GO:0004798
JSON
thymidylate kinase activity
Molecular Function
Definition (GO:0004798 GONUTS page)
Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
TMPK activity | related |
thymidylic kinase activity | related |
ATP:dTMP phosphotransferase activity | related |
dTMP kinase activity | exact |
thymidine monophosphate kinase activity | related |
thymidylic acid kinase activity | related |
deoxythymidine 5'-monophosphate kinase activity | related |
thymidine 5'-monophosphate kinase activity | related |
thymidylate monophosphate kinase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z6G6 | 7227 | A1Z6G6_DROME | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6IDC6 | 10116 | A6IDC6_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8L7 | 10116 | A6K8L7_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8L8 | 10116 | A6K8L8_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZHG3 | 10116 | D3ZHG3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZK09 | 10116 | D3ZK09_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.4.9 | |
InterPro | IPR018094 | Thymidylate kinase |
InterPro | IPR018095 | Thymidylate kinase, conserved site |
MetaCyc | DTMPKI-RXN | |
RHEA | 13517 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:58369 | dTDP(3-) |
has_participant | CHEBI | CHEBI:63528 | dTMP(2-) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004798 based on ALL annotations
The top 100 of 383 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thymidylate kinase activity
|
3,845.78 | 100.00 | 50,689 | 50,689 |
dTDP biosynthetic process
|
3,845.78 | 98.84 | 50,101 | 50,101 |
dUDP biosynthetic process
|
3,845.70 | 96.01 | 48,670 | 48,671 |
dTTP biosynthetic process
|
2,153.73 | 55.40 | 49,719 | 88,780 |
nucleoside monophosphate phosphorylation
|
874.64 | 22.74 | 50,689 | 222,879 |
nucleotide biosynthetic process
|
698.35 | 17.87 | 46,605 | 256,651 |
nucleoside diphosphate kinase activity
|
320.17 | 5.05 | 5,756 | 69,139 |
(d)CMP kinase activity
|
93.31 | 1.22 | 1,206 | 49,703 |
kinase activity
|
36.29 | 0.94 | 49,265 | 5,220,332 |
cytosol
|
10.92 | 0.28 | 38,961 | 13,724,995 |
Totals | 500386 | 181614328 |
No co-occurrence statistics for GO:0004798 based on MANUAL annotations
The top 39 of 39 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thymidylate kinase activity
|
6,524.24 | 100.00 | 198 | 198 |
dTDP biosynthetic process
|
6,524.24 | 100.00 | 198 | 198 |
dUDP biosynthetic process
|
6,491.29 | 98.99 | 197 | 198 |
dTTP biosynthetic process
|
6,331.40 | 96.57 | 197 | 203 |
nucleoside diphosphate kinase activity
|
1,388.73 | 19.89 | 149 | 700 |
(d)CMP kinase activity
|
464.57 | 4.62 | 23 | 323 |
UMP/dUMP kinase activity
|
3,262.12 | 3.88 | 8 | 16 |
thymidine biosynthetic process
|
3,558.67 | 2.96 | 6 | 11 |
nucleotide biosynthetic process
|
1,151.34 | 2.65 | 6 | 34 |
nucleoside monophosphate phosphorylation
|
5,436.86 | 2.51 | 5 | 6 |
Totals | 1546 | 797192 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | thymidine monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | ATP:dTMP phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | thymidylic acid kinase activity |
2020-10-08 | Deleted | SYNONYM | TMPK activity |
2020-10-08 | Added | SYNONYM | deoxythymidine 5'-monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | thymidylic acid kinase activity |
2020-10-08 | Added | SYNONYM | thymidine 5'-monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | TMPK activity |
2020-10-08 | Added | SYNONYM | thymidine monophosphate kinase activity |
2020-10-08 | Deleted | SYNONYM | thymidylic kinase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | thymidylate kinase activity |
2002-02-06 | Updated | TERM | thymidylate kinase |
2001-04-03 | Updated | TERM | thymidylate kinase |
2001-03-30 | Added | TERM | thymidylate kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | thymidine monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | ATP:dTMP phosphotransferase activity |
2020-10-08 | Deleted | SYNONYM | thymidylic acid kinase activity |
2020-10-08 | Deleted | SYNONYM | TMPK activity |
2020-10-08 | Added | SYNONYM | deoxythymidine 5'-monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | thymidylic acid kinase activity |
2020-10-08 | Added | SYNONYM | thymidine 5'-monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | TMPK activity |
2020-10-08 | Added | SYNONYM | thymidine monophosphate kinase activity |
2020-10-08 | Deleted | SYNONYM | thymidylic kinase activity |
2020-10-08 | Deleted | SYNONYM | thymidylate monophosphate kinase activity |
2020-10-08 | Added | SYNONYM | thymidylic kinase activity |
2020-10-08 | Deleted | SYNONYM | thymidine 5'-monophosphate kinase activity |
2020-10-08 | Deleted | SYNONYM | deoxythymidine 5'-monophosphate kinase activity |
2020-10-08 | Deleted | SYNONYM | ATP:dTMP phosphotransferase activity |
2020-10-08 | Added | SYNONYM | thymidylate monophosphate kinase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
2007-11-08 | Added | SYNONYM | ATP:dTMP phosphotransferase activity |
2007-11-08 | Added | SYNONYM | thymidylic kinase activity |
2007-11-08 | Added | SYNONYM | thymidylate monophosphate kinase activity |
2007-11-08 | Added | SYNONYM | thymidine monophosphate kinase activity |
2007-11-08 | Added | SYNONYM | thymidine 5'-monophosphate kinase activity |
2007-11-08 | Added | SYNONYM | deoxythymidine 5'-monophosphate kinase activity |
2007-09-06 | Added | SYNONYM | TMPK activity |
2007-09-06 | Added | SYNONYM | thymidylic acid kinase activity |
2007-08-09 | Added | SYNONYM | dTMP kinase activity |
2007-08-09 | Deleted | SYNONYM | dTMP kinase activity |
2004-04-19 | Added | SYNONYM | dTMP kinase activity |
2004-04-16 | Deleted | SYNONYM | dTMP kinase activity |
2003-10-27 | Added | SYNONYM | dTMP kinase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-13 | Deleted | RELATION | is a GO:0019201 (nucleotide kinase activity) |
2018-05-13 | Deleted | RELATION | is a GO:0016776 (phosphotransferase activity, phosphate group as acceptor) |
2018-05-13 | Added | RELATION | is a GO:0050145 (nucleoside monophosphate kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016776 (phosphotransferase activity, phosphate group as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0019201 (nucleotide kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Added | XREF | RHEA:13517 |
2018-07-13 | Deleted | XREF | RHEA:13520 |
2011-09-16 | Added | XREF | RHEA:13520 |
2003-10-27 | Added | XREF | MetaCyc:DTMPKI-RXN |
2001-03-30 | Added | XREF | EC:2.7.4.9 |
Timestamp | Action | Category | Detail |
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