | XREF | RHEA:17740 |
2003-10-27 | Added | XREF | MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.25 |
Timestamp | Action | Category | Detail |
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