This term is obsolete.

GO:0004798 JSON

thymidylate kinase activity

Molecular Function

Definition (GO:0004798 GONUTS page)

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.

50,892 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
TMPK activity related
thymidylic kinase activity related
ATP:dTMP phosphotransferase activity related
dTMP kinase activity exact
thymidine monophosphate kinase activity related
thymidylic acid kinase activity related
deoxythymidine 5'-monophosphate kinase activity related
thymidine 5'-monophosphate kinase activity related
thymidylate monophosphate kinase activity related

Ancestor Chart

Ancestor chart for GO:0004798
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z6G6 7227 A1Z6G6_DROME GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6IDC6 10116 A6IDC6_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8L7 10116 A6K8L7_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8L8 10116 A6K8L8_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZHG3 10116 D3ZHG3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZK09 10116 D3ZK09_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 2.7.4.9
InterPro IPR018094 Thymidylate kinase
InterPro IPR018095 Thymidylate kinase, conserved site
MetaCyc DTMPKI-RXN
RHEA 13517

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:58369 dTDP(3-)
has_participant CHEBI CHEBI:63528 dTMP(2-)
has_participant CHEBI CHEBI:456216 ADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004798 based on ALL annotations
The top 100 of 383 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thymidylate kinase activity
3,845.78 100.00 50,689 50,689
dTDP biosynthetic process
3,845.78 98.84 50,101 50,101
dUDP biosynthetic process
3,845.70 96.01 48,670 48,671
dTTP biosynthetic process
2,153.73 55.40 49,719 88,780
nucleoside monophosphate phosphorylation
874.64 22.74 50,689 222,879
nucleotide biosynthetic process
698.35 17.87 46,605 256,651
nucleoside diphosphate kinase activity
320.17 5.05 5,756 69,139
(d)CMP kinase activity
93.31 1.22 1,206 49,703
kinase activity
36.29 0.94 49,265 5,220,332
cytosol
10.92 0.28 38,961 13,724,995
Totals 500386 181614328
No co-occurrence statistics for GO:0004798 based on MANUAL annotations
The top 39 of 39 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thymidylate kinase activity
6,524.24 100.00 198 198
dTDP biosynthetic process
6,524.24 100.00 198 198
dUDP biosynthetic process
6,491.29 98.99 197 198
dTTP biosynthetic process
6,331.40 96.57 197 203
nucleoside diphosphate kinase activity
1,388.73 19.89 149 700
(d)CMP kinase activity
464.57 4.62 23 323
UMP/dUMP kinase activity
3,262.12 3.88 8 16
thymidine biosynthetic process
3,558.67 2.96 6 11
nucleotide biosynthetic process
1,151.34 2.65 6 34
nucleoside monophosphate phosphorylation
5,436.86 2.51 5 6
Totals 1546 797192

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM thymidine monophosphate kinase activity
2020-10-08 Added SYNONYM ATP:dTMP phosphotransferase activity
2020-10-08 Deleted SYNONYM thymidylic acid kinase activity
2020-10-08 Deleted SYNONYM TMPK activity
2020-10-08 Added SYNONYM deoxythymidine 5'-monophosphate kinase activity
2020-10-08 Added SYNONYM thymidylic acid kinase activity
2020-10-08 Added SYNONYM thymidine 5'-monophosphate kinase activity
2020-10-08 Added SYNONYM TMPK activity
2020-10-08 Added SYNONYM thymidine monophosphate kinase activity
2020-10-08 Deleted SYNONYM thymidylic kinase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM thymidylate kinase activity
2002-02-06 Updated TERM thymidylate kinase
2001-04-03 Updated TERM thymidylate kinase
2001-03-30 Added TERM thymidylate kinase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM thymidine monophosphate kinase activity
2020-10-08 Added SYNONYM ATP:dTMP phosphotransferase activity
2020-10-08 Deleted SYNONYM thymidylic acid kinase activity
2020-10-08 Deleted SYNONYM TMPK activity
2020-10-08 Added SYNONYM deoxythymidine 5'-monophosphate kinase activity
2020-10-08 Added SYNONYM thymidylic acid kinase activity
2020-10-08 Added SYNONYM thymidine 5'-monophosphate kinase activity
2020-10-08 Added SYNONYM TMPK activity
2020-10-08 Added SYNONYM thymidine monophosphate kinase activity
2020-10-08 Deleted SYNONYM thymidylic kinase activity
2020-10-08 Deleted SYNONYM thymidylate monophosphate kinase activity
2020-10-08 Added SYNONYM thymidylic kinase activity
2020-10-08 Deleted SYNONYM thymidine 5'-monophosphate kinase activity
2020-10-08 Deleted SYNONYM deoxythymidine 5'-monophosphate kinase activity
2020-10-08 Deleted SYNONYM ATP:dTMP phosphotransferase activity
2020-10-08 Added SYNONYM thymidylate monophosphate kinase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
2007-11-08 Added SYNONYM ATP:dTMP phosphotransferase activity
2007-11-08 Added SYNONYM thymidylic kinase activity
2007-11-08 Added SYNONYM thymidylate monophosphate kinase activity
2007-11-08 Added SYNONYM thymidine monophosphate kinase activity
2007-11-08 Added SYNONYM thymidine 5'-monophosphate kinase activity
2007-11-08 Added SYNONYM deoxythymidine 5'-monophosphate kinase activity
2007-09-06 Added SYNONYM TMPK activity
2007-09-06 Added SYNONYM thymidylic acid kinase activity
2007-08-09 Added SYNONYM dTMP kinase activity
2007-08-09 Deleted SYNONYM dTMP kinase activity
2004-04-19 Added SYNONYM dTMP kinase activity
2004-04-16 Deleted SYNONYM dTMP kinase activity
2003-10-27 Added SYNONYM dTMP kinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
Timestamp Action Category Detail
2018-05-13 Deleted RELATION is a GO:0019201 (nucleotide kinase activity)
2018-05-13 Deleted RELATION is a GO:0016776 (phosphotransferase activity, phosphate group as acceptor)
2018-05-13 Added RELATION is a GO:0050145 (nucleoside monophosphate kinase activity)
2008-04-01 Updated RELATION is a GO:0016776 (phosphotransferase activity, phosphate group as acceptor)
2008-04-01 Updated RELATION is a GO:0019201 (nucleotide kinase activity)
Timestamp Action Category Detail
2018-07-13 Added XREF RHEA:13517
2018-07-13 Deleted XREF RHEA:13520
2011-09-16 Added XREF RHEA:13520
2003-10-27 Added XREF MetaCyc:DTMPKI-RXN
2001-03-30 Added XREF EC:2.7.4.9
Timestamp Action Category Detail
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