GO:0004808
JSON
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
Molecular Function
Definition (GO:0004808 GONUTS page)
Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.
Secondary IDs
GO:0016425
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity | exact |
tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.61 | |
InterPro | IPR023032 | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC |
InterPro | IPR047785 | tRNA mnm(5)s(2)U biosynthesis bifunctional protein MnmC, N-terminal |
KEGG_REACTION | R00601 | |
MetaCyc | RXN0-5144 | |
RHEA | 19569 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:74454 | 5-aminomethyl-2-thiouridine 5'-monophosphate zwitterion residue |
has_participant | CHEBI | CHEBI:74455 | 5-methylaminomethyl-2-thiouridine 5'-monophosphate zwitterion residue |
has_participant | CHEBI | CHEBI:57856 | S-adenosyl-L-homocysteine zwitterion |
has_participant | CHEBI | CHEBI:59789 | S-adenosyl-L-methionine zwitterion |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004808 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
|
14,259.29 | 100.00 | 13,671 | 13,671 |
oxidoreductase activity, acting on the CH-NH group of donors
|
11,422.19 | 77.69 | 13,161 | 16,430 |
tRNA wobble base modification
|
14,255.11 | 49.83 | 6,813 | 6,815 |
tRNA wobble uridine modification
|
390.76 | 2.61 | 4,839 | 176,583 |
S-adenosylmethionine-dependent methyltransferase activity
|
160.79 | 1.11 | 6,818 | 604,634 |
tRNA processing
|
65.14 | 0.46 | 7,987 | 1,748,269 |
flavin adenine dinucleotide binding
|
58.54 | 0.41 | 6,817 | 1,660,475 |
methylation
|
44.16 | 0.31 | 11,162 | 3,603,867 |
methyltransferase activity
|
42.57 | 0.30 | 11,162 | 3,739,251 |
tRNA wobble position uridine thiolation
|
24.68 | 0.15 | 151 | 87,241 |
Totals | 99747 | 282868560 |
No co-occurrence statistics for GO:0004808 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
|
161,474.88 | 100.00 | 8 | 8 |
tRNA wobble uridine modification
|
1,509.11 | 0.93 | 7 | 749 |
tRNA wobble position uridine thiolation
|
421.61 | 0.26 | 1 | 383 |
FAD binding
|
125.86 | 0.08 | 1 | 1,283 |
RNA processing
|
105.47 | 0.07 | 1 | 1,531 |
tRNA methylation
|
88.92 | 0.05 | 1 | 1,816 |
cytoplasm
|
7.20 | 0.00 | 8 | 179,389 |
cellular_component
|
5.15 | 0.00 | 2 | 62,739 |
biological_process
|
4.86 | 0.00 | 2 | 66,439 |
molecular_function
|
4.64 | 0.00 | 2 | 69,561 |
Totals | 33 | 383898 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Deleted | SYNONYM | S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2023-09-23 | Added | RELATION | is a GO:0016300 (tRNA (uridine) methyltransferase activity) |
2023-09-23 | Deleted | RELATION | is a GO:0008175 (tRNA methyltransferase activity) |
2023-09-23 | Deleted | SYNONYM | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity |
2023-09-23 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate. |
2023-09-23 | Added | SYNONYM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity |
2023-08-11 | Added | XREF | MetaCyc:RXN0-5144 |
2023-08-11 | Deleted | XREF | MetaCyc:2.1.1.61-RXN |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity |
2003-09-09 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity |
2003-03-19 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase activity |
2002-10-25 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase |
2002-02-06 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase |
2001-04-03 | Updated | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase |
2001-03-30 | Added | TERM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Deleted | SYNONYM | S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2023-09-23 | Deleted | SYNONYM | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate. |
2023-09-23 | Added | SYNONYM | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity |
2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity |
2020-10-08 | Added | SYNONYM | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity |
2020-10-08 | Added | SYNONYM | tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity |
2013-12-18 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2013-12-18 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2007-11-08 | Added | SYNONYM | tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity |
2007-11-08 | Added | SYNONYM | S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity |
2007-11-08 | Added | SYNONYM | transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity |
2003-03-19 | Deleted | SYNONYM | tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. |
2001-10-01 | Added | SYNONYM | tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Added | RELATION | is a GO:0016300 (tRNA (uridine) methyltransferase activity) |
2023-09-23 | Deleted | RELATION | is a GO:0008175 (tRNA methyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008175 (tRNA methyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:RXN0-5144 |
2023-08-11 | Deleted | XREF | MetaCyc:2.1.1.61-RXN |
2020-06-22 | Added | XREF | RHEA:19569 |
2019-06-20 | Deleted | XREF | KEGG:R00601 |
2019-06-20 | Added | XREF | KEGG_REACTION:R00601 |
2013-12-18 | Added | XREF | KEGG:R00601 |
2003-10-27 | Added | XREF | MetaCyc:2.1.1.61-RXN |
2001-03-30 | Added | XREF | EC:2.1.1.61 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2001-10-01 | Added | SECONDARY | GO:0016425 (tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase) |
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