GO:0004787
JSON
thiamine diphosphate phosphatase activity
Molecular Function
Definition (GO:0004787 GONUTS page)
Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
thiaminpyrophosphatase activity | related |
thiamine-diphosphatase activity | exact |
thiamin-pyrophosphatase activity | exact |
thiamin pyrophosphatase activity | exact |
thiamine pyrophosphatase activity | exact |
thiamine diphosphatase activity | broad |
TPPase activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR033713 | Phosphatase NudJ |
RHEA | 27998 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:58937 | thiamine(1+) diphosphate(3-) |
has_participant | CHEBI | CHEBI:37575 | thiamine(1+) monophosphate(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004787 based on ALL annotations
The top 42 of 42 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thiamine diphosphate phosphatase activity
|
31,518.19 | 100.00 | 6,287 | 6,287 |
nucleoside diphosphate phosphatase activity
|
10,115.56 | 32.09 | 6,286 | 19,586 |
ribonucleoside triphosphate phosphatase activity
|
861.25 | 2.73 | 6,286 | 230,041 |
hydrolase activity
|
16.95 | 0.05 | 6,280 | 11,680,370 |
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
|
11.84 | 0.03 | 11 | 29,276 |
AMP biosynthetic process
|
11.57 | 0.03 | 11 | 29,962 |
catalytic activity
|
5.28 | 0.02 | 780 | 4,655,290 |
4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
|
96.09 | 0.02 | 1 | 328 |
GDP phosphatase activity
|
6.61 | 0.01 | 3 | 14,301 |
8-oxo-GDP phosphatase activity
|
4.28 | 0.01 | 4 | 29,446 |
Totals | 26018 | 173670460 |
No co-occurrence statistics for GO:0004787 based on MANUAL annotations
The top 7 of 7 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thiamine diphosphate phosphatase activity
|
705,766.50 | 100.00 | 2 | 2 |
thiamine metabolic process
|
12,381.87 | 1.72 | 1 | 57 |
pyrophosphatase activity
|
3,877.84 | 0.55 | 1 | 182 |
ribonucleoside triphosphate phosphatase activity
|
2,094.26 | 0.30 | 1 | 337 |
nucleoside diphosphate phosphatase activity
|
1,833.16 | 0.26 | 1 | 385 |
phosphatase activity
|
213.74 | 0.03 | 1 | 3,302 |
cellular_component
|
11.28 | 0.00 | 1 | 62,590 |
Totals | 8 | 66855 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-12 | Updated | TERM | thiamine diphosphate phosphatase activity |
2022-06-12 | Deleted | DEFINITION | Catalysis of the reaction: TPP + H2O = TMP + phosphate. |
2022-06-12 | Added | DEFINITION | Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. |
2022-06-12 | Added | SYNONYM | thiamine-diphosphatase activity |
2022-06-12 | Added | SYNONYM | thiamine diphosphatase activity |
2021-02-17 | Added | RELATION | is a GO:0016462 (pyrophosphatase activity) |
2021-02-17 | Added | DEFINITION | Catalysis of the reaction: TPP + H2O = TMP + phosphate. |
2021-02-17 | Deleted | RELATION | is a GO:0017110 (nucleoside diphosphate phosphatase activity) |
2021-02-17 | Added | XREF | RHEA:27998 |
2021-02-17 | Deleted | DEFINITION | Catalysis of the reaction: TDP + H2O = TMP + phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-12 | Updated | TERM | thiamine diphosphate phosphatase activity |
2020-08-01 | Updated | TERM | thiamine-diphosphatase activity |
2010-12-16 | Updated | TERM | thiamine-pyrophosphatase activity |
2004-09-16 | Updated | TERM | thiamin-pyrophosphatase activity |
2003-03-19 | Updated | TERM | thiamin pyrophosphatase activity |
2002-02-06 | Updated | TERM | thiamin pyrophosphatase |
2001-11-04 | Updated | TERM | thiamin pyrophosphatase |
2001-04-03 | Updated | TERM | thiamine pyrophosphatase |
2001-03-30 | Added | TERM | thiamine pyrophosphatase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-12 | Deleted | DEFINITION | Catalysis of the reaction: TPP + H2O = TMP + phosphate. |
2022-06-12 | Added | DEFINITION | Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. |
2022-06-12 | Added | SYNONYM | thiamine-diphosphatase activity |
2022-06-12 | Added | SYNONYM | thiamine diphosphatase activity |
2021-02-17 | Added | DEFINITION | Catalysis of the reaction: TPP + H2O = TMP + phosphate. |
2021-02-17 | Deleted | DEFINITION | Catalysis of the reaction: TDP + H2O = TMP + phosphate. |
2020-10-08 | Deleted | SYNONYM | thiaminpyrophosphatase activity |
2020-10-08 | Added | SYNONYM | thiaminpyrophosphatase activity |
2010-12-16 | Added | SYNONYM | thiamin-pyrophosphatase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: TDP + H2O = TMP + phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: TDP + H2O = TMP + phosphate. |
2007-12-14 | Added | SYNONYM | thiaminpyrophosphatase activity |
2007-08-09 | Added | SYNONYM | thiamin pyrophosphatase activity |
2007-08-09 | Added | SYNONYM | thiamine pyrophosphatase activity |
2007-08-09 | Deleted | SYNONYM | TPPase activity |
2007-08-09 | Added | SYNONYM | TPPase activity |
2007-08-09 | Deleted | SYNONYM | thiamin pyrophosphatase activity |
2007-08-09 | Deleted | SYNONYM | thiamine pyrophosphatase activity |
2004-09-16 | Added | SYNONYM | TPPase activity |
2004-09-16 | Added | SYNONYM | thiamin pyrophosphatase activity |
2004-09-15 | Added | DEFINITION | Catalysis of the reaction: TDP + H2O = TMP + phosphate. |
2004-04-19 | Added | SYNONYM | thiamine pyrophosphatase activity |
2004-04-16 | Deleted | SYNONYM | thiamine pyrophosphatase activity |
2003-09-06 | Added | SYNONYM | thiamine pyrophosphatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | RELATION | is a GO:0016462 (pyrophosphatase activity) |
2021-02-17 | Deleted | RELATION | is a GO:0017110 (nucleoside diphosphate phosphatase activity) |
2008-04-01 | Updated | RELATION | is a GO:0017110 (nucleoside diphosphate phosphatase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | XREF | RHEA:27998 |
2020-08-01 | Deleted | XREF | EC:3.6.1 |
2016-10-03 | Deleted | XREF | EC:3.6.1.- |
2016-10-03 | Added | XREF | EC:3.6.1 |
2001-03-30 | Added | XREF | EC:3.6.1.- |
Timestamp | Action | Category | Detail |
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