This term is obsolete.

GO:0004787 JSON

thiamine diphosphate phosphatase activity

Molecular Function

Definition (GO:0004787 GONUTS page)

Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.

6,288 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
thiaminpyrophosphatase activity related
thiamine-diphosphatase activity exact
thiamin-pyrophosphatase activity exact
thiamin pyrophosphatase activity exact
thiamine pyrophosphatase activity exact
thiamine diphosphatase activity broad
TPPase activity exact

Ancestor Chart

Ancestor chart for GO:0004787
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
InterPro IPR033713 Phosphatase NudJ
RHEA 27998

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:58937 thiamine(1+) diphosphate(3-)
has_participant CHEBI CHEBI:37575 thiamine(1+) monophosphate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004787 based on ALL annotations
The top 42 of 42 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thiamine diphosphate phosphatase activity
31,518.19 100.00 6,287 6,287
nucleoside diphosphate phosphatase activity
10,115.56 32.09 6,286 19,586
ribonucleoside triphosphate phosphatase activity
861.25 2.73 6,286 230,041
hydrolase activity
16.95 0.05 6,280 11,680,370
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
11.84 0.03 11 29,276
AMP biosynthetic process
11.57 0.03 11 29,962
catalytic activity
5.28 0.02 780 4,655,290
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
96.09 0.02 1 328
GDP phosphatase activity
6.61 0.01 3 14,301
8-oxo-GDP phosphatase activity
4.28 0.01 4 29,446
Totals 26018 173670460
No co-occurrence statistics for GO:0004787 based on MANUAL annotations
The top 7 of 7 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thiamine diphosphate phosphatase activity
705,766.50 100.00 2 2
thiamine metabolic process
12,381.87 1.72 1 57
pyrophosphatase activity
3,877.84 0.55 1 182
ribonucleoside triphosphate phosphatase activity
2,094.26 0.30 1 337
nucleoside diphosphate phosphatase activity
1,833.16 0.26 1 385
phosphatase activity
213.74 0.03 1 3,302
cellular_component
11.28 0.00 1 62,590
Totals 8 66855

Change Log

Timestamp Action Category Detail
2022-06-12 Updated TERM thiamine diphosphate phosphatase activity
2022-06-12 Deleted DEFINITION Catalysis of the reaction: TPP + H2O = TMP + phosphate.
2022-06-12 Added DEFINITION Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.
2022-06-12 Added SYNONYM thiamine-diphosphatase activity
2022-06-12 Added SYNONYM thiamine diphosphatase activity
2021-02-17 Added RELATION is a GO:0016462 (pyrophosphatase activity)
2021-02-17 Added DEFINITION Catalysis of the reaction: TPP + H2O = TMP + phosphate.
2021-02-17 Deleted RELATION is a GO:0017110 (nucleoside diphosphate phosphatase activity)
2021-02-17 Added XREF RHEA:27998
2021-02-17 Deleted DEFINITION Catalysis of the reaction: TDP + H2O = TMP + phosphate.
Timestamp Action Category Detail
2022-06-12 Updated TERM thiamine diphosphate phosphatase activity
2020-08-01 Updated TERM thiamine-diphosphatase activity
2010-12-16 Updated TERM thiamine-pyrophosphatase activity
2004-09-16 Updated TERM thiamin-pyrophosphatase activity
2003-03-19 Updated TERM thiamin pyrophosphatase activity
2002-02-06 Updated TERM thiamin pyrophosphatase
2001-11-04 Updated TERM thiamin pyrophosphatase
2001-04-03 Updated TERM thiamine pyrophosphatase
2001-03-30 Added TERM thiamine pyrophosphatase
Timestamp Action Category Detail
2022-06-12 Deleted DEFINITION Catalysis of the reaction: TPP + H2O = TMP + phosphate.
2022-06-12 Added DEFINITION Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.
2022-06-12 Added SYNONYM thiamine-diphosphatase activity
2022-06-12 Added SYNONYM thiamine diphosphatase activity
2021-02-17 Added DEFINITION Catalysis of the reaction: TPP + H2O = TMP + phosphate.
2021-02-17 Deleted DEFINITION Catalysis of the reaction: TDP + H2O = TMP + phosphate.
2020-10-08 Deleted SYNONYM thiaminpyrophosphatase activity
2020-10-08 Added SYNONYM thiaminpyrophosphatase activity
2010-12-16 Added SYNONYM thiamin-pyrophosphatase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: TDP + H2O = TMP + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: TDP + H2O = TMP + phosphate.
2007-12-14 Added SYNONYM thiaminpyrophosphatase activity
2007-08-09 Added SYNONYM thiamin pyrophosphatase activity
2007-08-09 Added SYNONYM thiamine pyrophosphatase activity
2007-08-09 Deleted SYNONYM TPPase activity
2007-08-09 Added SYNONYM TPPase activity
2007-08-09 Deleted SYNONYM thiamin pyrophosphatase activity
2007-08-09 Deleted SYNONYM thiamine pyrophosphatase activity
2004-09-16 Added SYNONYM TPPase activity
2004-09-16 Added SYNONYM thiamin pyrophosphatase activity
2004-09-15 Added DEFINITION Catalysis of the reaction: TDP + H2O = TMP + phosphate.
2004-04-19 Added SYNONYM thiamine pyrophosphatase activity
2004-04-16 Deleted SYNONYM thiamine pyrophosphatase activity
2003-09-06 Added SYNONYM thiamine pyrophosphatase activity
Timestamp Action Category Detail
2021-02-17 Added RELATION is a GO:0016462 (pyrophosphatase activity)
2021-02-17 Deleted RELATION is a GO:0017110 (nucleoside diphosphate phosphatase activity)
2008-04-01 Updated RELATION is a GO:0017110 (nucleoside diphosphate phosphatase activity)
Timestamp Action Category Detail
2021-02-17 Added XREF RHEA:27998
2020-08-01 Deleted XREF EC:3.6.1
2016-10-03 Deleted XREF EC:3.6.1.-
2016-10-03 Added XREF EC:3.6.1
2001-03-30 Added XREF EC:3.6.1.-
Timestamp Action Category Detail
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