This term is obsolete.

GO:0004808 JSON

tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity

Molecular Function

Definition (GO:0004808 GONUTS page)

Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.

Secondary IDs

GO:0016425

13,680 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity exact
tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0004808
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH5 10116 A6JFH5_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7XRZ1 227321 TDIE_EMENI GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A629 10116 D4A629_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 2.1.1.61
InterPro IPR023032 tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
InterPro IPR047785 tRNA mnm(5)s(2)U biosynthesis bifunctional protein MnmC, N-terminal
KEGG_REACTION R00601
MetaCyc RXN0-5144
RHEA 19569

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:74454 5-aminomethyl-2-thiouridine 5'-monophosphate zwitterion residue
has_participant CHEBI CHEBI:74455 5-methylaminomethyl-2-thiouridine 5'-monophosphate zwitterion residue
has_participant CHEBI CHEBI:57856 S-adenosyl-L-homocysteine zwitterion
has_participant CHEBI CHEBI:59789 S-adenosyl-L-methionine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004808 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
14,259.29 100.00 13,671 13,671
oxidoreductase activity, acting on the CH-NH group of donors
11,422.19 77.69 13,161 16,430
tRNA wobble base modification
14,255.11 49.83 6,813 6,815
tRNA wobble uridine modification
390.76 2.61 4,839 176,583
S-adenosylmethionine-dependent methyltransferase activity
160.79 1.11 6,818 604,634
tRNA processing
65.14 0.46 7,987 1,748,269
flavin adenine dinucleotide binding
58.54 0.41 6,817 1,660,475
methylation
44.16 0.31 11,162 3,603,867
methyltransferase activity
42.57 0.30 11,162 3,739,251
tRNA wobble position uridine thiolation
24.68 0.15 151 87,241
Totals 99747 282868560
No co-occurrence statistics for GO:0004808 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term PR S% #Together #Compared
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
161,474.88 100.00 8 8
tRNA wobble uridine modification
1,509.11 0.93 7 749
tRNA wobble position uridine thiolation
421.61 0.26 1 383
FAD binding
125.86 0.08 1 1,283
RNA processing
105.47 0.07 1 1,531
tRNA methylation
88.92 0.05 1 1,816
cytoplasm
7.20 0.00 8 179,389
cellular_component
5.15 0.00 2 62,739
biological_process
4.86 0.00 2 66,439
molecular_function
4.64 0.00 2 69,561
Totals 33 383898

Change Log

Timestamp Action Category Detail
2023-09-23 Deleted SYNONYM S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
2023-09-23 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2023-09-23 Added RELATION is a GO:0016300 (tRNA (uridine) methyltransferase activity)
2023-09-23 Deleted RELATION is a GO:0008175 (tRNA methyltransferase activity)
2023-09-23 Deleted SYNONYM transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
2023-09-23 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
2023-09-23 Added DEFINITION Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.
2023-09-23 Added SYNONYM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
2023-08-11 Added XREF MetaCyc:RXN0-5144
2023-08-11 Deleted XREF MetaCyc:2.1.1.61-RXN
Timestamp Action Category Detail
2023-09-23 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
2003-09-09 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
2003-03-19 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase activity
2002-10-25 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
2002-02-06 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
2001-04-03 Updated TERM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
2001-03-30 Added TERM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Timestamp Action Category Detail
2023-09-23 Deleted SYNONYM S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
2023-09-23 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2023-09-23 Deleted SYNONYM transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
2023-09-23 Added DEFINITION Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.
2023-09-23 Added SYNONYM tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
2020-10-08 Added SYNONYM S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
2020-10-08 Deleted SYNONYM transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
2020-10-08 Deleted SYNONYM tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
2020-10-08 Deleted SYNONYM S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
2020-10-08 Added SYNONYM transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
2020-10-08 Added SYNONYM tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
2013-12-18 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2013-12-18 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2008-05-13 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2007-11-08 Added SYNONYM tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity
2007-11-08 Added SYNONYM transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity
2003-03-19 Deleted SYNONYM tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
2002-11-27 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate.
2001-10-01 Added SYNONYM tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
Timestamp Action Category Detail
2023-09-23 Added RELATION is a GO:0016300 (tRNA (uridine) methyltransferase activity)
2023-09-23 Deleted RELATION is a GO:0008175 (tRNA methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008175 (tRNA methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Timestamp Action Category Detail
2023-08-11 Added XREF MetaCyc:RXN0-5144
2023-08-11 Deleted XREF MetaCyc:2.1.1.61-RXN
2020-06-22 Added XREF RHEA:19569
2019-06-20 Deleted XREF KEGG:R00601
2019-06-20 Added XREF KEGG_REACTION:R00601
2013-12-18 Added XREF KEGG:R00601
2003-10-27 Added XREF MetaCyc:2.1.1.61-RXN
2001-03-30 Added XREF EC:2.1.1.61
Timestamp Action Category Detail
2001-10-01 Added SECONDARY GO:0016425 (tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.